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  1. Article ; Online: Clinical and molecular features of familial chronic lymphocytic leukemia: a pilot monocentric study.

    Benintende, Giulia / Innocenti, Idanna / Fresa, Alberto / Autore, Francesco / Tomasso, Annamaria / Piciocchi, Alfonso / Vuono, Florenzia / Stirparo, Luca / Mosca, Antonio / Bacigalupo, Andrea / Gattei, Valter / Efremov, Dimitar / Sangiorgi, Eugenio / Laurenti, Luca

    Haematologica

    2023  Volume 108, Issue 8, Page(s) 2240–2243

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics
    Language English
    Publishing date 2023-08-01
    Publishing country Italy
    Document type Letter
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.282268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
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  2. Article: VEGF and IL-6 Correlation in POEMS: a Potential Upcoming Marker of Active Disease and Early Autologous BMT Response.

    Tomasso, Annamaria / Innocenti, Idanna / Autore, Francesco / Fresa, Alberto / Benintende, Giulia / Vuono, Florenzia / Baroni, Silvia / Giannotta, Claudia / Chiusolo, Patrizia / Sorà, Federica / Sica, Simona / Laurenti, Luca

    Mediterranean journal of hematology and infectious diseases

    2022  Volume 14, Issue 1, Page(s) e2022007

    Language English
    Publishing date 2022-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2022.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Subcutaneous immunoglobulins in chronic lymphocytic leukemia with secondary antibody deficiency. A monocentric experience during Covid-19 pandemics.

    Innocenti, Idanna / Tomasso, Annamaria / Benintende, Giulia / Autore, Francesco / Fresa, Alberto / Vuono, Florenzia / Stirparo, Luca / Galli, Eugenio / D'Arena, Giovanni / Sorà, Federica / Efremov, Dimitar / Laurenti, Luca

    Hematological oncology

    2022  Volume 40, Issue 3, Page(s) 469–474

    Abstract: Secondary antibody deficiency (SAD) is a frequent manifestation of chronic lymphocytic leukemia (CLL) that increases the risk of infections. However, no formal guideline are available regarding the eligibility for prophylaxis or the delivery method, ... ...

    Abstract Secondary antibody deficiency (SAD) is a frequent manifestation of chronic lymphocytic leukemia (CLL) that increases the risk of infections. However, no formal guideline are available regarding the eligibility for prophylaxis or the delivery method, dosage, frequency of administration and duration of immunoglobulin replacement therapy (IgRT). The aim of this study was to assess the efficacy and safety of subcutaneous IgRT (SCIg) and its impact on quality of life (QoL) of CLL pts in the Covid-19 era. Ten CLL pts with SAD were treated with subcutaneous IgRT (SCIg) at our institution between October 2019 and December 2020. Median age was 66 years and five patients had comorbidities. Seven patients were receiving therapy for CLL when treatment with SCIg was initiated. All pts received 10 g total dose hyaluronidase-free SCIg independently from body weight. The IgG level and CD4/CD8, CD19 and CD16/56 lymphocytes subset were recorded at baseline and every 3 months. No patient experienced infectious events nor Covid-19 mediated interstitial pneumonia while on SCIg therapy. All patients tolerated well the therapy and experienced an increase of IgG levels, which was then stable in time. We conclude that SCIg administration in CLL pts with SAD is efficacious and safe as infectious prophylaxis. This route of administration appears particularly advantageous in the Covid-19 era, because of the self-administration at home which results in improvement in the QoL and reduced treatment expenditures.
    MeSH term(s) Aged ; COVID-19/complications ; Humans ; Immunoglobulin G ; Immunologic Deficiency Syndromes/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Pandemics ; Quality of Life
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Letter
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Prenatal exposure to valproate induces sex-, age-, and tissue-dependent alterations of cholesterol metabolism: Potential implications on autism.

    Cartocci, Veronica / Tonini, Claudia / Di Pippo, Tiziana / Vuono, Florenzia / Schiavi, Sara / Marino, Maria / Trezza, Viviana / Pallottini, Valentina

    Journal of cellular physiology

    2018  Volume 234, Issue 4, Page(s) 4362–4374

    Abstract: Here, we investigated the protein network regulating cholesterol metabolism in the liver and brain of adolescent and adult male and female rats prenatally exposed to valproate (VPA), a well validated experimental model of autism spectrum disorders (ASD). ...

    Abstract Here, we investigated the protein network regulating cholesterol metabolism in the liver and brain of adolescent and adult male and female rats prenatally exposed to valproate (VPA), a well validated experimental model of autism spectrum disorders (ASD). We were aimed at studying whether prenatal VPA exposure affected the proteins involved in cholesterol homeostasis in a sex-dependent manner. To this aim the protein network of cholesterol metabolism, in term of synthesis and plasma membrane trafficking, was analyzed by western blot in the liver and different brain areas (amygdala, cerebellum, cortex, hippocampus, nucleus accumbens, and dorsal striatum) of adolescent and adult male and female rats prenatally exposed to VPA. Our results show that physiological sex-dependent differences are present both in the liver and in brain of rats. Interestingly, VPA affects specifically the brain in an age- and region-specific manner; indeed, cerebellum, cortex, hippocampus and nucleus accumbens are affected in a sex-dependent way, while this does not occur in amygdala and dorsal striatum. Overall, we demonstrate that each brain area responds differently to the same external stimulus and males and females respond in a different way, suggesting that this could be related to the diverse incidences, between the sexes, of some neurodevelopmental pathologies such as autism, which displays a 3:1 male to female ratio.
    MeSH term(s) Age Factors ; Animals ; Anticonvulsants/toxicity ; Autistic Disorder/chemically induced ; Autistic Disorder/metabolism ; Autistic Disorder/physiopathology ; Brain/metabolism ; Brain/physiopathology ; Cholesterol/metabolism ; Female ; Liver/metabolism ; Male ; Maternal Exposure ; Pregnancy ; Prenatal Exposure Delayed Effects ; Protein Interaction Maps ; Rats, Wistar ; Risk Factors ; Sex Characteristics ; Sex Factors ; Sexual Development ; Valproic Acid/toxicity
    Chemical Substances Anticonvulsants ; Valproic Acid (614OI1Z5WI) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2018-10-20
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.27218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
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