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Article: Impact of haemoglobin A1c on wound infection in patients with diabetes with implanted synthetic graft.

Matić, Predrag / Atanasijević, Igor / Stojković, Vera Maravić / Soldatović, Ivan / Tanasković, Slobodan / Babić, Srđan / Gajin, Predrag / Lozuk, Branko / Vučurević, Goran / Đoković, Aleksandra / Živić, Rastko / Đulejić, Vuk / Nešković, Mihailo / Babić, Aleksandar / Ilijevski, Nenad

Journal of wound care

2024 Volume 33, Issue 2, Page(s) 136–142

Abstract: Objective: The aim of this study was to assess the relationship between haemoglobin A1c (HbA1c) values and operative wound infection.: Method: During the period from 2013-2016, consecutive patients with type 2 diabetes were prospectively evaluated. ... ...

Abstract	Objective: The aim of this study was to assess the relationship between haemoglobin A1c (HbA1c) values and operative wound infection. Method: During the period from 2013-2016, consecutive patients with type 2 diabetes were prospectively evaluated. Data were retrospectively analysed. All included patients were admitted for an elective surgical procedure, requiring the use of prosthetic graft in a groin wound. The patients were divided into two groups according to their preoperative HbA1c values. The main outcome was groin wound infection. The association between preoperative long-term glycoregulation and wound infection was evaluated, as well as the impact of postoperative glycaemic values, regardless of the level of HbA1c. Results: Of the 93 participating patients, wound infection occurred in 20 (21.5%). Wound infection occurred in 28.2% of patients with uncontrolled diabetes (HbA1c >7%) and 16.7% of patients with controlled diabetes (HbA1c <7%); however, the difference did not reach statistical significance (p=0.181). In regression modelling, operative time (p=0.042) was a significant predictor of wound infection, while patients' age (p=0.056) was on the borderline of statistical significance. Females had a higher probability for wound infection (odds ratio (OR): 1.739; 95% confidence interval (CI):0.483-6.265), but there was no statistical significance (p=0.397). Patients with elevated levels of HbA1c had a higher chance of wound infection compared with patients with controlled diabetes (OR: 2.243; 95% CI: 0.749-6.716), nevertheless, this was not statistically significant (p=0.149). Conclusion: We found no statistically significant correlation between elevated values of preoperative HbA1c and postoperative groin wound infection.
MeSH term(s)	Female ; Humans ; Glycated Hemoglobin ; Retrospective Studies ; Diabetes Mellitus, Type 2 ; Surgical Wound Infection/epidemiology
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2024.33.2.136
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Article ; Conference proceedings: Brain network course patterns observed with fMRI during movie presentation

Konrad, A / Vucurevic, G

Klinische Neurophysiologie

2010

Abstract: Objective: : Previous functional magnetic resonance imaging (fMRI) studies mostly used abstracted paradigms to investigate different aspects of human brain function and pathological alterations of brain function in neuropsychiatric diseases. Though, the ...

Event/congress	54. Jahrestagung der Deutschen Gesellschaft für Klinische Neurophysiologie und funktionelle Bildgebung, Halle (Saale), 2010
Abstract	Objective: : Previous functional magnetic resonance imaging (fMRI) studies mostly used abstracted paradigms to investigate different aspects of human brain function and pathological alterations of brain function in neuropsychiatric diseases. Though, the application of those particular tasks underlie several restrictions, subjects have to be compliant and without relevant cognitive impairment. Therefore, we decided to investigate human brain function in more natural conditions in subjects which freely viewed a film. Material and Methods: We investigated N=6 healthy subjects (age 20–65 years), fMRI was acquired on a 3 Tesla Trio® Scanner (Siemens, Erlangen, Germany). The subjects freely viewed a 45min film of the Carmen Opera during fMRI acquisition. We selected the film Carmen because it includes particularly expressive scenes and music. In the initial analysis, spatiotemporal activity patterns in one brain were identified with independent component analysis (ICA). In the following intersubject correlation analysis, these patterns were used to model common brain activation, using first eigenvariate of temporal courses. Common time courses (first eigenvariates ) were used as input regressors for the reanalysis of single subject fMRIs using standard SPM (statistical parametric mapping) first level procedure after which we made also second level analysis using SPM. Fig.1: Results: ICA provided a number of brain network patterns activated during our paradigm. Common time courses from primary visual and acoustic activations induced activation in higher level cortical networks beyond primary sensory brain areas. Figure 1 shows an example of the difference between the single subject acoustical independent component (A) and a common acoustical timecourse activation (B) applied to the same subject. Conclusion: : The simple experimental design of this study gives us the possibility to include groups of subjects not compliant to follow abstract fMRI paradigms requiring also a higher level of concentration over a longer time. It may be particularly useful in the examination of children as well as in patients with specific neuropsychiatric diseases. It would be of special interest to find differences in functional connectivity between sensory and higher brain processing networks in such groups.
Language	English
Publishing date	2010-03-02
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80107-0
ISSN	1439-4081 ; 1434-0275 ; 0012-7590
ISSN (online)	1439-4081
ISSN	1434-0275 ; 0012-7590
DOI	10.1055/s-0030-1250936
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Article: Anatomy and radiology of the variations of aortic arch branches in 1,266 patients.

Vučurević, G / Marinković, S / Puškaš, L / Kovačević, I / Tanasković, S / Radak, D / Ilić, A

Folia morphologica

2013 Volume 72, Issue 2, Page(s) 113–122

Abstract: Background: The most reliable data about arterial variations, which are very important in surgery and radiology, can be obtained from a large series of patients.: Materials and methods: We examined angiographic and multislice computerised tomography ( ...

Abstract	Background: The most reliable data about arterial variations, which are very important in surgery and radiology, can be obtained from a large series of patients. Materials and methods: We examined angiographic and multislice computerised tomography (MSCT) images in a group of 1,265 patients and in 1 dissected specimen. Results: While in 946 (74.72%) of the patients a normal vascular pattern (type I) was noticed, in the remaining 320 (25.28%) patients variations of the branches of the aortic arch were found, which were classified into types II through VIII and a few subtypes. Type II (2.84%) comprised a common origin of the left commoncarotid and subclavian arteries. Type III (15.56%) was related to an origin of the left subclavian artery from the brachiocephalic trunk. Type IV (0.55%) included the aortic origin of both common carotid and subclavian arteries, with the right subclavian artery having a retroesophageal course. Type V (0.24%) included the same 4 supra-aortic branches, which, however, arose from a double or a right--sided aortic arch. Type VI (3.63%) comprised the aortic origin of the left vertebral artery, type VII (0.24%) the same origin of the right vertebral artery, and type VIII(2.22%) the aortic origin of the thyroideaima artery. A corresponding embryological background and clinical implications of the described aberrant vessels were presented. Conclusions: In more than one quarter of the cases, the branching pattern of the examined arteries did not follow the classical pattern. Detailed knowledge of aortic branch variations is of great significance in anatomy, embryology, and clinical medicine, especially in radiology and thoracic surgery.
MeSH term(s)	Aged ; Angiography/methods ; Aorta, Thoracic/anatomy & histology ; Aorta, Thoracic/diagnostic imaging ; Female ; Humans ; Male
Language	English
Publishing date	2013-06-01
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	419361-1
ISSN	1644-3284 ; 0015-5659
ISSN (online)	1644-3284
ISSN	0015-5659
DOI	10.5603/fm.2013.0019
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Zs.A 577: Show issues

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Article ; Online: Duplication of the superior vena cava associated with atrial termination of the left hepatic vein.

Milisavljevic, M / Marinkovic, S / Radak, D / Cetkovic, M / Vucurevic, G / Trifunovic, D

Phlebology

2013 Volume 28, Issue 7, Page(s) 369–374

Abstract: Duplication of the superior vena cava (SVC), associated with an aberrant left hepatic vein (LHV), was found in one of the 58 dissected specimens. The right SVC virtually showed a typical appearance. The persistent left SVC, which drained into the right ... ...

Abstract	Duplication of the superior vena cava (SVC), associated with an aberrant left hepatic vein (LHV), was found in one of the 58 dissected specimens. The right SVC virtually showed a typical appearance. The persistent left SVC, which drained into the right atrium via the enlarged coronary sinus, was formed by the persistence of the left anterior cardinal vein. The LHV opened into the right atrium, due to the persistent left hepatocardiac channel. The left common carotid artery arose from the brachiocephalic trunk as a consequence of a regression of the embryonic aortic sac. The revealed venous and arterial variations seem to be the first reported vascular combination of this type.
MeSH term(s)	Adult ; Heart Atria/abnormalities ; Hepatic Veins/abnormalities ; Humans ; Male ; Vascular Malformations/pathology ; Vena Cava, Superior/abnormalities
Language	English
Publishing date	2013-10
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645172-x
ISSN	1758-1125 ; 0268-3555
ISSN (online)	1758-1125
ISSN	0268-3555
DOI	10.1258/phleb.2012.011156
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Zs.A 2538: Show issues

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Article ; Online: Carotid Restenosis Rate After Stenting for Primary Lesions Versus Restenosis After Endarterectomy With Creation of Risk Index.

Tanaskovic, Slobodan / Sagic, Dragan / Radak, Djordje / Antonic, Zelimir / Kovacevic, Vladimir / Vukovic, Mira / Aleksic, Nikola / Radak, Sandra / Nenezic, Dragoslav / Cvetkovic, Slobodan / Isenovic, Esma / Vucurevic, Goran / Lozuk, Branko / Babic, Aleksandar / Babic, Srdjan / Matic, Predrag / Gajin, Predrag / Unic-Stojanovic, Dragana / Ilijevski, Nenad

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2022 Volume 30, Issue 4, Page(s) 580–591

Abstract: Purpose: Carotid artery stenting (CAS) is an option for carotid restenosis (CR) treatment with favorable outcomes. However, CAS has also emerged as an alternative to carotid endarterectomy (CEA) for the management of patients with primary carotid ... ...

Abstract	Purpose: Carotid artery stenting (CAS) is an option for carotid restenosis (CR) treatment with favorable outcomes. However, CAS has also emerged as an alternative to carotid endarterectomy (CEA) for the management of patients with primary carotid stenosis. This study aimed to report CR rates after CAS was performed in patients with primary lesions versus restenosis after CEA, to identify predictors of CR, and to report both neurological and overall outcomes. Materials and methods: From January 2000 to September 2018, a total of 782 patients were divided into 2 groups: The CAS (prim) group consisted of 440 patients in whom CAS was performed for primary lesions, and the CAS (res) group consisted of 342 patients with CAS due to restenosis after CEA. Indications for CAS were symptomatic stenosis/restenosis >70% and asymptomatic stenosis/restenosis >85%. A color duplex scan (CDS) of carotid arteries was performed 6 months after CAS, after 1 year, and annually afterward. Follow-up ranged from 12 to 88 months, with a mean follow-up of 34.6±18.0 months. Results: There were no differences in terms of CR rate between the patients in the CAS (prim) and CAS (res) groups (8.7% vs 7.2%, χ Conclusions: There was no difference in CR rate after CAS between the patients with primary stenosis and restenosis after CEA. A CRRI score >-4 is a criterion for identifying high-risk patients for post-CAS CR that should be tested in future randomized trials.
MeSH term(s)	Humans ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/therapy ; Carotid Stenosis/complications ; Constriction, Pathologic ; Treatment Outcome ; Stents/adverse effects ; Time Factors ; Endarterectomy, Carotid/adverse effects ; Carotid Arteries ; Risk Factors ; Recurrence ; Stroke/etiology
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028221091895
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Zs.A 4547: Show issues

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Article ; Online: In situ revascularisation for femoropopliteal graft infection: ten years of experience with silver grafts.

Matic, P / Tanaskovic, S / Babic, S / Gajin, P / Jocic, D / Nenezic, D / Ilijevski, N / Vucurevic, G / Radak, D J

Vascular

2014 Volume 22, Issue 5, Page(s) 323–327

Abstract: Purpose: The purpose of this study was to analyze clinical outcome of patients for femoropopliteal graft infection who were treated by in situ reconstruction with a silver-coated prosthesis.: Basic methods: From December 2001 to December 2011, 27 ... ...

Abstract	Purpose: The purpose of this study was to analyze clinical outcome of patients for femoropopliteal graft infection who were treated by in situ reconstruction with a silver-coated prosthesis. Basic methods: From December 2001 to December 2011, 27 patients were treated for femoropopliteal graft infection. Twenty patients (74%) were male and seven (26%) were female. Mean age was 65 years. The primary endpoint was recurrence of infection. Secondary endpoints were early and late mortality and morbidity, primary graft patency, major amputation rates and patient survival. Principal findings: Early reinfection occurred in 11% and late in 8% of patients. Perioperative mortality was 7% and late was 4%. Above-knee amputation was performed in 4% of patients during early postoperative course and in 12% of patients during follow-up. Early and late graft patency was 96% and 72%, respectively. Conclusions: Results of in situ implantation of silver-coated grafts for femoropopliteal prosthesis infection are according to our opinion acceptable, but the risk of reinfection remains.
MeSH term(s)	Aged ; Amputation/statistics & numerical data ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Debridement ; Drainage ; Female ; Femoral Artery/surgery ; Humans ; Male ; Middle Aged ; Popliteal Artery/surgery ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/mortality ; Prosthesis-Related Infections/surgery ; Recurrence ; Silver/pharmacology ; Survival Rate ; Treatment Outcome ; Vascular Patency
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/1708538113504399
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Article ; Online: VBM-DTI correlates of verbal intelligence: a potential link to Broca's area.

Konrad, Andreas / Vucurevic, Goran / Musso, Francesco / Winterer, Georg

Journal of cognitive neuroscience

2012 Volume 24, Issue 4, Page(s) 888–895

Abstract: Human brain lesion studies first investigated the biological roots of cognitive functions including language in the late 1800s. Neuroimaging studies have reported correlation findings with general intelligence predominantly in fronto-parietal cortical ... ...

Abstract	Human brain lesion studies first investigated the biological roots of cognitive functions including language in the late 1800s. Neuroimaging studies have reported correlation findings with general intelligence predominantly in fronto-parietal cortical areas. However, there is still little evidence about the relationship between verbal intelligence and structural properties of the brain. We predicted that verbal performance is related to language regions of Broca's and Wernicke's areas. Verbal intelligence quotient (vIQ) was assessed in 30 healthy young subjects. T1-weighted MRI and diffusion tensor imaging data sets were acquired. Voxel-wise regression analyses were used to correlate fractional anisotropy (FA) and mean diffusivity values with vIQ. Moreover, regression analyses of regional brain volume with vIQ were performed adopting voxel-based morphometry (VBM) and ROI methodology. Our analyses revealed a significant negative correlation between vIQ and FA and a significant positive correlation between vIQ and mean diffusivity in the left-hemispheric Broca's area. VBM regression analyses did not show significant results, whereas a subsequent ROI analysis of Broca's area FA peak cluster demonstrated a positive correlation of gray matter volume and vIQ. These findings suggest that cortical thickness in Broca's area contributes to verbal intelligence. Diffusion parameters predicted gray matter ratio in Broca's area more sensitive than VBM methodology.
MeSH term(s)	Adult ; Anisotropy ; Brain Mapping ; Diffusion Tensor Imaging ; Female ; Frontal Lobe/anatomy & histology ; Frontal Lobe/physiology ; Humans ; Image Processing, Computer-Assisted ; Intelligence ; Intelligence Tests ; Language ; Magnetic Resonance Imaging ; Male ; Statistics as Topic ; Temporal Lobe/anatomy & histology ; Temporal Lobe/physiology ; Young Adult
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1007410-7
ISSN	1530-8898 ; 0898-929X ; 1096-8857
ISSN (online)	1530-8898
ISSN	0898-929X ; 1096-8857
DOI	10.1162/jocn_a_00187
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Zs.A 2623: Show issues

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Article ; Conference proceedings: 32-Kanal-Kopfspule in einem 3T-MR-Scanner: Auflösungssteigerungen bei klinischen und experimentellen Anwendungen

Gawehn, J / Vucurevic, G / Kronfeld, A / Stoeter, P

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

2009

Abstract: Ziele: Anhand anatomischer und klinischer Fragestellungen werden bei verschiedenen klinischen und experimentellen Einsätzen die Vorzüge einer 32-Kanal-Kopfspule gegenüber einer 12-Kanal-Kopfspule aufgezeigt. : Methode: In einem 3T-System (Siemens ... ...

Event/congress	90. Deutscher Röntgenkongress, Berlin, 2009
Abstract	Ziele: Anhand anatomischer und klinischer Fragestellungen werden bei verschiedenen klinischen und experimentellen Einsätzen die Vorzüge einer 32-Kanal-Kopfspule gegenüber einer 12-Kanal-Kopfspule aufgezeigt. Methode: In einem 3T-System (Siemens Trio) wurde der mit einer 32-Kanal-Kopfspule in Relation zu einer 12-Kanal-Kopfspule erreichbare Auflösungsgewinn unter Berücksichtigung der Akquisitionszeit anhand konkreter anatomischer Probleme an mehreren Probanden und Patienten untersucht. Vorausgegangen waren vergleichende Phantomaufnahmen in beiden Spulen. Im einzelnen wurde geprüft, ob T1- oder T2-gewichtet eine Differenzierung des Gennari- Streifens gelingt, inwieweit sich die Auflösung der intrakraniellen MR-Angiographie erhöht, ob die Qualität von Diffusionsbildern sich steigern lässt und ob ein Gewinn für die funktionelle MRT besteht. Ergebnis: Die vergleichenden Phantomuntersuchungen zeigen oberflächennahe ein signifikant höheres Signal-zu-Rausch-Verhältnis der 32-Kanal-Spule. Sequenzabhängig konnten SNR-Erhöhungen bis 80% gemessen werden. Im Spulenzentrum ist der Gewinn dagegen geringer. An Probanden gelang im Gegensatz zur 12-Kanal-Spule sowohl T1- als auch T2- gewichtet eine sichere Differenzierung des Gennari- Streifens. MR-angiographisch lassen sich die Äste der A. c. media bis weit in die Peripherie verfolgen, die A. ophtalmica ist bis intraorbital identifizierbar, und nur die 32-Kanal-Spule erreicht die für eine Dextroskop-gestützte operative Planung eines IC/EC-Bypass' gewünschte Hochauflösung arterieller Hirngefäße. Diffusionstensoraufnahmen mit 2mm Schichtdicke sind artefaktarm und mit guten SNR-Verhältnis gewinnbar; auch die Detailzeichnung von SWI- Aufnahmen profitiert. Bei funktioneller Bildgebung ermöglicht die hohe Signalqualität zusätzliche Filterungen durch Anhebung des Signifikanzniveaus oder die Registrierung geringer aktiver Areale. Schlussfolgerung: Eine 32-Kanal-Kopfspule ist für klinische und experimentelle Fragestellungen, die eine besonders hohe Auflösung erfordern, zu empfehlen. Korrespondierender Autor: Gawehn J Universitätsklinik Mainz, Institut für Neuroradiologie, Langenbeckstr. 1, 55131 Mainz E-Mail: gawehn@gmxpro.de
Keywords	32- Kanal- Kopfspule ; Gennari ; IC/EC- Bypass ; 32 Kanäle ; Dextroskop
Language	German
Publishing date	2009-05-13
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	554830-5
ISSN	1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
ISSN (online)	1438-9010
ISSN	1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
DOI	10.1055/s-0029-1221364
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Article ; Conference proceedings: Evaluierung eines Dialysator-Modells zur Bestimmung des regionalen Blutflusses mittels perfusionsgewichteter MRT

Maciak, A / Vucurevic, G / Kronfeld, A / Stoeter, P

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

2009

Abstract: Ziel: Ermittlung der Reproduzierbarkeit von Flussmessungen in einem Dialysator-Phantom mittels perfusionsgewichteter MRT im Vergleich zum Wert der physikalisch festgelegten steady-state-Durchströmung: Material und Methode: Der Phantomkörper besteht ... ...

Event/congress	Experimentelle Radiologie 2009, Mainz, 2009
Abstract	Ziel: Ermittlung der Reproduzierbarkeit von Flussmessungen in einem Dialysator-Phantom mittels perfusionsgewichteter MRT im Vergleich zum Wert der physikalisch festgelegten steady-state-Durchströmung Material und Methode: Der Phantomkörper besteht aus einem MRT-tauglichen Dialysator mit 12800 Kapillaren von jeweils 200µm Durchmesser. Über eine Pumpe wird ein kontinuierlicher pulsatiler Zu- und Abfluss erzeugt. Zur Perfusionsmessung wird bolusartig ein niedermolekulares MR-Kontrastmittel unterschiedlicher Konzentration zugesetzt. Die Messung erfolgt sowohl mit T1- als auch mit T2-gewichteten Sequenzen und die Auswertung mittels verschiedener Programme unter Verwendung der Input-Funktion. Ergebnis: Die bislang durchgeführten Messungen der Flussgeschwindigkeiten ergaben trotz unterschiedlicher Bolus-Kinetik eine hohe Übereinstimmung mit der von der Pumpe erzeugten Flussgeschwindigkeit sowie eine gute Reproduzierbarkeit. Dabei zeigte sich eine relativ homogene Verteilung der Flussgeschwindigkeiten über den Zylinder-Querschnitt, so dass auch der Volumenfluss zuverlässig ermittelt werden kann. Schlussfolgerung: Nach den bisherigen Ergebnissen erlaubt das Dialysator-Modell zuverlässige MRT-Perfusionsmessungen eines physikalisch festgelegten pulsatilen Flusses in Kapillaren und erscheint damit geeignet, die Zuverlässigkeit verschiedener Auswerteprogramme zur MRT-Perfusionsmessung miteinander zu vergleichen.
Language	German
Publishing date	2009-02-20
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	554830-5
ISSN	1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
ISSN (online)	1438-9010
ISSN	1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
DOI	10.1055/s-0029-1208341
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Article ; Conference proceedings: 32-Kanal-Kopfspule in einem 3T-MR-Scanner: Sensitivitäts- und Auflösungssteigerungen bei funktionellen und anatomischen Anwendungen

Gawehn, J / Vucurevic, G / Kronfeld, A / Stoeter, P

Klinische Neurophysiologie

2009

Abstract: Ziel: Anhand verschiedener funktioneller Fragestellungen werden nach ersten klinischen und experimentellen Einsätzen die Vorzüge einer 32-Kanal-Kopfspule gegenüber einer 12-Kanal-Kopfspule aufgezeigt.: Methode: In einem 3T-System (Siemens Magnetom ... ...

Event/congress	53. Jahrestagung der Deutschen Gesellschaft für Klinische Neurophysiologie und Funktionelle Bildgebung, München, 2009
Abstract	Ziel: Anhand verschiedener funktioneller Fragestellungen werden nach ersten klinischen und experimentellen Einsätzen die Vorzüge einer 32-Kanal-Kopfspule gegenüber einer 12-Kanal-Kopfspule aufgezeigt. Methode: In einem 3T-System (Siemens Magnetom Trio) wurden die mit einer 32-Kanal-Kopfspule in Relation zu einer 12-Kanal-Kopfspule beobachtete Steigerung der Sensitivität anhand grundlegender funktioneller Paradigmen wie Motorik und Sprache sowie der in anatomischen Aufnahmen erreichbare Auflösungsgewinn untersucht. Vorausgegangen waren vergleichende Phantomaufnahmen in beiden Spulen. Im einzelnen wurde an einem Phantom das räumliche Profil des Signal-zu-Rausch-Verhältnisses aufgezeichnet. An Probanden erfolgten unter gleichen Bedingungen identische funktionelle Untersuchungen konsekutiv mit der 32-Kanal- und der 12-Kanal-Spule, und die Ergebnisse wurden einem individuellen Paar-t-Test-Vergleich unterzogen. Ferner wurde geprüft, ob eine Qualitätssteigerung von Tensordiffusionsbildern für korrelierende traktographische Darstellungen möglich ist. Zur Evaluation der anatomischen Auflösbarkeit bestand die Aufgabe, T1- oder T2-gewichtet eine Differenzierung des Gennari-Streifens zu erreichen – hierfür wurden jeweils isotrope 3D-Sequenzen mit einer Voxelbreite von 0,5mm verwendet und 8 bzw. 6 Akquisitionen mit SPM gemittelt. Ergebnisse: Die vergleichend durchgeführten Phantomuntersuchungen zeigen oberflächennahe ein signifikant höheres Signal-zu-Rausch-Verhältnis der 32-Kanal-Spule. Sequenzabhängig konnten SNR-Erhöhungen bis zu 80% gemessen werden. Im Spulenzentrum ist der Gewinn dagegen gering. Bei funktioneller Bildgebung ermöglicht die hohe Signalqualität zusätzliche Filterungen durch Erhöhung des Signifikanzniveaus. In vergleichenden motorischen Aktivierungsstudien der 32- und der 12-Kanal-Spule konnte mittels individueller Paar-t-Test-Differenzen der motorische Cortex in hoher Qualität dargestellt und somit der Beweis der überlegenen Signalqualität der 32-Kanal-Spule erbracht werden. An Probanden gelang ferner im Gegensatz zur 12-Kanal-Spule sowohl T1- als auch T2- gewichtet eine sichere Differenzierung des Gennari-Streifens. Diffusionstensoraufnahmen mit 2mm Schichtdicke sind artefaktarm und mit gutem Signal-zu-Rausch-Verhältnis gewinnbar. Schlussfolgerung: Eine 32-Kanal-Kopfspule ist für funktionelle Untersuchungen mit besonderen Ansprüchen an die Sensitivität und für anatomische Fragestellungen mit hohen Auflösungsanforderungen zu empfehlen.
Language	German
Publishing date	2009-03-13
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80107-0
ISSN	1439-4081 ; 1434-0275 ; 0012-7590
ISSN (online)	1439-4081
ISSN	1434-0275 ; 0012-7590
DOI	10.1055/s-0029-1216078
Database	Thieme publisher's database

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