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  1. AU="Vrolijk, Misha F"
  2. AU="Marra, A M"
  3. AU="Haider, Kathryn M"
  4. AU="Shang, Hongcai" AU="Shang, Hongcai"
  5. AU="Ho, Collin Elijah Rui Hung"
  6. AU="Akbar, Ansa"
  7. AU="Heinrich, N"
  8. AU="Almeida, Carolina Aparecida de Faria"
  9. AU="Müller, Pavel"
  10. AU="Carosi, Mariantonia"
  11. AU="Bindu Sen"
  12. AU="Kohaut, Eva"
  13. AU="Adam F. Cohen"
  14. AU="Daniele Tomassoni"
  15. AU="Bergado, Gretchen"
  16. AU="Schomberg, Harry H"
  17. AU="Halder, Prolay"
  18. AU="Miyaguchi, Ken"
  19. AU="Zhan, Na-ping"
  20. AU="Stewart Quigg"

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  1. Artikel ; Online: Androgen Receptor and Cardiovascular Disease: A Potential Risk for the Abuse of Supplements Containing Selective Androgen Receptor Modulators.

    Hall, Ellis / Vrolijk, Misha F

    Nutrients

    2023  Band 15, Heft 15

    Abstract: The androgen receptor (AR) is a member of the family of ligand-activated transcription factors. Selective androgen receptor modulators (SARMs) exert their biological function through complex interactions with the AR. It has been speculated that ... ...

    Abstract The androgen receptor (AR) is a member of the family of ligand-activated transcription factors. Selective androgen receptor modulators (SARMs) exert their biological function through complex interactions with the AR. It has been speculated that overexertion of AR signaling cascades as a result of SARM abuse can be a risk factor for the development of various cardiovascular diseases. The present literature review explores the implications of the interaction between SARMs and the AR on cardiovascular health by focusing on the AR structure, function, and mechanisms of action, as well as the current clinical literature on various SARMs. It is shown that SARMs may increase the risk of cardiovascular diseases through implications on the renin-angiotensin system, smooth muscle cells, sympathetic nervous system, lipid profile, inflammation, platelet activity, and various other factors. More research on this topic is necessary as SARM abuse is becoming increasingly common. There is a noticeable lack of clinical trials and literature on the relationship between SARMs, cardiovascular diseases, and the AR. Future in vivo and in vitro studies within this field are vital to understand the mechanisms that underpin these complex interactions and risk factors.
    Mesh-Begriff(e) Humans ; Receptors, Androgen ; Cardiovascular Diseases ; Androgens ; Androgen Receptor Antagonists ; Ligands
    Chemische Substanzen Receptors, Androgen ; Androgens ; Androgen Receptor Antagonists ; Ligands
    Sprache Englisch
    Erscheinungsdatum 2023-07-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15153330
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  2. Artikel ; Online: EU's next generation risk assessment: hurdles and opportunities for new approach methodologies

    Otto, Sarah / Vrolijk, Misha F. / de Boer, Alie

    J Consum Prot Food Saf. 2023 Mar., v. 18, no. 1 p.3-17

    2023  

    Abstract: The EU's decision to ban animal testing for toxicity testing, has positively influenced the pace of developing New Approach Methodologies (NAMs). This development also supports replacing animal methods in other forms of risk assessment (RA), such as for ... ...

    Abstract The EU's decision to ban animal testing for toxicity testing, has positively influenced the pace of developing New Approach Methodologies (NAMs). This development also supports replacing animal methods in other forms of risk assessment (RA), such as for oral-toxicity testing. This study aims to identify the hurdles and opportunities for validation and implementation of NAMs in the current EU's chemical RA. Through conducting semi-structured interviews with 14 stakeholders, experiences and perspectives about the validation and implementation of NAMs in RA for orally ingested chemicals were analyzed. Stakeholders considered the use of NAMs for RA processes both a cultural and generational issue. Both were perceived as hurdles for reaching the next generation RA approach. The differing views on NAMs originated from experience and stakeholder positions, but communication and collaboration on developing future RA approaches could support overcoming this skepticism. Irrespectively of their background, all interviewees were generally optimistic that NAMs will support the development of more accurate and sustainable RA. This research highlights the need for the EU to adjust legislation and guidance documents to shift in testing requirements from the traditional overexposure approach to more predictive, mechanistic testing in RA, which will take time. This study, however, shows that-when all stakeholders engage in communication and confidence building-NAMs can already play an important role in reducing and refining animal testing.
    Schlagwörter animals ; laws and regulations ; risk assessment ; stakeholders ; toxicity
    Sprache Englisch
    Erscheinungsverlauf 2023-03
    Umfang p. 3-17.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel ; Online
    ZDB-ID 2232114-7
    ISSN 1661-5867 ; 1661-5751
    ISSN (online) 1661-5867
    ISSN 1661-5751
    DOI 10.1007/s00003-022-01403-y
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    Verfügbar in ZB MED Bonn

    Z 7689: Hefte anzeigen

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  3. Artikel ; Online: Current approaches and challenges of sample preparation procedures for the safety assessment of paper and cardboard food contact materials: A comprehensive review.

    Kourkopoulos, Athanasios / Sijm, Dick T H M / Vrolijk, Misha F

    Comprehensive reviews in food science and food safety

    2022  Band 21, Heft 5, Seite(n) 4108–4129

    Abstract: In the European Union (EU), Regulation (EC) 1935/2004 provides a harmonized legal EU framework and sets out the general principles for safety and inertness for all Food Contact Materials (FCMs) and Food Contact Articles. From a food safety point of view, ...

    Abstract In the European Union (EU), Regulation (EC) 1935/2004 provides a harmonized legal EU framework and sets out the general principles for safety and inertness for all Food Contact Materials (FCMs) and Food Contact Articles. From a food safety point of view, however, specific EU legislation for paper and cardboard FCMs is lacking, while at Member State level, national legislation differs among countries. More than 11,000 chemicals have been identified in all types of FCMs, most of them without any information on toxicity or migration potential from FCM to food. The present review shows a wide variability of protocols, approaches, and conditions used in scientific studies, which are difficult to compare. In this regard, procedures and conditions laid down in EU legislation for plastics and European Standards (EN protocols) may serve as a good basis for the future sample preparation procedures in the framework of paper and cardboard FCMs safety assessment. Challenges on sample preparation procedures are presented involving the interlinked steps of sample preparation, conditions used and their impact in chemical analysis and in vitro bioassay testing. Currently, there is no general consensus on the criteria for structuring, evaluating, and tuning sample preparation procedures for paper and cardboard FCMs. For this purpose, a set of modified criteria and a decision tree are proposed based on the literature. Along this, mass transfer processes occurring in paper and cardboard FCMs and parameters affecting chemical migration need to be accounted for prior to reaching general consensus on criteria for sample preparation procedures.
    Mesh-Begriff(e) Allergens/analysis ; European Union ; Food Contamination/analysis ; Food Packaging ; Food Safety/methods ; Plastics/analysis
    Chemische Substanzen Allergens ; Plastics
    Sprache Englisch
    Erscheinungsdatum 2022-07-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185829-9
    ISSN 1541-4337 ; 1541-4337
    ISSN (online) 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.13009
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  4. Artikel: Current approaches and challenges of sample preparation procedures for the safety assessment of paper and cardboard food contact materials: A comprehensive review

    Kourkopoulos, Athanasios / Sijm, Dick T.H.M. / Vrolijk, Misha F.

    Comprehensive reviews in food science and food safety. 2022 Sept., v. 21, no. 5

    2022  

    Abstract: In the European Union (EU), Regulation (EC) 1935/2004 provides a harmonized legal EU framework and sets out the general principles for safety and inertness for all Food Contact Materials (FCMs) and Food Contact Articles. From a food safety point of view, ...

    Abstract In the European Union (EU), Regulation (EC) 1935/2004 provides a harmonized legal EU framework and sets out the general principles for safety and inertness for all Food Contact Materials (FCMs) and Food Contact Articles. From a food safety point of view, however, specific EU legislation for paper and cardboard FCMs is lacking, while at Member State level, national legislation differs among countries. More than 11,000 chemicals have been identified in all types of FCMs, most of them without any information on toxicity or migration potential from FCM to food. The present review shows a wide variability of protocols, approaches, and conditions used in scientific studies, which are difficult to compare. In this regard, procedures and conditions laid down in EU legislation for plastics and European Standards (EN protocols) may serve as a good basis for the future sample preparation procedures in the framework of paper and cardboard FCMs safety assessment. Challenges on sample preparation procedures are presented involving the interlinked steps of sample preparation, conditions used and their impact in chemical analysis and in vitro bioassay testing. Currently, there is no general consensus on the criteria for structuring, evaluating, and tuning sample preparation procedures for paper and cardboard FCMs. For this purpose, a set of modified criteria and a decision tree are proposed based on the literature. Along this, mass transfer processes occurring in paper and cardboard FCMs and parameters affecting chemical migration need to be accounted for prior to reaching general consensus on criteria for sample preparation procedures.
    Schlagwörter European Union ; bioassays ; cardboard ; chemical analysis ; decision support systems ; food safety ; laws and regulations ; mass transfer ; paper ; safety assessment ; toxicity
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Umfang p. 4108-4129.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 2185829-9
    ISSN 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.13009
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  5. Artikel ; Online: Determination of

    Janssen, Aafke W F / Jansen Holleboom, Wendy / Rijkers, Deborah / Louisse, Jochem / Hoekstra, Sjoerdtje A / Schild, Sanne / Vrolijk, Misha F / Hoogenboom, Ron L A P / Beekmann, Karsten

    Frontiers in toxicology

    2024  Band 6, Seite(n) 1347965

    Abstract: Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limited ... ...

    Abstract Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limited understanding of the underlying mechanisms involved. Moreover, there is only a restricted amount of immunotoxicity data available for a limited number of PFASs. In the current study the effects of 15 PFASs, including short- and long-chain perfluorinated carboxylic and sulfonic acids, fluorotelomer alcohols, and perfluoralkyl ether carboxylic acids were studied on the expression of recombinant activating gene 1 (
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2024.1347965
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  6. Artikel ; Online: Role of antioxidants in the treatment of gastroesophageal reflux disease-associated idiopathic pulmonary fibrosis.

    Nelkine, Lauryna / Vrolijk, Misha F / Drent, Marjolein / Bast, Aalt

    Current opinion in pulmonary medicine

    2020  Band 26, Heft 4, Seite(n) 363–371

    Abstract: Purpose of review: Idiopathic pulmonary fibrosis (IPF) is a terminal lung disease of largely unknown cause. Gastroesophageal reflux disease (GERD) was recently discovered to be a trigger for the development of IPF. The current pharmaceutical approach to ...

    Abstract Purpose of review: Idiopathic pulmonary fibrosis (IPF) is a terminal lung disease of largely unknown cause. Gastroesophageal reflux disease (GERD) was recently discovered to be a trigger for the development of IPF. The current pharmaceutical approach to IPF falls short and there is a pressing need for improved therapeutic options. The present review describes the currently available knowledge regarding the role of oxidative stress and inflammation in the pathophysiology of IPF and GERD and determines the potential use of antioxidants as a treatment option for GERD-associated IPF.
    Recent findings: IPF and GERD share a similar pathophysiology, as oxidative stress and inflammation play a pivotal role in both conditions. This raises the question whether antioxidant treatment could be a well-tolerated and effective means to alleviate at least some of the symptoms of both conditions. In IPF, antioxidant supplementation complements the inadequately working antioxidant defense system of the lung, reducing oxidative stress and inflammation. In GERD, antioxidants increase levels of endogenous antioxidants, decrease pepsin and gastric acid production, lipid peroxidation, and ulceration, and alleviate subsequent damage to the gastric mucosa.
    Summary: The increased comorbidity of GERD in IPF patients makes it clear that there is a connection between GERD and IPF. As current treatment options are still inadequate to improve the condition and increase the survival rate of IPF patients, alternative treatment options are crucial. Based on the reviewed scientific evidence, antioxidant supplementation could complement standard IPF treatment, certainly in GERD-associated IPF.
    Mesh-Begriff(e) Antioxidants/therapeutic use ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/drug therapy ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/etiology
    Chemische Substanzen Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2020-05-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000684
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  7. Artikel ; Online: Red yeast rice (Monascus purpureus) supplements: Case series assessment of spontaneously reported cases to The Netherlands Pharmacovigilance Centre Lareb.

    Vrolijk, Misha F / van de Koppel, Sonja / van Hunsel, Florence

    British journal of clinical pharmacology

    2020  Band 87, Heft 4, Seite(n) 2146–2151

    Abstract: Serious concerns are expressed on the safe use of red yeast rice (RYR) supplements. The aim of the present study was to analyse cases received by Lareb on RYR-related adverse health events. These cases were analysed for the number of reports, number of ... ...

    Abstract Serious concerns are expressed on the safe use of red yeast rice (RYR) supplements. The aim of the present study was to analyse cases received by Lareb on RYR-related adverse health events. These cases were analysed for the number of reports, number of adverse drug reactions (ADRs), causality, seriousness of the reaction, latency-period, age and sex of the patients, concomitant medication and type of reporter. A total of 94 individual reports were collected by Lareb, corresponding with 187 ADRs. The analysis showed most reported ADRs were labelled musculoskeletal and connective tissue disorders (n = 64), gastrointestinal disorders (n = 33) and general disorders and administration site conditions (n = 23). The use of RYR supplements should be considered as a significant safety concern. Exposure to monacolin K could lead to serious adverse effects. To fully assess the safety profile of RYR supplements, more research is necessary to compose a complete ADR profile of RYR supplements.
    Mesh-Begriff(e) Adverse Drug Reaction Reporting Systems ; Biological Products/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Monascus ; Netherlands ; Pharmacovigilance
    Chemische Substanzen Biological Products ; red yeast rice
    Sprache Englisch
    Erscheinungsdatum 2020-11-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.14599
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    Zs.A 1118: Hefte anzeigen Standort:
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  8. Artikel: Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

    van der Lugt, Timme / Opperhuizen, Antoon / Bast, Aalt / Vrolijk, Misha F

    Nutrients. 2020 Sept. 14, v. 12, no. 9

    2020  

    Abstract: The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and ... ...

    Abstract The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and often include thermal treatment. During thermal treatment, the Maillard reaction can occur, leading to the formation of dietary advanced glycation endproducts (dAGEs). In this review, different biological effects of dAGEs are discussed, including their digestion, absorption, formation, and degradation in the gastrointestinal tract, with an emphasis on their pro-inflammatory effects. In addition, potential mechanisms in the inflammatory effects of dAGEs are discussed. This review also specifically elaborates on the involvement of the effects of dAGEs in IBD and focuses on evidence regarding the involvement of dAGEs in the symptoms of IBD. Finally, knowledge gaps that still need to be filled are identified.
    Schlagwörter Maillard reaction ; Western diets ; absorption ; advanced glycation end products ; degradation ; digestion ; digestive tract ; glycation ; heat treatment ; knowledge ; prevalence ; processed foods
    Sprache Englisch
    Erscheinungsverlauf 2020-0914
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092814
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  9. Artikel ; Online: Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro.

    Tukker, Anke M / Vrolijk, Misha F / van Kleef, Regina G D M / Sijm, Dick T H M / Westerink, Remco H S

    Toxicology letters

    2022  Band 373, Seite(n) 53–61

    Abstract: Tetrodotoxin (TTX) potently inhibits TTX-sensitive voltage-gated sodium ( ... ...

    Abstract Tetrodotoxin (TTX) potently inhibits TTX-sensitive voltage-gated sodium (Na
    Sprache Englisch
    Erscheinungsdatum 2022-11-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2022.11.005
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  10. Artikel ; Online: Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract.

    van der Lugt, Timme / Opperhuizen, Antoon / Bast, Aalt / Vrolijk, Misha F

    Nutrients

    2020  Band 12, Heft 9

    Abstract: The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and ... ...

    Abstract The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and often include thermal treatment. During thermal treatment, the Maillard reaction can occur, leading to the formation of dietary advanced glycation endproducts (dAGEs). In this review, different biological effects of dAGEs are discussed, including their digestion, absorption, formation, and degradation in the gastrointestinal tract, with an emphasis on their pro-inflammatory effects. In addition, potential mechanisms in the inflammatory effects of dAGEs are discussed. This review also specifically elaborates on the involvement of the effects of dAGEs in IBD and focuses on evidence regarding the involvement of dAGEs in the symptoms of IBD. Finally, knowledge gaps that still need to be filled are identified.
    Mesh-Begriff(e) Diet, Western/adverse effects ; Dietary Proteins/metabolism ; Gastrointestinal Tract/drug effects ; Glycation End Products, Advanced/metabolism ; Humans ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/etiology ; Maillard Reaction/drug effects ; Prevalence
    Chemische Substanzen Dietary Proteins ; Glycation End Products, Advanced
    Sprache Englisch
    Erscheinungsdatum 2020-09-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092814
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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