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  1. Article ; Online: Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.

    Ramirez, AnnJosette / Vyzas, Christina A / Zhao, Huaning / Eng, Kevin / Degenhardt, Karl / Astrof, Sophie

    Circulation research

    2024  

    Abstract: Background: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in ... ...

    Abstract Background: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in neonatal lethality are exemplified by congenital heart disease arising from defective morphogenesis of pharyngeal arch arteries (PAAs) and their derivatives.
    Objective: To uncover mechanisms underlying the robustness of PAA morphogenesis.
    Methods and results: The second heart field (SHF) gives rise to the PAA endothelium. Here, we show that the number of SHF-derived endothelial cells (ECs) is regulated by
    Conclusions: Our studies uncover a novel buffering mechanism underlying the resiliency of PAA development and remodeling.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Identification of novel buffering mechanisms in aortic arch artery development and congenital heart disease.

    Ramirez, AnnJosette / Vyzas, Christina A / Zhao, Huaning / Eng, Kevin / Degenhardt, Karl / Astrof, Sophie

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Rationale: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in ... ...

    Abstract Rationale: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in neonatal lethality are exemplified by congenital heart disease (CHD) arising from defective morphogenesis of pharyngeal arch arteries (PAA) and their derivatives.
    Objective: To uncover mechanisms underlying the robustness of PAA morphogenesis.
    Methods and results: The second heart field (SHF) gives rise to the PAA endothelium. Here, we show that the number of SHF-derived ECs is regulated by
    Conclusions: Our studies uncover a novel buffering mechanism underlying the resiliency of PAA development and remodeling.
    Nonstandard abbreviations and acronyms in alphabetical order: CHD - congenital heart disease; ECs - endothelial cells; IAA-B - interrupted aortic arch type B; PAA - pharyngeal arch arteries; RERSA - retro-esophageal right subclavian artery; SHF - second heart field; VEGFR2 - Vascular endothelial growth factor receptor 2.
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.02.530833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vertebral pattern and morphology is determined during embryonic segmentation.

    Serra, Kevin M / Vyzas, Christina / Shehreen, Sarah / Chipendo, Iris / Clifford, Katherine M / Youngstrom, Daniel W / Devoto, Stephen H

    Developmental dynamics : an official publication of the American Association of Anatomists

    2023  Volume 253, Issue 2, Page(s) 204–214

    Abstract: Background: The segmented nature of the adult vertebral column is based on segmentation of the paraxial mesoderm during early embryogenesis. Disruptions to embryonic segmentation, whether caused by genetic lesions or environmental stress, result in ... ...

    Abstract Background: The segmented nature of the adult vertebral column is based on segmentation of the paraxial mesoderm during early embryogenesis. Disruptions to embryonic segmentation, whether caused by genetic lesions or environmental stress, result in adult vertebral pathologies. However, the mechanisms linking embryonic segmentation and the details of adult vertebral morphology are poorly understood.
    Results: We induced border defects using two approaches in zebrafish: heat stress and misregulation of embryonic segmentation genes tbx6, mesp-ba, and ripply1. We assayed vertebral length, regularity, and polarity using microscopic and radiological imaging. In population studies, we find a correlation between specific embryonic border defects and specific vertebral defects, and within individual fish, we trace specific adult vertebral defects to specific embryonic border defects.
    Conclusions: Our data reveal that transient disruptions of embryonic segment border formation led to significant vertebral anomalies that persist through adulthood. The spacing of embryonic borders controls the length of the vertebra. The positions of embryonic borders control the positions of ribs and arches. Embryonic borders underlie fusions and divisions between adjacent spines and ribs. These data suggest that segment borders have a dominant role in vertebral development.
    MeSH term(s) Animals ; Zebrafish ; Spine/diagnostic imaging ; Mesoderm ; Zebrafish Proteins ; Embryonic Development ; Somites ; T-Box Domain Proteins/genetics
    Chemical Substances Zebrafish Proteins ; tbx6 protein, zebrafish ; T-Box Domain Proteins
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.60: Show issues Location:
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    Zs.MG 64: Show issues

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  4. Article: Vascular Stiffness in Aging and Disease.

    Vatner, Stephen F / Zhang, Jie / Vyzas, Christina / Mishra, Kalee / Graham, Robert M / Vatner, Dorothy E

    Frontiers in physiology

    2021  Volume 12, Page(s) 762437

    Abstract: The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases. Differences in stiffness down the aortic tree are discussed, a topic requiring ... ...

    Abstract The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases. Differences in stiffness down the aortic tree are discussed, a topic requiring further research, because most prior work only examined one location in the aorta. It is also important to understand the divergent effects of increased aortic stiffness between males and females, principally due to the protective role of female sex hormones prior to menopause. Another goal is to review human and non-human primate data and contrast them with data in rodents. This is particularly important for understanding sex differences in vascular stiffness with aging as well as the changes in vascular stiffness before and after menopause in females, as this is controversial. This area of research necessitates studies in humans and non-human primates, since rodents do not go through menopause. The most important mechanism studied as a cause of age-related increases in vascular stiffness is an alteration in the vascular extracellular matrix resulting from an increase in collagen and decrease in elastin. However, there are other mechanisms mediating increased vascular stiffness, such as collagen and elastin disarray, calcium deposition, endothelial dysfunction, and the number of vascular smooth muscle cells (VSMCs). Populations with increased longevity, who live in areas called "Blue Zones," are also discussed as they provide additional insights into mechanisms that protect against age-related increases in vascular stiffness. Such increases in vascular stiffness are important in mediating the adverse effects of major cardiovascular diseases, including atherosclerosis, hypertension and diabetes, but require further research into their mechanisms and treatment.
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.762437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genomics analysis of hexanoic acid exposure in Drosophila species.

    Drum, Zachary A / Lanno, Stephen M / Gregory, Sara M / Shimshak, Serena J / Ahamed, Mukshud / Barr, Will / Bekele, Bethlehem / Biester, Alison / Castro, Colleen / Connolly, Lauren / DelGaudio, Nicole / Humphrey, William / Karimi, Helen / Karolczak, Sophie / Lawrence, Tay-Shaun / McCracken, Andrew / Miller-Medzon, Noah / Murphy, Leah / Park, Cameron /
    Park, Sojeong / Qiu, Chloe / Serra, Kevin / Snyder, Gigi / Strauss, Alexa / Tang, Spencer / Vyzas, Christina / Coolon, Joseph D

    G3 (Bethesda, Md.)

    2021  Volume 12, Issue 1

    Abstract: Drosophila sechellia is a dietary specialist endemic to the Seychelles islands that has evolved to consume the fruit of Morinda citrifolia. When ripe, the fruit of M. citrifolia contains octanoic acid and hexanoic acid, two medium-chain fatty acid ... ...

    Abstract Drosophila sechellia is a dietary specialist endemic to the Seychelles islands that has evolved to consume the fruit of Morinda citrifolia. When ripe, the fruit of M. citrifolia contains octanoic acid and hexanoic acid, two medium-chain fatty acid volatiles that deter and are toxic to generalist insects. Drosophila sechellia has evolved resistance to these volatiles allowing it to feed almost exclusively on this host plant. The genetic basis of octanoic acid resistance has been the focus of multiple recent studies, but the mechanisms that govern hexanoic acid resistance in D. sechellia remain unknown. To understand how D. sechellia has evolved to specialize on M. citrifolia fruit and avoid the toxic effects of hexanoic acid, we exposed adult D. sechellia, D. melanogaster and D. simulans to hexanoic acid and performed RNA sequencing comparing their transcriptional responses to identify D. sechellia specific responses. Our analysis identified many more genes responding transcriptionally to hexanoic acid in the susceptible generalist species than in the specialist D. sechellia. Interrogation of the sets of differentially expressed genes showed that generalists regulated the expression of many genes involved in metabolism and detoxification whereas the specialist primarily downregulated genes involved in the innate immunity. Using these data, we have identified interesting candidate genes that may be critically important in aspects of adaptation to their food source that contains high concentrations of HA. Understanding how gene expression evolves during dietary specialization is crucial for our understanding of how ecological communities are built and how evolution shapes trophic interactions.
    MeSH term(s) Animals ; Caproates/metabolism ; Caproates/toxicity ; Drosophila/physiology ; Drosophila melanogaster/genetics ; Genomics ; Species Specificity
    Chemical Substances Caproates ; hexanoic acid (1F8SN134MX)
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkab354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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