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Article: Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment.

Čegar, Bojan / Šipetić Grujičić, Sandra / Bjekić, Jovana / Vuksanović, Aleksandar / Bojanić, Nebojša / Bartolović, Daniela / Jovanović, Darko / Zeković, Milica

Life (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: The experience of an infertility diagnosis and treatment imposes a profound burden on affected individuals, encompassing not only physical and medical aspects but also a plethora of psychological, social, and emotional factors. By employing a multimodal ... ...

Abstract	The experience of an infertility diagnosis and treatment imposes a profound burden on affected individuals, encompassing not only physical and medical aspects but also a plethora of psychological, social, and emotional factors. By employing a multimodal assessment featuring validated self-report questionnaires, physical measurements, and clinical records, the present study aimed to explore the quality of life and psycho-emotional distress of men undergoing infertility treatment in Serbia, thereby addressing the dearth of research on the underrepresented male perspective in this domain. Findings revealed diverse semen abnormalities among participants (n = 96, average age 37.69 ± 5.72), with significant associations between longer treatment durations and reduced sperm motility. The observed rates of men surpassing predetermined DASS-42 questionnaire thresholds for depression, anxiety, and stress in the analyzed cohort were 13.54%, 11.46%, and 22.92%, respectively. Summary scores in conceptual areas comprised in the SF-36 questionnaire ranged from 49.00 ± 6.25 for the mental health dimension to 90.16 ± 17.75 obtained in the physical functioning subscale. Patients with a longer treatment duration demonstrated lower scores in the role emotional domain, indicative of a less favorable emotional state. Expectedly, inverse correlations were found between the SF-36 mental health score and DASS-42 subscales. By addressing the existing knowledge gap and highlighting the unique needs of infertile men, the finding of this study may contribute to a more inclusive and holistic approach to infertility research and management.
Language	English
Publishing date	2023-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13091894
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Article ; Online: Single-stage repair of obliterated anterior urethral strictures using buccal mucosa graft and dorsal penile skin flap.

Kojovic, Vladimir / Djordjevic, Miroslav L / Vuksanovic, Aleksandar

International journal of urology : official journal of the Japanese Urological Association

2018 Volume 26, Issue 1, Page(s) 90–95

Abstract: Objective: To present a single-stage repair of obliterative urethral strictures by simultaneous use of a buccal mucosa graft and longitudinal dorsal penile skin flap.: Methods: Between February 2007 and October 2016, 51 patients with obliterative ... ...

Abstract	Objective: To present a single-stage repair of obliterative urethral strictures by simultaneous use of a buccal mucosa graft and longitudinal dorsal penile skin flap. Methods: Between February 2007 and October 2016, 51 patients with obliterative anterior urethral stricture underwent single-stage substitution urethroplasty. A buccal mucosa graft was harvested and fixed to the corpora cavernosa as the dorsal part of the neourethra, and a vascularized dorsal penile skin flap was created, transposed ventrally and sutured to the buccal mucosa graft to form ventral part of the neourethra. Results: The follow-up period was 12-129 months (mean 49 months). The mean age of the patients was 48 years (range 15-71 years). The mean length of the obliterated urethral segment, measured during the operative procedure, was 5.2 cm. The etiology of strictures was: unknown, hypospadias and trauma in 19, 27 and five patients, respectively. Five patients were lost to follow up, and 46 patients were analyzed for the outcome. At the end of the follow-up period, recurrence of the stricture occurred in seven (15.2%) patients, whereas 39 (84.8%) patients did not develop stricture. An additional three (6.5%) patients developed fistula, resulting in overall successful voiding in 36 (78.3%) patients. Conclusions: A combined buccal mucosa graft and longitudinal dorsal penile skin flap could be a good choice for one-stage substitution urethroplasty in complex obliterative urethral strictures, with an acceptable complication rate.
MeSH term(s)	Adolescent ; Adult ; Aged ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mouth Mucosa/transplantation ; Penis/surgery ; Reconstructive Surgical Procedures/methods ; Surgical Flaps/transplantation ; Treatment Outcome ; Urethra/surgery ; Urethral Stricture/surgery ; Urologic Surgical Procedures, Male/methods ; Young Adult
Language	English
Publishing date	2018-10-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13816
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Article ; Online: Urosepsis in adults

Lađević Nebojša / Vuksanović Aleksandar / Durutović Otaš / Jovičić Jelena / Lađević Nikola / Likić-Lađević Ivana / Nešić Dejan / Jovanović Vesna

Archives of Biological Sciences, Vol 73, Iss 2, Pp 205-

2021 Volume 214

Abstract: Urosepsis is defined as sepsis caused by urinary tract infection (UTI). Urosepsis represents a quarter of all cases of sepsis in adults. Complications of UTIs are the most common risk factor for urosepsis development. These infections, especially ... ...

Abstract	Urosepsis is defined as sepsis caused by urinary tract infection (UTI). Urosepsis represents a quarter of all cases of sepsis in adults. Complications of UTIs are the most common risk factor for urosepsis development. These infections, especially pyelonephritis, often occur in patients with structural or functional malformations that interfere with normal urine flow. The problem of a significant increase in UTIs with multiresistant bacteria should be emphasized, especially in patients with recurrent UTI and their frequent treatments. As the urogenital tract is one of the most common sources of infection in sepsis in general, a detailed assessment of the tract should be carried out in all septic patients. Even though urosepsis is associated with a relatively good prognosis and lower mortality than sepsis of another etiology, it occurs rapidly and progresses at a significant speed. Since urosepsis is mainly the result of obstruction of the urinary tract, the development of septic shock can most often be prevented by implementing early deobstruction. Knowledge of the most common causes of urosepsis and the category of high-risk patients will provide clinicians with the tools with which to prevent its occurrence.
Keywords	urosepsis ; urinary tract infections ; risk factors ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	University of Belgrade, University of Novi Sad
Document type	Article ; Online
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Article ; Online: The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.

Pejčić, Tomislav / Tosti, Tomislav / Džamić, Zoran / Gašić, Uroš / Vuksanović, Aleksandar / Dolićanin, Zana / Tešić, Živoslav

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 21

Abstract: In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight ... ...

Abstract	In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight represent measures that greatly reduce the risk of various diseases. The type of diet is very important for disease development. Numerous epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of polyphenols, and their protective effects against the development of prostate diseases.
MeSH term(s)	Flavonoids/therapeutic use ; Humans ; Isoflavones/therapeutic use ; Male ; Polyphenols/therapeutic use ; Prostatic Diseases/drug therapy ; Prostatic Diseases/prevention & control
Chemical Substances	Flavonoids ; Isoflavones ; Polyphenols ; flavan-3-ol (35HDD3NRIE)
Language	English
Publishing date	2019-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24213982
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Article ; Online: Response to: Correspondence on 'Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma' by Lorzadeh

Radovanovic, Milan / Vidicevic, Sasenka / Tasic, Jelena / Tomonjic, Nina / Stanojevic, Zeljka / Nikic, Predrag / Vuksanovic, Aleksandar / Dzamic, Zoran / Bumbasirevic, Uros / Isakovic, Aleksandra / Trajkovic, Vladimir

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2021 Volume 69, Issue 8, Page(s) 1485

MeSH term(s)	AMP-Activated Protein Kinases ; Autophagy ; Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; TOR Serine-Threonine Kinases
Chemical Substances	MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2021-09-07
Publishing country	England
Document type	Letter
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1136/jim-2021-002081
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Article ; Online: Vesicovaginal fistulas

Radovanović Milan / Džamić Zoran / Vuksanović Aleksandar / Pejčić Tomislav / Nikić Predrag

Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 11-12, Pp 756-

Results of surgical treatment during ten years

2012 Volume 759

Abstract: Introduction. Vesicovaginal fistulas (VVF) are the most common and the most frequent type of urogenital fistulas. They may have a different etiology. In most cases, surgery is required for treatment. Objective. The aim of the study was to analyze the ... ...

Abstract	Introduction. Vesicovaginal fistulas (VVF) are the most common and the most frequent type of urogenital fistulas. They may have a different etiology. In most cases, surgery is required for treatment. Objective. The aim of the study was to analyze the results of surgical therapy of VVF in a tertiary level institution over the last decade. Methods. The retrospective study of results was conducted involving a total number of 99 women who were surgically treated for VVF at the Clinic of Urology of the Clinical Center of Serbia in Belgrade in the period from 2001–2010. Results. Over the past ten years VVF occurred after hysterectomy in 74.7% of cases, and almost twice more frequently after hysterectomy for a benign gynecological disease. In the surgical treatment of primary VVF transvesical approach was used in 53.53% (52/99) of cases. Relapses were treated surgically using transperitoneal approach in all cases. No significant difference was found in respect to the applied approach in the surgical treatment of primary fistulas. In even 94% (93/99) of cases the problem of VVF was solved by a single surgical intervention only. In total, in 107 interventions 8 (7.4%) relapses were recorded. Conclusion. The study showed that VVF occurred after hysterectomy in three quarters of cases, more frequently after hysterectomy due to a benign gynecological disease. Early detection with timely and appropriate treatment of gynecological diseases will reduce the number of conditions that may lead to VVF. Surgical treatment of VVF yielded satisfactory results; it was shown that even in 94% of cases the problem of VVF was solved by a single surgical intervention only, however further improvement is certainly necessary.
Keywords	vesicovaginal fistula ; surgical treatment ; hysterectomy ; Medicine ; R
Subject code	630
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2020 Volume 68, Issue 8, Page(s) 1386–1393

Abstract: We examined the status and role of autophagy, a process of lysosomal recycling of cellular material, in clear cell renal cell carcinoma (ccRCC). Paired samples of tumor and adjacent non-malignant tissue were collected from 20 patients with ccRCC after ... ...

Abstract	We examined the status and role of autophagy, a process of lysosomal recycling of cellular material, in clear cell renal cell carcinoma (ccRCC). Paired samples of tumor and adjacent non-malignant tissue were collected from 20 patients with ccRCC after radical nephrectomy. The mRNA levels of apoptosis (
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Aged ; Aged, 80 and over ; Apoptosis/genetics ; Autophagy/genetics ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Middle Aged ; Models, Biological ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	RNA, Messenger ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2020-10-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1136/jim-2020-001524
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Article: [Vesicovaginal fistulas: results of surgical treatment during ten years].

Radovanović, Milan / Džamić, Zoran / Vuksanović, Aleksandar / Pejčić, Tomislav / Nikić, Predrag

Srpski arhiv za celokupno lekarstvo

2013 Volume 140, Issue 11-12, Page(s) 756–759

Abstract: Introduction: Vesicovaginal fistulas (VVF) are the most common and the most frequent type of urogenital fistulas. They may have a different etiology. In most cases, surgery is required for treatment.: Objective: The aim of the study was to analyze ... ...

Abstract	Introduction: Vesicovaginal fistulas (VVF) are the most common and the most frequent type of urogenital fistulas. They may have a different etiology. In most cases, surgery is required for treatment. Objective: The aim of the study was to analyze the results of surgical therapy of VVF in a tertiary level institution over the last decade. Methods: The retrospective study of results was conducted involving a total number of 99 women who were surgically treated for VVF at the Clinic of Urology of the Clinical Center of Serbia in Belgrade in the period from 2001-2010. Results: Over the past ten years VVF occurred after hysterectomy in 74.7% of cases, and almost twice more frequently after hysterectomy for a benign gynecological disease. In the surgical treatment of primary VVF transvesical approach was used in 53.53% (52/99) of cases. Relapses were treated surgically using transperitoneal approach in all cases. No significant difference was found in respect to the applied approach in the surgical treatment of primary fistulas. In even 94% (93/99) of cases the problem of VVF was solved by a single surgical intervention only. In total, in 107 interventions 8 (7.4%) relapses were recorded. Conclusion: The study showed that VVF occurred after hysterectomy in three quarters of cases, more frequently after hysterectomy due to a benign gynecological disease. Early detection with timely and appropriate treatment of gynecological diseases will reduce the number of conditions that may lead to VVF. Surgical treatment of VVF yielded satisfactory results; it was shown that even in 94% of cases the problem of VVF was solved by a single surgical intervention only, however further improvement is certainly necessary.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Middle Aged ; Recurrence ; Vesicovaginal Fistula/etiology ; Vesicovaginal Fistula/surgery
Language	Serbian
Publishing date	2013-01-23
Publishing country	Serbia
Document type	English Abstract ; Journal Article
ZDB-ID	128567-1
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
DOI	10.2298/sarh1212756r
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Article ; Online: Glycosaminoglycans in the urinary bladder mucosa, tumor tissue and mucosal tissue around tumor

Bojanić Nebojša / Nale Đorđe / Mićić Sava / Lalić Nataša / Vuksanović Aleksandar / Tulić Cane

Vojnosanitetski Pregled, Vol 69, Iss 2, Pp 147-

2012 Volume 150

Abstract: Introduction/Aim. Glycosaminoglycans (GAG) are one of the main constituents of the connective tissue and cellular membrane. Their presence has been evidenced in mucosa and muscular tissue of the urinary bladder of both healthy individuals and those ... ...

Abstract	Introduction/Aim. Glycosaminoglycans (GAG) are one of the main constituents of the connective tissue and cellular membrane. Their presence has been evidenced in mucosa and muscular tissue of the urinary bladder of both healthy individuals and those affected by carcinoma. This suggest their potential role in the onset of bladder carcinoma and follow-up of those patients. The aim of the study was to determine GAG levels in tumor tissue and the surrounding bladder mucosa in patients with bladder tumor, as well as in the bladder mucosa in patients with bladder carcinoma, and to compare the results according to the grade and stage of tumor and relapse. Methods. Tissue samples were taken in 61 patients (48 males and 13 females), mean age 61.5 years, range 40-92 years, obtained by transurethral resection (TUR) of bladder tumor, and 8 healthy persons. Determination of a total GAG content in the tissue samples was done by the Whiteman's method and then compared regarding the tumor grade and stage. Results. Tumor grade and stage directly correlated with the levels of GAG. The GAG levels were significantly higher in tumor samples as compared to healthy mucosa. Conclusion. Higher GAG levels were recorded in all the patients with bladder tumors comparing to smples obtained from healthy individuals. GAG levels do not predict tumor relapse.
Keywords	urinary bladder neoplasms ; recurrence ; glycosaminoglycans ; sensitivity and specificity ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Military Health Department, Ministry of Defance, Serbia
Document type	Article ; Online
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Article ; Online: Influence of lithotripsy modalities on complication rate

Radulović Slobodan / Milenković-Petronić Dragica / Vuksanović Aleksandar / Vavić Božo

Srpski Arhiv za Celokupno Lekarstvo, Vol 137, Iss 5-6, Pp 259-

2009 Volume 265

Abstract: Introduction. Localization of ureteric stones and difference in disintegration success are the most important factors in determining the first treatment approach for ureteric stones. Objective. The aim of our study was to evaluate the difference in ... ...

Abstract	Introduction. Localization of ureteric stones and difference in disintegration success are the most important factors in determining the first treatment approach for ureteric stones. Objective. The aim of our study was to evaluate the difference in complication rate between different ureteric stone lithotripsy modalities. Methods. Two hundred sixty patients with ureteric stones were analyzed in a prospective bicentric study that lasted 1 year. The patients were divided into two groups: I - 120 patients who underwent ESWL (extracorporeal shockwave lithotripsy) treatment and II - 140 patients who were treated endoscopically with ballistic lithotripsy. Results. Ureteroscopic lithotripsy of all pelvic and iliac stones was significantly more successful comparing to ESWL, while lumbar ureteric stone treatment with ureteroscopic lithotripsy was not significantly more successful than ESWL, except for lumbar stones larger than 100mm2 that were significantly better treated endoscopically. In the I group complications after lithotripsy were recorded in 64 (59.3%) and in the II group in 58 (42.0%) patients, meaning that complications were statistically significantly more frequent in the I than in the II group. In the II group complications were significantly more often recorded after treatment of proximal comparing to ureteric stones of other localizations, while in the I group complications were significantly more often detected after treatment of impacted stones than in the II group. Conclusion. Being significantly successful comparing to ESWL, ureteric stone treatment with ureteroscopic lithotripsy should be considered as the first therapeutic option for all, especially impacted stones located in the iliac and pelvic ureteric portion. In spite of absent statistical difference in the success rate, ESWL should be chosen as the first treatment option in all cases of lumbar ureteric stones due to lower complication rate except for stones larger than 100mm2 that should be primarily treated endoscopically.
Keywords	ESWL ; ureteroscopy ; lithotripsy ; ureteric stones ; Complications ; Medicine ; R
Subject code	616
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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