Article ; Online: A Comprehensive Profile of Chemokine Gene Expression in the Tissues of the Female Reproductive Tract in Mice.
2019 Volume 49, Issue 3, Page(s) 264–286
Abstract: Homeostatic leukocyte trafficking into and within the female reproductive tract (FRT) contributes to fertility and reproductive health. It is unclear how this process is regulated in the anatomically distinct reproductive tissues, or whether the genes ... ...
Abstract | Homeostatic leukocyte trafficking into and within the female reproductive tract (FRT) contributes to fertility and reproductive health. It is unclear how this process is regulated in the anatomically distinct reproductive tissues, or whether the genes involved are affected by cyclical changes in reproductive hormones. In tissues such as skin and intestine, mouse studies have defined evolutionarily conserved molecular mechanisms for tissue-specific homing, interstitial positioning, and leukocyte egress. Chemokine family members are invariably involved, with the chemokine expression profile of a tissue regulating leukocyte content. Reproductive tissues (ovary, vagina, cervix, uterine horn) of 8 week old virgin female C57BL/6 mice ( |
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MeSH term(s) | Animals ; Chemokines/genetics ; Estrous Cycle/immunology ; Female ; Gene Expression Profiling ; Genitalia, Female/cytology ; Genitalia, Female/metabolism ; Leukocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Myeloid Cells/metabolism ; Organ Specificity/immunology |
Chemical Substances | Chemokines |
Language | English |
Publishing date | 2019-08-20 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 632565-8 |
ISSN | 1532-4311 ; 0882-0139 |
ISSN (online) | 1532-4311 |
ISSN | 0882-0139 |
DOI | 10.1080/08820139.2019.1655573 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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