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Article ; Online: Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague.

Wagner, Danielle A / Kelly, Sean M / Petersen, Andrew C / Peroutka-Bigus, Nathan / Darling, Ross J / Bellaire, Bryan H / Wannemuehler, Michael J / Narasimhan, Balaji

Acta biomaterialia

2019 Volume 100, Page(s) 326–337

Abstract: Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however, USAMRIID has developed a recombinant fusion protein, F1-V, that has ...

Abstract	Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however, USAMRIID has developed a recombinant fusion protein, F1-V, that has been shown to induce protection against pneumonic plague. Many F1-V-based vaccine formulations require prime-boost immunization to achieve protective immunity, and there are limited reports of rapid induction of protective immunity (≤ 14 days post-immunization (DPI)). The STimulator of INterferon Genes agonists cyclic dinucleotides (CDNs) have been shown to be promising vaccine adjuvants. Polyanhydride nanoparticle-based vaccines (i.e., nanovaccines) have also shown to enhance immune responses due to their dual functionality as adjuvants and delivery vehicles. In this work, a combination nanovaccine was designed that comprised F1-V-loaded nanoparticles combined with the CDN, dithio-R
MeSH term(s)	Animals ; Antibody Formation/immunology ; Dose-Response Relationship, Immunologic ; Epitopes/immunology ; Female ; Immunoglobulin G/immunology ; Mice, Inbred C57BL ; Nanoparticles/therapeutic use ; Nanoparticles/ultrastructure ; Plague/complications ; Plague/immunology ; Plague/prevention & control ; Plasma Cells/metabolism ; Pneumonia/complications ; Pneumonia/immunology ; Pneumonia/prevention & control ; Vaccines/immunology ; Yersinia pestis/immunology
Chemical Substances	Epitopes ; Immunoglobulin G ; Vaccines
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2019.10.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.

Sankhala, Rajeshwer S / Lal, Kerri G / Jensen, Jaime L / Dussupt, Vincent / Mendez-Rivera, Letzibeth / Bai, Hongjun / Wieczorek, Lindsay / Mayer, Sandra V / Zemil, Michelle / Wagner, Danielle A / Townsley, Samantha M / Hajduczki, Agnes / Chang, William C / Chen, Wei-Hung / Donofrio, Gina C / Jian, Ningbo / King, Hannah A D / Lorang, Cynthia G / Martinez, Elizabeth J /

Rees, Phyllis A / Peterson, Caroline E / Schmidt, Fabian / Hart, Tricia J / Duso, Debra K / Kummer, Lawrence W / Casey, Sean P / Williams, Jazmean K / Kannan, Shruthi / Slike, Bonnie M / Smith, Lauren / Swafford, Isabella / Thomas, Paul V / Tran, Ursula / Currier, Jeffrey R / Bolton, Diane L / Davidson, Edgar / Doranz, Benjamin J / Hatziioannou, Theodora / Bieniasz, Paul D / Paquin-Proulx, Dominic / Reiley, William W / Rolland, Morgane / Sullivan, Nancy J / Vasan, Sandhya / Collins, Natalie D / Modjarrad, Kayvon / Gromowski, Gregory D / Polonis, Victoria R / Michael, Nelson L / Krebs, Shelly J / Joyce, M Gordon

Nature communications

2024 Volume 15, Issue 1, Page(s) 200

Abstract: The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the antibody ... ...

Abstract	The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the antibody response induced by the SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine candidate adjuvanted with the Army Liposomal Formulation including QS21 (ALFQ) in non-human primates. By isolating and characterizing several monoclonal antibodies directed against the Spike Receptor Binding Domain (RBD), N-Terminal Domain (NTD), or the S2 Domain, we define the molecular recognition of vaccine-elicited cross-reactive monoclonal antibodies (mAbs) elicited by SpFN. We identify six neutralizing antibodies with broad sarbecovirus cross-reactivity that recapitulate serum polyclonal antibody responses. In particular, RBD mAb WRAIR-5001 binds to the conserved cryptic region with high affinity to sarbecovirus clades 1 and 2, including Omicron variants, while mAb WRAIR-5021 offers complete protection from B.1.617.2 (Delta) in a murine challenge study. Our data further highlight the ability of SpFN vaccination to stimulate cross-reactive B cells targeting conserved regions of the Spike with activity against SARS CoV-1 and SARS-CoV-2 variants.
MeSH term(s)	Animals ; Mice ; Antibodies, Neutralizing ; Macaca mulatta ; Vaccination ; Antibodies, Viral ; Antibodies, Monoclonal ; COVID-19 Vaccines ; Ferritins ; Nanoparticles ; Severe acute respiratory syndrome-related coronavirus ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Antibodies, Monoclonal ; COVID-19 Vaccines ; Ferritins (9007-73-2) ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44265-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates.

Moliva, Juan I / Andrew, Shayne F / Flynn, Barbara J / Wagner, Danielle A / Foulds, Kathryn E / Gagne, Matthew / Flebbe, Dillon R / Lamb, Evan / Provost, Samantha / Marquez, Josue / Mychalowych, Anna / Lorag, Cynthia G / Honeycutt, Christopher Cole / Burnett, Matthew R / McCormick, Lauren / Henry, Amy R / Godbole, Sucheta / Davis-Gardner, Meredith E / Minai, Mahnaz /

Bock, Kevin W / Nagata, Bianca M / Todd, John-Paul M / McCarthy, Elizabeth / Dodson, Alan / Kouneski, Katelyn / Cook, Anthony / Pessaint, Laurent / Ry, Alex Van / Valentin, Daniel / Young, Steve / Littman, Yoav / Boon, Adrianus C M / Suthar, Mehul S / Lewis, Mark G / Andersen, Hanne / Alves, Derron A / Woodward, Ruth / Leuzzi, Adriano / Vitelli, Alessandra / Colloca, Stefano / Folgori, Antonella / Raggiolli, Angelo / Capone, Stefania / Nason, Martha C / Douek, Daniel C / Roederer, Mario / Seder, Robert A / Sullivan, Nancy J

bioRxiv : the preprint server for biology

2023

Abstract: SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there's a need for vaccines that induce mucosal immunity and can rapidly control ...

Abstract	SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there's a need for vaccines that induce mucosal immunity and can rapidly control the virus. In this study, we demonstrate that a single immunization with a novel gorilla adenovirus-based vaccine (GRAd) carrying the pre-fusion stabilized Spike protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P) accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P) modestly improved protection compared to its matched intramuscular regimen, but showed dramatically superior boosting by mRNA and, importantly, total virus clearance in the upper airway by day 4 post infection. GrAd vaccination regimens elicited robust and durable systemic and mucosal antibody responses to multiple SARS-CoV-2 variants, but only GRAd(AE)+S-2P generated long-lasting T cell responses in the lung. This research underscores the flexibility of the GRAd vaccine platform to provide durable immunity against SARS-CoV-2 in both the lower and upper airways.
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.22.567930
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Article: Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

Lima, Noemia S / Musayev, Maryam / Johnston, Timothy S / Wagner, Danielle A / Henry, Amy R / Wang, Lingshu / Yang, Eun Sung / Zhang, Yi / Birungi, Kevina / Black, Walker P / O'Dell, Sijy / Schmidt, Stephen D / Moon, Damee / Lorang, Cynthia G / Zhao, Bingchun / Chen, Man / Boswell, Kristin L / Roberts-Torres, Jesmine / Davis, Rachel L /

Peyton, Lowrey / Narpala, Sandeep R / O'Connell, Sarah / Wang, Jennifer / Schrager, Alexander / Talana, Chloe Adrienna / Leung, Kwanyee / Shi, Wei / Khashab, Rawan / Biber, Asaf / Zilberman, Tal / Rhein, Joshua / Vetter, Sara / Ahmed, Afeefa / Novik, Laura / Widge, Alicia / Gordon, Ingelise / Guech, Mercy / Teng, I-Ting / Phung, Emily / Ruckwardt, Tracy J / Pegu, Amarendra / Misasi, John / Doria-Rose, Nicole A / Gaudinski, Martin / Koup, Richard A / Kwong, Peter D / McDermott, Adrian B / Amit, Sharon / Schacker, Timothy W / Levy, Itzchak / Mascola, John R / Sullivan, Nancy J / Schramm, Chaim A / Douek, Daniel C

bioRxiv : the preprint server for biology

2022

Abstract: An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. The basis for such cross-protection at the molecular level is incompletely understood. Here we characterized the repertoire and epitope ...

Abstract	An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. The basis for such cross-protection at the molecular level is incompletely understood. Here we characterized the repertoire and epitope specificity of antibodies elicited by Beta, Gamma and ancestral variant infection and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a high-throughput approach to obtain immunoglobulin sequences and produce monoclonal antibodies for functional assessment from single B cells. Infection with any variant elicited similar cross-binding antibody responses exhibiting a remarkably conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may represent a general immunological principle that accounts for the continued efficacy of vaccines based on a single ancestral variant.
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.03.28.486152
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Article: Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Gagne, Matthew / Corbett, Kizzmekia S. / Flynn, Barbara J. / Foulds, Kathryn E. / Wagner, Danielle A. / Andrew, Shayne F. / Todd, John-Paul M. / Honeycutt, Christopher Cole / McCormick, Lauren / Nurmukhambetova, Saule T. / Davis-Gardner, Meredith E. / Pessaint, Laurent / Bock, Kevin W. / Nagata, Bianca M. / Minai, Mahnaz / Werner, Anne P. / Moliva, Juan I. / Tucker, Courtney / Lorang, Cynthia G. /

Zhao, Bingchun / McCarthy, Elizabeth / Cook, Anthony / Dodson, Alan / Teng, I-Ting / Mudvari, Prakriti / Roberts-Torres, Jesmine / Laboune, Farida / Wang, Lingshu / Goode, Adrienne / Kar, Swagata / Boyoglu-Barnum, Seyhan / Yang, Eun Sung / Shi, Wei / Ploquin, Aurélie / Doria-Rose, Nicole / Carfi, Andrea / Mascola, John R. / Boritz, Eli A. / Edwards, Darin K. / Andersen, Hanne / Lewis, Mark G. / Suthar, Mehul S. / Graham, Barney S. / Roederer, Mario / Moore, Ian N. / Nason, Martha C. / Sullivan, Nancy J. / Douek, Daniel C. / Seder, Robert A.

Cell. 2022 Jan. 06, v. 185, no. 1

2022

Abstract: mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. Here, we immunized rhesus macaques and assessed immune responses over 1 year in blood and ... ...

Abstract	mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. Here, we immunized rhesus macaques and assessed immune responses over 1 year in blood and upper and lower airways. Serum neutralizing titers to Delta were 280 and 34 reciprocal ID₅₀ at weeks 6 (peak) and 48 (challenge), respectively. Antibody-binding titers also decreased in bronchoalveolar lavage (BAL). Four days after Delta challenge, the virus was unculturable in BAL, and subgenomic RNA declined by ∼3-log₁₀ compared with control animals. In nasal swabs, sgRNA was reduced by 1-log₁₀, and the virus remained culturable. Anamnestic antibodies (590-fold increased titer) but not T cell responses were detected in BAL by day 4 post-challenge. mRNA-1273-mediated protection in the lungs is durable but delayed and potentially dependent on anamnestic antibody responses. Rapid and sustained protection in upper and lower airways may eventually require a boost.
Keywords	RNA ; Severe acute respiratory syndrome coronavirus 2 ; T-lymphocytes ; antibodies ; antibody formation ; blood serum ; durability ; lungs ; nose ; vaccination ; vaccines ; viruses
Language	English
Dates of publication	2022-0106
Size	p. 113-130.e15.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.12.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

Moliva, Juan I. / Andrew, Shayne F. / Flynn, Barbara J. / Wagner, Danielle A. / Foulds, Kathryn E. / Gagne, Matthew / Flebbe, Dillon R. / Lamb, Evan / Provost, Samantha / Marquez, Josue / Mychalowych, Anna / Lorag, Cynthia G. / Honeycutt, Christopher Cole / Burnett, Matthew R. / McCormick, Lauren / Henry, Amy R. / Godbole, Sucheta / Davis-Gardner, Meredith E. / Minai, Mahnaz /

Bock, Kevin W. / Nagata, Bianca M. / Todd, John-Paul M. / McCarthy, Elizabeth / Dodson, Alan / Kouneski, Katelyn / Cook, Anthony / Pessaint, Laurent / Van Ry, Alex / Valentin, Daniel / Young, Steve / Littman, Yoav / Boon, Adrianus C. M. / Suthar, Mehul S. / Lewis, Mark G. / Andersen, Hanne / Alves, Derron A. / Woodward, Ruth / Leuzzi, Adriano / Vitelli, Alessandra / Colloca, Stefano / Folgori, Antonella / Raggiolli, Angelo / Capone, Stefania / Nason, Martha C. / Douek, Daniel C. / Roederer, Mario / Seder, Robert A. / Sullivan, Nancy J.

bioRxiv

Abstract: SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there9s a need for vaccines that induce mucosal immunity and can rapidly control ...

Abstract	SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there9s a need for vaccines that induce mucosal immunity and can rapidly control the virus. In this study, we demonstrate that a single immunization with a novel gorilla adenovirus-based vaccine (GRAd) carrying the pre-fusion stabilized Spike protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P) accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P) modestly improved protection compared to its matched intramuscular regimen, but showed dramatically superior boosting by mRNA and, importantly, total virus clearance in the upper airway by day 4 post infection. GrAd vaccination regimens elicited robust and durable systemic and mucosal antibody responses to multiple SARS-CoV-2 variants, but only GRAd(AE)+S-2P generated long-lasting T cell responses in the lung. This research underscores the flexibility of the GRAd vaccine platform to provide durable immunity against SARS-CoV-2 in both the lower and upper airways.
Keywords	covid19
Language	English
Publishing date	2023-11-22
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.11.22.567930
Database	COVID19

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Article ; Online: Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

Moliva, Juan I / Andrew, Shayne F / Flynn, Barbara J / Wagner, Danielle A / Foulds, Kathryn E / Gagne, Matthew / Flebbe, Dillon R / Lamb, Evan / Provost, Samantha / Marquez, Josue / Mychalowych, Anna / Lorag, Cynthia / Honeycutt, Christopher Cole / Burnett, Matthew R / McCormick, Lauren / Henry, Amy R / Godbole, Sucheta / Davis-Gardner, Meredith E / Minai, Mahnaz /

Bok, Kevin W / Nagata, Bianca M / Todd, John-Paul M / McCarthy, Elizabeth / Dodson, Alan / Kouneski, Katelyn / Cook, Anthony / Pessaint, Laurent / Van Ry, Alex / Valentin, Daniel / Young, Steve / Littman, Yoav / Boon, Adrianus C. M. / Suthar, Mehul S / Lewis, Mark G / Andersen, Hanne / Alves, Derron A / Woodward, Ruth / Leuzzi, Adriano / Vitelli, Alessandra / Colloca, Stefano / Folgori, Antonella / Raggiolli, Angelo / Capone, Stefania / Nason, Martha C / Douek, Daniel / Roederer, Mario / Seder, Robert A / Sullivan, Nancy J

bioRxiv

Abstract: SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there9s a need for vaccines that induce mucosal immunity and can rapidly control ...

Abstract	SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there9s a need for vaccines that induce mucosal immunity and can rapidly control the virus. In this study, we demonstrate that a single immunization with a novel gorilla adenovirus-based vaccine (GRAd) carrying the pre-fusion stabilized Spike protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P) accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P) modestly improved protection compared to its matched intramuscular regimen, but showed dramatically superior boosting by mRNA and, importantly, total virus clearance in the upper airway by day 4 post infection. GrAd vaccination regimens elicited robust and durable systemic and mucosal antibody responses to multiple SARS-CoV-2 variants, but only GRAd(AE)+S-2P generated long-lasting T cell responses in the lung. This research underscores the flexibility of the GRAd vaccine platform to provide durable immunity against SARS-CoV-2 in both the lower and upper airways.
Keywords	covid19
Language	English
Publishing date	2023-11-22
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.11.22.567930
Database	COVID19

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Article: Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in nonhuman primates is coincident with an anamnestic antibody response in the lower airway.

Gagne, Matthew / Corbett, Kizzmekia S / Flynn, Barbara J / Foulds, Kathryn E / Wagner, Danielle A / Andrew, Shayne F / Todd, John-Paul M / Honeycutt, Christopher Cole / McCormick, Lauren / Nurmukhambetova, Saule T / Davis-Gardner, Meredith E / Pessaint, Laurent / Bock, Kevin W / Nagata, Bianca M / Minai, Mahnaz / Werner, Anne P / Moliva, Juan I / Tucker, Courtney / Lorang, Cynthia G /

Zhao, Bingchun / McCarthy, Elizabeth / Cook, Anthony / Dodson, Alan / Mudvari, Prakriti / Roberts-Torres, Jesmine / Laboune, Farida / Wang, Lingshu / Goode, Adrienne / Kar, Swagata / Boyoglu-Barnum, Seyhan / Yang, Eun Sung / Shi, Wei / Ploquin, Aurélie / Doria-Rose, Nicole / Carfi, Andrea / Mascola, John R / Boritz, Eli A / Edwards, Darin K / Andersen, Hanne / Lewis, Mark G / Suthar, Mehul S / Graham, Barney S / Roederer, Mario / Moore, Ian N / Nason, Martha C / Sullivan, Nancy J / Douek, Daniel C / Seder, Robert A

bioRxiv : the preprint server for biology

2021

Abstract: mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. We immunized rhesus macaques at weeks 0 and 4 and assessed immune responses over one year ... ...

Abstract	mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. We immunized rhesus macaques at weeks 0 and 4 and assessed immune responses over one year in blood, upper and lower airways. Serum neutralizing titers to Delta were 280 and 34 reciprocal ID
Language	English
Publishing date	2021-10-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.10.23.465542
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

Peyton, Lowrey / Narpala, Sandeep R / O'Connell, Sarah / Serebryannyy, Leonid / Wang, Jennifer / Schrager, Alexander / Talana, Chloe Adrienna / Shimberg, Geoffrey / Leung, Kwanyee / Shi, Wei / Khashab, Rawan / Biber, Asaf / Zilberman, Tal / Rhein, Joshua / Vetter, Sara / Ahmed, Afeefa / Novik, Laura / Widge, Alicia / Gordon, Ingelise / Guech, Mercy / Teng, I-Ting / Phung, Emily / Ruckwardt, Tracy J / Pegu, Amarendra / Misasi, John / Doria-Rose, Nicole A / Gaudinski, Martin / Koup, Richard A / Kwong, Peter D / McDermott, Adrian B / Amit, Sharon / Schacker, Timothy W / Levy, Itzchak / Mascola, John R / Sullivan, Nancy J / Schramm, Chaim A / Douek, Daniel C

Nature communications

2022 Volume 13, Issue 1, Page(s) 7733

Abstract: An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at the molecular level is incompletely understood. Here, we characterized the repertoire ... ...

Abstract	An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at the molecular level is incompletely understood. Here, we characterized the repertoire and epitope specificity of antibodies elicited by infection with the Beta, Gamma and WA1 ancestral variants and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a method to obtain immunoglobulin sequences with concurrent rapid production and functional assessment of monoclonal antibodies from hundreds of single B cells sorted by flow cytometry. Infection with any variant elicited similar cross-binding antibody responses exhibiting a conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may account for the continued efficacy of vaccines based on a single ancestral variant.
MeSH term(s)	Humans ; Immunoglobulin Variable Region ; Epitopes/genetics ; SARS-CoV-2/genetics ; COVID-19 ; Clone Cells ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Immunoglobulin Variable Region ; Epitopes ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-35456-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung.

Zhao, Bingchun / McCarthy, Elizabeth / Cook, Anthony / Dodson, Alan / Teng, I-Ting / Mudvari, Prakriti / Roberts-Torres, Jesmine / Laboune, Farida / Wang, Lingshu / Goode, Adrienne / Kar, Swagata / Boyoglu-Barnum, Seyhan / Yang, Eun Sung / Shi, Wei / Ploquin, Aurélie / Doria-Rose, Nicole / Carfi, Andrea / Mascola, John R / Boritz, Eli A / Edwards, Darin K / Andersen, Hanne / Lewis, Mark G / Suthar, Mehul S / Graham, Barney S / Roederer, Mario / Moore, Ian N / Nason, Martha C / Sullivan, Nancy J / Douek, Daniel C / Seder, Robert A

Cell

2021 Volume 185, Issue 1, Page(s) 113–130.e15

Abstract	mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. Here, we immunized rhesus macaques and assessed immune responses over 1 year in blood and upper and lower airways. Serum neutralizing titers to Delta were 280 and 34 reciprocal ID
Language	English
Publishing date	2021-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.12.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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