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Article ; Online: Did implementation of three ligament tenodesis improve patient outcome after chronic scapholunate instability? A retrospective study.

Wagner, J M / Stammler, A / Harenberg, P / Reinkemeier, F / Lehnhardt, M / Behr, B

Archives of orthopaedic and trauma surgery

2022 Volume 142, Issue 9, Page(s) 2397–2403

Abstract: Introduction: Scapholunate instability frequently leads to chronic pain or even severe osteoarthritis of the wrist. Most favored reconstruction techniques of chronic SL-ligament injuries are based on the usage of a tendon, although there is still a lack ...

Abstract	Introduction: Scapholunate instability frequently leads to chronic pain or even severe osteoarthritis of the wrist. Most favored reconstruction techniques of chronic SL-ligament injuries are based on the usage of a tendon, although there is still a lack of consensus which technique is superior. Materials and methods: In a retrospective cohort analysis we compared 9 patients who underwent SL-ligament repair according to Van den Abbeele and 12 patients who underwent modified three ligament tenodesis according to Garcia-Elias, performed at a single institution. Results: Follow-up of Van den Abbeele group was 36-120 months and 13-39 months in the Garcia Elias cohort. Although both techniques showed good functional outcome in most cases, modified three ligament tenodesis seemed to be advantageous regarding wrist range of motion (162°) compared to Van den Abbeele cohort (87°). Moreover, pain score showed significant differences between the two cohorts during follow up (VAS Van den Abbeele 4.2; VAS Garcia Elias 1.7). Interestingly, DASH-score (16.1 Van den Abbeele; 16.8 Garcia Elias) and modified mayo wrist score (72 Van den Abbeele; 69 Garcia-Elias) did not show any differences between the two patient cohorts. Conclusions: Via implementation of modified three ligament tenodesis as a standard of care for our patients we could improve the functional outcome after SL-ligament injuries and effectively decrease postoperative pain.
MeSH term(s)	Humans ; Joint Instability/surgery ; Ligaments/surgery ; Ligaments, Articular/surgery ; Lunate Bone/surgery ; Retrospective Studies ; Scaphoid Bone/surgery ; Tenodesis/methods ; Wrist Joint/surgery
Language	English
Publishing date	2022-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-022-04435-z
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Article ; Online: Optimizing remote ischemic conditioning (RIC) of cutaneous microcirculation in humans: Number of cycles and duration of acute effects.

Sogorski, A / Spindler, S / Wallner, C / Dadras, M / Wagner, J M / Behr, B / Lehnhardt, M / Kolbenschlag, J

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2020 Volume 74, Issue 4, Page(s) 819–827

Abstract: Objective: Non-invasive Remote Ischemic Conditioning (RIC) offers an approach to reduce tissue damage in various organs/tissues. Besides attenuation of Ischemia-Reperfusion injury (I/R), beneficial effects on cutaneous microcirculation of free ... ...

Abstract	Objective: Non-invasive Remote Ischemic Conditioning (RIC) offers an approach to reduce tissue damage in various organs/tissues. Besides attenuation of Ischemia-Reperfusion injury (I/R), beneficial effects on cutaneous microcirculation of free microsurgical flaps have been reported. Given the recency of this technique, there are considerable gaps in the current understanding of its mechanism of action. As a result, clinical transfer of RIC is prolongated in several fields. We aimed to optimize the RIC protocol by examination of different RIC-cycle numbers and its effect on changes of cutaneous microcirculation and duration. Methods: 80 subjects were divided into groups (1, 3, 5, 7 RIC cycles). RIC was applied via an inflatable tourniquet. Cutaneous microcirculation was continuously assessed at the contralateral anterior lateral thigh utilizing a ©O2C-device continuously. Results: RIC caused significant and sustained changes in microcirculation. Four hours after completion of RIC, a maximum increase of +80.8% (CI 1.395-2.221) in blood flow and +23.5% (CI 1.098-1.372) in tissue oxygen saturation was measured (three-cycle group). A higher number of applied cycles was accompanied with significant higher mean pain. Conclusion: Acute improvement of cutaneous microcirculation due to RIC lasted for at least 4 h after completion of the RIC-protocol. Dose-dependent effects of RIC are likely. With regard to the increase in pain, we recommend a RIC protocol of 3 cycles for future clinical application.
MeSH term(s)	Adult ; Arm/blood supply ; Female ; Healthy Volunteers ; Humans ; Ischemic Preconditioning/methods ; Male ; Microcirculation ; Oxygen/blood ; Skin/blood supply ; Tourniquets
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2020.10.007
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Article ; Online: Myostatin serum concentration as an indicator for deviated muscle metabolism in severe burn injuries.

Wallner, C / Wagner, J M / Dittfeld, S / Drysch, M / Lehnhardt, M / Behr, B

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

2018 Volume 108, Issue 4, Page(s) 297–304

Abstract: Introduction: Patients experiencing thermal injuries with an extent of over 20% of total body surface area suffer from systemic catabolic disease. The thermal trauma-induced loss of muscle mass causes a higher incidence for comorbidities and ... ...

Abstract	Introduction: Patients experiencing thermal injuries with an extent of over 20% of total body surface area suffer from systemic catabolic disease. The thermal trauma-induced loss of muscle mass causes a higher incidence for comorbidities and subsequently a higher mortality. In this study, we aimed to investigate the role of myostatin in the interplay with follistatin during muscle cachexia. Methods: Patients with burn injuries (>10% total body surface area) between the ages of 18 and 75 were prospectively included within the first 48 h after trauma to determine deviations of parameters connected to muscle catabolism. In the chronic state of burn injury (9-12 months after trauma), we re-evaluated myostatin and follistatin concentrations as well as muscle strength of the non-dominant forearm. Results: We were able to show a time-dependent alteration (9-12 months after burn injury) of myostatin with an initial decrease ( Conclusion: With regard to the muscle metabolism after thermal trauma, our data suggest an acute anabolic response, presumably to spare muscle mass, which is converted to catabolic conditions accompanied by muscle strength reduction in the chronic phase. Myostatin plays a crucial role in this orchestration and initial myostatin concentration may predict the long-term muscle strength.
MeSH term(s)	Adolescent ; Adult ; Aged ; Biomarkers/blood ; Burns/blood ; Burns/complications ; Cachexia/blood ; Cachexia/etiology ; Female ; Follistatin/blood ; Humans ; Male ; Middle Aged ; Muscle Strength ; Myostatin/blood ; Prospective Studies
Chemical Substances	Biomarkers ; Follistatin ; Myostatin
Language	English
Publishing date	2018-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2077691-3
ISSN	1799-7267 ; 1457-4969
ISSN (online)	1799-7267
ISSN	1457-4969
DOI	10.1177/1457496918812230
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Article: Handgelenkempyem. Diagnostik, Therapie und Langzeitergebnisse eines seltenen Gelenkinfektes

Dadras, M. / Wallner, C. / Wagner, J. M. / Lehnhardt, M. / Behr, B.

Trauma und Berufskrankheit

2019 Volume 21, Issue 4, Page(s) 247

Language	German
Document type	Article
ZDB-ID	1464516-6
ISSN	1436-6274
Database	Current Contents Medicine

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Article ; Online: Partial monosomy of chromosome 21 and congenital malformations monosomy of chromosome 21 and malformations.

Osiak, Lucas / Saraiva, João G / Mestre, Viviane de F / Ferrari, Lígia S L / Paiva, Wagner J M / de Lima, Renata L L F / Salles, Maria J S

Clinical dysmorphology

2020 Volume 29, Issue 3, Page(s) 165–166

MeSH term(s)	Child, Preschool ; Chromosome Deletion ; Chromosomes, Human, Pair 21/genetics ; Female ; Humans ; Infant ; Monosomy/genetics
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1121482-x
ISSN	1473-5717 ; 0962-8827
ISSN (online)	1473-5717
ISSN	0962-8827
DOI	10.1097/MCD.0000000000000310
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Article: Food Quality Protection Act: its impact on the pesticide industry.

Wagner, J M

Quality assurance (San Diego, Calif.)

1997 Volume 5, Issue 4, Page(s) 279–283

Abstract: Enacted into law by Congress in August 1996, the Food Quality Protection Act (FQPA) is the most significant piece of federal pesticide legislation since the 1988 amendments to the Federal Insecticide, Fungicide and Rodenticide Act. FQPA was hastily ... ...

Abstract	Enacted into law by Congress in August 1996, the Food Quality Protection Act (FQPA) is the most significant piece of federal pesticide legislation since the 1988 amendments to the Federal Insecticide, Fungicide and Rodenticide Act. FQPA was hastily drafted and approved towards the end of the 1996 Congressional session. The new law was advertised as resolving some long-standing problems; however, it is clear now that it has also created some new ones. Since the FQPA's passage, the U.S. Environmental Protection Agency has issued numerous rules and regulations that are being used to evaluate and judge the safety of pesticide use on foods. This article discusses some of the major provisions of the new law and their impact to the U.S. pesticide industry.
MeSH term(s)	Child ; Child, Preschool ; Female ; Food/standards ; Humans ; Infant ; Infant, Newborn ; Legislation, Food ; Male ; Pest Control/legislation & jurisprudence ; Pesticide Residues/analysis ; Pesticides ; Quality Control ; Risk ; United States ; United States Environmental Protection Agency
Chemical Substances	Pesticide Residues ; Pesticides
Language	English
Publishing date	1997-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1097078-2
ISSN	1521-0677 ; 1052-9411
ISSN (online)	1521-0677
ISSN	1052-9411
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Article ; Online: Regulation des Knochenstoffwechsels durch den Wnt-Signalweg.

Houschyar, K S / Tapking, C / Duscher, D / Harati, K / Wallner, C / Wagner, J M / Maan, Z N / Rein, S / Chelliah, M P / Reumuth, G / Grieb, G / Siemers, F / Lehnhardt, M / Behr, B

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...

2018 Volume 51, Issue 4, Page(s) 309–318

Abstract: The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt ... ...

Title translation	Regulation of bone metabolism by the Wnt signaling pathway.
Abstract	The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.
MeSH term(s)	Bone and Bones/metabolism ; Cell Differentiation ; Mesenchymal Stem Cells ; Osteogenesis ; Wnt Proteins ; Wnt Signaling Pathway
Chemical Substances	Wnt Proteins
Language	German
Publishing date	2018-10-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392414-2
ISSN	1439-3980 ; 0722-1819
ISSN (online)	1439-3980
ISSN	0722-1819
DOI	10.1055/a-0642-1830
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Article: Trading away public health: WTO obstacles to effective toxics controls.

Goldman, P / Wagner, J M

Journal of public health policy

2000 Volume 21, Issue 3, Page(s) 260–267

MeSH term(s)	Environmental Health/legislation & jurisprudence ; Environmental Health/standards ; Global Health ; Hazardous Substances/standards ; Humans ; International Agencies ; Product Labeling ; Public Health/economics ; United States
Chemical Substances	Hazardous Substances
Language	English
Publishing date	2000
Publishing country	England
Document type	Journal Article
ZDB-ID	603208-4
ISSN	0197-5897
ISSN	0197-5897
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Article: "WHITE LIVER" DISEASE.

UTIAN, H L / WAGNER, J M / SICHEL, R J

Lancet (London, England)

2003 Volume 2, Issue 7368, Page(s) 1043–1045

MeSH term(s)	Acidosis ; Adolescent ; Animals ; Brain ; Brain Damage, Chronic ; Coma ; Diagnosis ; Enterovirus ; European Continental Ancestry Group ; Fatty Liver ; Hepatomegaly ; Humans ; Hypernatremia ; Hypoglycemia ; Infant ; Mortality ; Pathology ; Reoviridae ; Respiratory Tract Infections ; Seizures ; Uremia ; Vertebrates ; Viruses
Language	English
Publishing date	2003-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0140-6736 ; 0023-7507
ISSN (online)	1474-547X
ISSN	0140-6736 ; 0023-7507
DOI	10.1016/s0140-6736(64)90992-4
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Article: Exact inversion of the exponential x-ray transform for rotating slant-hole (RSH) SPECT.

Wagner, J M / Noo, F / Clackdoyle, R

Physics in medicine and biology

2002 Volume 47, Issue 15, Page(s) 2713–2726

Abstract: The RSH SPECT scanner provides parallel-beam attenuated projections for a fully 3D acquisition geometry. The geometry can be represented by circles on the unit sphere of projection directions, one circle for each position of the detector head. Unlike ... ...

Abstract	The RSH SPECT scanner provides parallel-beam attenuated projections for a fully 3D acquisition geometry. The geometry can be represented by circles on the unit sphere of projection directions, one circle for each position of the detector head. Unlike most other fully 3D geometries this one is particularly challenging because there are no 2D subsets in the data. When no attenuation is present, it is well known that an unmeasured projection can be synthesized if it lies inside one of the measured circles. The main result of this work is that under some assumptions on the attenuation distribution, attenuated projections within a circle can be synthesized from available attenuated projections. One consequence is that RSH SPECT projections can be rebinned into a conventional SPECT geometry for which analytic attenuation correction techniques are available.
MeSH term(s)	Algorithms ; Computer Simulation ; Heart/diagnostic imaging ; Humans ; Image Enhancement/methods ; Imaging, Three-Dimensional/methods ; Phantoms, Imaging ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon/instrumentation ; Tomography, Emission-Computed, Single-Photon/methods ; X-Rays
Language	English
Publishing date	2002-08-07
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/0031-9155/47/15/312
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