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  1. Book ; Conference proceedings: Lost in Translation? Translationsforschung in den Lebenswissenschaften

    Wübbeler, Markus / Lippmann, Kristina / Wünsch, Désirée / Docter, Dominic

    Beiträge des Symposiums vom 1. Februar 2018 in der Akademie der Wissenschaften und der Literatur, Mainz

    (Schriftenreihe der Jungen Akademie der Wissenschaften und der Literatur | Mainz ; Nr. 3)

    2019  

    Event/congress Lost in Translation? Translationsforschung in den Lebenswissenschaften (2018, Mainz)
    Series title Schriftenreihe der Jungen Akademie der Wissenschaften und der Literatur | Mainz ; Nr. 3
    Schriftenreihe der Jungen Akademie der Wissenschaften und der Literatur, Mainz
    Collection Schriftenreihe der Jungen Akademie der Wissenschaften und der Literatur, Mainz
    Keywords Versorgungsforschung ; Neurologie ; Krebsforschung ; Gesundheitspolitik ; Lebenswissenschaften ; Translationsforschung ; Medizin ; Grundlagenforschung ; Medizinische Versorgung
    Subject Gesundheitsversorgung ; Gesundheitliche Versorgung ; Patientenversorgung ; Grundlagentheorie ; Humanmedizin ; Heilkunst ; Medicine
    Subject code 490
    Language English ; German
    Size 144 Seiten, Illustrationen, Diagramme, 24 cm x 17 cm, 356 g
    Publisher Akademie der Wissenschaften und der Literatur ; Franz Steiner Verlag
    Publishing place Mainz ; Stuttgart
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020156649
    ISBN 978-3-515-12284-9 ; 3-515-12284-2 ; 9783515122870 ; 3515122877
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1573 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; Thesis: Funktionelle Analyse der onkologisch relevanten Protease Threonin-Aspartase 1

    Wünsch, Désirée

    2015  

    Author's details Désirée Wünsch
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 2015
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Online ; Thesis: Funktionelle Analyse der onkologisch relevanten Protease Threonin-Aspartase 1

    Wünsch, Désirée

    2015  

    Author's details Désirée Wünsch
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 2015
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Online ; Thesis: Funktionelle Analyse der onkologisch relevanten Protease Threonin-Aspartase 1

    Wünsch, Désirée [Verfasser]

    2015  

    Author's details Désirée Wünsch
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients.

    Künzel, Julian / Gribko, Alena / Lu, Qiang / Stauber, Roland H / Wünsch, Désirée

    Biological chemistry

    2019  Volume 400, Issue 11, Page(s) 1465–1479

    Abstract: The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of ... ...

    Abstract The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detection methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a comprehensive overview on (nanomedical) detection methods for circulating tumor cells and discuss their merits, pitfalls and future perspectives especially for head and neck solid squamous cell carcinoma (HNSCC) patients.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Head and Neck Neoplasms/diagnosis ; Humans ; Nanomedicine ; Neoplastic Cells, Circulating/pathology
    Language English
    Publishing date 2019-03-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2019-0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.

    Kiweler, Nicole / Wünsch, Désirée / Wirth, Matthias / Mahendrarajah, Nisintha / Schneider, Günter / Stauber, Roland H / Brenner, Walburgis / Butter, Falk / Krämer, Oliver H

    Journal of cancer research and clinical oncology

    2020  Volume 146, Issue 2, Page(s) 343–356

    Abstract: Purpose: We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic process.: Methods: We treated permanent and primary renal, lung, and breast cancer cells with ... ...

    Abstract Purpose: We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic process.
    Methods: We treated permanent and primary renal, lung, and breast cancer cells with the class I histone deacetylase inhibitors (HDACi) entinostat (MS-275) and valproic acid (VPA), the replicative stress inducer hydroxyurea (HU), the DNA-damaging agent cis-platinum (L-OHP), and the cytokine transforming growth factor-β (TGFβ). We used proteomics, quantitative PCR, immunoblot, single cell DNA damage assays, and flow cytometry to analyze cell fate after drug exposure.
    Results: We show that HDACi interfere with DNA repair protein expression and trigger DNA damage and apoptosis alone and in combination with established chemotherapeutics. Furthermore, HDACi disrupt the balance of cell adhesion protein expression and abrogate TGFβ-induced cellular plasticity of transformed cells.
    Conclusion: HDACi suppress the epithelial-mesenchymal transition (EMT) and compromise the DNA integrity of cancer cells. These data encourage further testing of HDACi against tumor cells.
    MeSH term(s) Animals ; Benzamides/pharmacology ; Cell Plasticity/drug effects ; Cisplatin/pharmacology ; DNA Repair/physiology ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/metabolism ; Drug Resistance, Neoplasm ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Hydroxyurea/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Neoplasm Metastasis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Pyridines/pharmacology ; Transforming Growth Factor beta/pharmacology ; Valproic Acid/pharmacology
    Chemical Substances Benzamides ; DNA-Binding Proteins ; Histone Deacetylase Inhibitors ; Pyridines ; Transforming Growth Factor beta ; entinostat (1ZNY4FKK9H) ; Valproic Acid (614OI1Z5WI) ; DNA Repair Enzymes (EC 6.5.1.-) ; Cisplatin (Q20Q21Q62J) ; Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2020-01-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-019-03118-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.10: Show issues Location:
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  7. Article ; Online: An Old Flame Never Dies: Survivin in Cancer and Cellular Senescence.

    Unruhe, Britta / Schröder, Elisabeth / Wünsch, Désirée / Knauer, Shirley K

    Gerontology

    2016  Volume 62, Issue 2, Page(s) 173–181

    Abstract: Survivin (BIRC5) is highly expressed in the vast majority of human cancers and is associated with chemotherapy resistance, increased tumor recurrence and shortened patient survival, making it an attractive therapeutic target. Initially identified as an ... ...

    Abstract Survivin (BIRC5) is highly expressed in the vast majority of human cancers and is associated with chemotherapy resistance, increased tumor recurrence and shortened patient survival, making it an attractive therapeutic target. Initially identified as an inhibitor of apoptosis protein, it also plays a major role in the regulation of cell division. As such, it acts as a subunit of the chromosomal passenger complex, composed of the mitotic kinase aurora B, borealin and inner centromere protein, and is essential for proper chromosome segregation and cytokinesis. For both biological functions, interaction of survivin's nuclear export signal with the nuclear export receptor chromosome region maintenance 1 is absolutely essential. The timely orchestration of survivin's wide protein interaction repertoire is further modulated by different posttranslational modifications occurring in a cell-cycle-dependent manner. Recent data furthermore indicate additional roles of survivin in the DNA damage response, contributing to therapy resistance, yet the underlying molecular details are still not completely resolved. This also holds true for a potential involvement of survivin in senescence regulation. An age-related accumulation of survivin probably contributes to the apoptosis resistance observed in aged as well as in senescent cells, while it might promote escape from therapy-induced senescence. This review seeks to integrate the current knowledge on survivin's diverse and complex biological functions. By linking the 'old' facts about survivin with recent findings in research areas such as DNA damage response and aging, we want to highlight survivin's crucial role in a variety of cellular processes.
    MeSH term(s) Aging ; Apoptosis ; Cellular Senescence ; DNA Repair ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; Mitosis ; Neoplasms/metabolism
    Chemical Substances BIRC5 protein, human ; Inhibitor of Apoptosis Proteins
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000432398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.201: Show issues Location:
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  8. Article ; Online: Cleaving for growth: threonine aspartase 1--a protease relevant for development and disease.

    Stauber, Roland H / Hahlbrock, Angelina / Knauer, Shirley K / Wünsch, Désirée

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2016  Volume 30, Issue 3, Page(s) 1012–1022

    Abstract: From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and cell growth. Regulated proteolytic activity is essential for the orchestration of multiple developmental pathways, and defects ...

    Abstract From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and cell growth. Regulated proteolytic activity is essential for the orchestration of multiple developmental pathways, and defects in protease activity can account for multiple disease patterns. The highly conserved protease threonine aspartase 1 is a member of such developmental proteases and critically involved in the regulation of complex processes, including segmental identity, head morphogenesis, spermatogenesis, and proliferation. Additionally, threonine aspartase 1 is overexpressed in numerous liquid as well as in solid malignancies. Although threonine aspartase 1 is able to cleave the master regulator mixed lineage leukemia protein as well as other regulatory proteins in humans, our knowledge of its detailed pathobiological function and the underlying molecular mechanisms contributing to development and disease is still incomplete. Moreover, neither effective genetic nor chemical inhibitors for this enzyme are available so far precluding the detailed dissection of the pathobiological functions of threonine aspartase 1. Here, we review the current knowledge of the structure-function relationship of threonine aspartase 1 and its mechanistic impact on substrate-mediated coordination of the cell cycle and development. We discuss threonine aspartase 1-mediated effects on cellular transformation and conclude by presenting a short overview of recent interference strategies.
    MeSH term(s) Animals ; Cell Cycle/physiology ; Endopeptidases/metabolism ; Humans ; Peptide Hydrolases/metabolism
    Chemical Substances Endopeptidases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.15-270611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives.

    Gribko, Alena / Künzel, Julian / Wünsch, Désirée / Lu, Qiang / Nagel, Sophie Madeleine / Knauer, Shirley K / Stauber, Roland H / Ding, Guo-Bin

    International journal of nanomedicine

    2019  Volume 14, Page(s) 4187–4209

    Abstract: Circulating tumor cells (CTCs) are disseminated cancer cells. The occurrence and circulation of CTCs seem key for metastasis, still the major cause of cancer-associated deaths. As such, CTCs are investigated as predictive biomarkers. However, due to ... ...

    Abstract Circulating tumor cells (CTCs) are disseminated cancer cells. The occurrence and circulation of CTCs seem key for metastasis, still the major cause of cancer-associated deaths. As such, CTCs are investigated as predictive biomarkers. However, due to their rarity and heterogeneous biology, CTCs' practical use has not made it into the clinical routine. Clearly, methods for the effective isolation and reliable detection of CTCs are urgently needed. With the development of nanotechnology, various nanosystems for CTC isolation and enrichment and CTC-targeted cancer therapy have been designed. Here, we summarize the relationship between CTCs and tumor metastasis, and describe CTCs' unique properties hampering their effective enrichment. We comment on nanotechnology-based systems for CTC isolation and recent achievements in microfluidics and lab-on-a-chip technologies. We discuss recent advances in CTC-targeted cancer therapy exploiting the unique properties of nanomaterials. We conclude by introducing developments in CTC-directed nanosystems and other advanced technologies currently in (pre)clinical research.
    MeSH term(s) Biomarkers, Tumor/analysis ; Biomarkers, Tumor/isolation & purification ; Biomimetic Materials ; Cell Separation/methods ; Graphite ; Humans ; Lab-On-A-Chip Devices ; Microfluidics/instrumentation ; Microfluidics/methods ; Nanomedicine/methods ; Nanostructures/chemistry ; Nanotechnology/methods ; Nanotubes, Carbon ; Neoplastic Cells, Circulating/pathology
    Chemical Substances Biomarkers, Tumor ; Nanotubes, Carbon ; Graphite (7782-42-5)
    Language English
    Publishing date 2019-06-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S198319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6606: Show issues Location:
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  10. Article ; Online: Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure.

    Heinrich, Ulf R / Schmidtmann, Irene / Meuser, Regina / Ernst, Benjamin P / Wünsch, Desiree / Siemer, Svenja / Gribko, Alena / Stauber, Roland H / Strieth, Sebastian

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2019  Volume 67, Issue 11, Page(s) 845–855

    Abstract: Constitutively expressed endothelial nitric oxide synthase (eNOS) is supposed to play a role in noise-induced nitric oxide (NO)-production. It is commonly known that intense noise exposure results in inducible NOS (iNOS) expression and increased NO- ... ...

    Abstract Constitutively expressed endothelial nitric oxide synthase (eNOS) is supposed to play a role in noise-induced nitric oxide (NO)-production. It is commonly known that intense noise exposure results in inducible NOS (iNOS) expression and increased NO-production, but knowledge about a contribution of the eNOS isoform is still lacking. Effects of noise exposure on eNOS immunolabeling were determined in male guinea pigs (
    MeSH term(s) Animals ; Cochlea/metabolism ; Cochlea/ultrastructure ; Guinea Pigs/metabolism ; Hearing Loss, Noise-Induced/metabolism ; Immunohistochemistry ; Male ; Nitric Oxide Synthase Type III/analysis ; Nitric Oxide Synthase Type III/metabolism ; Noise/adverse effects
    Chemical Substances Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155419876644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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