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  1. Article: The role of quantitative imaging in chronic obstructive pulmonary disease.

    Wada, Danilo Tadao

    Radiologia brasileira

    2022  Volume 55, Issue 5, Page(s) V–VI

    Language English
    Publishing date 2022-10-18
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2022.55.5e1-en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiac Magnetic Resonance as an Etiological Diagnosis Tool in Recovered Sudden Cardiac Death or Unstable Ventricular Arrhythmia Patients.

    Marçal, Paula C / Braggion-Santos, Maria Fernanda / Wada, Danilo Tadao / Santos, Marcel Koenigkam / Moreira, Henrique Turin / Volpe, Gustavo Jardim / Schmidt, André

    Arquivos brasileiros de cardiologia

    2023  Volume 120, Issue 4, Page(s) e20220411

    Abstract: Background: Cardiac magnetic resonance (CMR) has an increasing diagnostic relevance in survivors of sudden cardiac death (SCD) or unstable ventricular arrhythmia (UVA) in developed countries.: Objective: To evaluate retrospectively the additional ... ...

    Title translation Ressonância Magnética Cardíaca como Ferramenta Diagnóstica Etiológica em Pacientes Recuperados de Morte Súbita Cardíaca ou Arritmias Ventriculares Instáveis.
    Abstract Background: Cardiac magnetic resonance (CMR) has an increasing diagnostic relevance in survivors of sudden cardiac death (SCD) or unstable ventricular arrhythmia (UVA) in developed countries.
    Objective: To evaluate retrospectively the additional role of CMR in a developing country where few resources are available, and should be used more effectively.
    Methods: The study included SCD or UVA survivors admitted between 2009 and 2019 at a tertiary academic institution referred to CMR. Demographic, clinical, and laboratory data were collected from the medical records. CMR images and reports were reviewed and their impact on the final etiological diagnosis was determined. A descriptive analysis was performed and p<0.05 established as significant.
    Results: Sixty-four patients, 54.9±15.4 years old, and 42 (71.9%) males. Most events (81.3%) were out of the hospital and ventricular tachycardia was the most common rhythm. Cardiovascular medications were previously used by 55 patients, and beta-blockers were the most used medications (37.5%). Electrocardiogram had electrical inactive areas in 21.9% and all of them had fibrosis at CMR. Mean left ventricular ejection fraction (LVEF) was 44±14%, with 60.9% ≤50% and only 29.7% ≤35%. Late gadolinium enhancement was identified in 71.9%, with a transmural pattern in 43.8%. Chagas cardiomyopathy was the most common etiology (28.1%), followed by ischemic cardiomyopathy (17.2%). Among 26 without a previously identified etiology, CMR could define it (15 patients - 57%).
    Conclusion: In accordance with previous studies in developed countries, CMR was capable of increasing etiological diagnosis and identifying the arrhythmogenic substrate, allowing better care in half of the underdiagnosed patients.
    MeSH term(s) Male ; Humans ; Adult ; Middle Aged ; Aged ; Female ; Contrast Media ; Stroke Volume ; Retrospective Studies ; Ventricular Function, Left ; Gadolinium ; Arrhythmias, Cardiac/diagnostic imaging ; Arrhythmias, Cardiac/complications ; Death, Sudden, Cardiac/etiology ; Magnetic Resonance Spectroscopy/adverse effects ; Magnetic Resonance Imaging, Cine
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language Portuguese
    Publishing date 2023-04-21
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20220411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Post-Traumatic Giant Left Ventricular Pseudoaneurysm: a Multimedia Presentation.

    Wada, Danilo Tadao / Koenigkam-Santos, Marcel / Schmidt, André / Rodrigues, Alfredo José / Evora, Paulo Roberto B

    Brazilian journal of cardiovascular surgery

    2020  Volume 35, Issue 1, Page(s) 109–112

    Abstract: Traumatic left ventricular pseudoaneurysms are rare and surgical correction is the treatment of choice. In this article, it is reported a case of a myocardial stab injury with primary suture and development of a giant pseudoaneurysm, five years later, ... ...

    Abstract Traumatic left ventricular pseudoaneurysms are rare and surgical correction is the treatment of choice. In this article, it is reported a case of a myocardial stab injury with primary suture and development of a giant pseudoaneurysm, five years later, that underwent surgical repair.
    MeSH term(s) Aneurysm, False ; Heart Aneurysm ; Heart Ventricles ; Humans ; Multimedia ; Wounds, Stab
    Language English
    Publishing date 2020-02-01
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 2183753-3
    ISSN 1678-9741 ; 0102-7638
    ISSN (online) 1678-9741
    ISSN 0102-7638
    DOI 10.21470/1678-9741-2019-0169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SARS-Cov-2 pneumonia phenotyping on imaging exams of patients submitted to minimally invasive autopsy.

    Koenigkam-Santos, Marcel / Wada, Danilo Tadao / Benatti, Maira Nilson / Siyuan, Li / Batah, Sabrina Setembre / Cetlin, Andrea Antunes / de Menezes, Marcelo Bezerra / Fabro, Alexandre Todorovic

    Annals of translational medicine

    2022  Volume 10, Issue 3, Page(s) 140

    Abstract: Background: Correlation between pathology and imaging of the new SARS-Cov-2 disease (COVID-19) is scarce. This study aimed to characterize SARS-Cov-2 pneumonia on imaging of patients submitted to minimally invasive autopsy (MIA).: Methods: This ... ...

    Abstract Background: Correlation between pathology and imaging of the new SARS-Cov-2 disease (COVID-19) is scarce. This study aimed to characterize SARS-Cov-2 pneumonia on imaging of patients submitted to minimally invasive autopsy (MIA).
    Methods: This unicentric retrospective observational study included 46 consecutive patients with confirmed COVID-19 who underwent MIA. All clinical chest images were reviewed and classified for the presence and grade of viral pneumonia, as well as disease evolution. On CT, phenotypes were described as consistent with mild, moderate, or severe viral pneumonia, with or without radiological signs of organizing pneumonia (OP). In severe pneumonia, CT could also be classified as diffuse progressive OP or radiological diffuse alveolar damage (DAD). Specific features on CT were noted, including fibroproliferative signs that could indicate potential or initial fibrosis.
    Results: MIA showed a heterogeneous panel of alterations, with a high prevalence of OP and acute fibrinous and organizing pneumonia (AFOP). Also, signs of interstitial fibrosis corresponded to the most prevalent pathological feature. Initial chest radiography (CXR) findings were mainly consistent with moderate or severe viral pneumonia. Most patients showed stability or improvement (reduction of opacities) on imaging. CTs were performed on 15 patients. Consolidations were found in most patients, frequently showing features consistent with an OP phenotype. Fibroproliferative changes were also prevalent on CT.
    Conclusions: In this study, SARS-Cov-2 pneumonia showed heterogeneous radiological and pathological patterns. Signs of organization and potential or initial fibrosis were prevalent on both imaging and pathology. Imaging phenotyping may help to predict post-infection fibrosing interstitial pneumonitis in COVID-19.
    Language English
    Publishing date 2022-02-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-4354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Artificial intelligence, machine learning, computer-aided diagnosis, and radiomics: advances in imaging towards to precision medicine.

    Santos, Marcel Koenigkam / Ferreira Júnior, José Raniery / Wada, Danilo Tadao / Tenório, Ariane Priscilla Magalhães / Barbosa, Marcello Henrique Nogueira / Marques, Paulo Mazzoncini de Azevedo

    Radiologia brasileira

    2020  Volume 52, Issue 6, Page(s) 387–396

    Abstract: The discipline of radiology and diagnostic imaging has evolved greatly in recent years. We have observed an exponential increase in the number of exams performed, subspecialization of medical fields, and increases in accuracy of the various imaging ... ...

    Abstract The discipline of radiology and diagnostic imaging has evolved greatly in recent years. We have observed an exponential increase in the number of exams performed, subspecialization of medical fields, and increases in accuracy of the various imaging methods, making it a challenge for the radiologist to "know everything about all exams and regions". In addition, imaging exams are no longer only qualitative and diagnostic, providing now quantitative information on disease severity, as well as identifying biomarkers of prognosis and treatment response. In view of this, computer-aided diagnosis systems have been developed with the objective of complementing diagnostic imaging and helping the therapeutic decision-making process. With the advent of artificial intelligence, "big data", and machine learning, we are moving toward the rapid expansion of the use of these tools in daily life of physicians, making each patient unique, as well as leading radiology toward the concept of multidisciplinary approach and precision medicine. In this article, we will present the main aspects of the computational tools currently available for analysis of images and the principles of such analysis, together with the main terms and concepts involved, as well as examining the impact that the development of artificial intelligence has had on radiology and diagnostic imaging.
    Language English
    Publishing date 2020-02-29
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2019.0049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Automatic Quantitative Computed Tomography Evaluation of the Lungs in Patients With Systemic Sclerosis Treated With Autologous Stem Cell Transplantation.

    Wada, Danilo Tadao / de Almeida, Fabrício Arantes / de Moraes, Daniela Aparecida / Dias, Juliana Bernardes Elias / Baddini-Martinez, José / Oliveira, Maria Carolina / Koenigkam-Santos, Marcel

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2019  Volume 26, Issue 7S Suppl 2, Page(s) S158–S164

    Abstract: Background/objective: Interstitial lung disease stands among the leading causes of death in systemic sclerosis (SSc) patients. Autologous hematopoietic stem cell transplantation (AHSCT) has been proven superior to conventional immunosuppressive therapy ... ...

    Abstract Background/objective: Interstitial lung disease stands among the leading causes of death in systemic sclerosis (SSc) patients. Autologous hematopoietic stem cell transplantation (AHSCT) has been proven superior to conventional immunosuppressive therapy in severe and progressive SSc. Here, pulmonary quantitative measurements were obtained in high-resolution computed tomography (HRCT) scans of patients with SSc before and after AHSCT.
    Methods: The medical records of thirthy-three patients who underwent AHSCT between 2011 and 2017 were evaluated for clinical and tomographic features at baseline (pre-AHCST) and 18 months after the procedure. Quantitative analysis of HRCT images by a fully automated program calculated lung volumes, densities, attenuation percentiles, and vascular volume. Patients were divided into 2 groups, according to changes in forced vital capacity (FVC). The "best response" group included patients that had an increased FVC of 10% or greater, and the "stable response" group included those who had a decreased or an increased FVC of less than 10%.
    Results: In the best response group (15 patients), there was reduction (p < 0.05) of mean lung density and density percentile values after AHSCT. In the stable response group (18 patients), there were no significant changes in lung volumes and pulmonary densities after AHSCT. Pulmonary HRCT densities showed moderate/strong correlation with function.
    Conclusions: Quantitative HRCT analysis identified significant reduction in pulmonary densities in patients with improved pulmonary function after AHSCT. Lung density, as evaluated by the quantitative HRCT analysis tool, has potential to become a biomarker in the evaluation of interstitial lung disease treatment in patients with SSc.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Lung/diagnostic imaging ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy ; Tomography, X-Ray Computed ; Transplantation, Autologous
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Use of computed tomography and automated software for quantitative analysis of the vasculature of patients with pulmonary hypertension.

    Wada, Danilo Tadao / de Pádua, Adriana Ignácio / Lima Filho, Moyses Oliveira / Marin Neto, José Antonio / Elias Júnior, Jorge / Baddini-Martinez, José / Santos, Marcel Koenigkam

    Radiologia brasileira

    2017  Volume 50, Issue 6, Page(s) 351–358

    Abstract: Objective: To perform a quantitative analysis of the lung parenchyma and pulmonary vasculature of patients with pulmonary hypertension (PH) on computed tomography angiography (CTA) images, using automated software.: Materials and methods: We ... ...

    Abstract Objective: To perform a quantitative analysis of the lung parenchyma and pulmonary vasculature of patients with pulmonary hypertension (PH) on computed tomography angiography (CTA) images, using automated software.
    Materials and methods: We retrospectively analyzed the CTA findings and clinical records of 45 patients with PH (17 males and 28 females), in comparison with a control group of 20 healthy individuals (7 males and 13 females); the mean age differed significantly between the two groups (53 ± 14.7 vs. 35 ± 9.6 years;
    Results: The automated analysis showed that, in comparison with the controls, the patients with PH showed lower 10th percentile values for lung density, higher vascular volumes in the right upper lung lobe, and higher vascular volume ratios between the upper and lower lobes. In our quantitative analysis, we found no differences among the various PH subgroups. We inferred that a difference in the 10th percentile values indicates areas of hypovolemia in patients with PH and that a difference in pulmonary vascular volumes indicates redistribution of the pulmonary vasculature and an increase in pulmonary vasculature resistance.
    Conclusion: Automated analysis of pulmonary vessels on CTA images revealed alterations and could represent an objective diagnostic tool for the evaluation of patients with PH.
    Language English
    Publishing date 2017-12-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2016.0163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    Crippa, José Alexandre S / Pacheco, Julia Cozar / Zuardi, Antonio W / Guimarães, Francisco S / Campos, Alline Cristina / Osório, Flávia de Lima / Loureiro, Sonia Regina / Dos Santos, Rafael G / Souza, José Diogo S / Ushirohira, Juliana Mayumi / Ferreira, Rafael Rinaldi / Mancini Costa, Karla Cristinne / Scomparin, Davi Silveira / Scarante, Franciele Franco / Pires-Dos-Santos, Isabela / Mechoulam, Raphael / Kapczinski, Flávio / Fonseca, Benedito A L / Esposito, Danillo L A /
    Passos, Afonso Dinis Costa / Dal Fabbro, Amaury Lelis / Bellissimo-Rodrigues, Fernando / Arruda, Eurico / Scarpelini, Sandro / Andraus, Maristela Haddad / Nather Junior, Julio Cesar / Wada, Danilo Tadao / Koenigkam-Santos, Marcel / Santos, Antonio Carlos / Busatto Filho, Geraldo / Hallak, Jaime E C

    Cannabis and cannabinoid research

    2021  Volume 7, Issue 5, Page(s) 658–669

    Abstract: Importance: ...

    Abstract Importance:
    MeSH term(s) Humans ; SARS-CoV-2 ; Cannabidiol/therapeutic use ; Antiviral Agents/adverse effects ; Double-Blind Method ; COVID-19 Drug Treatment
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Antiviral Agents
    Language English
    Publishing date 2021-10-07
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2021.0093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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