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  1. Article ; Online: Gallium-68 Labelled Radiopharmaceuticals for Imaging Inflammatory Disorders.

    Vorster, Mariza

    Seminars in nuclear medicine

    2022  Volume 53, Issue 2, Page(s) 199–212

    Abstract: Inflammation is an important component of several chronic and debilitating diseases that result in significant morbidity and mortality. This is best evidenced within the cardiovascular system where it may manifest as atherosclerosis or myocarditis, and ... ...

    Abstract Inflammation is an important component of several chronic and debilitating diseases that result in significant morbidity and mortality. This is best evidenced within the cardiovascular system where it may manifest as atherosclerosis or myocarditis, and at the extreme end of the spectrum as myocardial infarction, ventricular remodeling, or cardiac failure. Early non-invasive detection and monitoring of inflammation in these and other settings may better guide patient management with resultant improved outcomes. Key role players in inflammation pathophysiology include chemokines, macrophages, neutrophils, fibroblasts, integrins, and reactive oxygen species, amongst others. Examples of receptor expression and over-expression include somatostatin receptors, CXCR4-, folate-, mannose-, TSPO- receptors and secretion of various vascular adhesion molecules (such as VCAM and ICAM). Gallium-68-based PET offers imaging possibilities for nearly all the major pathophysiological role players in inflammation, with mounting recent interest in macrophage differentiation, various forms of receptor expression and secretion of chemokines and vascular adhesion molecules. The advantages in terms of logistics and costs of having generator-produced PET probes available is well known, and a
    MeSH term(s) Humans ; Gallium Radioisotopes ; Radiopharmaceuticals ; Positron-Emission Tomography/methods ; Inflammation ; Receptors, GABA
    Chemical Substances Gallium-68 (98B30EPP5S) ; Gallium Radioisotopes ; Radiopharmaceuticals ; TSPO protein, human ; Receptors, GABA
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2022.08.005
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  2. Article ; Online: Advances in PSMA Alpha Theragnostics.

    Vorster, Mariza / Sathekge, Mike

    Seminars in nuclear medicine

    2024  

    Abstract: Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented ... ...

    Abstract Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented with
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2024.03.004
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  3. Article: Management of a permanent lateral incisor with a talon cusp and immature apex: A case report.

    van der Vyver, Peet / Potgieter, Nicoline / Vorster, Martin

    Clinical case reports

    2024  Volume 12, Issue 1, Page(s) e8404

    Abstract: This case report focuses on the diagnosis and treatment of a maxillary lateral incisor affected by a talon cusp, a rare developmental dental anomaly. The case presented with irreversible pulpitis and an immature apex. The article discusses the prevalence, ...

    Abstract This case report focuses on the diagnosis and treatment of a maxillary lateral incisor affected by a talon cusp, a rare developmental dental anomaly. The case presented with irreversible pulpitis and an immature apex. The article discusses the prevalence, etiology, classification, and treatment options for talon cusps, highlighting their clinical significance and potential complications. Clinical and radiographic findings obtained from a periapical radiograph and a cone-beam computed tomography (CBCT) scan are outlined. The treatment approach involved the removal of the talon cusp, endodontic therapy including apexification with mineral trioxide aggregate, and aesthetic restoration of the tooth. The report underscores the value of precise diagnosis, careful treatment planning, and the utility of CBCT scans in effectively managing talon cusps.
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8404
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  4. Article: Potency Assays: The 'Bugaboo' of Stem Cell Therapy.

    Torrents, Sílvia / Grau-Vorster, Marta / Vives, Joaquim

    Advances in experimental medicine and biology

    2023  Volume 1420, Page(s) 29–38

    Abstract: Substantially manipulated cell-based products for human use are considered medicines and therefore regulatory authorities require extensive characterisation in terms of identity, purity and potency. The latter critical quality attribute is probably the ... ...

    Abstract Substantially manipulated cell-based products for human use are considered medicines and therefore regulatory authorities require extensive characterisation in terms of identity, purity and potency. The latter critical quality attribute is probably the most challenging to identify and measure, requiring provision that potency assays should reflect the intended mechanism of action and demonstrate the drugs' biological effect. However, in most cases, the mechanisms involved are not fully understood, making the definition and validation of suitable potency tests difficult, a 'bugaboo' quest to be feared. Although it is evident that much work is still needed in the scientific arena, the present chapter focuses on strategies currently used by developers of cell- and gene-based therapies to demonstrate potency of innovative medicines, the regulatory framework and need for standardisation seeking to demystify critical factors to consider when designing a potency assay.
    MeSH term(s) Humans ; Reference Standards ; Stem Cell Transplantation ; Genetic Therapy ; Cell- and Tissue-Based Therapy
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-30040-0_3
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  5. Article: Illustrative Potency Assay Examples from Approved Therapies.

    Torrents, Sílvia / Grau-Vorster, Marta / Vives, Joaquim

    Advances in experimental medicine and biology

    2023  Volume 1420, Page(s) 139–149

    Abstract: Advanced therapy medicinal products (ATMP) encompass a new type of drugs resulting from the manipulation of genes, cells, and tissues to generate innovative medicinal entities with tailored pharmaceutical activity. Definition of suitable potency tests ... ...

    Abstract Advanced therapy medicinal products (ATMP) encompass a new type of drugs resulting from the manipulation of genes, cells, and tissues to generate innovative medicinal entities with tailored pharmaceutical activity. Definition of suitable potency tests for product release are challenging in this context, in which the active ingredient is composed of living cells and the mechanism of action often is poorly understood. In this chapter, we present and discuss actual potency assays used for the release of representative commercial ATMP from each category of products (namely, KYMRIAH
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-30040-0_9
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  6. Article ; Online: Viewpoint: Support for grassroots could rescue general practice.

    Vorster, Mark

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2017  Volume 67, Issue 655, Page(s) 73

    MeSH term(s) General Practice/organization & administration ; General Practice/standards ; Health Planning Support ; Humans ; Workload
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp17X689173
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    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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  7. Article ; Online: Assessment of pharmacovigilance guidelines in the Southern African Development Community: A document review.

    Makhene, Nokuthula L / Steyn, Hanlie / Vorster, Martine / Lubbe, Martha S / Burger, Johanita R

    Pharmacoepidemiology and drug safety

    2024  Volume 33, Issue 2, Page(s) e5755

    Abstract: Background: Lack of harmonization in pharmacovigilance (PV) practice in resource-limited states in Africa has led to differentiation and marginalization, thus creating an environment where weak or absent PV systems may benefit from regional guidelines.!# ...

    Abstract Background: Lack of harmonization in pharmacovigilance (PV) practice in resource-limited states in Africa has led to differentiation and marginalization, thus creating an environment where weak or absent PV systems may benefit from regional guidelines.
    Purpose: To compare the PV guidelines of Southern African Development Community (SADC) member states to international guidelines and identify areas for improvement for aligning PV practice within the SADC region.
    Methods: We utilized a 73-item checklist to assess the PV guidelines of the SADC member states. Checklist parameters were rated using binary scoring.
    Results: Only seven (Botswana, Mauritius, Namibia, South Africa, Tanzania, Zambia, and Zimbabwe) of the 16 SADC member states had guidelines to assess. Of these, only four had supporting legislation. All seven national medicines regulatory authorities (NMRA)'s guidelines required reporting of local serious adverse drug reactions (ADRs). Four NMRAs implemented device vigilance; none specified submission timelines for ADRs associated with substandard or falsified medicines. Only three NMRAs required electronic transmission of individual case safety reports in the E2B format. Five NMRAs mandated safety monitoring during interventional clinical trials. Five NMRAs required aggregate reporting through periodic safety update reports. Only two NMRAs required submission of the development safety update report. Regarding risk management, four NMRAs required notification of actions taken by foreign NMRAs and four NMRAs expected to review Dear Healthcare Professional Letters before distribution by the marketing authorization holder.
    Conclusions: Areas for improvement of guidelines to establish common process standards and allow for synchronized submissions of comparable data to SADC NMRAs are provided.
    MeSH term(s) Humans ; Pharmacovigilance ; Risk Management
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5755
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    Zs.A 3395: Show issues Location:
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  8. Article: The Role of PET/CT in Breast Cancer.

    Hadebe, Bawinile / Harry, Lerwine / Ebrahim, Tasmeera / Pillay, Venesen / Vorster, Mariza

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, with an estimated 2.3 million new cases (11.7%), followed by lung cancer (11.4%) The current literature and the National Comprehensive Cancer Network (NCCN) ... ...

    Abstract Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, with an estimated 2.3 million new cases (11.7%), followed by lung cancer (11.4%) The current literature and the National Comprehensive Cancer Network (NCCN) guidelines state that
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13040597
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  9. Article: Apexification of dens evaginatus in a mandibular premolar: A case report.

    van der Vyver, Peet J / Vorster, Martin / Buchanan, Glynn Dale

    Clinical case reports

    2023  Volume 11, Issue 5, Page(s) e07316

    Abstract: Key clinical message: Dens evaginatus is an uncommon dental anomaly presenting on mandibular premolar teeth. Affected teeth are difficult to diagnose and manage, and often demonstrate immature apices requiring complex endodontic treatment approaches.: ...

    Abstract Key clinical message: Dens evaginatus is an uncommon dental anomaly presenting on mandibular premolar teeth. Affected teeth are difficult to diagnose and manage, and often demonstrate immature apices requiring complex endodontic treatment approaches.
    Abstract: Dens evaginatus (DE) is an uncommon anomaly affecting mandibular premolars, frequently requiring endodontic intervention. This report documents the treatment of an immature mandibular premolar presenting with DE. Early diagnosis and preventive strategies remain the preferred management for these anomalies, however endodontic approaches may be successfully applied to retain these teeth.
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7316
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  10. Article ; Online: PET/CT features of a novel gallium-68 labelled hypoxia seeking agent in patients diagnosed with tuberculosis: a proof-of-concept study.

    Bresser, Philippa L / Sathekge, Mike M / Vorster, Mariza

    Nuclear medicine communications

    2022  Volume 43, Issue 7, Page(s) 787–793

    Abstract: Introduction: Positron emission tomography/computed tomography (PET/CT) in infection and inflammation has yielded promising results across a range of radiopharmaceuticals. In particular, PET/CT imaging of tuberculosis (TB) allows for a better ... ...

    Abstract Introduction: Positron emission tomography/computed tomography (PET/CT) in infection and inflammation has yielded promising results across a range of radiopharmaceuticals. In particular, PET/CT imaging of tuberculosis (TB) allows for a better understanding of this complex disease by providing insights into molecular processes within the TB microenvironment. TB lesions are hypoxic with research primarily focussed on cellular processes occurring under hypoxic stress. With the development of hypoxia seeking PET/CT radiopharmaceuticals, that can be labelled in-house using a germanium-68/gallium-68 (68Ge/68Ga) generator, a proof-of-concept for imaging hypoxia in TB is presented.
    Methods: Ten patients diagnosed with TB underwent whole-body PET/CT imaging, 60-90 min after intravenous administration of 74-185 MBq (2-5 mCi) 68Ga-nitroimidazole. No oral or intravenous contrast was administered. Images were visually and semiquantitatively assessed for abnormal 68Ga-uptake in the lungs.
    Results: A total of 28 lesions demonstrating hypoxic uptake were identified. Low- to moderate-uptake was seen in nodules, areas of consolidation and cavitation as well as effusions. The mean standard uptake value (SUVmean) of the lesions was 0.47 (IQR, 0.32-0.82) and SUVmax was 0.71 (IQR, 0.41-1.11). The lesion to muscle ratio (median, 1.70; IQR, 1.15-2.31) was higher than both the left ventricular and the aorta lesion to blood ratios.
    Conclusion: Moving towards the development of unique host-directed therapies (HDT), modulation of oxygen levels may improve therapeutic outcome by reprogramming TB lesions to overcome hypoxia. This proof-of-concept study suggests that hypoxia in TB lesions can be imaged and quantified using 68Ga-nitroimidazole PET/CT. Subsequently, hypoxic load can be estimated to inform personalised treatment plans of patients diagnosed with TB.
    MeSH term(s) Humans ; Gallium Radioisotopes ; Hypoxia/diagnostic imaging ; Lung Diseases/microbiology ; Lung Diseases/pathology ; Nitroimidazoles ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Tuberculosis/diagnostic imaging
    Chemical Substances Gallium Radioisotopes ; Gallium-68 (98B30EPP5S) ; Nitroimidazoles ; Radiopharmaceuticals
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001580
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    Zs.A 1577: Show issues Location:
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