LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 18

Search options

  1. Book ; Thesis: Funktionenbasierte Vorgehensweise zur Ideenfindung für hybride Produkte in den frühen Phasen der Produktentwicklung

    Wagner, Lena

    (Schriftenreihe zu Arbeitswissenschaft und Technologiemanagement ; 5)

    2013  

    Author's details Lena Wagner
    Series title Schriftenreihe zu Arbeitswissenschaft und Technologiemanagement ; 5
    Keywords Produktentwicklung ; Hybrides Leistungsbündel ; Kreativität
    Language German
    Size 202 S., Ill., graph. Darst.
    Publisher Fraunhofer-Verl
    Publishing place Stuttgart
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss (Nicht für den Austausch)--Stuttgart, 2013
    ISBN 9783839605295 ; 3839605296
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Thesis: Funktionenbasierte Vorgehensweise zur Ideenfindung für hybride Produkte in den frühen Phasen der Produktentwicklung

    Wagner, Lena

    (Schriftenreihe zu Arbeitswissenschaft und Technologiemanagement ; 5)

    2013  

    Author's details Lena Wagner
    Series title Schriftenreihe zu Arbeitswissenschaft und Technologiemanagement ; 5
    Keywords Produktentwicklung ; Hybrides Leistungsbündel ; Kreativität
    Language German
    Size 202 S., Ill., graph. Darst.
    Publisher Fraunhofer-Verl
    Publishing place Stuttgart
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss (Nicht für den Austausch)--Stuttgart, 2013
    ISBN 9783839605295 ; 3839605296
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells.

    Cichoń, Małgorzata Anna / Pfisterer, Karin / Leitner, Judith / Wagner, Lena / Staud, Clement / Steinberger, Peter / Elbe-Bürger, Adelheid

    eLife

    2022  Volume 11

    Abstract: Skin is an active immune organ where professional antigen-presenting cells such as epidermal Langerhans cells (LCs) link innate and adaptive immune responses. While Reticulon 1A (RTN1A) was recently identified in LCs and dendritic cells in cutaneous and ... ...

    Abstract Skin is an active immune organ where professional antigen-presenting cells such as epidermal Langerhans cells (LCs) link innate and adaptive immune responses. While Reticulon 1A (RTN1A) was recently identified in LCs and dendritic cells in cutaneous and lymphoid tissues of humans and mice, its function is still unclear. Here, we studied the involvement of this protein in cytoskeletal remodeling and immune responses toward pathogens by stimulation of Toll-like receptors (TLRs) in resident LCs (rLCs) and emigrated LCs (eLCs) in human epidermis ex vivo and in a transgenic THP-1 RTN1A
    MeSH term(s) Animals ; Dendrites/immunology ; Epidermis/metabolism ; Humans ; Immunity ; Langerhans Cells/immunology ; Lipoproteins/metabolism ; Mice ; Nerve Tissue Proteins/metabolism ; RNA/metabolism ; Toll-Like Receptor 1/metabolism ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptors/metabolism
    Chemical Substances Lipoproteins ; Nerve Tissue Proteins ; RTN1 protein, human ; Toll-Like Receptor 1 ; Toll-Like Receptor 2 ; Toll-Like Receptor 7 ; Toll-Like Receptors ; RNA (63231-63-0)
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.80578
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Situated Visual Analysis and Live Monitoring for Manufacturing.

    Becher, Michael / Herr, Dominik / Muller, Christoph / Kurzhals, Kuno / Reina, Guido / Wagner, Lena / Ertl, Thomas / Weiskopf, Daniel

    IEEE computer graphics and applications

    2022  Volume 42, Issue 2, Page(s) 33–44

    Abstract: Modern machines continuously log status reports over long periods of time, which are valuable data to optimize working routines. Data visualization is a commonly used tool to gain insights into these data, mostly in retrospective (e.g., to determine ... ...

    Abstract Modern machines continuously log status reports over long periods of time, which are valuable data to optimize working routines. Data visualization is a commonly used tool to gain insights into these data, mostly in retrospective (e.g., to determine causal dependencies between the faults of different machines). We present an approach to bring such visual analyses to the shop floor to support reacting to faults in real time. This approach combines spatio-temporal analyses of time series using a handheld touch device with augmented reality for live monitoring. Important information augments machines directly in their real-world context, and detailed logs of current and historical events are displayed on the handheld device. In collaboration with an industry partner, we designed and tested our approach on a live production line to obtain feedback from operators. We compare our approach for monitoring and analysis with existing solutions that are currently deployed.
    MeSH term(s) Augmented Reality ; Commerce ; Feedback ; Industry ; Retrospective Studies
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1558-1756
    ISSN (online) 1558-1756
    DOI 10.1109/MCG.2022.3157961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability.

    Benabdallah, Nezha S / Dalal, Vineet / Scott, R Wilder / Marcous, Fady / Sotiriou, Afroditi / Kommoss, Felix K F / Pejkovska, Anastasija / Gaspar, Ludmila / Wagner, Lena / Sánchez-Rivera, Francisco J / Ta, Monica / Thornton, Shelby / Nielsen, Torsten O / Underhill, T Michael / Banito, Ana

    Nature structural & molecular biology

    2023  Volume 30, Issue 11, Page(s) 1640–1652

    Abstract: The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich ... ...

    Abstract The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C terminus, which can be exploited by fusion to transcriptional regulators beyond SS18. Accordingly, SS18-SSX recruitment occurs in a manner that is independent of the core components and catalytic activity of BAF. Alternative SSX fusions are also recruited to H2AK119ub1-rich chromatin and reproduce the expression signatures of SS18-SSX by engaging with transcriptional activators. Variant Polycomb repressive complex 1.1 (PRC1.1) acts as the main depositor of H2AK119ub1 and is therefore required for SS18-SSX occupancy. Importantly, the SSX C terminus not only depends on H2AK119ub1 for localization, but also further increases it by promoting PRC1.1 complex stability. Consequently, high H2AK119ub1 levels are a feature of murine and human synovial sarcomas. These results uncover a critical role for SSX-C in mediating gene deregulation in synovial sarcoma by providing specificity to chromatin and further enabling oncofusion binding by enhancing PRC1.1 stability and H2AK119ub1 deposition.
    MeSH term(s) Humans ; Animals ; Mice ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/metabolism ; Polycomb Repressive Complex 1/genetics ; Transcriptional Activation ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Oncogene Proteins, Fusion/metabolism ; Cell Cycle Proteins/metabolism
    Chemical Substances Polycomb Repressive Complex 1 (EC 2.3.2.27) ; Chromatin ; Oncogene Proteins, Fusion ; PRC1 protein, human ; Cell Cycle Proteins
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-023-01096-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 56: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online ; Thesis: In vitro Aktivitätsbestimmung von experimentellen Chemotherapeutika gegen Plasmodium falciparum in Lambaréné, Gabun

    Wagner, Lena [Verfasser] / Kremsner, Peter [Akademischer Betreuer]

    2015  

    Author's details Lena Ines Wagner ; Betreuer: Peter G. Kremsner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies.

    Lukas, Marina / Velten, Britta / Sellner, Leopold / Tomska, Katarzyna / Hüellein, Jennifer / Walther, Tatjana / Wagner, Lena / Muley, Carolin / Wu, Bian / Oleś, Małgorzata / Dietrich, Sascha / Jethwa, Alexander / Bohnenberger, Hanibal / Lu, Junyan / Huber, Wolfgang / Zenz, Thorsten

    Leukemia

    2020  Volume 34, Issue 11, Page(s) 2934–2950

    Abstract: Drug combinations that target critical pathways are a mainstay of cancer care. To improve current approaches to combination treatment of chronic lymphocytic leukemia (CLL) and gain insights into the underlying biology, we studied the effect of 352 drug ... ...

    Abstract Drug combinations that target critical pathways are a mainstay of cancer care. To improve current approaches to combination treatment of chronic lymphocytic leukemia (CLL) and gain insights into the underlying biology, we studied the effect of 352 drug combination pairs in multiple concentrations by analysing ex vivo drug response of 52 primary CLL samples, which were characterized by "omics" profiling. Known synergistic interactions were confirmed for B-cell receptor (BCR) inhibitors with Bcl-2 inhibitors and with chemotherapeutic drugs, suggesting that this approach can identify clinically useful combinations. Moreover, we uncovered synergistic interactions between BCR inhibitors and afatinib, which we attribute to BCR activation by afatinib through BLK upstream of BTK and PI3K. Combinations of multiple inhibitors of BCR components (e.g., BTK, PI3K, SYK) had effects similar to the single agents. While PI3K and BTK inhibitors produced overall similar effects in combinations with other drugs, we uncovered a larger response heterogeneity of combinations including PI3K inhibitors, predominantly in CLL with mutated IGHV, which we attribute to the target's position within the BCR-signaling pathway. Taken together, our study shows that drug combination effects can be effectively queried in primary cancer cells, which could aid discovery, triage and clinical development of drug combinations.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards ; Drug Resistance, Neoplasm/genetics ; Drug Synergism ; High-Throughput Nucleotide Sequencing/methods ; High-Throughput Nucleotide Sequencing/standards ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Primary Cell Culture ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Receptors, Antigen, B-Cell/antagonists & inhibitors ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; Reproducibility of Results
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-bcl-2 ; Receptors, Antigen, B-Cell
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-020-0846-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.

    Li, Jinxiu / Mulvihill, Timothy S / Li, Li / Barrott, Jared J / Nelson, Mary L / Wagner, Lena / Lock, Ian C / Pozner, Amir / Lambert, Sydney Lynn / Ozenberger, Benjamin B / Ward, Michael B / Grossmann, Allie H / Liu, Ting / Banito, Ana / Cairns, Bradley R / Jones, Kevin B

    Cancer discovery

    2021  Volume 11, Issue 10, Page(s) 2620–2637

    Abstract: Reduced protein levels of SMARCB1 (also known as BAF47, INI1, SNF5) have long been observed in synovial sarcoma. Here, we show that ... ...

    Abstract Reduced protein levels of SMARCB1 (also known as BAF47, INI1, SNF5) have long been observed in synovial sarcoma. Here, we show that combined
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Oncogene Proteins, Fusion/genetics ; SMARCB1 Protein/genetics ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/pathology
    Chemical Substances Oncogene Proteins, Fusion ; SMARCB1 Protein ; SMARCB1 protein, human ; SS18-SSX1 fusion protein
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-1219
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Diversity-Management in öffentlichen Einrichtungen

    Ehrenmann, Steffen / Spitzley, Anne / Wagner, Lena

    Diversity im Innovationssystem , p. 197-209

    2010  , Page(s) 197–209

    Author's details Steffen Ehrenmann, Lena Wagner und Anne Spitzley
    Keywords Öffentlicher Sektor ; Diversity Management ; Kommunalverwaltung ; Frauenpolitik ; München
    Language German
    Publisher Fraunhofer-Verl.
    Publishing place Stuttgart
    Document type Article
    ISBN 978-3-8396-0105-1 ; 3-8396-0105-3
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Drug-microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL.

    Bruch, Peter-Martin / Giles, Holly Ar / Kolb, Carolin / Herbst, Sophie A / Becirovic, Tina / Roider, Tobias / Lu, Junyan / Scheinost, Sebastian / Wagner, Lena / Huellein, Jennifer / Berest, Ivan / Kriegsmann, Mark / Kriegsmann, Katharina / Zgorzelski, Christiane / Dreger, Peter / Zaugg, Judith B / Müller-Tidow, Carsten / Zenz, Thorsten / Huber, Wolfgang /
    Dietrich, Sascha

    Molecular systems biology

    2022  Volume 18, Issue 8, Page(s) e10855

    Abstract: The tumour microenvironment and genetic alterations collectively influence drug efficacy in cancer, but current evidence is limited and systematic analyses are lacking. Using chronic lymphocytic leukaemia (CLL) as a model disease, we investigated the ... ...

    Abstract The tumour microenvironment and genetic alterations collectively influence drug efficacy in cancer, but current evidence is limited and systematic analyses are lacking. Using chronic lymphocytic leukaemia (CLL) as a model disease, we investigated the influence of 17 microenvironmental stimuli on 12 drugs in 192 genetically characterised patient samples. Based on microenvironmental response, we identified four subgroups with distinct clinical outcomes beyond known prognostic markers. Response to multiple microenvironmental stimuli was amplified in trisomy 12 samples. Trisomy 12 was associated with a distinct epigenetic signature. Bromodomain inhibition reversed this epigenetic profile and could be used to target microenvironmental signalling in trisomy 12 CLL. We quantified the impact of microenvironmental stimuli on drug response and their dependence on genetic alterations, identifying interleukin 4 (IL4) and Toll-like receptor (TLR) stimulation as the strongest actuators of drug resistance. IL4 and TLR signalling activity was increased in CLL-infiltrated lymph nodes compared with healthy samples. High IL4 activity correlated with faster disease progression. The publicly available dataset can facilitate the investigation of cell-extrinsic mechanisms of drug resistance and disease progression.
    MeSH term(s) Disease Progression ; Humans ; Interleukin-4/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Nuclear Proteins/genetics ; Prognosis ; Transcription Factors/genetics ; Trisomy ; Tumor Microenvironment
    Chemical Substances Nuclear Proteins ; Transcription Factors ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.202110855
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top