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  1. Article ; Online: The boundary between real and fictional others in the medial prefrontal cortex is blurred in lonelier individuals.

    Broom, Timothy W / Wagner, Dylan D

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Volume 33, Issue 16, Page(s) 9677–9689

    Abstract: People spend much of their free time engaging with narrative fiction. Research shows that, like real-life friends, fictional characters can sometimes influence individuals' attitudes, behaviors, and self-beliefs. Moreover, for certain individuals, ... ...

    Abstract People spend much of their free time engaging with narrative fiction. Research shows that, like real-life friends, fictional characters can sometimes influence individuals' attitudes, behaviors, and self-beliefs. Moreover, for certain individuals, fictional characters can stand in for real-life friends by providing the experience of belonging. Despite these parallels between how people think of real and fictional others, it is unclear whether, and to what degree, their neural representations are similar. Does the brain treat psychologically close fictional others as it does close real-world friends, or are real others somehow privileged in their neural representation? In the present study, fans of the HBO series Game of Thrones performed a trait-evaluation task for the self, 9 real-life friends/acquaintances, and 9 fictional characters from Game of Thrones while undergoing functional magnetic resonance imaging. Using both brain decoding and representational similarity analysis, we found evidence of a categorical boundary between real and fictional others within the medial prefrontal cortex. However, the boundary between these categories was blurred in lonelier individuals. These results suggest that lonelier individuals may turn to fictional characters to meet belongingness needs, and this, in turn, alters the manner in which these categories are encoded within the social brain.
    MeSH term(s) Humans ; Brain ; Brain Mapping ; Friends ; Magnetic Resonance Imaging ; Prefrontal Cortex
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The orbitofrontal cortex spontaneously encodes food health and contains more distinct representations for foods highest in tastiness.

    Londerée, Allison M / Wagner, Dylan D

    Social cognitive and affective neuroscience

    2020  Volume 16, Issue 8, Page(s) 816–826

    Abstract: The human orbitofrontal cortex (OFC) has long been associated with food reward processing and is thought to represent modality-independent signals of value. Food tastiness and health are core attributes of many models of food choice and dietary self- ... ...

    Abstract The human orbitofrontal cortex (OFC) has long been associated with food reward processing and is thought to represent modality-independent signals of value. Food tastiness and health are core attributes of many models of food choice and dietary self-control. Here we used functional neuroimaging to examine the neural representation of tastiness and health for a set of 28 food categories selected to be orthogonal with respect to both dimensions. Using representational similarity analysis, in conjunction with linear mixed-effects modeling, we demonstrate that the OFC spontaneously encodes food health, whereas tastiness was associated with greater neural dissimilarity. Subsequent analyses using model dissimilarity matrices that encode overall tastiness magnitude demonstrated that the neural representation of foods grows more distinct with increasing tastiness but not with increasing health. In a separate study, we use lexical analysis of natural language descriptions of food to show that food tastiness is associated with more elaborate descriptions of food. Together these data show not only that the OFC spontaneously encodes the dimensions of health and tastiness when viewing appetitive food cues, but also that the neural and cognitive representations of food categories that are the highest in tastiness are more refined than those lower in tastiness.
    MeSH term(s) Food ; Food Preferences ; Humans ; Prefrontal Cortex/diagnostic imaging ; Reward ; Taste
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsaa083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Becoming the King in the North: identification with fictional characters is associated with greater self-other neural overlap.

    Broom, Timothy W / Chavez, Robert S / Wagner, Dylan D

    Social cognitive and affective neuroscience

    2021  Volume 16, Issue 6, Page(s) 541–551

    Abstract: During narrative experiences, identification with a fictional character can alter one's attitudes and self-beliefs to be more similar to those of the character. The ventral medial prefrontal cortex (vMPFC) is a brain region that shows increased activity ... ...

    Abstract During narrative experiences, identification with a fictional character can alter one's attitudes and self-beliefs to be more similar to those of the character. The ventral medial prefrontal cortex (vMPFC) is a brain region that shows increased activity when introspecting about the self but also when thinking of close friends. Here, we test whether identification with fictional characters is associated with increased neural overlap between self and fictional others. Nineteen fans of the HBO series Game of Thrones performed trait evaluations for the self, 9 real-world friends and 9 fictional characters during functional neuroimaging. Overall, the participants showed a larger response in the vMPFC for self compared to friends and fictional others. However, among the participants higher in trait identification, we observed a greater neural overlap in the vMPFC between self and fictional characters. Moreover, the magnitude of this association was greater for the character that participants reported feeling closest to/liked the most as compared to those they felt least close to/liked the least. These results suggest that identification with fictional characters leads people to incorporate these characters into their self-concept: the greater the immersion into experiences of 'becoming' characters, the more accessing knowledge about characters resembles accessing knowledge about the self.
    MeSH term(s) Adolescent ; Adult ; Brain/diagnostic imaging ; Brain Mapping ; Female ; Friends/psychology ; Humans ; Knowledge ; Magnetic Resonance Imaging/methods ; Male ; Social Identification ; Young Adult
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsab021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The neural representation of self is recapitulated in the brains of friends: A round-robin fMRI study.

    Chavez, Robert S / Wagner, Dylan D

    Journal of personality and social psychology

    2019  Volume 118, Issue 3, Page(s) 407–416

    Abstract: Humans continually form and update impressions of each other's identities based on the disclosure of thoughts, feelings, and beliefs. At the same time, individuals also have specific beliefs and knowledge about their own self-concept. Over a decade of ... ...

    Abstract Humans continually form and update impressions of each other's identities based on the disclosure of thoughts, feelings, and beliefs. At the same time, individuals also have specific beliefs and knowledge about their own self-concept. Over a decade of social neuroscience research has shown that retrieving information about the self and about other persons recruits similar areas of the medial prefrontal cortex (MPFC), however it remains unclear if an individual's neural representation of self is reflected in the brains of well-known others or if instead the two representations share no common relationship. Here we examined this question in a tight-knit network of friends as they engaged in a round-robin trait evaluation task in which each participant was both perceiver and target for every other participant and in addition also evaluated their self. Using functional MRI and a multilevel modeling approach, we show that multivoxel brain activity patterns in the MPFC during a person's self-referential thought are correlated with those of friends when thinking of that same person. Moreover, the similarity of neural self-other patterns was itself positively associated with the similarity of self-other trait judgments ratings as measured behaviorally in a separate session. These findings suggest that accuracy in person perception may be predicated on the degree to which the brain activity pattern associated with an individual thinking about their own self-concept is similarly reflected in the brains of others. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
    MeSH term(s) Adult ; Brain Mapping ; Female ; Friends ; Humans ; Magnetic Resonance Imaging ; Male ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiology ; Self Concept ; Social Perception
    Language English
    Publishing date 2019-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3103-3
    ISSN 1939-1315 ; 0022-3514
    ISSN (online) 1939-1315
    ISSN 0022-3514
    DOI 10.1037/pspa0000178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Demographic and Behavioral Differences Between Adolescents and Young Adults Who Use E-Cigarettes at Low and High Frequency.

    Singer, Jill M / Tackett, Alayna P / Klein, Elizabeth G / Lu, Bo / Wagner, Dylan D / Wold, Loren E / Roberts, Megan E

    Substance use & addiction journal

    2024  Volume 45, Issue 2, Page(s) 232–239

    Abstract: Background: Among adolescents and young adults (AYAs), "current use" of electronic cigarettes (e-cigarettes) is commonly defined as any use in the past 30 days. However, few studies have examined differences among those within this broad category. This ... ...

    Abstract Background: Among adolescents and young adults (AYAs), "current use" of electronic cigarettes (e-cigarettes) is commonly defined as any use in the past 30 days. However, few studies have examined differences among those within this broad category. This study examined characteristics of AYAs who used e-cigarettes at a low frequency (within the last 3 months but <6 days out of the past 30 days) and those who used e-cigarettes at a high frequency (6+ days out of the past 30 days).
    Methods: We conducted cross-sectional analyses among 551 Ohio AYAs (15- to 24-year-olds) who reported using an e-cigarette to vape nicotine in the past 3 months. We used descriptive statistics and logistic regression to characterize those using e-cigarettes at a low frequency and a high frequency.
    Results: Among our sample of AYAs who reported past 3-month e-cigarette use, about half (50.8%) reported using an e-cigarette 6 or more days out of the past 30 days (ie, high frequency). In the multivariable analysis, reported nicotine dependence (Odds Ratio [OR]: 7.0, 95% CI: 4.8, 10.3) and current other tobacco product use (OR: 1.8, 95% CI: 1.1, 2.9) were associated with high-frequency e-cigarette use.
    Conclusion: Our results suggest that frequency of use is an important characteristic in understanding AYA e-cigarette use. Any use in the past 30 days may not be sensitive enough to understand dependence and tobacco-use behaviors. Further characterizing "current" e-cigarette use by frequency of use may provide meaningful information for public health professionals to better target intervention and cessation efforts to AYAs.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Electronic Nicotine Delivery Systems ; Cross-Sectional Studies ; Tobacco Use Disorder ; Vaping ; Demography
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2976-7350
    ISSN (online) 2976-7350
    DOI 10.1177/29767342231214115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nicotine information disclosed online by e-cigarette brands popular with young people.

    Rykaczewski, Clara / Tackett, Alayna P / Klein, Elizabeth G / Singer, Jill M / Lu, Bo / Wold, Loren E / Wagner, Dylan D / Roberts, Megan E

    Tobacco prevention & cessation

    2024  Volume 10

    Abstract: Introduction: E-cigarette use is most prevalent among adolescents and young adults - and there are often misperceptions about product risk. The purpose of this study was to determine what nicotine information is provided on e-cigarette brand websites.!## ...

    Abstract Introduction: E-cigarette use is most prevalent among adolescents and young adults - and there are often misperceptions about product risk. The purpose of this study was to determine what nicotine information is provided on e-cigarette brand websites.
    Methods: Based on national and local surveys, we identified 44 e-cigarette brands commonly used in the US by adolescents and young adults. For each of these brands, their associated websites were analyzed for disclosed nicotine information. Specifically, for each brand's website, we coded whether there was information on nicotine concentration (recorded if a numerical value was provided such as '5% nicotine'), nicotine form (free-base, nicotine salts, or not stated), and nicotine type (tobacco-derived, synthetically derived, or not stated). Coding allowed for both lay (e.g. 'nic salts') as well as scientific (e.g. 'isomers') terms.
    Results: Of the 44 brands examined, all provided basic information on nicotine concentration (e.g. '5% nicotine'). However, 23% of brands did not disclose information on nicotine form (i.e. nicotine salt vs free-base), and 66% of brands did not disclose information on nicotine type (i.e. synthetic vs tobacco-derived).
    Conclusions: Overall, these results suggest that the e-cigarette industry is not fully informing its consumers about the nicotine in their products. Given that nicotine form and type have implications for e-cigarette addiction potential, these findings highlight a public health concern. There is a need for more comprehensive national regulations for mandating product constituents and emissions disclosures.
    Language English
    Publishing date 2024-04-25
    Publishing country Greece
    Document type Journal Article
    ISSN 2459-3087
    ISSN (online) 2459-3087
    DOI 10.18332/tpc/186953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: They Saw a Debate: Political Polarization Is Associated with Greater Multivariate Neural Synchrony When Viewing the Opposing Candidate Speak.

    Broom, Timothy W / Stahl, Jonathan L / Ping, Elliot E C / Wagner, Dylan D

    Journal of cognitive neuroscience

    2022  Volume 35, Issue 1, Page(s) 60–73

    Abstract: With rampant polarization in current U.S. politics, it seems as though political partisans with opposing viewpoints are living in parallel realities. Indeed, prior research shows that people's impressions/attitudes toward political candidates are ... ...

    Abstract With rampant polarization in current U.S. politics, it seems as though political partisans with opposing viewpoints are living in parallel realities. Indeed, prior research shows that people's impressions/attitudes toward political candidates are intertwined with their political affiliation. The current study investigated the relationship between political affiliation and intersubject neural synchrony of multivariate patterns of activity during naturalistic viewing of a presidential debate. Before the 2016 U.S. presidential election, 20 individuals varying in political affiliation underwent functional neuroimaging while watching the first debate between candidates Hillary Clinton and Donald Trump. Pairs of participants with more polarized political affiliations were higher in neural synchrony in a system of brain regions involved in self-referential processing when viewing the opposing candidate speak compared with that candidate's supporters regardless of which extreme of the political spectrum they occupied. Moreover, pairs of political partisans matching in the candidate they supported were higher in neural synchrony when watching the candidate they opposed compared with the one they both supported. These findings suggest that political groups' shared understanding may be driven more by perceptions of outgroups than of their own party/candidates.
    MeSH term(s) Humans ; United States ; Attitude ; Politics ; Brain/diagnostic imaging
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_01888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Recruitment of cognitive control regions during effortful self-control is associated with altered brain activity in control and reward systems in dieters during subsequent exposure to food commercials.

    Lopez, Richard B / Courtney, Andrea L / Wagner, Dylan D

    PeerJ

    2019  Volume 7, Page(s) e6550

    Abstract: Engaging in effortful self-control can sometimes impair people's ability to resist subsequent temptations. Existing research has shown that when chronic dieters' self-regulatory capacity is challenged by prior exertion of effort, they demonstrate ... ...

    Abstract Engaging in effortful self-control can sometimes impair people's ability to resist subsequent temptations. Existing research has shown that when chronic dieters' self-regulatory capacity is challenged by prior exertion of effort, they demonstrate disinhibited eating and altered patterns of brain activity when exposed to food cues. However, the relationship between brain activity during self-control exertion and subsequent food cue exposure remains unclear. In the present study, we investigated whether individual differences in recruitment of cognitive control regions during a difficult response inhibition task are associated with a failure to regulate neural responses to rewarding food cues in a subsequent task in a cohort of 27 female dieters. During self-control exertion, participants recruited regions commonly associated with inhibitory control, including dorsolateral prefrontal cortex (DLPFC). Those dieters with higher DLPFC activity during the initial self-control task showed an altered balance of food cue elicited activity in regions associated with reward and self-control, namely: greater reward-related activity and less recruitment of the frontoparietal control network. These findings suggest that some dieters may be more susceptible to the effects of self-control exertion than others and, whether due to limited capacity or changes in motivation, these dieters subsequently fail to engage control regions that may otherwise modulate activity associated with craving and reward.
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.6550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Media multitasking is associated with higher risk for obesity and increased responsiveness to rewarding food stimuli.

    Lopez, Richard B / Heatherton, Todd F / Wagner, Dylan D

    Brain imaging and behavior

    2019  Volume 14, Issue 4, Page(s) 1050–1061

    Abstract: Obesity among children and adolescents has dramatically increased over the past two to three decades and is now a major public health issue. During this same period, youth exposure to media devices also became increasingly prevalent. Here, we present the ...

    Abstract Obesity among children and adolescents has dramatically increased over the past two to three decades and is now a major public health issue. During this same period, youth exposure to media devices also became increasingly prevalent. Here, we present the novel hypothesis that media multitasking (MMT)-the simultaneous use of and switching between unrelated forms of digital media-is associated with an imbalance between regulatory processes and reward-related responses to appetitive food stimuli, resulting in a greater sensitivity to external food cues among high media multitaskers. This, in turn, may contribute to overeating and weight gain over time. To test this hypothesis, we conducted two studies examining research participants who grew up during the recent period of escalating multitasking and obesity-and among whom 37% are overweight or obese. In Study 1, participants' propensity to engage in MMT behaviors was associated with a higher risk for obesity (as indicated by higher body mass index and body fat percentage). Next, in Study 2, a subset of participants from Study 1 were exposed to appetitive food cues while undergoing functional neuroimaging and then, using passive mobile sensing, the time participants spent in various food points-of-sale over an academic term was inferred from GPS coordinates of their mobile device. Study 2 revealed that MMT was associated with an altered pattern of brain activity in response to appetizing food cues, specifically an imbalance favoring reward-related activity in ventral striatum and orbitofrontal cortex-relative to recruitment of the frontoparietal control network. This relationship was further tested in a mediation model, whereby increased MMT, via a brain imbalance favoring reward over control, was associated with greater time spent in campus eateries. Taken together, findings from both studies suggest the possibility that media multitasking may be implicated in the recent obesity epidemic.
    MeSH term(s) Adolescent ; Child ; Cues ; Food ; Humans ; Internet ; Magnetic Resonance Imaging ; Obesity ; Reward
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2377165-3
    ISSN 1931-7565 ; 1931-7557
    ISSN (online) 1931-7565
    ISSN 1931-7557
    DOI 10.1007/s11682-019-00056-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Decoding the neural representation of self and person knowledge with multivariate pattern analysis and data-driven approaches.

    Wagner, Dylan D / Chavez, Robert S / Broom, Timothy W

    Wiley interdisciplinary reviews. Cognitive science

    2018  Volume 10, Issue 1, Page(s) e1482

    Abstract: Multivariate pattern analysis and data-driven approaches to understand how the human brain encodes sensory information and higher level conceptual knowledge have become increasingly dominant in visual and cognitive neuroscience; however, it is only in ... ...

    Abstract Multivariate pattern analysis and data-driven approaches to understand how the human brain encodes sensory information and higher level conceptual knowledge have become increasingly dominant in visual and cognitive neuroscience; however, it is only in recent years that these methods have been applied to the domain of social information processing. This review examines recent research in the field of social cognitive neuroscience focusing on how multivariate pattern analysis (e.g., pattern classification, representational similarity analysis) and data-driven methods (e.g., reverse correlation, intersubject correlation) have been used to decode and characterize high-level information about the self, other persons, and social groups. We begin with a review of what is known about how self-referential processing and person perception are represented in the medial prefrontal cortex based on conventional activation-based neuroimaging approaches. This is followed by a nontechnical overview of current multivariate pattern-based and data-driven neuroimaging methods designed to characterize and/or decode neural representations. The remainder of the review focuses on examining how these methods have been applied to the topic of self, person perception, and the perception of social groups. In this review, we highlight recent trends (e.g., analysis of social networks, decoding race and social groups, and the use of naturalistic stimuli) and discuss several theoretical challenges that arise from the application of these new methods to the question of how the brain represents knowledge about the self and others. This article is categorized under: Neuroscience > Cognition.
    MeSH term(s) Brain/physiology ; Brain Mapping/methods ; Cognition/physiology ; Humans ; Knowledge ; Magnetic Resonance Imaging/methods ; Multivariate Analysis ; Neurosciences ; Social Networking
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2553336-8
    ISSN 1939-5086 ; 1939-5078
    ISSN (online) 1939-5086
    ISSN 1939-5078
    DOI 10.1002/wcs.1482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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