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Article ; Online: Nonadditive functional interactions between ligand-binding sites of the multidrug efflux pump AdeB from

Leus, Inga V / Roberts, Sean R / Trinh, Anhthu / W Yu, Edward / Zgurskaya, Helen I

Journal of bacteriology

2023  Volume 206, Issue 1, Page(s) e0021723

Abstract: Multidrug efflux is one of the major mechanisms of antibiotic resistance identified in clinical isolates of the human ... ...

Abstract Multidrug efflux is one of the major mechanisms of antibiotic resistance identified in clinical isolates of the human pathogen
MeSH term(s) Humans ; Acinetobacter baumannii/genetics ; Acinetobacter baumannii/metabolism ; Bacterial Proteins/metabolism ; Ligands ; Anti-Bacterial Agents/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Binding Sites ; Escherichia coli/metabolism ; Drug Resistance, Multiple, Bacterial/genetics ; Microbial Sensitivity Tests ; Multidrug Resistance-Associated Proteins/metabolism ; Escherichia coli Proteins/metabolism
Chemical Substances Bacterial Proteins ; Ligands ; Anti-Bacterial Agents ; Membrane Transport Proteins ; AcrB protein, E coli ; Multidrug Resistance-Associated Proteins ; Escherichia coli Proteins
Language English
Publishing date 2023-10-18
Publishing country United States
Document type Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID 2968-3
ISSN 1098-5530 ; 0021-9193
ISSN (online) 1098-5530
ISSN 0021-9193
DOI 10.1128/jb.00217-23
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