LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 90

Search options

  1. Article ; Online: Editorial comment to activity of axitinib in patients with metastatic renal cell carcinoma previously treated with both vascular endothelial growth factor receptor tyrosine-kinase inhibitor and mammalian target of rapamycin inhibitor.

    Wada, Yoshihiro

    International journal of urology : official journal of the Japanese Urological Association

    2014  Volume 21, Issue 7, Page(s) 741

    MeSH term(s) Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Imidazoles/therapeutic use ; Indazoles/therapeutic use ; Kidney Neoplasms/drug therapy ; Male ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-1/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
    Chemical Substances Imidazoles ; Indazoles ; axitinib (C9LVQ0YUXG) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; KDR protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2014-07
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.12423
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: [Comparison of the Accuracy of Measuring the Amount of Urine in the Bladder by Ultrasound Devices and Their Operability for the Bladder].

    Yamanaka, Tatsuro / Tajiri, Ryo / Kasejima, Yutaka / Wada, Yoshihiro

    Hinyokika kiyo. Acta urologica Japonica

    2021  Volume 67, Issue 6, Page(s) 215–219

    Abstract: We investigated the accuracy and operability of two ultrasound devices for the bladder. The study included 232 adult patients who underwent surgery at our hospital. Before surgery, a nurse measured the amount of urine in the bladder using Lilium α-200® ... ...

    Abstract We investigated the accuracy and operability of two ultrasound devices for the bladder. The study included 232 adult patients who underwent surgery at our hospital. Before surgery, a nurse measured the amount of urine in the bladder using Lilium α-200® and Bladder Scan BVI 6100®. The amount was measured accurately later using a catheter. The measurements by the devices were compared with the amount measured by the catheter. Both Lilium and Bladder Scan had high accuracy (correlation coefficient for Lilium is 0.56 [95% CI : 0.46-0.64], and the correlation coefficient for Bladder Scan was 0.70 [95% CI : 0.63-0.76]). However, values obtained by the two devices significantly differed from the catheter measurement. The accuracy was improved by excluding patients with 0- ml readings by the two devices (the correlation coefficient for Lilium was 0.69 (95% CI : 0.61-0.76), and the correlation coefficient for Bladder Scan was 0.81 (95% CI : 0.76-0.86). Next, the operability was evaluated using a questionnaire. Both devices had high operability, but Bladder Scan was easier to operate. Based on the above, Bladder Scan had significantly higher accuracy and operability, but both devices had a sufficiently high accuracy and operability for clinical practice.
    MeSH term(s) Adult ; Hospitals ; Humans ; Surveys and Questionnaires ; Ultrasonography ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/surgery
    Language Japanese
    Publishing date 2021-07-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    DOI 10.14989/ActaUrolJap_67_6_215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Clinical features of pasteurellosis without an animal bite or scratch in comparison with bite/scratch pasteurellosis.

    Asaeda, Tsubasa / Ueda, Takashi / Nozaki, Yasuhiro / Murakami, Yasushi / Morosawa, Mika / Inaba, Hiroko / Ogashiwa, Hitoshi / Doi, Miki / Nakajima, Kazuhiko / Shirakawa, Manabu / Nakamura, Akifumi / Ikeda, Naoto / Sugiyama, Yuya / Wada, Yoshihiro / Ito, Takahiro / Takesue, Yoshio

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2024  

    Abstract: Pasteurellosis is a common zoonotic infection that occurs after an animal bite or scratch (B/S). We compared the clinical features of six patients with non-B/S pasteurellosis with those of 14 patients with B/S infections. Pasteurella multocida was ... ...

    Abstract Pasteurellosis is a common zoonotic infection that occurs after an animal bite or scratch (B/S). We compared the clinical features of six patients with non-B/S pasteurellosis with those of 14 patients with B/S infections. Pasteurella multocida was identified with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all six non-B/S infections, whereas 13 of the 14 B/S infections were identified with diagnostic kits. The non-B/S infections were pneumonia (n = 3), skin and soft tissue infections (n = 2), and bacteremia (n = 1). Pneumonia occurred in two patients with underlying pulmonary disease, whereas ventilator-associated pneumonia developed in one patient with cerebral infarction. Pasteurella multocida was isolated from a blood specimen and nasal swab from a patient with liver cirrhosis (Child-Pugh class C) and diabetes. Cellulitis developed in one patient with diabetes and normal-pressure hydrocephalus, who had an open wound following a fall, and in one patient with diabetes and a foot ulcer. Three patients with non-B/S infections had no pet and no episode of recent animal contact. The rate of moderate-to-severe comorbidities was significantly higher in patients with non-B/S infections than in those with B/S infections (100% and 14.3%, respectively, p < 0.001). In conclusion, non-B/S infections can develop in patients with chronic pulmonary disease, invasive mechanical ventilation, or open wounds, or who are immunocompromised, irrespective of obvious animal exposure. In contrast to B/S infections, non-B/S pasteurellosis should be considered opportunistic.
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2024.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Comparison of the 24-h efficacy and safety of fixed combination carteolol/latanoprost and timolol/latanoprost in patients with primary open-angle glaucoma and ocular hypertension: a prospective crossover study.

    Saito, Yuta / Kizaki, Junichiro / Wada, Yoshihiro / Shibasaki, Yoshiyuki / Kishimoto, Nobuharu / Aihara, Makoto

    Japanese journal of ophthalmology

    2021  Volume 65, Issue 5, Page(s) 598–607

    Abstract: Purpose: To evaluate the 24-h efficacy and safety of fixed combination carteolol/latanoprost (LCFC) and timolol/latanoprost (LTFC) in patients with primary open-angle glaucoma and ocular hypertension.: Study design: Prospective, randomized, crossover ...

    Abstract Purpose: To evaluate the 24-h efficacy and safety of fixed combination carteolol/latanoprost (LCFC) and timolol/latanoprost (LTFC) in patients with primary open-angle glaucoma and ocular hypertension.
    Study design: Prospective, randomized, crossover study METHODS: Twenty-two patients pretreated with a prostaglandin analog at baseline were randomly assigned at a 1:1 ratio to either LCFC or LTFC treatment. The patients received the assigned study drug in both eyes daily in the evening (20:00). Each treatment group crossed over after a 2-month treatment period. The 24-h curves of intraocular pressure (IOP), pulse rate, and blood pressure were evaluated. Safety was also assessed.
    Results: The changes in mean daytime IOP from baseline at the end of the 2-month treatment period in the LCFC and LTFC groups were  - 0.93 and  - 1.15 mmHg, respectively. The changes in peak IOP in the 2 groups were  - 0.91 and  - 0.68 mmHg, respectively. The nighttime pulse rate in the LCFC group increased; that in the LTFC group was lower at all time points. The changes in pulse rate from baseline at 22:00, 2:00, 4:00, and 6:00 differed statistically between the 2 groups. No differences in changes from baseline in systolic and diastolic blood pressures were found between the groups.
    Conclusion: The 24-h IOP curve of patients in the LCFC group was similar to that of the LTFC group, but on the basis of the pulse rate findings, the effect of LCFC on the cardiovascular system over 24 h was less than that of LTFC.
    MeSH term(s) Antihypertensive Agents/adverse effects ; Carteolol ; Cross-Over Studies ; Drug Combinations ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/drug therapy ; Humans ; Intraocular Pressure ; Latanoprost ; Ocular Hypertension/diagnosis ; Ocular Hypertension/drug therapy ; Prospective Studies ; Prostaglandins F, Synthetic ; Timolol ; Treatment Outcome
    Chemical Substances Antihypertensive Agents ; Drug Combinations ; Prostaglandins F, Synthetic ; Latanoprost (6Z5B6HVF6O) ; Timolol (817W3C6175) ; Carteolol (8NF31401XG)
    Language English
    Publishing date 2021-07-19
    Publishing country Japan
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 82032-5
    ISSN 1613-2246 ; 0021-5155
    ISSN (online) 1613-2246
    ISSN 0021-5155
    DOI 10.1007/s10384-021-00856-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Japanese case of Bothnian-type palmoplantar keratoderma with a novel missense mutation of p.Trp35Ser in extracellular loop A of aquaporin-5.

    Wada, Yoshihiro / Kusakabe, Minori / Nagai, Makoto / Imai, Yasutomo / Yamanishi, Kiyofumi

    The Journal of dermatology

    2018  Volume 46, Issue 3, Page(s) e104–e106

    MeSH term(s) Adult ; Aquaporin 5/genetics ; DNA Mutational Analysis ; Humans ; Japan ; Keratoderma, Palmoplantar, Diffuse/diagnosis ; Keratoderma, Palmoplantar, Diffuse/genetics ; Keratoderma, Palmoplantar, Diffuse/pathology ; Male ; Mutation, Missense ; Skin/pathology
    Chemical Substances AQP5 protein, human ; Aquaporin 5
    Language English
    Publishing date 2018-08-25
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.14621
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis.

    Nagai, Makoto / Imai, Yasutomo / Wada, Yoshihiro / Kusakabe, Minori / Yamanishi, Kiyofumi

    Disease markers

    2018  Volume 2018, Page(s) 9758473

    Abstract: Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP ... ...

    Abstract Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP levels in patients with psoriatic diseases. The enrolled patients included 27 with psoriasis vulgaris (PV) (22 males, 5 females; mean age 47.7 years), 12 with psoriatic arthritis (PsA) (8 males, 4 females; mean age 51.3 years), and 15 with GPP (10 males, 5 females; mean age 63.7 years). The mean serum PCT levels in patients with PV, PsA, and GPP were 0.01 ng/mL (25th-75th percentile; 0.00-0.03), 0.013 ng/mL (0.00-0.03), and 0.12 ng/mL (0.05-0.18), respectively; the levels of PCT were higher for patients with GPP than with PV or PsA but were lower than the PCT cutoff value (0.5 ng/mL) for the diagnosis of infection. The mean serum P-SEP levels in patients with PV, PsA, and GPP were 144.9 pg/mL (25th-75th percentile; 78-181), 168.1 pg/mL (124-203), and 479.9 pg/mL (216-581), respectively. Unexpectedly, the levels of P-SEP in the patients with GPP were as high as the P-SEP cutoff value (317 to 647 pg/mL) used for the diagnosis of infection. We also found that neutrophils produced P-SEP, suggesting that the high serum P-SEP levels in patients with GPP might arise at least in part due to the P-SEP derived from neutrophils activated in GPP. Both serum PCT and P-SEP might therefore be useful as novel serum biomarkers for GPP because their levels were decreased by GPP treatments. However, the measurement of PCT might be more useful than the measurement of P-SEP for discriminating between GPP and sepsis.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lipopolysaccharide Receptors/blood ; Male ; Middle Aged ; Neutrophils/cytology ; Peptide Fragments/blood ; Procalcitonin/blood ; Psoriasis/blood ; Psoriasis/diagnosis ; Psoriasis/metabolism ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/metabolism ; Young Adult
    Chemical Substances Lipopolysaccharide Receptors ; Peptide Fragments ; Procalcitonin ; presepsin protein, human
    Language English
    Publishing date 2018-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2018/9758473
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Complete remission with tyrosine kinase inhibitors in renal cell carcinoma.

    Wada, Yoshihiro / Tanoue, Kenichiro / Takahashi, Wataru / Eto, Masatoshi

    Translational andrology and urology

    2016  Volume 1, Issue 4, Page(s) 204–206

    Language English
    Publishing date 2016-01-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.3978/j.issn.2223-4683.2012.05.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Effect of the long-term care prevention project on the motor functions and daily life activities of the elderly.

    Wada, Yoshihiro / Sakuraba, Keisyoku / Kubota, Atsushi

    Journal of physical therapy science

    2015  Volume 27, Issue 1, Page(s) 199–203

    Abstract: Purpose] The purpose of this study was to verify the effects of the long-term care prevention project and develop an effective program. [Subjects] A total of 81 elderly people (age, 79 ± 5.1 years; height, 149.2 ± 9.2 cm; weight, 54.2 ± 11.4 kg). [ ... ...

    Abstract [Purpose] The purpose of this study was to verify the effects of the long-term care prevention project and develop an effective program. [Subjects] A total of 81 elderly people (age, 79 ± 5.1 years; height, 149.2 ± 9.2 cm; weight, 54.2 ± 11.4 kg). [Methods] Grip, knee extension muscular strength, 10 m walking speed, and Timed Up and Go time were measured for evaluation of motor functions, and the "Locomo 25", a 25-question risk assessment questionnaire, was used as the judgment criterion for evaluation of daily life activities, with measurements being taken at the beginning of the project and after three months. [Results] In the motor functions evaluation, significant differences were observed in 10 m walking speed, Timed Up and Go time, and knee extension strength. In the daily life activities evaluation, scores for pain, rising movement, standing movement, indoor walking, outdoor walking, and fear of falling were significantly reduced. In addition, a significant correlation was also observed between motor functions and daily life activities. [Conclusion] The result of this study indicated that the long-term care prevention project is effective in maintaining or improving muscular strength and mitigating pain in the elderly and that it is an effective program for maintaining daily life activities. We were also able to show that it would be effective to develop programs with a low exercise intensity that can be performed on a continuing by the elderly.
    Language English
    Publishing date 2015-01-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.27.199
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Immature T cell neoplasms in three young cattle.

    Yokota, Rie / Sato, Kenshi / Wada, Yoshihiro / Ishikawa, Yoshiharu / Kadota, Koichi

    The Journal of veterinary medical science

    2016  Volume 77, Issue 12, Page(s) 1697–1700

    Abstract: Immature T cell neoplasms in three young Holstein cattle with neoplastic involvement of the thymus are described. Case 1, with a precursor T lymphoblastic leukemia (calf form of leukosis), was an 86-day-old female calf. The leukemia was characterized by ... ...

    Abstract Immature T cell neoplasms in three young Holstein cattle with neoplastic involvement of the thymus are described. Case 1, with a precursor T lymphoblastic leukemia (calf form of leukosis), was an 86-day-old female calf. The leukemia was characterized by replacement of the bone marrow and spleen by leukemia cells, but preservation of epithelial frameworks throughout the thymus. The other two neoplasms were thymic γδ T cell lymphomas, which were observed in a 246-day-old steer (case 2) and a 16-month-old heifer (case 3). Histological examination revealed obliteration of the normal thymic architecture and stromal fibrosis, with the spleen and liver far less severely affected than in case 1. There were cytological differences bewteen the tumors in case 1 and cases 2 and 3. Additionally, WC1 and CD8 were expressed only in the latter. Thus, the leukemia and these lymphomas should be regarded as independent disease entities on the basis of histological and immunohistochemical characteristics.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases/pathology ; Female ; Lymphoma/metabolism ; Lymphoma/pathology ; Lymphoma/veterinary ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/veterinary ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Thymus Neoplasms/pathology ; Thymus Neoplasms/veterinary
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2016-01
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.15-0218
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Current status of pharmacotherapy against metastatic renal cell carcinoma in Japan.

    Wada, Yoshihiro / Takahashi, Wataru / Kawano, Yoshiaki / Eto, Masatoshi

    International journal of urology : official journal of the Japanese Urological Association

    2012  Volume 19, Issue 4, Page(s) 284–295

    Abstract: So far, metastatic renal cell carcinoma has been one of the most treatment-resistant cancers. The extensive use of cytokines, such as interferon-α and interleukin-2, were carried out for metastatic renal cell carcinoma. However, significant advances in ... ...

    Abstract So far, metastatic renal cell carcinoma has been one of the most treatment-resistant cancers. The extensive use of cytokines, such as interferon-α and interleukin-2, were carried out for metastatic renal cell carcinoma. However, significant advances in understanding the molecular mechanisms underlying renal cell carcinoma have led to the development of molecular target-based drugs, which were desperately awaited for a long time, and now two types of molecular target-based drugs are available. Two vascular endothelial growth factor receptor tyrosine kinase inhibitors and two mammalian target of rapamycin inhibitors have been approved and available in Japan. The molecular target-based drugs have unique and characteristic adverse events, whose profile are not well understood in Japanese patients, because most of the clinical trials were carried out in Europe and America. In contrast, immunotherapy is being reconsidered in the selection of more appropriate patients or as a combined treatment form with other drugs, because of few complete responses obtained and unexpected adverse events by molecular targeted treatments. We have several molecular targeted-drugs available at present and will have more, and we will actually use these drugs in various clinical settings, such as the presurgical setting, the adjuvant setting, sequential administration and combined administration, in addition to cytokines. Therefore, we need more elaborate studies to obtain the optimal treatment methods to maximize the effect of such agents to extend overall survival while maintaining quality of life of metastatic renal cell carcinoma patients. In this article, we reviewed the issues related to the current status of pharmacotherapy available for metastatic renal cell carcinoma.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/secondary ; Humans ; Japan/epidemiology ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2012-04
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/j.1442-2042.2012.02962.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top