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Article ; Online: Inclusion body myositis, viral infections, and TDP-43: a narrative review.

Văcăraş, Vitalie / Vulturar, Romana / Chiş, Adina / Damian, Laura

2024 Volume 24, Issue 1, Page(s) 91

Abstract: The ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy. TDP-43 solubility and function are disrupted in certain viral infections. Certain viruses, ... ...

Abstract	The ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy. TDP-43 solubility and function are disrupted in certain viral infections. Certain viruses, high viremia, co-infections, reactivation of latent viruses, and post-acute expansion of cytotoxic T cells may all contribute to inclusion body myositis, mainly in an age-shaped immune landscape. The virally induced senescent, interferon gamma-producing cytotoxic CD8+ T cells with increased inflammatory, and cytotoxic features are involved in the occurrence of inclusion body myositis in most such cases, in a genetically predisposed host. We discuss the putative mechanisms linking inclusion body myositis, TDP-43, and viral infections untangling the links between viruses, interferon, and neuromuscular degeneration could shed a light on the pathogenesis of the inclusion body myositis and other TDP-43-related neuromuscular diseases, with possible therapeutic implications.
MeSH term(s)	Myositis, Inclusion Body/virology ; Humans ; Virus Diseases/immunology ; Virus Diseases/virology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human
Language	English
Publishing date	2024-05-02
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-024-01353-9
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Article: PFAPA Syndrome: Clinical, Laboratory and Therapeutic Features in a Single-Centre Cohort.

Lazea, Cecilia / Damian, Laura / Vulturar, Romana / Lazar, Calin

International journal of general medicine

2022 Volume 15, Page(s) 6871–6880

Abstract: Objective: The aim of this study is to describe a group of Romanian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome.: Materials: This consisted of 39 children diagnosed with PFAPA syndrome ... ...

Abstract	Objective: The aim of this study is to describe a group of Romanian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. Materials: This consisted of 39 children diagnosed with PFAPA syndrome according to Thomas' criteria (eight patients with an age at diagnosis <1 year and 31 patients with an age at diagnosis >1 year). Methods: Retrospective analysis of the patients with PFAPA syndrome was focused on clinical features, laboratory findings and therapeutic methods. Comparison between the two groups divided by age at onset was also investigated. Results: Median age at onset was 1.58 years, and median age at diagnosis was 2.97 years. The mean interval between episodes was 35.5 days and the mean duration per febrile episode was 4.1 days. The median diagnosis delay was 2.42 years. The patients presented pharyngitis (100%), adenitis (94.8%) and aphthous lesions (66.7%). The frequency of febrile attacks was higher in children with an age at diagnosis under 1 year ( Conclusion: We present a cohort of children with PFAPA syndrome, with clinical and laboratory features similar to those described in the literature. Febrile attacks had a higher incidence in children with younger age at the onset of the disease. The patients had a favorable response to corticosteroids.
Language	English
Publishing date	2022-08-29
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S373942
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Article ; Online: Frail Silk: Is the Hughes-Stovin Syndrome a Behçet Syndrome Subtype with Aneurysm-Involved Gene Variants?

Manole, Simona / Rancea, Raluca / Vulturar, Romana / Simon, Siao-Pin / Molnar, Adrian / Damian, Laura

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Hughes-Stovin syndrome is a rare disease characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. The etiology and pathogenesis of HSS are incompletely known. The current consensus is that vasculitis underlies the pathogenic ... ...

Abstract	Hughes-Stovin syndrome is a rare disease characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. The etiology and pathogenesis of HSS are incompletely known. The current consensus is that vasculitis underlies the pathogenic process, and pulmonary thrombosis follows arterial wall inflammation. As such, Hughes-Stovin syndrome may belong to the vascular cluster with lung involvement of Behçet syndrome, although oral aphtae, arthritis, and uveitis are rarely found. Behçet syndrome is a multifactorial polygenic disease with genetic, epigenetic, environmental, and mostly immunological contributors. The different Behçet syndrome phenotypes are presumably based upon different genetic determinants involving more than one pathogenic pathway. Hughes-Stovin syndrome may have common pathways with fibromuscular dysplasias and other diseases evolving with vascular aneurysms. We describe a Hughes-Stovin syndrome case fulfilling the Behçet syndrome criteria. A
MeSH term(s)	Humans ; Aneurysm/complications ; Aneurysm/diagnosis ; Aneurysm/pathology ; Behcet Syndrome/diagnosis ; Pulmonary Artery/pathology ; Vasculitis/pathology
Language	English
Publishing date	2023-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043160
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Article ; Online: Osteogenesis imperfecta and rheumatoid arthritis: connective issues.

Damian, Laura Otilia / Miclea, Diana / Vulturar, Romana / Crăciun, Alexandra

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2022 Volume 33, Issue 10, Page(s) 2237–2239

Abstract: The coexistence of osteogenesis imperfecta and inflammatory arthritis has been very rarely described. Nevertheless, systemic inflammation has been found in osteogenesis imperfecta. The COL1A1 mutations may affect collagen synthesis as well as post- ... ...

Abstract	The coexistence of osteogenesis imperfecta and inflammatory arthritis has been very rarely described. Nevertheless, systemic inflammation has been found in osteogenesis imperfecta. The COL1A1 mutations may affect collagen synthesis as well as post-translational modifications, extracellular matrix interactions, and receptor-mediated signaling. Major collagen binding ligands forming the interactome, such as cytokines, cell adhesion molecules, matrix metalloproteinases, proteoglycans, and other molecules, are autoimmunity targets involved in rheumatoid arthritis pathogenesis. Cross-talk between bone remodeling and inflammatory pathways involving osteoclasts is important in osteogenesis imperfecta and rheumatoid arthritis. In osteogenesis imperfecta, the structural abnormalities and repeated traumatism, including fractures, could activate locally the innate immunity and trigger arthritis, similar to post-traumatic arthritis. Currently, the therapy of osteogenesis imperfecta is a suboptimally met need. Understanding the complex putative pathogenic links between osteogenesis imperfecta and inflammatory arthritis could hopefully lead to new therapeutic targets. Raising awareness regarding a possible association between osteogenesis imperfecta and arthritis could help improve the quality of life in these patients.
MeSH term(s)	Arthritis, Rheumatoid/complications ; Collagen Type I/genetics ; Cytokines ; Humans ; Ligands ; Mutation ; Osteogenesis Imperfecta/complications ; Osteogenesis Imperfecta/drug therapy ; Osteogenesis Imperfecta/genetics ; Proteoglycans ; Quality of Life
Chemical Substances	Collagen Type I ; Cytokines ; Ligands ; Proteoglycans
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Letter
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-022-06530-8
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Article ; Online: Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes.

Chiș, Adina / Oltean, Lia-Ecaterina / Bîlc, Mirela / Vulturar, Romana / Șoflău, Radu / David, Daniel / Szentágotai-Tătar, Aurora / Miu, Andrei C

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Cognitive behavioral therapy is based on the view that maladaptive thinking is the causal mechanism of mental disorders. While this view is supported by extensive evidence, very limited work has addressed the factors that contribute to the development of ...

Abstract	Cognitive behavioral therapy is based on the view that maladaptive thinking is the causal mechanism of mental disorders. While this view is supported by extensive evidence, very limited work has addressed the factors that contribute to the development of maladaptive thinking. The present study aimed to uncover interactions between childhood maltreatment and multiple genetic differences in irrational beliefs. Childhood maltreatment and irrational beliefs were assessed using multiple self-report instruments in a sample of healthy volunteers (
MeSH term(s)	Humans ; Gene-Environment Interaction ; Female ; Male ; Polymorphism, Single Nucleotide ; Adult ; Receptors, Oxytocin/genetics ; Receptors, Corticotropin-Releasing Hormone/genetics ; Child Abuse/psychology ; Middle Aged ; Adverse Childhood Experiences/psychology ; Serotonin Plasma Membrane Transport Proteins/genetics ; Dopamine Plasma Membrane Transport Proteins/genetics ; Young Adult ; Child ; Receptors, Glucocorticoid
Chemical Substances	Receptors, Oxytocin ; Receptors, Corticotropin-Releasing Hormone ; OXTR protein, human ; SLC6A4 protein, human ; CRF receptor type 1 (5CLY6W2H1M) ; NR3C1 protein, human ; Serotonin Plasma Membrane Transport Proteins ; Dopamine Plasma Membrane Transport Proteins ; Receptors, Glucocorticoid
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084206
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Article ; Online: Ethnobotanical Survey on Plants Used to Manage Febrile Illnesses among Herbalists in Casablanca, Morocco

Dagni, Amal / Suharoschi, Ramona / Hegheș, Simona-Codruta / Vârban, Rodica / Lelia Pop, Oana / Vulturar, Romana / Fodor, Adriana / Cozma, Angela / Soukri, Abdelaziz / El Khalfi, Bouchra

Diversity. 2023 July 24, v. 15, no. 7

2023

Abstract: Plants have been recognized since antiquity in Morocco as a heritage and a remedy for a variety of ailments with a diverse range of pharmacological effects. The current work is ethnomedicinal research conducted to collect herbalists’ knowledge about ... ...

Abstract	Plants have been recognized since antiquity in Morocco as a heritage and a remedy for a variety of ailments with a diverse range of pharmacological effects. The current work is ethnomedicinal research conducted to collect herbalists’ knowledge about plants utilized in traditional medicine to treat febrile illnesses. In Casablanca, Morocco, 105 herbalists provided information. The data were examined using seven quantitative indices: The Fidelity Level (FL), Use Value (UV), Frequency of Citation (FC), Relative Frequency of Citation (RFC), and Informant Consensus Factor (ICF). During the current investigation, twenty-two different species of medicinal plants from eleven families have been reported as being used to treat fevers. The most recommended plant with a high Relative Frequency of Citation (RFC = 0.15) is Dysphania ambrosioides L., which indicates the importance of this species in controlling fever, especially when it is combined with Citrus × limon (L.) Osbeck (RFC = 0.139). Hence, the use of these plants was compared to the literature review. This research contributed to documenting and preserving important Moroccan traditional herbalists’ knowledge about plants used to cure febrile illnesses.
Keywords	Citrus ; Dysphania ambrosioides ; ethnobotany ; fever ; surveys ; traditional medicine ; Morocco
Language	English
Dates of publication	2023-0724
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15070879
Database	NAL-Catalogue (AGRICOLA)

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Article: Rheumatoid Arthritis and CLOVES Syndrome: A Tricky Diagnosis.

Damian, Laura / Lebovici, Andrei / Pamfil, Cristina / Belizna, Cristina / Vulturar, Romana

Diagnostics (Basel, Switzerland)

2020 Volume 10, Issue 7

Abstract: The PI3K/AKT/mTOR signaling pathway is significantly activated in rheumatoid arthritis. In addition, somatic activating mutations of the PI3K/AKT/mTOR pathway may result ... ...

Abstract	The PI3K/AKT/mTOR signaling pathway is significantly activated in rheumatoid arthritis. In addition, somatic activating mutations of the PI3K/AKT/mTOR pathway may result in
Language	English
Publishing date	2020-07-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics10070467
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Article: Anemia in Sports: A Narrative Review.

Damian, Marc-Tudor / Vulturar, Romana / Login, Cristian Cezar / Damian, Laura / Chis, Adina / Bojan, Anca

Life (Basel, Switzerland)

2021 Volume 11, Issue 9

Abstract: Recent years have brought about new understandings regarding the pathogenesis of anemia in sports. From hemodilution and redistribution considered to contribute to the so-called "sports anemia" to iron deficiency caused by increased demands, dietary ... ...

Abstract	Recent years have brought about new understandings regarding the pathogenesis of anemia in sports. From hemodilution and redistribution considered to contribute to the so-called "sports anemia" to iron deficiency caused by increased demands, dietary restrictions, decreased absorption, increased losses, hemolysis, and sequestration, to genetic determinants of different types of anemia (some related to sport), the anemia in athletes deserves a careful and multifactorial approach. Dietary factors that reduce iron absorption (e.g., phytate, polyphenols) and that augment iron's bioavailability (e.g., ascorbic acid) should be considered. Celiac disease, more prevalent in female athletes, may underlie an unexplained iron deficiency anemia. Iron loss during exercise occurs in several ways: sweating, hematuria, gastrointestinal bleeding, inflammation, and intravascular and extravascular hemolysis. From a practical point of view, assessing iron status, especially in the athletes at risk for iron deficiency (females, adolescents, in sports with dietary restrictions, etc.), may improve the iron balance and possibly the performance. Hemoglobin and serum ferritin are measures that are easily employable for the evaluation of patients' iron status. Cutoff values should probably be further assessed with respect to the sex, age, and type of sport. A healthy gut microbiome influences the iron status. Athletes at risk of iron deficiency should perform non-weight-bearing, low-intensity sports to avoid inducing hemolysis.
Language	English
Publishing date	2021-09-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11090987
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Article: Oral Microbiome: Getting to Know and Befriend Neighbors, a Biological Approach.

Bacali, Cecilia / Vulturar, Romana / Buduru, Smaranda / Cozma, Angela / Fodor, Adriana / Chiș, Adina / Lucaciu, Ondine / Damian, Laura / Moldovan, Mirela Liliana

Biomedicines

2022 Volume 10, Issue 3

Abstract: The oral microbiome, forming a biofilm that covers the oral structures, contains a high number of microorganisms. Biofilm formation starts from the salivary pellicle that allows bacterial adhesion-colonization-proliferation, co-aggregation and biofilm ... ...

Abstract	The oral microbiome, forming a biofilm that covers the oral structures, contains a high number of microorganisms. Biofilm formation starts from the salivary pellicle that allows bacterial adhesion-colonization-proliferation, co-aggregation and biofilm maturation in a complex microbial community. There is a constant bidirectional crosstalk between human host and its oral microbiome. The paper presents the fundamentals regarding the oral microbiome and its relationship to modulator factors, oral and systemic health. The modern studies of oral microorganisms and relationships with the host benefits are based on genomics, transcriptomics, proteomics and metabolomics. Pharmaceuticals such as antimicrobials, prebiotics, probiotics, surface active or abrasive agents and plant-derived ingredients may influence the oral microbiome. Many studies found associations between oral dysbiosis and systemic disorders, including autoimmune diseases, cardiovascular, diabetes, cancers and neurodegenerative disorders. We outline the general and individual factors influencing the host-microbial balance and the possibility to use the analysis of the oral microbiome in prevention, diagnosis and treatment in personalized medicine. Future therapies should take in account the restoration of the normal symbiotic relation with the oral microbiome.
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10030671
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Article ; Online: Inclusion Body Myositis and Neoplasia: A Narrative Review.

Damian, Laura / Login, Cristian Cezar / Solomon, Carolina / Belizna, Cristina / Encica, Svetlana / Urian, Laura / Jurcut, Ciprian / Stancu, Bogdan / Vulturar, Romana

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Inclusion body myositis (IBM) is an acquired, late-onset inflammatory myopathy, with both inflammatory and degenerative pathogenesis. Although idiopathic inflammatory myopathies may be associated with malignancies, IBM is generally not considered ... ...

Abstract	Inclusion body myositis (IBM) is an acquired, late-onset inflammatory myopathy, with both inflammatory and degenerative pathogenesis. Although idiopathic inflammatory myopathies may be associated with malignancies, IBM is generally not considered paraneoplastic. Many studies of malignancy in inflammatory myopathies did not include IBM patients. Indeed, IBM is often diagnosed only after around 5 years from onset, while paraneoplastic myositis is generally defined as the co-occurrence of malignancy and myopathy within 1 to 3 years of each other. Nevertheless, a significant association with large granular lymphocyte leukemia has been recently described in IBM, and there are reports of cancer-associated IBM. We review the pathogenic mechanisms supposed to be involved in IBM and outline the common mechanisms in IBM and malignancy, as well as the therapeutic perspectives. The terminally differentiated, CD8+ highly cytotoxic T cells expressing NK features are central in the pathogenesis of IBM and, paradoxically, play a role in some cancers as well. Interferon gamma plays a central role, mostly during the early stages of the disease. The secondary mitochondrial dysfunction, the autophagy and cell cycle dysregulation, and the crosstalk between metabolic and mitogenic pathways could be shared by IBM and cancer. There are intermingled subcellular mechanisms in IBM and neoplasia, and probably their co-existence is underestimated. The link between IBM and cancers deserves further interest, in order to search for efficient therapies in IBM and to improve muscle function, life quality, and survival in both diseases.
MeSH term(s)	Autoantibodies/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Myositis/pathology ; Myositis, Inclusion Body/etiology ; Myositis, Inclusion Body/therapy ; Neoplasms/metabolism
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137358
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