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  1. Book: Traumatic brain injury

    Vos, Pieter E. / Diaz-Arrastia, Ramon

    2015  

    Author's details ed. by Pieter E. Vos ; Ramon Diaz-Arrastia
    Keywords Brain Injuries / diagnosis ; Brain Injuries / therapy
    Language English
    Size XII, 231 S. : Ill., graph. Darst.
    Publisher Wiley Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index ; The clinical problem of traumatic head injury / Ramon Diaz-Arrastia and Pieter E. Vos -- Neuroimaging in traumatic brain injury / Pieter E. Vos, Carlos Marquez de la Plata, and Ramon Diaz-Arrastia -- Out of hospital management in traumatic brain injury / Peter R.G. Brink -- Emergency department evaluation of mild traumatic brain injury / Noel S. Zuckerbraun, C. Christopher King, and Rachel P. Berger -- In-hospital observation for mild traumatic brain injury / Pieter E. Vos and Dafin F. Muresanu -- ICU care : surgical and medical management : indications for immediate surgery / Peter S. Amenta and Jack Jallo -- ICU Care : surgical and medical management : neurological monitoring and treatment / Luzius A. Steiner -- ICU Care : surgical and medical management : systemic treatment / Lori Shutter -- Rehabilitation of cognitive deficits after traumatic brain injury / Philippe Azouvi and Claire Vallat-Azouvi -- Epidemiology of traumatic brain injury / Ramon Diaz-Arrastia and Kimbra Kenney -- Neuropsychiatric and behavioral sequelae / Kathleen F. Pagulayan and Jesse R. Fann -- Follow-up and community integration of mild traumatic brain injury / Joukje van der Naalt and Joke M. Spikman
    HBZ-ID HT018540105
    ISBN 978-1-4443-3770-9 ; 1-4443-3770-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 646 available for loan (reading room) Lesesaal EG

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  2. Book ; Thesis: Molecular cloning and expression of full-length DNA copies of the genomic RNAs of cowpea mosaic virus

    Vos, Pieter

    1987  

    Author's details door Pieter Vos
    Size 127 S., Ill., graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Wageningen, Landbouwuniv., Diss., 1987
    HBZ-ID HT005026996
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    AY 12779 order for loan Geschlossenes Magazin (U2)

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  3. Book ; Online: The Law of God

    Vos, Pieter / Zijlstra, Onno

    Exploring God and Civilization

    (Studies in Reformed Theology ; 28)

    2014  

    Abstract: In today's society, religion as adherence to 'the law of God' is often considered inherently violent and a threat to civilization. This volume contains theological and philosophical explorations of clashes as well as disclosures of God and ... ...

    Series title Studies in Reformed Theology ; 28
    Abstract In today's society, religion as adherence to 'the law of God' is often considered inherently violent and a threat to civilization. This volume contains theological and philosophical explorations of clashes as well as disclosures of God and civilization
    Language English
    Size Online-Ressource (336 p)
    Publisher BRILL
    Publishing place Leiden
    Document type Book ; Online
    ISBN 9789004281837 ; 9004281835
    DOI 10.1163/9789004281844
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Successful epilepsy surgery in two cases with multiple sclerosis.

    van Klink, Nicole / Tousseyn, Simon / Schijns, Olaf / van Eijsden, Pieter / Vos, Pieter / Hilkman, Danny / Killestein, Joep / Leijten, Frans

    Epileptic disorders : international epilepsy journal with videotape

    2023  Volume 25, Issue 6, Page(s) 890–894

    Abstract: Brain surgery is the only curative treatment for people with focal epilepsy, but it is unclear whether this induces active disease in multiple sclerosis (MS). This creates a barrier to evaluate MS patients for epilepsy surgery. We present two cases of ... ...

    Abstract Brain surgery is the only curative treatment for people with focal epilepsy, but it is unclear whether this induces active disease in multiple sclerosis (MS). This creates a barrier to evaluate MS patients for epilepsy surgery. We present two cases of successful epilepsy surgery in patients with pharmacoresistant epilepsy and stable MS and give an overview of the existing literature. (1) a 28-year-old woman with seizures arising from a right basal temporo-occipital ganglioglioma was seizure-free after surgery, without MS relapse but with one new MS lesion postsurgically. (2) a 46-year-old woman with seizures arising from a natalizumab-associated progressive multifocal leukoencephalopathy (PML) lesion in the right frontal lobe was seizure-free after surgery preceded by extraoperative subdural electrocorticography, with new subclinical MS lesions. We are the first to report brain surgery in a PML survivor. Both patients stabilized radiologically after initiating second-line therapies. Successful epilepsy surgery can substantially increase the quality of life in patients with pharmacoresistant epilepsy and MS. With increasing survival rates of brain tumors and PML, the risk-benefit ratio of epilepsy surgery compared to a potential MS relapse after surgery becomes critically important. Shared decision-making is valuable for balancing the risks related to both diseases.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/surgery ; Multiple Sclerosis/drug therapy ; Quality of Life ; Neoplasm Recurrence, Local ; Leukoencephalopathy, Progressive Multifocal/pathology ; Epilepsy ; Seizures ; Recurrence
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1002/epd2.20166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 252: Show issues
    Zs.MN 11: Show issues

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  5. Article ; Online: Biomarkers of focal and diffuse traumatic brain injury.

    Vos, Pieter E

    Critical care (London, England)

    2011  Volume 15, Issue 4, Page(s) 183

    Abstract: Traumatic brain injury (TBI) is a pathologically heterogeneous disease affecting people of all ages. The highest incidence of TBI occurs in young people and the average age is 30 to 40 years. Injury grading may range from mild with a low frequency (1 per ...

    Abstract Traumatic brain injury (TBI) is a pathologically heterogeneous disease affecting people of all ages. The highest incidence of TBI occurs in young people and the average age is 30 to 40 years. Injury grading may range from mild with a low frequency (1 per 100) of life-threatening intracranial hematoma that needs immediate neurosurgical operation and very low mortality (1 per 1,000) to severe with a high likelihood of life-threatening intracranial hematoma (up to 1 per 3), a 40% case fatality rate and a high disability rate (2 per 3) in survivors. Estimation of the prognosis in severe TBI is currently based on demographic and clinical predictors, including age, Glasgow Coma Scale, pupillary reactions, extracranial injury (hypotension and hypoxia) and computed tomography indices (brain swelling, focal mass lesions, subarachnoid hemorrhage). Biomarkers reflecting damage to neurons and astrocytes may add important complementary information to clinical predictors of outcome and provide insight into the pathophysiology of TBI.
    MeSH term(s) Brain Injuries/blood ; Brain Injuries/diagnostic imaging ; Female ; Glial Fibrillary Acidic Protein/blood ; Humans ; Male ; Tomography, X-Ray Computed ; Ubiquitin Thiolesterase/blood
    Chemical Substances Glial Fibrillary Acidic Protein ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2011-08-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/cc10290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Deep Learning Regression for Prostate Cancer Detection and Grading in Bi-Parametric MRI.

    Vente, Coen de / Vos, Pieter / Hosseinzadeh, Matin / Pluim, Josien / Veta, Mitko

    IEEE transactions on bio-medical engineering

    2021  Volume 68, Issue 2, Page(s) 374–383

    Abstract: One of the most common types of cancer in men is prostate cancer (PCa). Biopsies guided by bi-parametric magnetic resonance imaging (MRI) can aid PCa diagnosis. Previous works have mostly focused on either detection or classification of PCa from MRI. In ... ...

    Abstract One of the most common types of cancer in men is prostate cancer (PCa). Biopsies guided by bi-parametric magnetic resonance imaging (MRI) can aid PCa diagnosis. Previous works have mostly focused on either detection or classification of PCa from MRI. In this work, however, we present a neural network that simultaneously detects and grades cancer tissue in an end-to-end fashion. This is more clinically relevant than the classification goal of the ProstateX-2 challenge. We used the dataset of this challenge for training and testing. We use a 2D U-Net with MRI slices as input and lesion segmentation maps that encode the Gleason Grade Group (GGG), a measure for cancer aggressiveness, as output. We propose a method for encoding the GGG in the model target that takes advantage of the fact that the classes are ordinal. Furthermore, we evaluate methods for incorporating prostate zone segmentations as prior information, and ensembling techniques. The model scored a voxel-wise weighted kappa of 0.446 ±0.082 and a Dice similarity coefficient for segmenting clinically significant cancer of 0.370 ±0.046, obtained using 5-fold cross-validation. The lesion-wise weighted kappa on the ProstateX-2 challenge test set was 0.13 ±0.27. We show that our proposed model target outperforms standard multiclass classification and multi-label ordinal regression. Additionally, we present a comparison of methods for further improvement of the model performance.
    MeSH term(s) Deep Learning ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasm Grading ; Neural Networks, Computer ; Prostatic Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2020.2993528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Long-Term Stability of Blood Serum Biomarkers in Traumatic Brain Injury: A Feasibility Study.

    van der Horn, Harm Jan / Visser, Koen / Bijzet, Johan / Vos, Pieter / van der Naalt, Joukje / Jacobs, Bram

    Frontiers in neurology

    2022  Volume 13, Page(s) 877050

    Abstract: Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In the current feasibility study we analyzed acute phase serum samples from patients with mild TBI as well ... ...

    Abstract Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In the current feasibility study we analyzed acute phase serum samples from patients with mild TBI as well as patients with moderate and severe TBI that were collected more than 10 years ago (
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.877050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Nuclear cardiology

    VOS, PIETER H.

    FOURIER FUNCTIONAL IMAGES IN LEFT VENRTRICULAR WALL MOTION ANALYSIS AND AN INVESTIGATION INTO LESION DETECTABILITY IN MYOCARDIAL PERFUSION SCINTIGRAPHY

    1982  

    Author's details DOOR PIETER HERMAN VOS
    Size 128 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis LEIDEN, UNIV., DISS., 1982
    HBZ-ID HT002716830
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    84 E 1743 order for loan Magazin

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  9. Book: Traumatic brain injury

    Vos, Pieter E / Diaz-Arrastia, Ramon

    2015  

    Author's details edited by Pieter E. Vos, Ramon Diaz-Arrastia
    MeSH term(s) Brain Injuries/diagnosis ; Brain Injuries/therapy
    Language English
    Size xii, 231 pages :, illustrations.
    Document type Book
    ISBN 9781444337709 ; 144433770X
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Nanoporous microneedle arrays seamlessly connected to a drug reservoir for tunable transdermal delivery of memantine.

    Vos, Pieter Jan / Kuijt, Nico / Kaya, Misli / Rol, Sanne / van der Maaden, Koen

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2020  Volume 150, Page(s) 105331

    Abstract: Conventional transdermal drug patches have been on the market since 1997 but their applicability for drug delivery is limited: currently only nearly two dozen of molecules have been approved by the regulatory authorities for transdermal administration ... ...

    Abstract Conventional transdermal drug patches have been on the market since 1997 but their applicability for drug delivery is limited: currently only nearly two dozen of molecules have been approved by the regulatory authorities for transdermal administration and have reached the market. The possibilities for drug delivery via the skin can be improved and expanded by using microneedle patch technologies. However, most microneedle patches focus on the delivery of low amounts of drugs that are generally very potent due to the small dimensions of the microneedle systems. In this study nanoporous microneedle arrays (npMNAs) were combined with a liquid drug reservoir. The parameters that influence the diffusion of memantine from the drug reservoir through the npMNAs in an acceptor solution were investigated. Based on these results a model was developed to predict the diffusion of low-molecular-weight drugs as a function of npMNA properties (i.e., backplate thickness and surface area) and reservoir properties (i.e., volume and drug concentration). This generated an in silico model to predict the release of low-molecular-weight drug from a drug reservoir through a microneedle array into receptor solution, showed a good correlation with the delivery of memantine in a preclinical minipig study. The drug release rates by the npMNAs can be tuned and allow for both zero and first order release kinetics. Summarizing, this work shows that the npMNA technology is a versatile drug delivery system. The npMNAs can be combined with a (seamlessly connected) external drug reservoir and this integrated drug delivery system can be used to deliver at least 9 mg of memantine over 72 h in a preclinical minipig study.
    MeSH term(s) Administration, Cutaneous ; Animals ; Drug Delivery Systems ; Memantine/administration & dosage ; Memantine/blood ; Memantine/pharmacokinetics ; Microinjections ; Nanopores ; Needles ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/blood ; Neuroprotective Agents/pharmacokinetics ; Porosity ; Swine ; Swine, Miniature
    Chemical Substances Neuroprotective Agents ; Memantine (W8O17SJF3T)
    Language English
    Publishing date 2020-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2020.105331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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