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Article ; Online: Some Non-Obvious Consequences of Non-Extensiveness of Entropy.

Wilk, Grzegorz / Włodarczyk, Zbigniew

2023 Volume 25, Issue 3

Abstract: Non-additive (or non-extensive) entropies have long been intensively studied and used in various fields of scientific research. This was due to the desire to describe the commonly observed quasi-power rather than the exponential nature of various ... ...

Abstract	Non-additive (or non-extensive) entropies have long been intensively studied and used in various fields of scientific research. This was due to the desire to describe the commonly observed quasi-power rather than the exponential nature of various distributions of the variables of interest when considered in the full available space of their variability. In this work we will concentrate on the example of high energy multiparticle production processes and will limit ourselves to only one form of non-extensive entropy, namely the Tsallis entropy. We will discuss some points not yet fully clarified and present some non-obvious consequences of non-extensiveness of entropy when applied to production processes.
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25030474
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Article ; Online: Impact of Levosimendan and Its Metabolites on Platelet Activation Mechanisms in Patients during Antiplatelet Therapy-Pilot Study.

Sikora, Joanna / Pstrągowski, Krzysztof / Karczmarska-Wódzka, Aleksandra / Wszelaki, Patrycja / Buszko, Katarzyna / Włodarczyk, Zbigniew

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: Levosimendan is used for the short-term treatment of severe heart failure or other cardiac conditions. The area of existing clinical applications for levosimendan has increased significantly. This study aimed to assess whether levosimendan and its ... ...

Abstract	Levosimendan is used for the short-term treatment of severe heart failure or other cardiac conditions. The area of existing clinical applications for levosimendan has increased significantly. This study aimed to assess whether levosimendan and its metabolites impact the mechanisms related to platelet activation. In this study, we included patients with coronary artery disease receiving antiplatelet therapy. We analyzed the pharmacodynamic profile using three independent methods to assess platelet activity. The results of the conducted studies indicate a mechanism of levosimendan that affects the function of platelets, causing higher inhibition of platelet receptors and, thus, their aggregation. It is essential to clarify whether levosimendan may affect platelets due to the need to maintain a balance between bleeding and thrombosis in patients treated with levosimendan. This is especially important in the case of perioperative bleeding. This study was conducted in vitro; the research should be continued and carried out in patients to check the complete pharmacokinetic and pharmacodynamic profile.
MeSH term(s)	Humans ; Simendan/pharmacology ; Simendan/therapeutic use ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Pilot Projects ; Platelet Aggregation ; Platelet Activation ; Blood Platelets
Chemical Substances	Simendan (349552KRHK) ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031824
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Article ; Online: Preface.

Wlodarczyk, Zbigniew

Transplantation proceedings

2014 Volume 46, Issue 8, Page(s) 2475

Language	English
Publishing date	2014
Publishing country	United States
Document type	Editorial
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2014.09.141
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Article ; Online: Abnormal diurnal blood pressure profile and hypertension-mediated organ damage in nondiabetic chronic kidney disease G1-G3b patients.

Stróżecki, Paweł / Pluta, Agnieszka / Donderski, Rafał / Włodarczyk, Zbigniew / Manitius, Jacek

Blood pressure monitoring

2021 Volume 26, Issue 1, Page(s) 22–29

Abstract: Objective: Chronic kidney disease (CKD) is associated with high cardiovascular risk. Prevalence of hypertension and hypertension-mediated organ damage (HMOD) increases with CKD progression. Nocturnal blood pressure (BP) is a strong predictor of ... ...

Abstract	Objective: Chronic kidney disease (CKD) is associated with high cardiovascular risk. Prevalence of hypertension and hypertension-mediated organ damage (HMOD) increases with CKD progression. Nocturnal blood pressure (BP) is a strong predictor of cardiovascular complications. This cross-sectional study investigated the link between the diurnal BP profile and HMOD in nondiabetic CKD G1-G3b patients. Methods: We investigated 109 CKD patients and 41 apparently healthy persons as controls. All subjects underwent 24-ambulatory blood pressure monitoring (ABPM), echocardiography with left ventricular mass index (LVMI) calculation and pulse wave velocity (PWV) measurement. Results: Hypertension was present in 84% of CKD patients. SBP-24 and DBP-24, SBP-day and DBP-day did not differ between CKD and controls. Significant differences were found in SBP-night and DBP-night. The nondipping BP profile (SBP-night/SBP-day ratio ≥0.9) was found in 62% of CKD patients and 32% of controls (P < 0.005). Nocturnal hypertension was found in 56% of CKD patients. LVMI was higher in CKD compared to controls, higher in nondipping than dipping CKD patients, and higher in patients with nocturnal hypertension than without nocturnal hypertension. Abnormal left ventricular geometry was found in 72% nondipping and 43% dipping CKD patients. PWV was higher in CKD than in controls, in patients with nocturnal hypertension than without nocturnal hypertension but did not differ between CKD nondippers and dippers. Conclusion: The nondipping BP profile and nocturnal hypertension are associated with HMOD in G1-G3b CKD patients. Hence, there is a need for more extensive use of ABPM for individual risk assessment and personalization of antihypertensive treatment in CKD patients.
MeSH term(s)	Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Circadian Rhythm ; Cross-Sectional Studies ; Humans ; Hypertension/complications ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1324472-3
ISSN	1473-5725 ; 1359-5237
ISSN (online)	1473-5725
ISSN	1359-5237
DOI	10.1097/MBP.0000000000000499
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Article ; Online: Initial state characteristics of proton-nucleus collisions from Glauber Monte Carlo

Rybczynski Maciej / Wlodarczyk Zbigniew

EPJ Web of Conferences, Vol 99, p

2015 Volume 10006

Abstract: Fluctuations in physics observables in high energy ion collisions have been a topic of particular interest in recent years as they may provide important signals regarding the formation of quark-gluon plasma and the existence of a critical point. We ... ...

Abstract	Fluctuations in physics observables in high energy ion collisions have been a topic of particular interest in recent years as they may provide important signals regarding the formation of quark-gluon plasma and the existence of a critical point. We provide predictions for basic initial state characteristics of proton-nucleus collisions from Glauber Monte Carlo models. The following systems were simulated and analysed: p + 12C, p + 14N, p + 63Cu, and p + 208Pb at wide energy range. We apply GLISSANDO accordingly fitted to tasks defined in this paper.
Keywords	Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Candida auris Infection in a Meningococcal Septicemia Survivor, Poland.

Prażyńska, Małgorzata / Zalas-Więcek, Patrycja / Bogiel, Tomasz / Włodarczyk, Zbigniew / Deptuła, Aleksander / Woźniak, Marcin / Gospodarek-Komkowska, Eugenia

Mycopathologia

2022 Volume 188, Issue 1-2, Page(s) 135–141

Abstract: Background: Candida auris is an emerging pathogen that constitutes a serious global health threat. It is difficult to identify without specific approaches, and it can be misidentified with standard laboratory methods, what may lead to inappropriate ... ...

Abstract	Background: Candida auris is an emerging pathogen that constitutes a serious global health threat. It is difficult to identify without specific approaches, and it can be misidentified with standard laboratory methods, what may lead to inappropriate management. Case presentation: We report, probably the first in Poland, C. auris isolation from blood cultures and wound swabs of a young male following meningococcal septicaemia, in February 2019. The patient had been previously hospitalized in the United Arab Emirates. The isolate was rapidly identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and therefore clinicians were promptly informed on the alert pathogen isolation. The targeted antifungal treatment was successful and infection control measures seemed effective. ITS-based identification and subsequent whole genome sequencing showed that the C. auris isolate belongs to South Asian lineage (clade I). Conclusions: C. auris is able to cause outbreaks in healthcare settings. Therefore, it is important to quickly identify C. auris isolates in hospital settings so that healthcare facilities can take proper precautions to limit its spread.
MeSH term(s)	Male ; Humans ; Candida ; Poland/epidemiology ; Microbial Sensitivity Tests ; Candidiasis, Invasive
Language	English
Publishing date	2022-12-30
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	391081-7
ISSN	1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
ISSN (online)	1573-0832
ISSN	0369-299X ; 0301-486X ; 0027-5530
DOI	10.1007/s11046-022-00697-8
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Article ; Online: System size dependence of the log-periodic oscillations of transverse momentum spectra ⋆

Rybczyński Maciej / Wilk Grzegorz / Włodarczyk Zbigniew

EPJ Web of Conferences, Vol 90, p

2015 Volume 01002

Abstract: Recently the inclusive transverse momentum distributions of primary charged particles were measured for different centralities in Pb + Pb collisions. A strong suppression of the nuclear modification factor in central collisions around pT ∼ 6 − 7 GeV/c ... ...

Abstract	Recently the inclusive transverse momentum distributions of primary charged particles were measured for different centralities in Pb + Pb collisions. A strong suppression of the nuclear modification factor in central collisions around pT ∼ 6 − 7 GeV/c was seen. As a possible explanation, the hydrodynamic description of the collision process was tentatively proposed. However, such effect, (albeit much weaker) also exists in the ratio of data/fits, both in nuclear Pb + Pb collisions, and in the elementary p + p data in the same range of transverse momenta for which such an explanation is doubtful. As shown recently, in this case, assuming that this effect is genuine, it can be attributed to a specific modification of a quasi-power like formula usually used to describe such pT data, namely the Tsallis distribution. Following examples from other branches of physics, one simply has to allow for the power index becoming a complex number. This results in specific log-periodic oscillations dressing the usual power-like distribution, which can fit the p + p data. In this presentation we demonstrate that this method can also describe Pb + Pb data for different centralities. We compare it also with a two component statistical model with two Tsallis distributions recently proposed showing that data at still larger pT will be sufficient to discriminate between these two approaches.
Keywords	Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Book ; Online: Oscillations in counting statistics

Wilk, Grzegorz / Wlodarczyk, Zbigniew

2016

Abstract: The very large transverse momenta and large multiplicities available in present LHC experiments on pp collisions allow a much closer look at the corresponding distributions. Some time ago we discussed a possible physical meaning of apparent log-periodic ... ...

Abstract	The very large transverse momenta and large multiplicities available in present LHC experiments on pp collisions allow a much closer look at the corresponding distributions. Some time ago we discussed a possible physical meaning of apparent log-periodic oscillations showing up in p_T distributions (suggesting that the exponent of the observed power-like behavior is complex). In this talk we concentrate on another example of oscillations, this time connected with multiplicity distributions P(N). We argue that some combinations of the experimentally measured values of P(N) (satisfying the recurrence relations used in the description of cascade-stochastic processes in quantum optics) exhibit distinct oscillatory behavior, not observed in the usual Negative Binomial Distributions used to fit data. These oscillations provide yet another example of oscillations seen in counting statistics in many different, apparently very disparate branches of physics further demonstrating the universality of this phenomenon. Comment: Invited talk at ISMD2016, Seogwipo, Jeju Island, South Korea, 29.08-02.09.2016, to be published in EPJ Web of Conferences
Keywords	High Energy Physics - Phenomenology ; Nuclear Theory
Subject code	612
Publishing date	2016-10-06
Publishing country	us
Document type	Book ; Online
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Article ; Online: Early outcomes and long-term survival after kidney transplantation in elderly versus younger recipients from the same donor in a matched-pairs analysis.

Jankowska, Magdalena / Bzoma, Beata / Małyszko, Jolanta / Małyszko, Jacek / Słupski, Maciej / Kobus, Grażyna / Włodarczyk, Zbigniew / Rutkowski, Bolesław / Dębska-Ślizień, Alicja

Medicine

2021 Volume 100, Issue 51, Page(s) e28159

Abstract: Abstract: The elderly are the fastest-growing population on waiting lists for kidney transplantation (KTx). Recognized barriers to KTx in the elderly is early post-transplant mortality and morbidity. To analyze the outcomes of KTx in recipients older ... ...

Abstract	Abstract: The elderly are the fastest-growing population on waiting lists for kidney transplantation (KTx). Recognized barriers to KTx in the elderly is early post-transplant mortality and morbidity. To analyze the outcomes of KTx in recipients older than 60 years and, simultaneously, in their younger paired recipients, receiving a graft from the same donor.We included 328 kidney transplant recipients in the study. The elderly kidney transplant recipients (EKT) group included 164 patients aged 65 standard deviation (SD4) years. They were paired with younger kidney transplant recipients (YKT) aged 45 (SD12) years.The studied groups (EKT vs YKT) did not differ from the graft function estimated 1 year after the transplantation (50.7 mL/min vs 54.0 mL/min), while the estimated glomerular filtration rate decline was significantly faster in the YKT group. One-year patient survival (93.9% vs 97.0%), 1-year graft survival (90.4% vs 82.3%), and incidences of delayed graft function and acute rejection did not differ between the EKT and YKT groups. Significantly more cardiovascular complications and post-transplant diabetes mellitus were noticed in the EKT group. The long-term patient and graft survivals were poorer in the EKT group versus the YKT group, but death-censored graft survivals were the same. After having excluded donor-derived graft factors, there were no differences in the first-year outcome of KTx between recipients younger and older than 60 years. As life expectancy is lower in the EKT group, the probability of patient and graft survival was also significantly lower in this group. However, death-censored graft survival was not different in the EKT and YKT groups.
MeSH term(s)	Age Distribution ; Age Factors ; Aged ; Graft Rejection/epidemiology ; Graft Survival ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Postoperative Complications/epidemiology ; Retrospective Studies ; Survival Analysis ; Tissue Donors ; Transplant Recipients ; Treatment Outcome
Language	English
Publishing date	2021-12-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028159
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Article ; Online: Analysis of Factors Affecting Employment Status of Kidney Transplant Recipients in Selected European Union Member States.

Wlodarczyk, Elzbieta / Viklický, Ondřej / Budde, Klemens / Kolářová, Marie / Bergfeld, Leon / Paczek, Leszek / Mucha, Krzysztof / Glyda, Maciej / Wlodarczyk, Zbigniew

International journal of environmental research and public health

2021 Volume 18, Issue 19

Abstract: Despite an increasing quality of life after renal transplantation, the number of recipients undertaking paid professional work remains relatively low. Employment after kidney transplantation became a new important marker of clinically significant health ... ...

Abstract	Despite an increasing quality of life after renal transplantation, the number of recipients undertaking paid professional work remains relatively low. Employment after kidney transplantation became a new important marker of clinically significant health recovery. Furthermore, for social and economic reasons, returning to work and participation in social life may be considered as an objective parameter that demonstrate the effectiveness of transplantation. The objectives of the following study were to evaluate the factors that determine resuming paid work after renal transplantation, to assess a patient's decision about returning to professional activity by comparative analysis of renal transplant recipients from Poland, Czech Republic and Germany, and to identify groups of patients exposed to professional exclusion in those EU countries. Five hundred renal transplant recipients from three EU countries were included into the study. The two main research methods used in the study were the SF-36 questionnaire, constructed and validated to assess the quality of life after kidney transplantation and a questionnaire constructed for the purposes of this study. Multifactorial analysis identified several risk factors associated with professional exclusions after kidney transplantation, namely young or advanced age, female gender, lack of education, place of residence in rural areas, long period of illness, and lack of occupational activity before transplantation. Despite the high standards of social care and rehabilitation support, patients in Germany failed to take up professional activity after kidney transplantation in more cases than those in Poland and Czech Republic. Surprisingly, the objective function of the kidney (creatinine level) and the multidimensional assessment of quality of life (SF-36 survey) did not have a significant association with the employment status after renal transplantation.
MeSH term(s)	Employment ; European Union ; Female ; Humans ; Kidney Transplantation ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph181910284
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