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Article ; Online: Myositis-associated interstitial lung disease.

Vu, Trang T T / Brown, Kevin K / Solomon, Joshua J

2023 Volume 29, Issue 5, Page(s) 427–435

Abstract: Purpose of review: In idiopathic inflammatory myopathies (IIMs), interstitial lung disease (ILD) is common and the autoantibody profile, made up of myositis-specific and myositis-associated (MSA and MAA) antibodies, can predict the clinical phenotype ... ...

Abstract	Purpose of review: In idiopathic inflammatory myopathies (IIMs), interstitial lung disease (ILD) is common and the autoantibody profile, made up of myositis-specific and myositis-associated (MSA and MAA) antibodies, can predict the clinical phenotype and progression over time. This review will focus on the characteristics and management of antisynthetase syndrome related ILD and anti-MDA5 positive ILD, which are the most clinically relevant subtypes. Recent findings: The prevalence of ILD in IIM has been estimated in Asia, North America and Europe at 50, 23 and 26%, respectively, and is increasing. In antisynthetase syndrome related ILD, the clinical presentation, progression and prognosis varies among anti-ARS antibodies. ILD is more common and severe in patients with anti-PL-7/anti-PL-12 antibodies when compared with anti Jo-1 patients. The prevalence of anti-MDA5 antibodies is higher in Asians (11-60%) than in whites (7-16%). Sixty-six percent of antisynthetase syndrome patients had 'chronic ILD' compared with the more rapidly progressive ILD (RP-ILD) seen in 69% of patients with anti-MDA5 antibodies. Summary: ILD is most common in the antisynthetase subtype of IIM and can be a chronic indolent or RP- ILD. The MSA and MAAs are associated with different clinical phenotypes of ILD. Treatments typically involve combinations of corticosteroids and other immunosuppressants.
MeSH term(s)	Humans ; Myositis/complications ; Myositis/drug therapy ; Autoantibodies ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/complications ; Immunosuppressive Agents
Chemical Substances	Autoantibodies ; Immunosuppressive Agents
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1285505-4
ISSN	1531-6971 ; 1070-5287 ; 1078-1641
ISSN (online)	1531-6971
ISSN	1070-5287 ; 1078-1641
DOI	10.1097/MCP.0000000000001000
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Article ; Online: Coaggregation of micro polystyrene particles and suspended minerals under concentrated salt solution: A perspective of terrestrial-to-ocean transfer of microplastics.

Vu, Trang T T / Nguyen, Duc T / Nguyen, Ngoc T M / Nguyen, Minh N

Marine pollution bulletin

2022 Volume 185, Issue Pt B, Page(s) 114317

Abstract: This study evaluates the colloidal stability of polystyrene microplastics (PSMPs) in the presence of various mineral colloids. Although PSMPs were highly dispersive, they were found to be involved in the aggregation of each mineral colloid. The ... ...

Abstract	This study evaluates the colloidal stability of polystyrene microplastics (PSMPs) in the presence of various mineral colloids. Although PSMPs were highly dispersive, they were found to be involved in the aggregation of each mineral colloid. The efficiency of mineral colloids to stimulate the coaggregation of PSMPs follows the order bentonite > kaolinitic soil clay > illitic soil clay > kaolinite > goethite > haematite. Surface charge density is likely a crucial factor that determines the efficiency of mineral colloids. In concentrated salt solution, PSMPs together with mineral colloids can be involved in various continuous and simultaneous electrochemical processes such as charge neutralization, double electric layer compression, van der Waals attraction stimulation and heteroaggregation. These processes may also occur in the estuary environments, where suspended mineral colloids may play an ultimate role in reducing the transport of microplastics into oceans while also intensifying microplastic enrichment in coastal sediments.
MeSH term(s)	Microplastics ; Polystyrenes ; Plastics ; Clay ; Sodium Chloride, Dietary ; Sodium Chloride ; Minerals ; Soil
Chemical Substances	Microplastics ; Polystyrenes ; Plastics ; Clay (T1FAD4SS2M) ; Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X) ; Minerals ; Soil
Language	English
Publishing date	2022-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2022.114317
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Article: Effects of rice-straw derived phytoliths on the surface charge properties of paddy soils

Nguyen, Anh M / Tran, Chinh T / Nguyen, Van T / Vu, Trang T.T / Nguyen, Ly N / Dultz, Stefan / Nguyen, Minh N

Geoderma. 2021 Oct. 15, v. 400

2021

Abstract: Straw of rice (Oryza sativa), a high Si-accumulating plant, is typically composed of amorphous silica bodies (namely phytoliths) that are deposited within the plant tissues. Recycling of rice straw is a traditional agricultural practice that introduces ... ...

Abstract	Straw of rice (Oryza sativa), a high Si-accumulating plant, is typically composed of amorphous silica bodies (namely phytoliths) that are deposited within the plant tissues. Recycling of rice straw is a traditional agricultural practice that introduces phytoliths into soil in many paddy regions. While the role of phytoliths as a carrier for nutrients, e.g., K, P, or terminal sink of Si, has been reported, it remains unclear to what extent phytolith can carry charges and act as a charge-interchange constituent in soils. Therefore, it was hypothesized that soil phytoliths can be involved in charge-related interactions e.g., pH buffering, multivalent cation exchange, polymerization, colloid stability or reactive transports. Based on a polyelectrolyte titration technique, our study evaluated surface charge (SC) dynamics of straw-derived phytoliths and paddy soils in the Mekong river and Red river deltas to characterize the possible contribution of phytoliths to soil SC properties. Phytoliths were extracted by both dry and wet ashing techniques and the SC of the obtained phytoliths were measured in the pH range from 3.5 to 8.0. The SC was detected to vary from slightly positive at low pH to –78.5 mmolc kg⁻¹ at slightly alkaline pH, suggesting that these materials carry variable charges and could be a significant source of charge when they are returned to soil in relatively large quantities. Multiple regressions indicated that phytoliths, to some extents, can together with other soil constituents such as clay minerals, organic matter and iron oxides, regulate the SC of paddy soils. Despite phytoliths being more or less soluble, their SC properties suggest that the annual recycling of rice straw to paddy soils, particularly after burning, can contribute to the negative SC system. The phytolith-derived charge in turn might affect soil cation exchange capacity (CEC), dispersibility of clay particles and transport of solutes.
Keywords	Oryza sativa ; ashing ; cation exchange ; cation exchange capacity ; clay ; dispersibility ; electrolytes ; organic matter ; pH ; paddies ; phytoliths ; polymerization ; rice ; rice straw ; silica ; titration ; Mekong River
Language	English
Dates of publication	2021-1015
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	281080-3
ISSN	1872-6259 ; 0016-7061
ISSN (online)	1872-6259
ISSN	0016-7061
DOI	10.1016/j.geoderma.2021.115234
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Article: Effects of microsized rice straw on soil clay dispersibility

Tran, Thu T. T. / Dao, Trang T. / Dinh, Van M. / Vu, Trang T. T. / Nguyen, Hue T. / Nguyen, Phuong M. / Ngo, Thu H. A. / Nguyen, Minh N.

European journal of soil science. 2022 May, v. 73, no. 3

2022

Abstract: The incorporation of straw into soil has been encouraged as an alternative straw‐disposal strategy to the on‐site burning that occurs in many paddy regions. However, this practice may lead to changes in the colloidal properties of soil clays that ... ...

Abstract	The incorporation of straw into soil has been encouraged as an alternative straw‐disposal strategy to the on‐site burning that occurs in many paddy regions. However, this practice may lead to changes in the colloidal properties of soil clays that potentially intensify clay and nutrient losses. This study aimed to demonstrate the effect of engineered microsized straw powder on the colloidal properties of two soil clays, that is, illitic and kaolinitic soil clays. Dynamic light scattering was coupled with the test tube method to evaluate time‐resolved changes in the particle size, zeta potential and dispersibility for the suspensions of straw powder and its mixtures with illitic and kaolinitic soil clays. Data from kinetic experiments over a time span of 20 days revealed that straw powder remarkably increased the dispersibility of soil clays. It was found that straw particles carried negative charges; thus, the introduction of straw powder into the clay suspensions increased the number of negative charges in the system, thereby increasing internal repulsive forces and eventually favouring clay dispersion. Moreover, certain mutual processes, that is, the biodegradation and dissolution of phytoliths (silica in straw), resulted in the release of dissolved organic matter and silicon, which aggravated clay dispersibility. In addition to the “traditional” awareness of the impacts of straw incorporation, for example, creating toxic, reduced environments or increasing CH₄ emissions, the changes in the colloidal properties of soil clays should also be highlighted. We propose that the incorporation of straw requires additional solutions for the prevention of clay loss. HIGHLIGHTS: Straw powder was examined for possible effect on colloidal properties of soil clays It was found that straw particles carried negative charges Introduction of straw powder increase repulsive forces and favor clay dispersion Microorganism, B. amyloliquefaciens, enhances the effect of straw powder
Keywords	biodegradation ; clay ; dispersibility ; dissolved organic matter ; kaolinitic soils ; paddies ; particle size ; phytoliths ; rice straw ; silica ; silicon ; toxicity ; zeta potential
Language	English
Dates of publication	2022-05
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1191614-x
ISSN	1365-2389 ; 1351-0754
ISSN (online)	1365-2389
ISSN	1351-0754
DOI	10.1111/ejss.13246
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Article: Comparative effects of crystalline, poorly crystalline and freshly formed iron oxides on the colloidal properties of polystyrene microplastics

Vu, Trang T.T. / Nguyen, Phat H. / Pham, Trinh V. / Do, Phuong Q. / Dao, Trang T. / Nguyen, Anh D. / Nguyen-Thanh, Lan / Dinh, Van M. / Nguyen, Minh N.

Environmental pollution. 2022 Aug. 01, v. 306

2022

Abstract: Colloid-sized microplastics (MPs) are ubiquitous in aquatic environments and can share the same transport route together with various crystalline, poorly crystalline and freshly formed iron oxides. However, the colloidal interactions between these ... ...

Abstract	Colloid-sized microplastics (MPs) are ubiquitous in aquatic environments and can share the same transport route together with various crystalline, poorly crystalline and freshly formed iron oxides. However, the colloidal interactions between these colloid constituents are not fully understood. This study was designed to investigate the colloidal properties of polystyrene microplastics (PSMPs) under the influence of haematite, goethite, ferrihydrite and freshly formed Fe oxide (FFFO). Dynamic light scattering was coupled with a test tube method to observe changes in the surface charge and colloidal dynamics of suspensions of PSMPs and Fe oxides. The overall effects on the aggregation of PSMPs are found to decrease in the following order: FFFO > ferrihydrite > goethite > haematite. The effects of these Fe oxides are found to strongly depend on pH. While the crystalline oxides play a dominant role in the acidic environment, poorly crystalline oxides show greater effects on PSMP aggregation in an alkaline environment. Heteroaggregation due to decreasing electrostatic interactions is the major mechanism that governs the colloidal dynamics of PSMPs and Fe oxides. It can be inferred that the copresence of Fe oxides and MPs can delay the transport of MPs or even change the destination for MPs.
Keywords	ferrihydrite ; goethite ; hematite ; microplastics ; pH ; pollution ; polystyrenes
Language	English
Dates of publication	2022-0801
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119474
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Article ; Online: Comparative effects of crystalline, poorly crystalline and freshly formed iron oxides on the colloidal properties of polystyrene microplastics.

Vu, Trang T T / Nguyen, Phat H / Pham, Trinh V / Do, Phuong Q / Dao, Trang T / Nguyen, Anh D / Nguyen-Thanh, Lan / Dinh, Van M / Nguyen, Minh N

Environmental pollution (Barking, Essex : 1987)

2022 Volume 306, Page(s) 119474

Abstract	Colloid-sized microplastics (MPs) are ubiquitous in aquatic environments and can share the same transport route together with various crystalline, poorly crystalline and freshly formed iron oxides. However, the colloidal interactions between these colloid constituents are not fully understood. This study was designed to investigate the colloidal properties of polystyrene microplastics (PSMPs) under the influence of haematite, goethite, ferrihydrite and freshly formed Fe oxide (FFFO). Dynamic light scattering was coupled with a test tube method to observe changes in the surface charge and colloidal dynamics of suspensions of PSMPs and Fe oxides. The overall effects on the aggregation of PSMPs are found to decrease in the following order: FFFO > ferrihydrite > goethite > haematite. The effects of these Fe oxides are found to strongly depend on pH. While the crystalline oxides play a dominant role in the acidic environment, poorly crystalline oxides show greater effects on PSMP aggregation in an alkaline environment. Heteroaggregation due to decreasing electrostatic interactions is the major mechanism that governs the colloidal dynamics of PSMPs and Fe oxides. It can be inferred that the copresence of Fe oxides and MPs can delay the transport of MPs or even change the destination for MPs.
MeSH term(s)	Colloids ; Ferric Compounds/chemistry ; Iron ; Microplastics ; Organic Chemicals ; Oxides ; Plastics ; Polystyrenes/chemistry
Chemical Substances	Colloids ; Ferric Compounds ; Microplastics ; Organic Chemicals ; Oxides ; Plastics ; Polystyrenes ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119474
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Article ; Online: Development and validation of a rabbit model of

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1297281

Abstract: Background: New drugs targeting antimicrobial resistant pathogens, including : Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with : Results: In a rabbit model of non-ventilated pneumonia, ... ...

Abstract	Background: New drugs targeting antimicrobial resistant pathogens, including Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with Results: In a rabbit model of non-ventilated pneumonia, endobronchial challenge with live Conclusion: The rabbit model may be used to help predict clinical efficacy of new antibacterial drugs for the treatment of non-ventilated
MeSH term(s)	Humans ; Animals ; Rabbits ; Meropenem/therapeutic use ; Pseudomonas aeruginosa ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Tobramycin/pharmacology ; Tobramycin/therapeutic use ; Pneumonia/drug therapy ; Drug Development
Chemical Substances	Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1297281
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Article ; Online: Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Vu, Trang T T / Nguyen, Nhu T Q / Tran, Vuvi G / Gras, Emmanuelle / Mao, Yanjie / Jung, David H / Tkaczyk, Christine / Sellman, Bret R / Diep, Binh An

Antimicrobial agents and chemotherapy

2020 Volume 64, Issue 3

Abstract: Staphylococcus ... ...

Abstract	Staphylococcus aureus
MeSH term(s)	Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/microbiology ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Disease Models, Animal ; Hemolysin Proteins/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/microbiology ; Leukocidins/therapeutic use ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Pneumonia, Necrotizing/drug therapy ; Pneumonia, Necrotizing/immunology ; Rabbits ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/pathogenicity
Chemical Substances	Antibodies, Monoclonal ; Hemolysin Proteins ; Leukocidins
Language	English
Publishing date	2020-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.02220-19
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Article ; Online: Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model.

Aguiar-Alves, Fábio / Le, Hoan N / Tran, Vuvi G / Gras, Emmanuelle / Vu, Trang T T / Dong, Oliver X / Quetz, Josiane Silva / Cheng, Lily I / Yu, Li / Sellman, Bret R / Stover, Charles K / DiGiandomenico, Antonio / Diep, Binh An

Antimicrobial agents and chemotherapy

2021 Volume 66, Issue 2, Page(s) e0202221

Abstract: Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogen Pseudomonas aeruginosa. We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets the P. ... ...

Abstract	Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogen Pseudomonas aeruginosa. We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets the P. aeruginosa type 3 secretion system PcrV protein and the Psl exopolysaccharide, in a rabbit model of ventilator-associated pneumonia using lung-protective, low-tidal-volume mechanical ventilation. Rabbits infused with MEDI3902 prophylactically were protected, whereas those pretreated with irrelevant isotype-matched control IgG (c-IgG) succumbed between 12 and 44 h postinfection (100% survival [8/8 rabbits] versus 0% survival [8/8 rabbits];
MeSH term(s)	Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Bacteremia/drug therapy ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/prevention & control ; Pseudomonas Infections ; Pseudomonas aeruginosa ; Rabbits
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.02022-21
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Article ; Online: Efficacy of Active Immunization With Attenuated α-Hemolysin and Panton-Valentine Leukocidin in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Tran, Vuvi G / Venkatasubramaniam, Arundhathi / Adhikari, Rajan P / Krishnan, Subramaniam / Wang, Xing / Le, Vien T M / Le, Hoan N / Vu, Trang T T / Schneider-Smith, Erika / Aman, M Javad / Diep, Binh An

The Journal of infectious diseases

2019 Volume 221, Issue 2, Page(s) 267–275

Abstract: Staphylococcus aureus is a common pathogen causing infections in humans with various degrees of severity, with pneumonia being one of the most severe infections. In as much as staphylococcal pneumonia is a disease driven in large part by α-hemolysin (Hla) ...

Abstract	Staphylococcus aureus is a common pathogen causing infections in humans with various degrees of severity, with pneumonia being one of the most severe infections. In as much as staphylococcal pneumonia is a disease driven in large part by α-hemolysin (Hla) and Panton-Valentine leukocidin (PVL), we evaluated whether active immunization with attenuated forms of Hla (HlaH35L/H48L) alone, PVL components (LukS-PVT28F/K97A/S209A and LukF-PVK102A) alone, or combination of all 3 toxoids could prevent lethal challenge in a rabbit model of necrotizing pneumonia caused by the USA300 community-associated methicillin-resistant S. aureus (MRSA). Rabbits vaccinated with Hla toxoid alone or PVL components alone were only partially protected against lethal pneumonia, whereas those vaccinated with all 3 toxoids had 100% protection against lethality. Vaccine-mediated protection correlated with induction of polyclonal antibody response that neutralized not only α-hemolysin and PVL, but also other related toxins, produced by USA300 and other epidemic MRSA clones.
MeSH term(s)	Animals ; Bacterial Toxins/administration & dosage ; Bacterial Toxins/immunology ; Disease Models, Animal ; Exotoxins/administration & dosage ; Exotoxins/immunology ; Hemolysin Proteins/administration & dosage ; Hemolysin Proteins/immunology ; Humans ; Leukocidins/administration & dosage ; Leukocidins/immunology ; Methicillin-Resistant Staphylococcus aureus ; Pneumonia, Necrotizing/immunology ; Pneumonia, Necrotizing/prevention & control ; Pneumonia, Staphylococcal/immunology ; Pneumonia, Staphylococcal/prevention & control ; Rabbits ; Vaccination
Chemical Substances	Bacterial Toxins ; Exotoxins ; Hemolysin Proteins ; Leukocidins ; Panton-Valentine leukocidin
Language	English
Publishing date	2019-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiz437
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