Article ; Online: Clinical and Ophthalmological Characteristics of Ocular Syphilis in a Retrospective Tertiary Hospital Cohort.
2020 Volume 48, Issue 6, Page(s) 436–442
Abstract: Background: Data on ocular syphilis (OS) and its clinical presentation are currently insufficient. This study aimed to investigate the characteristics of a cohort with a high OS incidence at a university hospital in Germany, focusing on the clinical ... ...
| Abstract | Background: Data on ocular syphilis (OS) and its clinical presentation are currently insufficient. This study aimed to investigate the characteristics of a cohort with a high OS incidence at a university hospital in Germany, focusing on the clinical presentation of OS. Methods: This single-center cohort study retrospectively analyzed data on 90 patients with 109 episodes of syphilis between 2008 and 2018. Cases of OS were identified and additionally reevaluated through a study-specific secondary assessment by an ophthalmologist specializing in uveitis. Results: Twenty-three patients (26%) were diagnosed with OS, 16 (70%) of whom were with binocular involvement. Uveitis, especially that of the posterior segment, showed a high prevalence. Lumbar puncture was performed in 20 OS patients (87%), of whom 17 (85% of those with lumbar puncture/74% in total) met the 2018 Centers for Disease Control and Prevention criteria for likely neurosyphilis. Five (22%) of 23 patients had HIV infection, of whom 2 did not receive antiretroviral therapy. The preferred syphilis treatment regimens were benzylpenicillin and ceftriaxone, which yielded favorable serological, clinical, and ophthalmological outcomes. Conclusions: A high incidence of OS was identified, and physicians should be aware of uveitis as a manifestation of syphilis. Most patients presented with uveitis and syphilis in an early or late latent stage and showed central nervous system involvement. |
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| MeSH term(s) | Cohort Studies ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Neurosyphilis/diagnosis ; Neurosyphilis/drug therapy ; Neurosyphilis/epidemiology ; Retrospective Studies ; Syphilis/diagnosis ; Syphilis/drug therapy ; Syphilis/epidemiology ; Syphilis Serodiagnosis ; Tertiary Care Centers | |||||
| Language | English | |||||
| Publishing date | 2020-12-15 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 435191-5 | |||||
| ISSN | 1537-4521 ; 0148-5717 | |||||
| ISSN (online) | 1537-4521 | |||||
| ISSN | 0148-5717 | |||||
| DOI | 10.1097/OLQ.0000000000001329 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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