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  1. Article: Active herpes zoster infection with cutaneous manifestation and adenopathy on FDG PET/CT.

    Wadih, Antoine / Rehm, Patrice K / Deng, Chunli / Douvas, Michael

    Radiology case reports

    2015  Volume 10, Issue 3, Page(s) 27–29

    Abstract: We report a patient with history of Hodgkin lymphoma. Six months after treatment, 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography and/or computed tomography ([18F] FDG PET/CT) scan showed abnormal uptake in right axillary lymph nodes ... ...

    Abstract We report a patient with history of Hodgkin lymphoma. Six months after treatment, 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography and/or computed tomography ([18F] FDG PET/CT) scan showed abnormal uptake in right axillary lymph nodes concerning for recurrence. In addition, PET/CT showed a new hypermetabolic skin lesion overlying the right scapula. Clinical evaluation was consistent with shingles, and the patient was treated with valacyclovir. Subsequent PET/CT scan was normal with no evidence of lymphoma. Although there have been reported cases of abnormal FDG in nodes or in skin due to herpes zoster, our case is unique in the literature in that the PET/CT demonstrates abnormalities involving both the skin and associated lymph nodes. The possibility of false positive uptake, not because of recurrent malignancy, must always be considered when abnormal FDG uptake is noted in the follow-up of oncology patients. Careful review of the scan and correlation with clinical findings can avoid false positive interpretation and facilitate patient management.
    Language English
    Publishing date 2015-08-05
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2015.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison Between Digital and Synthetic 2D Mammograms in Breast Density Interpretation.

    Alshafeiy, Taghreed I / Wadih, Antoine / Nicholson, Brandi T / Rochman, Carrie M / Peppard, Heather R / Patrie, James T / Harvey, Jennifer A

    AJR. American journal of roentgenology

    2017  Volume 209, Issue 1, Page(s) W36–W41

    Abstract: Objective: The purpose of this study was to compare assessments of breast density on synthetic 2D images as compared with digital 2D mammograms.: Materials and methods: This retrospective study included consecutive women undergoing screening with ... ...

    Abstract Objective: The purpose of this study was to compare assessments of breast density on synthetic 2D images as compared with digital 2D mammograms.
    Materials and methods: This retrospective study included consecutive women undergoing screening with digital 2D mammography and tomosynthesis during May 2015 with a negative or benign outcome. In separate reading sessions, three radiologists with 5-25 years of clinical experience and 1 year of experience with synthetic 2D mammography read digital 2D and synthetic 2D images and assigned breast density categories according to the 5th edition of BI-RADS. Inter- and intrareader agreement was assessed for each BI-RADS density assessment and combined dense and nondense categories using percent agreement and Cohen kappa coefficient for consensus and all reads.
    Results: A total of 309 patients met study inclusion criteria. Agreement between consensus BI-RADS density categories assigned for digital and synthetic 2D mammography was 80.3% (95% CI, 75.4-84.5%) with κ = 0.73 (95% CI, 0.66-0.79). For combined dense and nondense categories, agreement reached 91.9% (95% CI, 88.2-94.7%). For consensus readings, similar numbers of patients were shifted between nondense and dense categories (11 and 14, respectively) with the synthetic 2D compared with digital 2D mammography. Interreader differences were apparent; assignment to dense categories was greater with digital 2D mammography for reader 1 (odds ratio [OR], 1.26; p = 0.002), the same for reader 2 (OR, 0.91; p = 0.262), and greater with synthetic 2D mammography for reader 3 (OR, 0.86; p = 0.033).
    Conclusion: Overall, synthetic 2D mammography is comparable with digital 2D mammography in assessment of breast density, though there is some variability by reader. Practices can readily adopt synthetic 2D mammography without concern that it will affect density assessment and subsequent recommendations for supplemental screening.
    MeSH term(s) Adult ; Aged ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Mammography/methods ; Middle Aged ; Radiographic Image Enhancement/methods ; Retrospective Studies
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.16.16966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extracranial venous stenosis is an unlikely cause of multiple sclerosis.

    Yamout, Bassem / Herlopian, Aline / Issa, Zeinab / Habib, Robert H / Fawaz, Ahmad / Salame, Joseph / Wadih, Antoine / Awdeh, Haytham / Muallem, Nadime / Raad, Roy / Al-Kutoubi, Aghiab

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2010  Volume 16, Issue 11, Page(s) 1341–1348

    Abstract: Background: Extracranial venous stenosis (EVS) has recently been implicated as the primary cause of multiple sclerosis (MS).: Objective: The aim of this study was to determine the presence of EVS in MS patients.: Methods: We performed selective ... ...

    Abstract Background: Extracranial venous stenosis (EVS) has recently been implicated as the primary cause of multiple sclerosis (MS).
    Objective: The aim of this study was to determine the presence of EVS in MS patients.
    Methods: We performed selective extracranial venography on 42 patients with early MS (EMS): clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS) of less than 5 years duration, and late MS (LMS): RRMS of more than 10 years duration. Magnetic resonance imaging (MRI) and clinical relapse data were reviewed for all patients with EVS.
    Results: EVS was present in 7/29 patients with EMS and 12/13 patients with LMS, a highly significant statistical difference (p< 0.001). Only 3/42 patients (all in the LMS group) had two vessel stenoses, while the rest had only one vessel involved. EVS was seen in 1/11 patients with CIS compared with 6/18 RRMS patients of less than 5 years duration. Disease duration was greater in patients with EVS overall (p < 0.005). LMS remained an independent predictor of EVS following multivariate adjustment for gender, age at disease onset and Expanded Disability Status Scale (EDSS) (Adjusted Odds Ratio = 29 (3-298); p = 0.005]. Within the EMS group, patients with (n = 7) and without (n = 22) EVS had similar EDSS and disease duration, suggesting similar disease severity. No clear correlation could be found between site of EVS and anatomic localization of either clinical relapses or MRI gadolinium-enhancing lesions.
    Conclusions: We conclude that EVS is an unlikely cause of MS since it is not present in most patients early in the disease and rarely involves more than one extracranial vein. It is likely to be a late secondary phenomenon.
    MeSH term(s) Adult ; Angiography ; Azygos Vein/pathology ; Constriction, Pathologic ; Female ; Humans ; Jugular Veins/pathology ; Male ; Middle Aged ; Multiple Sclerosis/etiology ; Multiple Sclerosis/pathology ; Vascular Diseases/complications
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458510385268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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