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  1. Article: High-dose amphotericin: yay or nay? A case series and literature review.

    Stover, Kayla R / Jordan, Taylor E / Wagner, Jamie L / Barber, Katie E

    Drugs in context

    2024  Volume 13

    Abstract: Invasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by toxicities and are increasingly susceptible to resistance, particularly amongst challenging fungal ...

    Abstract Invasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by toxicities and are increasingly susceptible to resistance, particularly amongst challenging fungal pathogens. The purpose of this case series and literature review was to characterize the use of a high-dose lipid formulation of amphotericin B. A case series is presented including patients who received high-dose lipid formulation amphotericin B (≥7.5 mg/kg/day) between June 2012 and August 2021. Additionally, a systematic literature review was conducted by searching the PubMed database for English-language studies involving individuals who received high-dose amphotericin B therapy (≥7.5 mg/kg) using lipid formulations. Nine patients were included in the case series, receiving an average of 8.9 ± 1.3 mg/kg liposomal amphotericin B over a mean of 11.0 ± 10.8 days predominantly for mould infections including Mucorales, aspergillosis and
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2719560-0
    ISSN 1740-4398 ; 1745-1981
    ISSN (online) 1740-4398
    ISSN 1745-1981
    DOI 10.7573/dic.2023-9-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ASO Author Reflections: Breast Cancer-Related Lymphedema (BCRL) Surveillance Recommendations with Bioimpedance Spectroscopy.

    Jeffers, Elizabeth J / Wagner, Jamie L / Kilgore, Lyndsey J

    Annals of surgical oncology

    2023  Volume 30, Issue 10, Page(s) 6266–6267

    MeSH term(s) Humans ; Female ; Breast Neoplasms/complications ; Breast Neoplasms/surgery ; Spectrum Analysis ; Lymphedema/diagnosis ; Lymphedema/etiology
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-14099-7
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  3. Article: Evaluation of the Closure of Patent Ductus Arteriosus With Ibuprofen Compared to Indomethacin.

    Jackson, Cory D / Capino, Amanda C / Stuart, Lindsay H / Wagner, Jamie L

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2023  Volume 28, Issue 7, Page(s) 618–627

    Abstract: Objective: Limited data exist comparing indomethacin and ibuprofen for the treatment of patent ductus arteriosus (PDA). The objective was to compare the safety and efficacy of indomethacin and ibuprofen for treatment of PDA closure.: Methods: This ... ...

    Abstract Objective: Limited data exist comparing indomethacin and ibuprofen for the treatment of patent ductus arteriosus (PDA). The objective was to compare the safety and efficacy of indomethacin and ibuprofen for treatment of PDA closure.
    Methods: This single-center, pre-test/post-test quasi-experiment included preterm infants admitted to the neonatal intensive care unit who received indomethacin (July 1, 2013-September 30, 2015) or ibuprofen (December 1, 2015-July 31, 2019) for PDA. Patients were excluded if they were thrombocytopenic, had existing kidney injury, unresolved intraventricular hemorrhage (IVH) or necrotizing enterocolitis (NEC) at treatment initiation. Data were obtained from the electronic health record. Study outcomes were complete PDA closure, degree of PDA closure, resolution of symptoms, and new-onset acute kidney injury (AKI), IVH, or NEC.
    Results: A total of 114 patients were included: 44 (39%) received indomethacin and 70 (61%) received -ibuprofen. Twenty-one (21%) patients experienced successful PDA closure within 1 week: 13 (32%) indomethacin patients and 8 (13%) ibuprofen patients (p = 0.023). PDA size reduction occurred in 43 (46%) patients with 29 (25%) experiencing complete symptom resolution. Significantly more indomethacin patients compared with ibuprofen patients experienced new-onset AKI (48% vs 17%; p < 0.001) and received concomitant nephrotoxins (68% vs 39%; p = 0.002). There were no significant differences in new-onset IVH or NEC.
    Conclusions: Indomethacin administration successfully closed the PDA in more neonates than ibuprofen but resulted in higher rates of AKI. However, this was confounded by more frequent administration of concomitant nephrotoxins. Larger trials are needed to help elucidate the optimal drug for closure of the PDA in neonates.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-28.7.618
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  4. Article ; Online: Contemporary pharmacologic treatments of MRSA for hospitalized adults: rationale for vancomycin versus non-vancomycin therapies as first line agents.

    Chang, Jack / Tasellari, Ardita / Wagner, Jamie L / Scheetz, Marc H

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 12, Page(s) 1309–1325

    Abstract: Introduction: Methicillin-resistant : Areas covered: Newer anti-MRSA antibiotics that have been approved since 2000 include linezolid, daptomycin, and ceftaroline. As clinical evidence has accumulated, these newer agents have become more frequently ... ...

    Abstract Introduction: Methicillin-resistant
    Areas covered: Newer anti-MRSA antibiotics that have been approved since 2000 include linezolid, daptomycin, and ceftaroline. As clinical evidence has accumulated, these newer agents have become more frequently used, and some are now recommended as co-first-line options (along with vancomycin) in clinical practice guidelines. For this review, a scoping review of the literature was conducted to support our findings and recommendations.
    Expert opinion: Vancomycin remains an important standard of care for MRSA infections but is limited with respect to nephrotoxicity and rapid target attainment. Newer agents such as linezolid, daptomycin, and ceftaroline have specific indications for treating different types of MRSA infections; however, newer agents also have unique attributes which require consideration during therapy.
    MeSH term(s) Adult ; Humans ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Linezolid/pharmacology ; Linezolid/therapeutic use ; Daptomycin/pharmacology ; Daptomycin/therapeutic use ; Anti-Bacterial Agents/adverse effects ; Staphylococcal Infections/drug therapy ; Ceftaroline
    Chemical Substances Vancomycin (6Q205EH1VU) ; Linezolid (ISQ9I6J12J) ; Daptomycin (NWQ5N31VKK) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2275663
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  5. Article ; Online: ASO Author Reflections: ADH Upgrade Rate is Not Elevated by Presence of Ipsilateral Concurrent Breast Cancer.

    Amin, Amanda L / Wagner, Jamie L

    Annals of surgical oncology

    2020  Volume 27, Issue Suppl 3, Page(s) 705–706

    MeSH term(s) Breast Neoplasms ; Humans
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08947-z
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  6. Article ; Online: A primer on Post-COVID-19 conditions and implications for clinical pharmacists.

    Cluck, David / Covert, Kelly L / Wagner, Jamie L / Chastain, Daniel B

    Journal of the American College of Clinical Pharmacy : JACCP

    2022  Volume 5, Issue 7, Page(s) 716–724

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and is largely viewed as an acute illness involving multiple organ systems. In the wake of the acute illness, many survivors fully recover and ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and is largely viewed as an acute illness involving multiple organ systems. In the wake of the acute illness, many survivors fully recover and return to baseline, while others suffer from a wide range of lingering symptoms collectively known as "post-COVID conditions". The recognition of these conditions as a clinical entity represents the first step in developing a targeted plan for recovery and symptom mitigation. While interventions to directly minimize or reduce new, recurrent, or persistent symptoms are currently unknown, pharmacists can play a key role in optimizing management of these patients.
    Language English
    Publishing date 2022-06-11
    Publishing country United States
    Document type Journal Article
    ISSN 2574-9870
    ISSN (online) 2574-9870
    DOI 10.1002/jac5.1655
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  7. Article ; Online: ASHP/SIDP Joint Statement on the Pharmacist's Role in Antimicrobial Stewardship.

    Collins, Curtis D / Dumkow, Lisa E / Kufel, Wesley D / Nguyen, Cynthia T / Wagner, Jamie L

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2023  Volume 80, Issue 21, Page(s) 1577–1581

    MeSH term(s) Humans ; Pharmacists ; Antimicrobial Stewardship ; Societies, Pharmaceutical
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxad164
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    Zs.A 419: Show issues Location:
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  8. Article ; Online: Developing Authentic Mentorship Through Professional Organizations.

    Shields, Kelly M / Eiland, Lea S / Zitko, Kimberly L / Wagner, Jamie L

    American journal of pharmaceutical education

    2022  Volume 87, Issue 3, Page(s) ajpe9006

    Abstract: Harsh realities in pandemic fatigue, burnout, inequities, and isolation are impacting academic pharmacy. Mentoring programs, especially inter-institutional programs such as those provided within the Sections and Special Interest Groups (SIGs) of the ... ...

    Abstract Harsh realities in pandemic fatigue, burnout, inequities, and isolation are impacting academic pharmacy. Mentoring programs, especially inter-institutional programs such as those provided within the Sections and Special Interest Groups (SIGs) of the American Association of Colleges of Pharmacy (AACP), may combat some of these issues. Unfortunately, year after year, Academy members continue to request information from these groups on mentoring, whether it be the opportunity to pair up, for advice on how to be better mentors, or for guidance on how to develop a program on mentoring for the Sections and SIGs without an existing program. The need for authentic mentoring is vital to the success and retention of faculty and staff within the Academy. Therefore, it may be appropriate to take a closer look at why, despite ongoing mentoring programs scattered within AACP Sections and SIGs, these programs are unable to fulfill the needs of participants.
    MeSH term(s) Humans ; Mentors ; Education, Pharmacy ; Mentoring ; Faculty ; Societies
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.5688/ajpe9006
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    Zs.A 924: Show issues Location:
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  9. Article ; Online: Activities to enhance introductory pharmacy practice experiences.

    Wagner, Jamie L / Barber, Katie E / Stover, Kayla R

    Currents in pharmacy teaching & learning

    2021  Volume 13, Issue 9, Page(s) 1127–1134

    Abstract: Introduction: The goal of this initiative was to provide a meaningful introductory pharmacy practice experience (IPPE) to third-year students when opportunities for direct patient interaction are limited.: Methods: A single, pretest/posttest quasi- ... ...

    Abstract Introduction: The goal of this initiative was to provide a meaningful introductory pharmacy practice experience (IPPE) to third-year students when opportunities for direct patient interaction are limited.
    Methods: A single, pretest/posttest quasi-experiment was used to evaluate the impact of a structured pharmacy-based education series (intervention 1) and an interprofessional simulation (intervention 2) during combined internal medicine (IM) and infectious diseases (ID) IPPEs. Intervention 1 consisted of five, three-part pharmacy-based educational sessions, while intervention 2 consisted of an interprofessional simulated rounding experience. Pre- and post-rotation examinations were given to evaluate the impact of the interventions on student knowledge. Confidence was measured in 11 or 12-question pre- and post-surveys using a four-point Likert scale: strongly disagree, disagree, agree, strongly agree.
    Results: Thirty-six students (30 in intervention 1 and six in intervention 2) were included. In intervention 1, there was a 19% improvement in IM knowledge (45% vs. 64%) and 10% improvement in ID knowledge (40% vs. 50%). In intervention 2, there was a significant improvement in both IM (30% vs. 40%) and ID (50% vs. 65%) and knowledge questions (10% and 15% improvements, respectively). In both interventions, most students reported increased confidence.
    Conclusions: Knowledge and confidence improved in both intervention groups, demonstrating that there are ways to enhance IPPEs without direct patient interaction.
    MeSH term(s) Curriculum ; Education, Pharmacy ; Humans ; Pharmaceutical Services ; Pharmacy ; Students, Pharmacy
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2021.06.028
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  10. Article ; Online: Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic.

    Veve, Michael P / Wagner, Jamie L

    Pharmacotherapy

    2018  Volume 38, Issue 9, Page(s) 935–946

    Abstract: The emergence and spread of antimicrobial resistance have led to a global public health emergency requiring development of new antimicrobial classes. Lefamulin (formally BC-3781) is a novel pleuromutilin antibiotic currently undergoing Food and Drug ... ...

    Abstract The emergence and spread of antimicrobial resistance have led to a global public health emergency requiring development of new antimicrobial classes. Lefamulin (formally BC-3781) is a novel pleuromutilin antibiotic currently undergoing Food and Drug Administration review for community-acquired bacterial pneumonia (CABP) as intravenous (IV) and oral (PO) formulations. Although pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial infections in humans. Lefamulin exhibits a unique mechanism of action through inhibition of protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer. Lefamulin displays activity against gram-positive and atypical organisms associated with CABP (i.e., Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae), with an expanded gram-positive spectrum including Staphylococcus aureus (i.e., methicillin-resistant, vancomycin-intermediate, and heterogeneous strains) and vancomycin-resistant Enterococcus faecium. Lefamulin was also shown to retain activity against multidrug-resistant Neisseria gonorrhoeae and Mycoplasma genitalium. Lefamulin exhibits time-dependent killing, and the pharmacodynamic target best associated with antibacterial activity is ƒAUC
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections/drug therapy ; Diterpenes/adverse effects ; Diterpenes/pharmacokinetics ; Diterpenes/pharmacology ; Diterpenes/therapeutic use ; Drug Resistance ; Drug Resistance, Microbial ; Humans ; Microbial Sensitivity Tests/statistics & numerical data ; Thioglycolates/adverse effects ; Thioglycolates/pharmacokinetics ; Thioglycolates/pharmacology ; Thioglycolates/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Diterpenes ; Thioglycolates ; lefamulin (21904A5386)
    Language English
    Publishing date 2018-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.2166
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    Zs.MO 585: Show issues

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