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  1. Article ; Online: Epidemiat

    Voutilainen, Miikka

    taloushistoriallinen katsaus

    2020  

    Abstract: Epidemioilla on lyhyen ja pitkän aikavälin taloudellisia ja demografisia vaikutuksia sekä yhteiskunnallisia seurauksia. Samankaltaisuuksistaan huolimatta epidemioiden lopputulokset ovat riippuvia tapahtumaympäristöistään – patogeenit saattavat vaatia ... ...

    Abstract Epidemioilla on lyhyen ja pitkän aikavälin taloudellisia ja demografisia vaikutuksia sekä yhteiskunnallisia seurauksia. Samankaltaisuuksistaan huolimatta epidemioiden lopputulokset ovat riippuvia tapahtumaympäristöistään – patogeenit saattavat vaatia hyvin erityiset olosuhteet levitäkseen ja tuottaakseen epidemioita. Historiallinen vertailu osoittaa, että yhteiskuntia muuttaneet suuret tartuntatautiepisodit (kuten musta surma) esiintyvät verrokkeina useammin kuin niiden yleistyvyys tai tyypillisyys puoltaisivat. Epidemiat saattavat haitata alue- ja makrotaloutta hyvinkin pitkällä aikavälillä, mutta tämä on riippuvaista sokkien kohdentumisesta ja laajemmasta taloudellisesta ympäristöstä. Kuolleisuuskriiseistä johtuvat pitkän aikavälin hyödyt eivät ole poissuljettuja, mutta ne – enemmän kuin pitkän aikavälin haittavaikutukset - ovat huomattavan tapaus- ja tilannekohtaisia

    nonPeerReviewed
    Keywords kriisit ; COVID-19 ; tartuntataudit ; epidemiat ; rutto ; taloushistoria ; yhteiskunnalliset vaikutukset ; pandemiat ; HIV-tartunta ; covid19
    Language Finnish
    Publisher Taloustieteellinen Yhdistys
    Publishing country fi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of inflammatory bowel diseases on household chores.

    Mattila, Kalle / Rankala, Rasmus / Voutilainen, Markku / Mustonen, Anssi

    JGH open : an open access journal of gastroenterology and hepatology

    2023  Volume 7, Issue 3, Page(s) 228–230

    Abstract: More than a half of inflammatory bowel disease (IBD) patients experienced a moderate negative effect on their household chores due to their IBD. The negative effect was more common amongst women. ...

    Abstract More than a half of inflammatory bowel disease (IBD) patients experienced a moderate negative effect on their household chores due to their IBD. The negative effect was more common amongst women.
    Language English
    Publishing date 2023-03-11
    Publishing country Australia
    Document type Journal Article
    ISSN 2397-9070
    ISSN (online) 2397-9070
    DOI 10.1002/jgh3.12887
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  3. Article ; Online: Costs of medications used to treat inflammatory bowel disease.

    Rankala, Rasmus / Mustonen, Anssi / Voutilainen, Markku / Mattila, Kalle

    Scandinavian journal of gastroenterology

    2023  Volume 59, Issue 1, Page(s) 34–38

    Abstract: Background: Inflammatory bowel disease (IBD), mainly Crohn's disease (CD) and ulcerative colitis (UC) are chronic diseases causing a lifelong burden and often need sustained treatment throughout a patient's life. Both the incidence and prevalence of IBD ...

    Abstract Background: Inflammatory bowel disease (IBD), mainly Crohn's disease (CD) and ulcerative colitis (UC) are chronic diseases causing a lifelong burden and often need sustained treatment throughout a patient's life. Both the incidence and prevalence of IBD has increased in the last decade. Evidence showing the drug costs to IBD patients in Finland is limited. No earlier study has evaluated the drug costs of IBD patients in Finland. Here, we thoroughly assessed these costs.
    Methods: A structured questionnaire, hospital records and national registers were combined to comprehensively assess the actual costs of drug purchases made by IBD patients. The study sample comprised 561 patients.
    Results: Total annual mean drug costs were 1428€ per patient. CD patients had higher annual costs than UC patients at 2369€ and 902€, respectively. CD patients also had higher costs in the immunosuppressant, corticosteroid, and biologic subgroup analyses. In addition, C-reactive protein, serum albumin and fecal calprotectin levels had a correlation with costs if the patient had needed corticosteroids. In addition, women reported having a worse quality of life (QoL) but had lower total costs.
    Conclusions: Pharmaceutical drugs are major factors that affect the costs of IBD treatment, and the increased use of biologics has raised these costs.
    MeSH term(s) Humans ; Female ; Quality of Life ; Inflammatory Bowel Diseases/drug therapy ; Colitis, Ulcerative/epidemiology ; Crohn Disease/epidemiology ; Adrenal Cortex Hormones/therapeutic use ; Pharmaceutical Preparations
    Chemical Substances Adrenal Cortex Hormones ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2023.2248539
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  4. Article: Should hepatocellular cancer by screened in Finland?

    Voutilainen, Markku

    Duodecim; laaketieteellinen aikakauskirja

    2016  Volume 132, Issue 16, Page(s) 1433–1437

    Abstract: Almost 2 000 people die each year from the adverse effects of alcohol use in Finland. Liver cirrhosis is the cause of death in half of the cases. Although the annual risk of hepatocellular cancer for a cirrhosis patient is 1 to 4%, more than 95% of the ... ...

    Abstract Almost 2 000 people die each year from the adverse effects of alcohol use in Finland. Liver cirrhosis is the cause of death in half of the cases. Although the annual risk of hepatocellular cancer for a cirrhosis patient is 1 to 4%, more than 95% of the deaths result from complications caused by the cirrhosis, not the cancer. It seems that nontargeted screening of hepatocellular cancer for those affected with alcoholic cirrhosis or nonalcoholic steatohepatitis is not cost-effective. Screening may, however, be advisable when the risk of cancer is high, provided that treatment of a detected cancer is possible.
    MeSH term(s) Finland/epidemiology ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/mortality ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Mass Screening ; Risk Factors
    Language English
    Publishing date 2016
    Publishing country Finland
    Document type Journal Article ; Review
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 109: Show issues Location:
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  5. Article ; Online: Inflammatory bowel disease: perceived impact on leisure-time activities.

    Mattila, Kalle / Rankala, Rasmus / Voutilainen, Markku / Mustonen, Anssi

    Scandinavian journal of gastroenterology

    2022  Volume 57, Issue 8, Page(s) 930–935

    Abstract: Objective: Inflammatory bowel disease, consisting of Crohn's disease and ulcerative colitis, is known to negatively impact an individual's quality of life. Leisure-time activities are an important part of life by creating and strengthening social ... ...

    Abstract Objective: Inflammatory bowel disease, consisting of Crohn's disease and ulcerative colitis, is known to negatively impact an individual's quality of life. Leisure-time activities are an important part of life by creating and strengthening social networks. The aim of this study was to thoroughly evaluate the perceived impact of inflammatory bowel disease on leisure-time activities by quantifying limitations in activities caused by the disease.
    Methods: A structured questionnaire, hospital records and national registers were combined to assess limitations caused by the disease in a patient's leisure-time activities. The final study sample was 561 patients.
    Results: More than half of the patients (52.8%) reported that IBD had caused limitations in their leisure-time activities. Women perceived that their limitations were greater when compared to the reports by men. One-third of the patients (33.3%) reported reducing and 17.6% abandoning at least one leisure-time activity due to their disease. Most often mentioned activities that were reduced and abandoned were physical activities. The IBDQ32 score had a significant correlation with all of the studied outcomes. Laboratory tests results and the patient's age or the level of income did not correlate with limitations in leisure-time activities.
    Conclusions: In conclusion, this study showed that patients with inflammatory bowel disease perceived a marked limitation in their leisure-time activities due to their disease.
    MeSH term(s) Chronic Disease ; Colitis, Ulcerative ; Crohn Disease ; Female ; Humans ; Inflammatory Bowel Diseases ; Leisure Activities ; Male ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2022.2042593
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    Zs.A 567: Show issues Location:
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  6. Article: Refluksitauti --hyvänlaatuinen mutta kallis sairaus.

    Voutilainen, Markku

    Duodecim; laaketieteellinen aikakauskirja

    2014  Volume 130, Issue 8, Page(s) 801–807

    Abstract: The prevalence of GORD has increased. GORD causes significant impairment of the quality of life and is the most costly gastrointestinal disease. In patients aged under 55 years and without alarming symptoms and signs, treatment may be started without ... ...

    Title translation Gastro-oesophageal reflux disease--a common and benign but costly disease.
    Abstract The prevalence of GORD has increased. GORD causes significant impairment of the quality of life and is the most costly gastrointestinal disease. In patients aged under 55 years and without alarming symptoms and signs, treatment may be started without endoscopy. Proton pump inhibitors are the most effective medical treatment. Most GORD patients have normal oesophageal findings on endoscopy. If medical treatment fails, the diagnosis of GORD should be verified. The indications for surgical treatment, i.e. laparoscopic fundoplication, include the failure of medical treatment, severe erosive esophagitis, regurgitation as the main symptom, and severe GORD with large hiatal hernia.
    MeSH term(s) Adult ; Esophagoscopy ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/therapy ; Humans ; Laparoscopy ; Middle Aged ; Prevalence ; Proton Pump Inhibitors/therapeutic use ; Quality of Life
    Chemical Substances Proton Pump Inhibitors
    Language Finnish
    Publishing date 2014
    Publishing country Finland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
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    Zs.B 109: Show issues Location:
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  7. Article ; Online: Inflammatory bowel disease-related economic costs due to presenteeism and absenteeism.

    Rankala, Rasmus / Mattila, Kalle / Voutilainen, Markku / Mustonen, Anssi

    Scandinavian journal of gastroenterology

    2021  Volume 56, Issue 6, Page(s) 687–692

    Abstract: Background: Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, can be a lifelong burden generating high costs to an economic system. Data regarding the cost of workplace presenteeism and absenteeism in workers with ... ...

    Abstract Background: Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, can be a lifelong burden generating high costs to an economic system. Data regarding the cost of workplace presenteeism and absenteeism in workers with IBD are limited. Our objective was to assess these costs in employed adults.
    Methods: A structured questionnaire, hospital records and national registers were combined to assess the economic costs involved with workplace presenteeism and absenteeism in employed patients. Our final sample comprised 320 IBD patients. The costs were calculated as productivity-loss costs by using a Human Capital Approach.
    Results: Due to IBD, the mean annual economic costs of workplace presenteeism were €643.90/patient, and mean annual absenteeism costs were €740.90/patient. Women had higher costs (€955/patient/year) from absenteeism compared to men (€531/patient/year) especially when working blue-collar jobs. These findings were also evident in presenteeism. CD and UC patients had similar total costs due to presenteeism and absenteeism. The use of biologics did not have a major impact on these costs.
    Conclusion: IBD patients had moderate economic costs from workplace presenteeism and absenteeism. Interestingly, women, working blue-collar jobs, had higher costs than men.
    MeSH term(s) Absenteeism ; Adult ; Colitis, Ulcerative ; Crohn Disease ; Efficiency ; Female ; Humans ; Inflammatory Bowel Diseases ; Male ; Presenteeism
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2021.1908416
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  8. Article ; Online: Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3-year follow-up study.

    Tenhami, Mervi / Polari, Lauri / Kujari, Harry / Löyttyniemi, Eliisa / Toivola, Diana M / Voutilainen, Markku

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11979

    Abstract: The diagnosis of inflammatory bowel diseases (IBD) may be challenging and their clinical course, characterized by relapses and spontaneous or drug-induced remissions, is difficult to predict. Novel prognostic biomarkers are needed. Keratin 7 (K7) is a ... ...

    Abstract The diagnosis of inflammatory bowel diseases (IBD) may be challenging and their clinical course, characterized by relapses and spontaneous or drug-induced remissions, is difficult to predict. Novel prognostic biomarkers are needed. Keratin 7 (K7) is a cytoskeletal intermediate filament protein which is not normally expressed in the colonic epithelium. It was recently shown that K7 expression in the colonic epithelium is associated with ulcerative colitis and Crohn's disease, the two main subtypes of IBD. Here we investigated IBD associated K7 neo-expression in different regions of colon and terminal ileum. The correlation of the K7 expression with the inflammatory activity of the epithelium was analyzed in each region. The prognostic value of K7 was estimated by comparing the clinical disease activity after 3 years with the K7 expression at the time of enrollment. Our data shows that the level of K7 expression in inflamed epithelium varies depending on the anatomical region and it is the most pronounced in ascending and descending colon, but it did not predict the severity of IBD for the following 3 years. These results warrant future studies focusing on the biological role of K7 in colon and its utilization as potential IBD biomarker.
    MeSH term(s) Prognosis ; Follow-Up Studies ; Keratin-7 ; Inflammatory Bowel Diseases ; Colon ; Intermediate Filament Proteins ; Epithelium
    Chemical Substances Keratin-7 ; Intermediate Filament Proteins
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39066-w
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  9. Article: Malthusian checks in pre-industrial Sweden and Finland

    Voutilainen, Miikka

    Scandinavian economic history review Vol. 63, No. 3 , p. 235-259

    a comparative analysis of the demographic regimes

    2015  Volume 63, Issue 3, Page(s) 235–259

    Author's details Miikka Voutilainen (The Department of History and Ethnology, University of Jyvaskyla, Jyväslylä, Finland)
    Keywords economic development ; Malthusian model ; demography
    Language English
    Publisher Routledge$h1953-
    Publishing place Abingdon
    Document type Article
    ZDB-ID 216112-6
    ISSN 0358-5522
    Database ECONomics Information System

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  10. Article ; Online: A Bayesian Reconstruction of a Historical Population in Finland, 1647-1850.

    Voutilainen, Miikka / Helske, Jouni / Högmander, Harri

    Demography

    2020  Volume 57, Issue 3, Page(s) 1171–1192

    Abstract: This article provides a novel method for estimating historical population development. We review the previous literature on historical population time-series estimates and propose a general outline to address the well-known methodological problems. We ... ...

    Abstract This article provides a novel method for estimating historical population development. We review the previous literature on historical population time-series estimates and propose a general outline to address the well-known methodological problems. We use a Bayesian hierarchical time-series model that allows us to integrate the parish-level data set and prior population information in a coherent manner. The procedure provides us with model-based posterior intervals for the final population estimates. We demonstrate its applicability by estimating the long-term development of Finland's population from 1647 onward and simultaneously place the country among the very few to have an annual population series of such length available.
    MeSH term(s) Bayes Theorem ; Censuses ; Finland ; History, 17th Century ; History, 18th Century ; History, 19th Century ; Humans ; Population Dynamics/history ; Population Dynamics/trends ; Residence Characteristics
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280612-5
    ISSN 1533-7790 ; 0070-3370
    ISSN (online) 1533-7790
    ISSN 0070-3370
    DOI 10.1007/s13524-020-00889-1
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