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Article: Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.

Vukašinović, Mila / Savić, Sanela / Cekić, Nebojša / Ilić, Tanja / Pantelić, Ivana / Savić, Snežana D

2023 Volume 15, Issue 2

Abstract: Since natural-origin, sustainable ingredients are preferred by modern consumers, novel emulsifiers and emollients keep entering the market. This study hypothesizes that a combination of in silico, instrumental tools and simplified sensory studies could ... ...

Abstract	Since natural-origin, sustainable ingredients are preferred by modern consumers, novel emulsifiers and emollients keep entering the market. This study hypothesizes that a combination of in silico, instrumental tools and simplified sensory studies could be used to efficiently characterize emulsions in a shorter timeframe. A total of 22 rather simple o/w emulsions were prepared by a time/energy-saving emulsification process. A natural mixed emulsifier (Lauryl Glucoside/Myristyl Glucoside/Polyglyceryl-6 Laurate) and two emollients (both with INCI name C15-19 Alkane) were used. The performed D-optimal experimental design within the response surface method (RSM) significantly narrowed down the number of samples about to enter the stage of texture, friction and sensory studies to the samples comprising 30% of a respective Emogreen emollient and 2% or 3% of the emulsifier. The sample comprising 2% emulsifier/30% Emogreen
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020486
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Article ; Online: Relationship between socio-demographic characteristics and vocal fold nodules, polyps and oedema.

Milovanovic, J / Vukasinovic, M / Jotic, A / Vlajinac, H / Milovanovic, A / Pavlovic, B / Banko, B / Maksimovic, J

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2019 Volume 38, Issue 5, Page(s) 424–430

Abstract: The aim of our study was to compare socio-demographic characteristics of vocal fold nodules, polyps and oedema. The study included patients diagnosed for the first time with vocal fold nodules, polyps and oedema at the Communication Disorders Care Center ...

Abstract	The aim of our study was to compare socio-demographic characteristics of vocal fold nodules, polyps and oedema. The study included patients diagnosed for the first time with vocal fold nodules, polyps and oedema at the Communication Disorders Care Center of Clinic for Otorhinolaryngology and Maxillofacial Surgery in Clinical Center of Serbia, Belgrade. Diagnosis was made on the basis of symptoms, clinical otorhinolaryngological and phoniatric examination and endovideolaryngostroboscopic findings. A self-administered questionnaire was used to collect the following data: socio-demographic status, exposure to occupational noise and air pollution, occupational voice demands, health habits, symptoms of the present voice problems and voice problems in the family. By multivariate logistic regression analyses, nodules and oedema were more frequent in women than men in comparison with polyps (p < 0.001). Patients with nodules and polyps were younger than those with oedema (p < 0.001). Patients with nodules were more frequently lecturers, singers and actors compared with polyp patients (p = 0.006), had occupational voice demands more frequently than patients with oedema (p = 0.037) and were less frequently smokers than patients with polyps (p = 0.043) and those with oedema (p < 0.001). Patients with oedema were more frequently current smokers than patients with nodules and those with polyps (p < 0.001). Hoarseness as the main symptom was more frequent among patients with nodules than among patients with polyps (p = 0.040) and those with oedema (p = 0.001).Voice problems in the family was more frequently reported by oedema patients than by patients with polyps (p = 0.005). These findings are in agreement with majority of previous studies and may be of help in investigations on the aetiology of the disease.
MeSH term(s)	Adult ; Demography ; Edema/epidemiology ; Edema/etiology ; Female ; Humans ; Laryngeal Diseases/epidemiology ; Laryngeal Diseases/etiology ; Male ; Polyps/epidemiology ; Polyps/etiology ; Socioeconomic Factors ; Vocal Cords
Language	English
Publishing date	2019-02-07
Publishing country	Italy
Document type	Comparative Study ; Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-1983
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Article: [What do we need to help laryngectomized speeking?].

Djukić, V / Vukasinović, M / Stanković, P / Milovanović, J / Folić, M

Acta chirurgica Iugoslavica

2010 Volume 56, Issue 3, Page(s) 11–15

Abstract: Multidisciplinary approach in rehabilitation of laryngectomized patients is the basic of esophageal voice and speech establishing. Well trained and dedicated stuff is cornerstone for such helpless patients. Communication Disorders Care Center and ... ...

Abstract	Multidisciplinary approach in rehabilitation of laryngectomized patients is the basic of esophageal voice and speech establishing. Well trained and dedicated stuff is cornerstone for such helpless patients. Communication Disorders Care Center and Laryngectomized Patients Society are minimal administrative precautions in organized community. Modern technology implementation gives us objective evaluation of therapy effects, that is 84% of successful treatment in our daily work.
MeSH term(s)	Humans ; Laryngectomy/rehabilitation ; Speech, Esophageal
Language	Serbian
Publishing date	2010-03-08
Publishing country	Serbia
Document type	English Abstract ; Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0903011d
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Article: Prevalence of Genotypes That Determine Resistance of Staphylococci to Macrolides and Lincosamides in Serbia.

Mišić, Milena / Čukić, Jelena / Vidanović, Dejan / Šekler, Milanko / Matić, Sanja / Vukašinović, Mihailo / Baskić, Dejan

Frontiers in public health

2017 Volume 5, Page(s) 200

Abstract: Macrolides, lincosamides, and streptogramins (MLS) resistance genes are responsible for resistance to these antibiotics ... ...

Abstract	Macrolides, lincosamides, and streptogramins (MLS) resistance genes are responsible for resistance to these antibiotics in
Language	English
Publishing date	2017-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2017.00200
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Article ; Online: Transcultural Adaptation and Validation of the Voice Handicap Index-10 into the Serbian Language.

Maksimovic, Jadranka / Vukasinovic, Milan / Vlajinac, Hristina / Jotic, Ana / Djukic, Vojko / Marinkovic, Jelena / Krejovic-Trivic, Sanja / Milovanovic, Jovica

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

2019 Volume 72, Issue 3, Page(s) 242–248

Abstract: Background: The Voice Handicap Index-10 (VHI-10) is used in clinics because of its validity and ease of use by patients.: Objectives: The aim of this paper was to evaluate the internal consistency, reliability, and clinical validity of the Serbian ... ...

Abstract	Background: The Voice Handicap Index-10 (VHI-10) is used in clinics because of its validity and ease of use by patients. Objectives: The aim of this paper was to evaluate the internal consistency, reliability, and clinical validity of the Serbian version of the VHI-10. Method: In this cross-sectional study, we translated the original English version of the VHI-10 into Serbian, after which it was back-translated into English. The Serbian version of the VHI-10 was completed by 161 patients with voice disorders, divided into 4 groups according disease etiology (structural, neurological, functional, and inflammatory) and 73 healthy control subjects. Results: The VHI-10 internal consistency was 0.88. Spearman's rank correlation coefficient for VHI-10 test-retest reliability was ρ = 0.991 (p< 0.001). Patients with voice disorders had higher median total VHI-10 scores compared with controls (p< 0.001). The patients' Grade, Instability, Roughness, Breathiness, Asthenia, and Strain (GIRBAS) scale scores were significantly correlated with the VHI-10 test scores (ρ = 0,682, p < 0.001) and VHI-10 retest scores (ρ = 0.716, p < 0.001). Conclusion: The Serbian version of the VHI-10 had good validity and reliability and can be used by Serbian patients with voice disorders.
MeSH term(s)	Cross-Sectional Studies ; Disability Evaluation ; Humans ; Language ; Reproducibility of Results ; Serbia ; Severity of Illness Index ; Surveys and Questionnaires ; Voice Disorders/diagnosis
Language	English
Publishing date	2019-05-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1179765-4
ISSN	1421-9972 ; 1021-7762
ISSN (online)	1421-9972
ISSN	1021-7762
DOI	10.1159/000499927
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Article ; Online: Laser transoral microsurgery in treatment of early laryngeal carcinoma.

Djukic, Vojko / Milovanović, Jovica / Jotić, Ana D / Vukasinovic, Milan / Folic, Miljan M / Ivanov, Sergey Yrievic / Satueva, Diana Bislanovna

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2019 Volume 276, Issue 6, Page(s) 1747–1755

Abstract: Purpose: Laser transoral laryngeal microsurgery has become widely accepted treatment method because of its organ and function preservation and shorter period of hospitalization. The aim of this study was to examine the overall, disease-specific and ... ...

Abstract	Purpose: Laser transoral laryngeal microsurgery has become widely accepted treatment method because of its organ and function preservation and shorter period of hospitalization. The aim of this study was to examine the overall, disease-specific and disease-free survival in patients with early laryngeal carcinoma treated with laser depending on age, gender, common risk factors (tobacco and alcohol use), histopathological tumor grade, anterior commissure involvement, performed tracheotomy, positive surgical margins, T stage, type of endoscopic cordectomy, postoperative radiotherapy and laryngeal preservation. Methods: Retrospective study included 234 patients with squamocellular carcinoma of the larynx treated with laser transoral laryngeal microsurgery. 5-year overall, disease-specific and disease-free survival and the prognostic impact of mentioned factors were evaluated using Kaplan-Meier and Cox proportional hazard analyses. Results: 5-year OS and DSS was 92.5% and 95.3%, respectively. OS was significantly lower for older patients and in patients with histologically poorly differentiated tumors, 3 and 5 years postoperatively (Log rank test; p = 0.031). DSS was significantly lower in patients with anterior commissure involvement, positive surgical margins and patients who underwent postoperative RT. DFS was significantly lower in patients with anterior commissure involvement, patients with T1b tumor stage and patients who underwent cordectomies type Vb and VI (Log rank, p < 0.05). Laryngeal preservation significantly influenced 5-year OS, DSS and DFS (Log rank, p ≤ 0.001). Multivariate Cox regression analysis showed that age, histological tumor grade and laryngeal preservation were significant negative prognostic factors for 5-year DSS and DFS. Conclusion: Transoral laryngeal microsurgery delivers excellent oncological results, even in selected patients with higher stages of early laryngeal cancer and anterior commissure involvement.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma/mortality ; Carcinoma/surgery ; Disease-Free Survival ; Female ; Humans ; Laryngeal Neoplasms/mortality ; Laryngeal Neoplasms/surgery ; Laser Therapy ; Male ; Margins of Excision ; Microsurgery ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Risk Factors ; Tracheostomy ; Tracheotomy
Language	English
Publishing date	2019-05-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-019-05453-1
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Article: Vocal fold masses removal--the sub epithelial micro flap technique.

Stanković, P / Vasić, M / Djukić, V / Janosević, Lj / Vukasinović, M

Acta chirurgica Iugoslavica

2009 Volume 55, Issue 4, Page(s) 43–47

Abstract: Vocal fold mass removal techniques were significantly modified back in 1970s by Hirano's laminar vocal structure and physiology of phonation works, as well as Titze's vibratory vocal cycle works. New methods were to come. Removing the lession by maximum ... ...

Abstract	Vocal fold mass removal techniques were significantly modified back in 1970s by Hirano's laminar vocal structure and physiology of phonation works, as well as Titze's vibratory vocal cycle works. New methods were to come. Removing the lession by maximum preservation of vocal laminar microstructure (lamina propria and epithelium) and minimal damage of surrounding normal vocal tissue, was pointed out. Microflap technique is based on presenting the superficial layer of lamina propria with the lesion and removing the lession without damage of the mucosa. Preserving of the mucosal layer provides the shield for vibratory substructures. There are two elementary approaches for microflap: lateral and medial. Lateral microflap technique enables better identification of vocal ligament and lowers the risk of it's injury, particulary when scars and tightly adherent lessions are present. This technique has been used in case of big or diffuse lesions, such as vocal oedema or vocal lygament identification difficulties (e.g. vocal scarification). Medial microflap technique seems to be appropriate in removing smaller, localised lessions, such as cysts and vocal polyps. Our 45 patients experience is presented in this article, in 30 patients lessions were removed by lateral microflap technique (46 vocal cords in total), while 15 patients were treated by medial microflap technique. The outcome was assumed by endovideolaryngostroboscopic analysis of glottal occlussion and mucosal wave prior and following to the procedure. Reinke oedema management results were analysed separately.
MeSH term(s)	Humans ; Laryngeal Diseases/surgery ; Microsurgery/methods ; Surgical Flaps ; Vocal Cords/surgery
Language	English
Publishing date	2009-01-20
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0804043s
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Article: Uticaj obima hirurske resekcije kod totalne laringektomije na uspostavljanje ezofagusnog glasa i govora.

Stanković, P / Djukić, V / Vukasinović, M / Janosević, Lj

Acta chirurgica Iugoslavica

2005 Volume 51, Issue 1, Page(s) 37–41

Abstract: The study of functional results of total laryngectomy cannot be separated from articulation of esophageal voice and speech. To achieve success of phoniatric rehabilitation in laringectomized patients, it is necessary to be well aware of pathological ... ...

Title translation	Effect of the extents of surgical resection in total laryngectomy on esophageal voice and speech rehabilitation.
Abstract	The study of functional results of total laryngectomy cannot be separated from articulation of esophageal voice and speech. To achieve success of phoniatric rehabilitation in laringectomized patients, it is necessary to be well aware of pathological sequelae of the very operation, long-term adverse effect of oncological risk factors as well as postoperative anatomo-physiological changes. Anatomic results of total laryngectomy depend on the type of surgical intervention and probable radiotherapy. The extent of surgical procedure, primary dictated by oncological indications, has the essential effect to articulation of esophageal voice and speech. If possible for oncological reasons, hyoid bone should be particularly left intact. Extensive surgical interventions of hypopharynx and the base of the tongue during laryngectomy, neck dissection--especially the radical one, and subsequent radiotherapy, all of them significantly reduce the possibility to produce esophageal voice and speech. Total laryngectomy eliminates the creator of voice and vibrations, which are acoustically perceived as esophageal voice, proceeding at the level of pharyngoesophageal junction. For this reason, the quality of newly created vibrating narrowing is especially important.
MeSH term(s)	Adult ; Aged ; Humans ; Laryngeal Neoplasms/surgery ; Laryngeal Neoplasms/therapy ; Laryngectomy/methods ; Laryngectomy/rehabilitation ; Middle Aged ; Speech, Esophageal
Language	Serbian
Publishing date	2005-02-21
Publishing country	Serbia
Document type	English Abstract ; Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0401037s
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Article ; Online: Stroboscopy in detection of laryngeal dysplasia effectiveness and limitations.

Djukic, Vojko / Milovanovic, Jovica / Jotic, Ana D / Vukasinovic, Milan

Journal of voice : official journal of the Voice Foundation

2014 Volume 28, Issue 2, Page(s) 262.e13–262.e21

Abstract: Vocal fold pathology changes the appearance and vibratory patterns observed during stroboscopic examination, but a strict correlation between the vibratory pattern and the dysplasia type does not exist. The aims of this study were to determine the role ... ...

Abstract	Vocal fold pathology changes the appearance and vibratory patterns observed during stroboscopic examination, but a strict correlation between the vibratory pattern and the dysplasia type does not exist. The aims of this study were to determine the role of stroboscopy in vocal fold dysplasia assessment and to determine whether stroboscopy is the deciding factor when performing laryngomicroscopy with biopsy in suspicious lesions. This prospective controlled study involved 112 patients with laryngeal dysplasia treated over a 2-year period at a tertiary medical center. Patient data and clinical, stroboscopy, laryngomicroscopy, and histopathologic reports were reviewed. During the stroboscopy, glottic occlusion, phase symmetry, periodicity, amplitude, mucosal wave, and nonvibratory segments were followed. Laryngomicroscopy with different types of endoscopic cordectomies (types I-III) was performed as a therapeutic measure, with a 12-month follow-up period. Nonvibrating segments were present in 15.1% of the patients with mild dysplasia and in 38.5% of the patients with moderate dysplasia. In 45.5% of the patients with severe dysplasia (carcinoma in situ), nonvibrating segments were absent. The amplitude of vocal fold vibrations in patients with mild dysplasia (P=0.03) was a significant factor indicative of recurrent disease, but none of the stroboscopic signs was significant for the disease progression. Severe dysplasia can be related to both nonvibrating and vibrating vocal fold segments. Stroboscopy cannot be used reliably for classifying laryngeal dysplasia and may indicate the need to perform laryngomicroscopy with biopsy in suspicious vocal fold lesions. The warning factors for recurrence and progression of dysplasia are treatment modality, abnormal amplitude of vibration, and nonvibrating segment.
MeSH term(s)	Biomechanical Phenomena ; Biopsy ; Carcinoma in Situ/diagnosis ; Carcinoma in Situ/pathology ; Carcinoma in Situ/physiopathology ; Carcinoma in Situ/surgery ; Humans ; Laryngeal Diseases/diagnosis ; Laryngeal Diseases/pathology ; Laryngeal Diseases/physiopathology ; Laryngeal Diseases/surgery ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/physiopathology ; Laryngeal Neoplasms/surgery ; Laryngoscopy ; Male ; Middle Aged ; Phonation ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Stroboscopy ; Tertiary Care Centers ; Time Factors ; Treatment Outcome ; Vibration ; Vocal Cords/pathology ; Vocal Cords/physiopathology ; Vocal Cords/surgery
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2013.07.006
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Article: Positive impact of prescribed physical activity on symptoms of schizophrenia: randomized clinical trial.

Curcic, Dorde / Stojmenovic, Tamara / Djukic-Dejanovic, Slavica / Dikic, Nenad / Vesic-Vukasinovic, Milica / Radivojevic, Nenad / Andjelkovic, Marija / Borovcanin, Milica / Djokic, Gorica

Psychiatria Danubina

2018 Volume 29, Issue 4, Page(s) 459–465

Abstract: Background: The purpose of this study was to examine functional capacity of cardio-respiratory system in patients with schizophrenia, and to evaluate the effects of 12 weeks prescribed physical activity on aerobic capacity and symptoms of schizophrenia.! ...

Abstract	Background: The purpose of this study was to examine functional capacity of cardio-respiratory system in patients with schizophrenia, and to evaluate the effects of 12 weeks prescribed physical activity on aerobic capacity and symptoms of schizophrenia. Subjects and methods: Study involved 80 hospitalized patients with any of the subtypes of schizophrenia (42 men, 38 women). They were divided into two groups: exercise and control group, both with 40 patients. Maximal aerobic capacity (VO2 max) as an indicator of cardiovascular fitness has been obtained by cardiopulmonary stress test on a treadmill. Twelve weeks program of prescribed physical activity (45 minutes, four times per week) was made for every patient individually. Patients in exercise group practiced in training zone between 65 and 75% of their maximum heart rate (HR). Target HR was controlled by Polar F4 monitors. Symptoms of schizophrenia were measured by using Positive and Negative Symptoms Scale (PANSS). Results: Before the exercise program was introduced, measured VO2 max was significantly lower in patients with schizophrenia, than the expected average value in matched healthy subjects (p<0.001). After twelve weeks, patients in exercise group showed a significant increase of VO2max (p=0.002), and significantly higher level of VO2max compared to the control group (p=0.000). Significant differences were also observed on PANSS general psychopathology subscale (p=0.007) and on PANSS total score (p=0.001). The pharmacotherapy and exercise had influence on PANSS general psychopathology (p=0.002) and PANSS total score (p=0.001). Conclusions: Individuals with schizophrenia have lower levels of aerobic capacity compared to general population. Prescribed physical activity significantly improves aerobic capacity in people with schizophrenia and it is effective in amelioration of some psychiatric symptoms. Prescribed physical activity could be an effective adjunctive treatment for patients with schizophrenia, not only for prevention and treatment of comorbidities, but also having an impact on symptoms of schizophrenia.
MeSH term(s)	Adult ; Combined Modality Therapy ; Exercise/psychology ; Exercise Test ; Exercise Tolerance ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Prescriptions ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychometrics ; Schizophrenia/diagnosis ; Schizophrenia/rehabilitation ; Schizophrenic Psychology ; Treatment Outcome
Language	English
Publishing date	2018-01-09
Publishing country	Croatia
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
DOI	10.24869/psyd.2017.459
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