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Article ; Online: Atypical presentation of cutaneous angiosarcoma: review of the literature.

Kostaki, Maria / Vourlakou, Christina / Polydorou, Doris / Stratigos, Alexandros J

2022 Volume 47, Issue 9, Page(s) 1636–1641

Abstract: Cutaneous angiosarcoma (CAS) is an aggressive tumour of vascular or lymphatic origin. Although relatively rare, it needs to be recognized and treated early. CAS typically arises on the head or neck as a bruise or raised purplish-red papule or plaque. ... ...

Abstract	Cutaneous angiosarcoma (CAS) is an aggressive tumour of vascular or lymphatic origin. Although relatively rare, it needs to be recognized and treated early. CAS typically arises on the head or neck as a bruise or raised purplish-red papule or plaque. However, it can sometimes resemble a benign skin lesion, leading to delay in diagnosis and consequent poor patient outcome. CAS may be mistaken for inflammatory, autoimmune or infectious disease, or for a benign skin tumour or post-traumatic lesion. We analyse the atypical clinical forms of this aggressive tumour and review the literature.
MeSH term(s)	Hemangiosarcoma/diagnosis ; Humans ; Skin Diseases ; Skin Neoplasms/pathology
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.15256
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Zs.A 1278: Show issues

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Article: Cytomegalovirus Infections in Patients Treated With Immune Checkpoint Inhibitors for Solid Malignancies.

Anastasopoulou, Amalia / Samarkos, Michael / Diamantopoulos, Panagiotis / Vourlakou, Christina / Ziogas, Dimitrios C / Avramopoulos, Pantelis / Kouzis, Panagiotis / Haanen, John / Gogas, Helen

Open forum infectious diseases

2023 Volume 10, Issue 4, Page(s) ofad164

Abstract: Cytomegalovirus (CMV) infection/disease has been repeatedly reported in patients treated with immune-checkpoint inhibitors (ICIs) and most commonly involves patients with relapsed/refractory (R/R) immune-related adverse events (irAEs). In the current ... ...

Abstract	Cytomegalovirus (CMV) infection/disease has been repeatedly reported in patients treated with immune-checkpoint inhibitors (ICIs) and most commonly involves patients with relapsed/refractory (R/R) immune-related adverse events (irAEs). In the current study, we present a patient with melanoma who developed CMV gastritis during treatment with pembrolizumab in the absence of irAEs and without previous or current immunosuppression. Moreover, we review the literature regarding CMV infection/disease in patients treated with ICIs for solid malignancies. We present the currently available data on the pathogenesis, clinical characteristics, endoscopic findings, and histologic features and highlight the potential differences among cases complicating R/R irAEs versus those occurring in patients who are immunosuppression naive. Finally, we discuss the currently available data regarding potential useful diagnostic tools as well as the management of these patients.
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad164
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Article ; Online: Recurrence of crescentic IgA nephropathy after renal transplantation.

Zagkotsis, Georgios / Vourlakou, Christina / Paraskevopoulos, Aristeidis / Apostolou, Theofanis

CEN case reports

2018 Volume 7, Issue 2, Page(s) 268–273

Abstract: IgA nephropathy (IgAN) is one of the most common recurrent glomerulonephritis after renal transplantation. Rarely, it is accompanied with the presence of crescents that leads to rapid deterioration of renal function and graft loss. We present a 54-year- ... ...

Abstract	IgA nephropathy (IgAN) is one of the most common recurrent glomerulonephritis after renal transplantation. Rarely, it is accompanied with the presence of crescents that leads to rapid deterioration of renal function and graft loss. We present a 54-year-old patient with IgAN that received a cadaveric kidney allograft, but developed biopsy proven recurrent IgAN 7 months after renal transplantation. He was treated with intravenous steroids and angiotensin-converting enzyme inhibitor and remission was achieved. 4 years later, he presented again with heavy proteinuria, hematuria and deterioration of renal function. Allograft biopsy revealed recurrent IgAN with crescents, which was successfully treated with pulse intravenous steroids and six monthly doses of intravenous cyclophosphamide. This regime resulted in long-term sustained remission with a stable functioning graft 3 years later. Although it is not an established treatment as in native kidneys, intravenous cyclophosphamide should probably be considered in kidney transplants with potentially reversible recurrent crescentic IgAN.
MeSH term(s)	Administration, Intravenous ; Biopsy ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/therapeutic use ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Postoperative Complications ; Proteinuria/diagnosis ; Proteinuria/etiology ; Recurrence ; Steroids/administration & dosage ; Steroids/therapeutic use ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents ; Steroids ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2018-05-25
Publishing country	Japan
Document type	Case Reports ; Journal Article
ISSN	2192-4449
ISSN (online)	2192-4449
DOI	10.1007/s13730-018-0341-2
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Article: COVID-19 Patients Presenting with Post-Intubation Upper Airway Complications: A Parallel Epidemic?

Stratakos, Grigoris / Anagnostopoulos, Nektarios / Alsaggaf, Rajaa / Koukaki, Evangelia / Bakiri, Katerina / Emmanouil, Philip / Zisis, Charalampos / Vachlas, Konstantinos / Vourlakou, Christina / Koutsoukou, Antonia

Journal of clinical medicine

2022 Volume 11, Issue 6

Abstract: During the current pandemic, we witnessed a rise of post-intubation tracheal stenosis (PITS) in patients intubated due to COVID-19. We prospectively analyzed data from patients referred to our institution during the last 18 months for severe symptomatic ... ...

Abstract	During the current pandemic, we witnessed a rise of post-intubation tracheal stenosis (PITS) in patients intubated due to COVID-19. We prospectively analyzed data from patients referred to our institution during the last 18 months for severe symptomatic post-intubation upper airway complications. Interdisciplinary bronchoscopic and/or surgical management was offered. Twenty-three patients with PITS and/or tracheoesophageal fistulae were included. They had undergone 31.85 (±22.7) days of ICU hospitalization and 17.35 (±7.4) days of intubation. Tracheal stenoses were mostly complex, located in the subglottic or mid-tracheal area. A total of 83% of patients had fracture and distortion of the tracheal wall. Fifteen patients were initially treated with rigid bronchoscopic modalities and/or stent placement and eight patients with tracheal resection-anastomosis. Post-treatment relapse in two of the bronchoscopically treated patients required surgery, while two of the surgically treated patients required rigid bronchoscopy and stent placement. Transient, non-life-threatening post-treatment complications developed in 60% of patients and were all managed successfully. The histopathology of the resected tracheal specimens didn't reveal specific alterations in comparison to pre-COVID-era PITS cases. Prolonged intubation, pronation maneuvers, oversized tubes or cuffs, and patient- or disease-specific factors may be pathogenically implicated. An increase of post-COVID PITS is anticipated. Careful prevention, early detection and effective management of these iatrogenic complications are warranted.
Language	English
Publishing date	2022-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11061719
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Article: A Giant solitary fibrous tumour resected through median sternotomy.

Rimpa, Theofani / Athanassiadi, Kalliopi / Eleftheriou, Kostantinos / Vourlakou, Christina / Chrysovergis, Ioannis / Diakonikolaou, Zacharias / Katsaounou, Paraskevi / Kalomenidis, Ioannis

Respirology case reports

2022 Volume 10, Issue 12, Page(s) e01031

Abstract: ... ...

Abstract	S
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1031
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Article ; Online: Cardioplegic storage solution: Is it the guardian of saphenous vein graft endothelium?

Papakonstantinou, Nikolaos A / Sykaras, Alexandros G / Vourlakou, Christina / Goudevenos, John / Papadopoulos, Georgios / Apostolakis, Efstratios

Journal of cardiac surgery

2020 Volume 35, Issue 5, Page(s) 996–1003

Abstract: Introduction: Despite their suboptimal long-term patency, saphenous vein grafts are the most widely used conduits to achieve complete revascularization during coronary artery bypass grafting (CABG). Although vein storage critically impairs endothelial ... ...

Abstract	Introduction: Despite their suboptimal long-term patency, saphenous vein grafts are the most widely used conduits to achieve complete revascularization during coronary artery bypass grafting (CABG). Although vein storage critically impairs endothelial integrity, contradictory data concerning optimal storage solutions exist. The aim of this study is to explore any in vitro impact of cardioplegic solutions and temperature on vein grafts endothelial integrity during their storage. Materials and methods: A single-center, prospective trial including 40 consecutive patients was conducted. Eligibility criteria included patients submitted to CABG receiving at least one vein graft. An excess segment of the graft was harvested and divided into four different parts. Each one of them was stored under different conditions; either in a conventional heparin-enriched blood solution or in a cardioplegic solution, at room temperature (20°C-22°C) and in the refrigerator (5°C). Endothelial integrity was evaluated via immunohistochemistry using an antibody against CD31. Results: Endothelial integrity (measured in a scale from 1-worst to 5-best) was significantly better after cardioplegic solution storage (2.83 ± 0.15 and 3.10 ± 0.13 in cold and room temperature, respectively) compared with storage in conventional solutions (2.23 ± 0.16 and 2.0 ± 0.15 in cold and room temperature, respectively). A significant effect of cardioplegic storage solution, as well as of cold temperature and cardioplegic solution interaction on endothelial preservation was reported, whereas storage temperature did not prove a significant factor by its own. Conclusions: Cardioplegic storage solutions result in significantly better endothelial preservation compared with conventional heparin-enriched blood solutions. The association with superior clinical outcomes remains to be proved.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cardioplegic Solutions ; Coronary Artery Bypass ; Endothelium, Vascular ; Female ; Humans ; Male ; Middle Aged ; Organ Preservation/methods ; Organ Preservation Solutions ; Prospective Studies ; Saphenous Vein/transplantation ; Temperature
Chemical Substances	Cardioplegic Solutions ; Organ Preservation Solutions
Language	English
Publishing date	2020-03-24
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.14519
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Zs.A 2221: Show issues

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Article ; Online: Pulmonary actinomycosis masquerading as lung cancer: keep it in mind.

Papakonstantinou, Nikolaos A / Vlachou, Garyfalia / Vourlakou, Christina / Zisis, Charalambos

ANZ journal of surgery

2018 Volume 89, Issue 7-8, Page(s) 966–968

MeSH term(s)	Actinomycosis/diagnosis ; Aged ; Bacterial Infections/diagnosis ; Diagnosis, Differential ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/microbiology ; Lung Neoplasms/diagnosis ; Male
Language	English
Publishing date	2018-02-08
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.14397
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Zs.A 180: Show issues

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Article ; Online: Multiple mononeuritis with peripheral blood eosinophilia in a patient with Q fever: An unusual presentation: Case report and review of the literature.

Kounatidis, Dimitris / Skourtis, Alexandros / Grivakou, Eugenia / Vourlakou, Christina / Geladari, Eleni / Jahaj, Edison / Panagopoulos, Fotis / Vadiaka, Maria

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2021 Volume 27, Issue 9, Page(s) 1357–1359

Abstract: Coxiella burnetii is a gram-negative bacterium that typically lives and multiplies within monocytes and macrophages of the host, being the etiologic agent of the zoonosis Q fever. Q fever is usually divided into acute and chronic forms, with a ... ...

Abstract	Coxiella burnetii is a gram-negative bacterium that typically lives and multiplies within monocytes and macrophages of the host, being the etiologic agent of the zoonosis Q fever. Q fever is usually divided into acute and chronic forms, with a significant percentage of patients being asymptomatic. In the wide spectrum of the disease, neurological involvement seems to be extremely rare and peripheral neuropathy presenting with mononeuritis multiplex is one of the possible presentations with low rates of occurrence. Hereby, we present an unusual case of a 55-year-old male with fever and multiple mononeuritis attributed to Q fever and we summarize a short review of C. burnetii infection.
MeSH term(s)	Coxiella burnetii ; Eosinophilia ; Humans ; Macrophages ; Male ; Middle Aged ; Mononeuropathies ; Q Fever/complications ; Q Fever/diagnosis ; Q Fever/drug therapy
Language	English
Publishing date	2021-04-23
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2021.04.007
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Zs.A 5236: Show issues

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Article ; Online: Acute Encephalitic Syndrome Induced by Scleromyxedema.

Magira, Eleni E / Malouchou, Aikaterini / Karathanasi, Vasiliki / Mavropoulou, Niki / Siempos, Ilias I / Vourlakou, Christina / Sykaras, Alexandros / Anastasiadis, Georgios

The American journal of the medical sciences

2020 Volume 360, Issue 2, Page(s) 192–195

Abstract: Dermato-neuro syndrome is a potentially fatal neurological complication of scleromyxedema consisting of fever, seizures, and coma. This is an overlooked scleromyxedema case of a 62-year-old female patient from 2-years ago. She was admitted to our ICU ... ...

Abstract	Dermato-neuro syndrome is a potentially fatal neurological complication of scleromyxedema consisting of fever, seizures, and coma. This is an overlooked scleromyxedema case of a 62-year-old female patient from 2-years ago. She was admitted to our ICU because of high fever, colloid speech, muscle ache, and nausea. Molecular methods in the cerebrospinal fluid for neurotropic viruses ruled out acute infectious encephalitis. Her thyroid hormones were within normal values while the serum protein electrophoresis confirmed the monoclonal gammopathy of immunoglobulin G lambda (IgG(λ)), known for the last 2 years. The subsequent bone-marrow biopsy excluded the development of multiple myeloma. The patient fulfilled fundamental diagnostic criteria of scleromyxedema (monoclonal gammopathy, normal thyroid function and the appearance of marked sclerosis and induration of the skin papules on the face, neck, extremities, and skin creases) presenting as dermato-neuro syndrome, which was histologically confirmed. She demonstrated a remarkable improvement after intravenous immunoglobulin treatment during the first 24 hours. Mimics of non-infectious acute encephalitis should include the clinical diagnosis of scleromyxedema, especially when patients present in the emergency department with acute fever, coma, and skin lesions of diffuse sclerodermoid and papular type.
MeSH term(s)	Acute Febrile Encephalopathy/diagnosis ; Acute Febrile Encephalopathy/etiology ; Acute Febrile Encephalopathy/therapy ; Biopsy ; Blood Protein Electrophoresis ; Brain/diagnostic imaging ; Coma/etiology ; Diagnosis, Differential ; Diagnostic Errors ; Female ; Humans ; Immunoglobulin G ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Infectious Encephalitis/diagnosis ; Intensive Care Units ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance/blood ; Monoclonal Gammopathy of Undetermined Significance/complications ; Scleromyxedema/complications ; Scleromyxedema/diagnosis ; Scleromyxedema/pathology ; Scleromyxedema/therapy ; Seizures/etiology ; Skin/pathology ; Thyrotropin/blood ; Thyroxine/blood ; Tomography, X-Ray Computed ; Triiodothyronine/blood
Chemical Substances	Immunoglobulin G ; Immunoglobulins, Intravenous ; Immunologic Factors ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2020-05-20
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2020.05.018
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Article ; Online: A case of successfully treated rhinocerebral mucormycosis: dental implications.

Papadogeorgakis, Nikolaos / Parara, Eleni / Petsinis, Vassilios / Vourlakou, Christina

International journal of dentistry

2011 Volume 2010, Page(s) 273127

Abstract: This paper presents a case of rhinocerebral mucormycosis in a 22-year-old female patient with type I diabetes mellitus, who was successfully treated with surgery and long-term antifungal medication. The patient had initially been submitted to extraction ... ...

Abstract	This paper presents a case of rhinocerebral mucormycosis in a 22-year-old female patient with type I diabetes mellitus, who was successfully treated with surgery and long-term antifungal medication. The patient had initially been submitted to extraction of an upper third molar by a general dental practitioner but was referred to our department three days postoperatively because of double vision. Immediately following histopathological confirmation of the infection, the patient was administered Amphotericin B and Posaconazole intravenously. Surgical excision of the affected site was relatively conservative. The patient was free of the disease 15 months after initial admission to the hospital and has recently returned for reconstruction. The aim of this paper is to increase the awareness of general dental practitioners regarding uncommon serious conditions in diabetic patients, which may be confused with periodontal or dental diseases.
Language	English
Publishing date	2011-02-15
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2546524-7
ISSN	1687-8736 ; 1687-8736
ISSN (online)	1687-8736
ISSN	1687-8736
DOI	10.1155/2010/273127
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