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  1. Article: [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti–CTLA-4 antibody in a mouse model

    Wada, Teiji

    http://lobid.org/resources/990155701200206441#!, 14(10):e0222280

    2019  

    Abstract: Fam-] trastuzumab deruxtecan (DS-8201a) is a HER2 (ERBB2)-targeting antibody-drug conjugate, composed of a HER2-targeting antibody and a topoisomerase I inhibitor, exatecan derivative, that has antitumor effects in preclinical xenograft models and ... ...

    Abstract [Fam-] trastuzumab deruxtecan (DS-8201a) is a HER2 (ERBB2)-targeting antibody-drug conjugate, composed of a HER2-targeting antibody and a topoisomerase I inhibitor, exatecan derivative, that has antitumor effects in preclinical xenograft models and clinical trials. Recently, [fam-] trastuzumab deruxtecan was reported to enhance antitumor immunity and was beneficial in combination with an anti–PD-1 antibody in a mouse model. In this study, the antitumor effect of [fam-] trastuzumab deruxtecan in combination with an anti–CTLA-4 antibody was evaluated. [Fam-] trastuzumab deruxtecan monotherapy had antitumor activity in an immunocompetent mouse model with EMT6 human HER2-expressing mouse breast cancer cells (EMT6-hHER2). [Fam-] trastuzumab deruxtecan in combination with the anti–CTLA-4 antibody induced more potent antitumor activity than that by monotherapy with either agent. The combination therapy increased tumor-infiltrating CD4+ and CD8+ T cells in vivo. Mechanistically, cured mice with treatment of [fam-] trastuzumab deruxtecan and an anti–CTLA-4 antibody completely rejected EMT6-mock cells similar to EMT6-hHER2 cells, and splenocytes from the cured mice responded to both EMT6-hHER2 and EMT6-mock cells as measured by interferon-gamma release. Taken together, these results indicate that antitumor immunity is induced by [fam-] trastuzumab deruxtecan and is facilitated in combination with anti–CTLA-4 antibody.
    Keywords Cancer treatment ; Antibodies ; Antibody therapy ; Breast cancer ; Enzyme-linked immunoassays ; Flow cytometry ; Mouse models ; T cells
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Book ; Online ; E-Book: Behavior of radionuclides in the environment / III :

    Nanba, Kenji / Konoplev, Alexei / Wada, Toshihiro

    Fukushima

    2022  

    Author's details Kenji Nanba, Alexei Konoplev and Toshihiro Wada, editors
    Keywords Radioisotopes/Environmental aspects ; Radioisotopes ; Nuclear accidents
    Subject code 574.5222
    Language English
    Size 1 online resource (501 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-6798-5 ; 981-16-6799-3 ; 978-981-16-6798-5 ; 978-981-16-6799-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Biomarkers of Hypercoagulability in COVID-19.

    Wada, Hideo

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: This issue focuses on the pathophysiology of coronavirus disease 2019 (COVID-19) [ ... ]. ...

    Abstract This issue focuses on the pathophysiology of coronavirus disease 2019 (COVID-19) [...].
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103525
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  4. Article ; Online: Foreword.

    Wada, Mitsuhiro

    Chemical & pharmaceutical bulletin

    2023  Volume 71, Issue 1, Page(s) 9

    Language English
    Publishing date 2023-01-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c23-ctf7101
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 770: Show issues Location:
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  5. Article ; Online: The 43rd Annual Meeting of the Japanese Society for Apheresis.

    Wada, Takashi

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2023  Volume 27, Issue 6, Page(s) 985–986

    Language English
    Publishing date 2023-08-17
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14055
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    Zs.A 5208: Show issues Location:
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  6. Article ; Online: From Basic Cardiac Electrophysiology to Mechanism-Based Therapy in Ion Channelopathies.

    Wada, Yuko

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 12, Page(s) 2491–2493

    MeSH term(s) Humans ; Channelopathies/therapy ; Electrophysiologic Techniques, Cardiac ; Arrhythmias, Cardiac/therapy ; Cardiac Electrophysiology
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.11.003
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  7. Book ; Online ; E-Book: Diabetic kidney disease

    Wada, Takashi / Furuichi, Kengo / Kashihara, Naoki

    2020  

    Author's details Takashi Wada, Kengo Furuichi, Naoki Kashihara editors
    Keywords Diabetic nephropathies ; Nephrology ; Diabetes ; Electronic books
    Language English
    Size 1 Online-Ressource (viii, 190 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021437504
    ISBN 978-981-15-9301-7 ; 9789811593000 ; 981-15-9301-9 ; 9811593000
    DOI 10.1007/978-981-15-9301-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online ; E-Book: Acute Kidney Injury and Regenerative Medicine

    Terada, Yoshio / Wada, Takashi / Doi, Kent

    2020  

    Abstract: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also ... ...

    Author's details edited by Yoshio Terada, Takashi Wada, Kent Doi
    Abstract This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
    Keywords Nephrology ; Regenerative medicine ; Tissue engineering ; Regenerative Medicine/Tissue Engineering
    Subject code 780
    Language English
    Size 1 online resource (IX, 396 p. 39 illus., 33 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-1108-X ; 981-15-1107-1 ; 978-981-15-1108-0 ; 978-981-15-1107-3
    DOI 10.1007/978-981-15-1108-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: [Role of ABC Transporters in Cancer Development and Malignant Alteration].

    Wada, Morimasa

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2022  Volume 142, Issue 11, Page(s) 1201–1225

    Abstract: ATP-binding cassette (ABC) transporters, which comprise the largest gene-family in humans, are membrane proteins that transport various substrates, depending on ATP hydrolysis. Among these transporters, several include ABCB1 (P-glycoprotein), identified ... ...

    Abstract ATP-binding cassette (ABC) transporters, which comprise the largest gene-family in humans, are membrane proteins that transport various substrates, depending on ATP hydrolysis. Among these transporters, several include ABCB1 (P-glycoprotein), identified here for the first time in humans, which exports anti-cancer drugs from cancer cells, thus participating in multidrug resistance (MDR). ABC transporters also export drugs, in general, from the human body, therefore affecting overall pharmacokinetics. We have contributed, here, to a better understanding of the role of these exporter proteins in two aspects. First, we have cloned the human ABCC2 gene and identified mutations in hereditary hyperbilirubinemia patients, demonstrating the role of ABCC2 as a xenobiotic export pump. Second, we also found an unexpected role of ABCB1 in cancer, in that it promotes tumor initiation independently of the MDR phenomenon, which was further confirmed by a chemoprevention experiment using verapamil, an ABCB1 inhibitor. In this review, I discuss the role of ABC transporters, both in biodefense against xenobiotics and in cancer development and malignant alterations, based on our results as well as the studies of others.
    MeSH term(s) Humans ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Drug Resistance, Multiple/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Xenobiotics ; Adenosine Triphosphate ; Drug Resistance, Neoplasm/genetics
    Chemical Substances ATP-Binding Cassette Transporters ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Xenobiotics ; Adenosine Triphosphate (8L70Q75FXE)
    Language Japanese
    Publishing date 2022-11-03
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.22-00108
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    Zs.A 643: Show issues Location:
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  10. Article: [Overview].

    Wada, Hideho

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2022  Volume 63, Issue 6, Page(s) 589

    Language Japanese
    Publishing date 2022-07-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.63.589
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