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  1. Article ; Online: Effectiveness of a Mobile Health and Self-Management App for High-Risk Patients With Chronic Obstructive Pulmonary Disease in Daily Clinical Practice: Mixed Methods Evaluation Study.

    Kooij, Laura / Vos, Petra J E / Dijkstra, Antoon / van Harten, Wim H

    JMIR mHealth and uHealth

    2021  Volume 9, Issue 2, Page(s) e21977

    Abstract: Background: Mobile health and self-management interventions may positively affect behavioral change and reduce hospital admissions for patients with chronic obstructive pulmonary disease (COPD). However, not all patients qualify for these interventions, ...

    Abstract Background: Mobile health and self-management interventions may positively affect behavioral change and reduce hospital admissions for patients with chronic obstructive pulmonary disease (COPD). However, not all patients qualify for these interventions, and systematic, comprehensive information on implementation- and compliance-related aspects of mobile self-management apps is lacking. Due to the tendency to target digital services to patients in stable phases of disease, it is especially relevant to focus on the use of these services in broad clinical practice for patients recently discharged from hospital.
    Objective: This study aims to evaluate the effects of a mobile health and self-management app in clinical practice for recently discharged patients with COPD on use of the app, self-management, expectations, and experiences (technology acceptance); patients' and nurses' satisfaction; and hospital readmissions.
    Methods: A prototype of the app was pilot tested with 6 patients with COPD. The COPD app consisted of an 8-week program including the Lung Attack Action Plan, education, medication overview, video consultation, and questionnaires (monitored by nurses). In the feasibility study, adult patients with physician-diagnosed COPD, access to a mobile device, and proficiency of the Dutch language were included from a large teaching hospital during hospital admission. Self-management (Partners in Health Scale), technology acceptance (Unified Theory Acceptance and Use of Technology model), and satisfaction were assessed using questionnaires at baseline, after 8 weeks, and 20 weeks. Use was assessed with log data, and readmission rates were extracted from the electronic medical record.
    Results: A total of 39 patients were included; 76.4% (133/174) of patients had to be excluded from participation, and 48.9% of those patients (65/133) were excluded because of lack of digital skills, access to a mobile device, or access to the internet. The COPD app was opened most often in the first week (median 6.0; IQR 3.5-10.0), but its use decreased over time. The self-management element knowledge and coping increased significantly over time (P=.04). The COPD app was rated on a scale of 1-10, with an average score by patients of 7.7 (SD 1.7) and by nurses of 6.3 (SD 1.2). Preliminary evidence about the readmission rate showed that 13% (5/39) of patients were readmitted within 30 days; 31% (12/39) of patients were readmitted within 20 weeks, compared with 14.1% (48/340) and 21.8% (74/340) in a preresearch cohort, respectively.
    Conclusions: The use of a mobile self-management app after hospital discharge seems to be feasible only for a small number of patients with COPD. Patients were satisfied with the service; however, use decreased over time, and only knowledge and coping changed significantly over time. Therefore, future research on digital self-management interventions in clinical practice should focus on including more difficult subgroups of target populations, a multidisciplinary approach, technology-related aspects (such as acceptability), and fine-tuning its adoption in clinical pathways.
    Trial registration: Clinicaltrials.gov NCT04540562; https://clinicaltrials.gov/ct2/show/NCT04540562.
    MeSH term(s) Adult ; Humans ; Mobile Applications ; Pulmonary Disease, Chronic Obstructive/therapy ; Self-Management ; Surveys and Questionnaires ; Telemedicine
    Language English
    Publishing date 2021-02-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719220-9
    ISSN 2291-5222 ; 2291-5222
    ISSN (online) 2291-5222
    ISSN 2291-5222
    DOI 10.2196/21977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using the Lower Limit of Normal Instead of the Conventional Cutoff Values to Define Predictors of Pulmonary Function Impairment in Subjects With Chronic Heart Failure.

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Respiratory care

    2016  Volume 61, Issue 2, Page(s) 173–183

    Abstract: Background: Using the newer lower limit of normal criterion instead of the conventional cutoff values to define pulmonary function abnormalities may result in different predictors of pulmonary function impairment in patients with heart failure. ... ...

    Abstract Background: Using the newer lower limit of normal criterion instead of the conventional cutoff values to define pulmonary function abnormalities may result in different predictors of pulmonary function impairment in patients with heart failure. Therefore, we assessed predictors of pulmonary function impairment in subjects with chronic heart failure according to the lower limit of normal in comparison with conventional cutoff values.
    Methods: In this prospective cross-sectional study, 164 chronic heart failure subjects (age 68 ± 10 y, 78% men, 88% New York Heart Association class I-II) with left ventricular ejection fraction <40% underwent pulmonary function tests. Predictors of pulmonary function impairment were assessed using the lower limit of normal and conventional cutoff values (ie, 80% predicted value and the fixed ratio of FEV1/FVC <0.7).
    Results: The lower limit of normal criterion identified an extra independent predictor of diffusion impairment compared with the 80% predicted value; in addition to body mass index, pack-years, and alveolar volume, female sex also turned out to be an independent predictor. A smoking history of ≥10 pack-years was a significant predictor of diffusion impairment and airway obstruction using the lower limit of normal criterion but not using the conventional cutoff values. However, lowering the cutoff points of conventional criteria to match the more stringent lower limit of normal and thus avoid overdiagnosis of diffusion impairment and airway obstruction in the elderly produced similar results as the lower limit of normal.
    Conclusions: The lower limit of normal identifies more predictors of diffusion impairment and airway obstruction compared with conventional cutoff values in subjects with chronic heart failure with left ventricular systolic dysfunction. However, lowering the conventional cutoff points yielded similar results as the lower limit of normal. (ClinicalTrials.gov registration NCT01429376.).
    MeSH term(s) Aged ; Airway Obstruction/diagnosis ; Airway Obstruction/etiology ; Body Mass Index ; Cross-Sectional Studies ; Female ; Heart Failure/complications ; Heart Failure/physiopathology ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/etiology ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Reference Values ; Respiratory Function Tests/standards ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/etiology ; Risk Factors ; Sex Factors ; Smoking/adverse effects
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.04101
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  3. Article: Tube breathing as a new potential method to perform respiratory muscle training: safety in healthy volunteers.

    Koppers, Ralph J H / Vos, Petra J E / Folgering, Hans Th M

    Respiratory medicine

    2006  Volume 100, Issue 4, Page(s) 714–720

    Abstract: Normocapnic hyperpnea has been established as a method of respiratory muscle endurance training (RMET). This technique has not been applied on a large scale because complicated and expensive equipment is needed to maintain CO(2)-homeostasis during ... ...

    Abstract Normocapnic hyperpnea has been established as a method of respiratory muscle endurance training (RMET). This technique has not been applied on a large scale because complicated and expensive equipment is needed to maintain CO(2)-homeostasis during hyperpnea. This CO(2)-homeostasis can be preserved during hyperpnea by enlarging the dead space of the ventilatory system. One of the possibilities to enlarge dead space is breathing through a tube. If tube breathing is safe and feasible, it may be a new and inexpensive method for RMET, enabling its widespread use. The aim of this study was to evaluate the safety of tube breathing and investigate the effect on CO(2)-homeostasis in healthy subjects. A total of 20 healthy volunteers performed 10 min of tube breathing (dead space 60% of vital capacity). Oxygen-saturation, PaCO(2), respiratory muscle function, hypercapnic ventilatory response and dyspnea (Borg-score) were measured. Tube breathing did not lead to severe complaints, adverse events or oxygen desaturations. A total of 14 out of 20 subjects became hypercapnic (PaCO(2)>6.0 kPa) during tube breathing. There were no significant correlations between PaCO(2) and respiratory muscle function or hypercapnic ventilatory responses. The normocapnic versus hypercapnic subjects showed no significant differences between decrease in oxygen saturation (-0.7% versus -0.2%, respectively, P=0.6), Borg score (4.3 versus 4.7, P=0.9), respiratory muscle function nor hypercapnic ventilatory responses. Our results show that tube breathing is well tolerated amongst healthy subjects. No complaints, nor desaturations occurred. Hypercapnia developed in a substantial number of subjects. When tube breathing will be applied as respiratory muscle training modality, this potential development of hypercapnia must be considered.
    MeSH term(s) Adolescent ; Adult ; Breathing Exercises ; Carbon Dioxide/blood ; Dyspnea/etiology ; Dyspnea/physiopathology ; Female ; Homeostasis ; Humans ; Hypercapnia/etiology ; Hypercapnia/physiopathology ; Male ; Oxygen/blood ; Partial Pressure ; Respiratory Dead Space ; Respiratory Function Tests ; Respiratory Mechanics/physiology ; Respiratory Muscles/physiopathology ; Spirometry/instrumentation
    Chemical Substances Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2006-04
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2005.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pulmonary function impairment in patients with chronic heart failure: lower limit of normal versus conventional cutoff values.

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Heart & lung : the journal of critical care

    2014  Volume 43, Issue 4, Page(s) 311–316

    Abstract: Objective: To determine the prevalence of pulmonary function abnormalities in patients with chronic heart failure (HF) according to recent American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines using the lower limit of normal (LLN) ... ...

    Abstract Objective: To determine the prevalence of pulmonary function abnormalities in patients with chronic heart failure (HF) according to recent American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines using the lower limit of normal (LLN) compared to conventional cutoff values.
    Background: Recent ATS/ERS guidelines recommend the use of the LLN instead of the conventional cutoff values to define pulmonary function impairment to avoid misclassification of patients. However, studies addressing the prevalence of pulmonary function abnormalities according to both definitions in patients with chronic HF are lacking.
    Methods: In this prospective cross-sectional study, 164 chronic HF outpatients (age 68 ± 10 years, 78% men, 88% New York Heart Association class I-II) with left ventricular ejection fraction < 40% underwent spirometry and measurement of diffusing capacity. Body plethysmography was performed in patients with abnormal spirometry results.
    Results: Diffusion impairment and airway obstruction were found in 44-58% and 26-37% of the patients, respectively, depending on the definition used (LLN versus conventional cutoff values, p < 0.05). However, restriction was infrequent, irrespective of the definition used (7% versus 5%, respectively, p > 0.05). The LLN identified fewer patients with abnormal lung function, whereas the conventional cutoff values classified more patients with diffusion impairment, airway obstruction, or a mixed category. Twenty-seven percent of patients were misclassified by the conventional cutoff values.
    Conclusion: Pulmonary function abnormalities, especially diffusion impairment and airway obstruction, were highly prevalent in patients with chronic HF. Conventional cutoff values classified more patients with diffusion impairment, airway obstruction, or a mixed category compared to the LLN.
    MeSH term(s) Aged ; Airway Obstruction/diagnosis ; Airway Obstruction/etiology ; Chronic Disease ; Cross-Sectional Studies ; Female ; Heart Failure/complications ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Diffusing Capacity ; Respiratory Function Tests/standards
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2014.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Exercise performance improves in patients with COPD due to respiratory muscle endurance training.

    Koppers, Ralph J H / Vos, Petra J E / Boot, Cecile R L / Folgering, Hans Th M

    Chest

    2006  Volume 129, Issue 4, Page(s) 886–892

    Abstract: Background: Impaired exercise tolerance is frequently observed in patients with COPD. Respiratory muscle endurance training (RMET) by means of normocapnic hyperpnea can be used to improve respiratory muscle function and probably exercise capacity. RMET ... ...

    Abstract Background: Impaired exercise tolerance is frequently observed in patients with COPD. Respiratory muscle endurance training (RMET) by means of normocapnic hyperpnea can be used to improve respiratory muscle function and probably exercise capacity. RMET is not applied on a large scale because complicated equipment is needed to maintain carbon dioxide homeostasis during hyperpnea, which can also be done by enlarging the dead space of the ventilatory system by breathing through a tube. Therefore, tube breathing might be a new, inexpensive method for home-based RMET. The aim of this study was to assess whether home-based RMET by means of tube breathing improves endurance exercise performance in patients with COPD.
    Methods: We randomized 36 patients with moderate-to-severe COPD to RMET by paced tube breathing (n = 18) or sham training (control, n = 18). Both groups trained twice daily for 15 min, 7 days per week, for 5 weeks.
    Results: Patients receiving RMET showed significant improvements in endurance exercise capacity (constant-load exercise on cycle ergometry; 18 min vs 28 min, p < 0.001), in perception of dyspnea (Borg score; 8.4 vs 5.4, p < 0.001), and respiratory muscle endurance capacity (sustainable inspiratory pressure; 25 cm H(2)O vs 31 cm H(2)O, p = 0.005). Quality of life (chronic respiratory disease questionnaire) also improved (78.7 to 86.6, p = 0.001). The control group showed no significant changes.
    Conclusion: Home-based RMET by means of tube breathing leads to a significant improvement of endurance exercise capacity, a reduction in perception of dyspnea, and an improvement in quality of life in patients with moderate-to-severe COPD.
    MeSH term(s) Aged ; Breathing Exercises ; Dyspnea/etiology ; Dyspnea/prevention & control ; Exercise Tolerance/physiology ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/rehabilitation ; Quality of Life ; Respiratory Function Tests ; Respiratory Muscles/physiopathology ; Treatment Outcome
    Language English
    Publishing date 2006-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.129.4.886
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  6. Article ; Online: Reply to letter to the Editor.

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Heart & lung : the journal of critical care

    2013  Volume 42, Issue 3, Page(s) 229–230

    MeSH term(s) Bronchi/drug effects ; Bronchodilator Agents/administration & dosage ; Female ; Heart Failure/physiopathology ; Humans ; Male
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2013.03.001
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  7. Article ; Online: Bronchodilator responsiveness in patients with chronic heart failure.

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Heart & lung : the journal of critical care

    2013  Volume 42, Issue 3, Page(s) 208–214

    Abstract: Objective: The aim of this study was to evaluate the effect of inhaled bronchodilators on pulmonary function and dyspnea in patients with chronic heart failure (HF).: Background: Conflicting data exist on whether bronchodilators may improve pulmonary ...

    Abstract Objective: The aim of this study was to evaluate the effect of inhaled bronchodilators on pulmonary function and dyspnea in patients with chronic heart failure (HF).
    Background: Conflicting data exist on whether bronchodilators may improve pulmonary function and dyspnea in patients with chronic HF.
    Methods: In this retrospective observational study we analyzed data of 116 chronic HF outpatients with systolic dysfunction who underwent spirometry and Borg dyspnea measurements before and after inhalation of 400 μg salbutamol and 80 μg ipratropium. Patients with chronic obstructive pulmonary disease (COPD) or asthma were excluded.
    Results: Bronchodilators fully reversed airway obstruction (AO) in 25 of 64 (39.1%) patients with pre-bronchodilator AO. All spirometric measurements, except for forced vital and inspiratory capacities, improved significantly post-bronchodilation. Absolute and percent improvements in forced expiratory volume in 1 s (FEV1) were more pronounced in patients with persistent AO post-bronchodilation compared to those without AO (0.19 ± 0.18 L and 8.4 ± 7.3% versus 0.11 ± 0.12 L and 4.3 ± 4.0%, p < 0.05). Significant bronchodilator responsiveness of FEV1 (>200 mL and >12%) was noted in 12.1% and was more frequent in patients with persistent AO and fully reversible AO than in those without AO (23.1% and 16.0% versus 1.9%, p < 0.05). We measured a small, albeit significant improvement in dyspnea (0.7 ± 1.2 versus 0.9 ± 1.3, p = 0.002).
    Conclusions: Inhaled bronchodilators may have an additional role in the management of patients with chronic HF because of their potential to improve pulmonary function, especially in those with AO. The clinical usefulness and possible adverse events of bronchodilators need to be further established.
    MeSH term(s) Administration, Inhalation ; Aged ; Albuterol/administration & dosage ; Bronchi/drug effects ; Bronchi/physiopathology ; Bronchodilator Agents/administration & dosage ; Female ; Follow-Up Studies ; Heart Failure/complications ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Male ; Prognosis ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Function Tests
    Chemical Substances Bronchodilator Agents ; Albuterol (QF8SVZ843E)
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2012.11.007
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  8. Article ; Online: COPD in chronic heart failure: less common than previously thought?

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Heart & lung : the journal of critical care

    2013  Volume 42, Issue 5, Page(s) 365–371

    Abstract: Background: Using a fixed ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) < 0.70 instead of the lower limit of normal (LLN) to define chronic obstructive pulmonary disease (COPD) may lead to overdiagnosis of COPD in elderly ... ...

    Abstract Background: Using a fixed ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) < 0.70 instead of the lower limit of normal (LLN) to define chronic obstructive pulmonary disease (COPD) may lead to overdiagnosis of COPD in elderly patients with heart failure (HF) and consequently unnecessary treatment with possible adverse health effects.
    Objective: The aim of this study was to determine COPD prevalence in patients with chronic HF according to two definitions of airflow obstruction.
    Methods: Spirometry was performed in 187 outpatients with stable chronic HF without pulmonary congestion who had a left ventricular ejection fraction <40% (mean age 69 ± 10 years, 78% men). COPD diagnosis was confirmed 3 months after standard treatment with tiotropium in newly diagnosed COPD patients.
    Results: COPD prevalence varied substantially between 19.8% (LLN-COPD) and 32.1% (GOLD-COPD). Twenty-three of 60 patients (38.3%) with GOLD-COPD were potentially misclassified as having COPD (FEV1/FVC < 0.7 but > LLN). In contrast to patients with LLN-COPD, potentially misclassified patients did not differ significantly from those without COPD regarding respiratory symptoms and risk factors for COPD.
    Conclusions: One fifth, rather than one third, of the patients with chronic HF had concomitant COPD using the LLN instead of the fixed ratio. LLN may identify clinically more important COPD than a fixed ratio of 0.7.
    MeSH term(s) Aged ; Aged, 80 and over ; Chronic Disease ; Cohort Studies ; Female ; Forced Expiratory Volume ; Heart Failure/complications ; Humans ; Male ; Middle Aged ; Prevalence ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Risk Factors ; Spirometry ; Vital Capacity
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2013.07.002
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  9. Article ; Online: Reply to letter to the Editor.

    Minasian, Armine G / van den Elshout, Frank J J / Dekhuijzen, P N Richard / Vos, Petra J E / Willems, Frank F / van den Bergh, Paul J P C / Heijdra, Yvonne F

    Heart & lung : the journal of critical care

    2013  Volume 42, Issue 5, Page(s) 388–389

    MeSH term(s) Bronchi/drug effects ; Bronchodilator Agents/administration & dosage ; Female ; Heart Failure/physiopathology ; Humans ; Male
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2013.07.003
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  10. Article ; Online: Manual vs. automated analysis of polysomnographic recordings in patients with chronic obstructive pulmonary disease.

    Stege, Gerben / Vos, Petra J E / Dekhuijzen, P N Richard / Hilkens, Pieter H E / van de Ven, Marjo J T / Heijdra, Yvonne F / van den Elshout, Frank J J

    Sleep & breathing = Schlaf & Atmung

    2012  Volume 17, Issue 2, Page(s) 533–539

    Abstract: Purpose: The sleep quality, as assessed by polysomnography (PSG), of patients with chronic obstructive pulmonary disease (COPD) can be severely disturbed. The manual analysis of PSGs is time-consuming, and computer systems have been developed to ... ...

    Abstract Purpose: The sleep quality, as assessed by polysomnography (PSG), of patients with chronic obstructive pulmonary disease (COPD) can be severely disturbed. The manual analysis of PSGs is time-consuming, and computer systems have been developed to automatically analyze PSGs. Studies on the reliability of automated analyses in healthy subjects show varying results, and the purpose of this study was to assess whether automated analysis of PSG by one certain automatic system in patients with COPD provide accurate outcomes when compared to manual analysis.
    Methods: In a retrospective study, the full-night polysomnographic recordings of patients with and without COPD were analyzed automatically by Matrix Sleep Analysis software and manually. The outcomes of manual and automated analyses in both groups were compared using Bland-Altman plots and Students' paired t tests.
    Results: Fifty PSGs from patients with COPD and 57 PSGs from patients without COPD were included. In both study groups, agreement between manual and automated analysis was poor in nearly all sleep and respiratory parameters, like total sleep time, sleep efficiency, sleep latency, amount of rapid eye movement sleep and other sleep stages, number of arousals, apnea-hypopnea index, and desaturation index.
    Conclusion: Automated analysis of PSGs by the studied automated system in patients with COPD has poor agreement with manual analysis when looking at sleep and respiratory parameters and should, therefore, not replace the manual analysis of PSG recordings in patients with COPD.
    MeSH term(s) Aged ; Arousal/physiology ; Female ; Humans ; Male ; Middle Aged ; Polysomnography/methods ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Retrospective Studies ; Signal Processing, Computer-Assisted ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology
    Language English
    Publishing date 2012-05-10
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-012-0714-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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