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Article ; Online: Lenalidomide induced pneumonitis.

Finch, Kelsey / Sharma, Deepankar / Wagner, Stephanie

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 29, Issue 4, Page(s) 971–974

Abstract: Introduction: Iatrogenic lung injury is a very rare, albeit serious complication with antineoplastic therapy, including immunomodulatory drugs. Pneumonitis typically presents clinically with symptoms such as cough, dyspnea, fever, and hypoxemia. ... ...

Abstract	Introduction: Iatrogenic lung injury is a very rare, albeit serious complication with antineoplastic therapy, including immunomodulatory drugs. Pneumonitis typically presents clinically with symptoms such as cough, dyspnea, fever, and hypoxemia. Radiographic evaluation often demonstrates diffuse, patchy infiltrates and ground-glass opacities. Case report: We present a case in which therapy from an immunomodulatory drug, lenalidomide, elicited a pneumonitis in the form of a 9 cm lung mass. An exhaustive workup was completed to rule out viral, bacterial, and fungal infections as well as malignant causes. Lenalidomide-induced lung injury was suspected. Management and outcome: Lenalidomide was discontinued and corticosteroid therapy was initiated. This resulted in a complete clinical and radiographic resolution of symptoms. Discussion: Several case reports of pneumonitis have been associated with immunomodulatory drug therapy, and while most of these exhibit diffuse ground-glass opacities radiographically, our patient presented with a 9 cm lung mass. Our findings stress the importance of a thorough medication review while ruling out other potential causes of lung injury.
MeSH term(s)	Humans ; Lenalidomide/adverse effects ; Lung Injury/drug therapy ; Lung Injury/pathology ; Pneumonia/chemically induced ; Pneumonia/diagnostic imaging ; Lung/pathology ; Antineoplastic Agents/adverse effects
Chemical Substances	Lenalidomide (F0P408N6V4) ; Antineoplastic Agents
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221124533
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Book ; Online ; Thesis: Analyse von DNA-Doppelstrangbrüchen in Protonenbestrahlten 3D-Epidermismodellen

Wagner, Stephanie-Quinta Malike [Verfasser] / Port, Matthias [Akademischer Betreuer]

2023

Author's details	Stephanie-Quinta Malike Wagner ; Akademischer Betreuer: Matthias Port ; Institut für Radiobiologie der Bundeswehr in München
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	German
Publisher	Bibliothek der Medizinischen Hochschule Hannover
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Underserved and Undermeasured: a Mixed-Method Analysis of Family-Centered Care and Care Coordination for Low-Income Minority Families of Children with Autism Spectrum Disorder.

Wagner, Stephanie / Rubin, I Leslie / Singh, Jennifer S

Journal of racial and ethnic health disparities

2021 Volume 9, Issue 4, Page(s) 1474–1487

Abstract: This study examined how a racially and socioeconomically diverse group of caregivers of children with autism spectrum disorder (ASD) responds to national standard measures of family-centered care (FCC) and care coordination (CC) and what aspects of ... ...

Abstract	This study examined how a racially and socioeconomically diverse group of caregivers of children with autism spectrum disorder (ASD) responds to national standard measures of family-centered care (FCC) and care coordination (CC) and what aspects of quality care are missing from these measures. Based on survey and interview data collected from 70 caregivers who have a child with ASD that receive services at a community-based autism clinic located in Atlanta, GA, we compared proportions of answers to FCC and CC questions to national and state representative data using chi-square analyses and contextualized our findings through a thematic analysis of qualitative interviews. Compared to national- and state-level data, the Atlanta autism clinic data had a higher percentage of participants who identified as Black, relied on public health insurance, and lived below 200% of the federal poverty line. The Atlanta autism clinic responses were significantly more positive in four measures of FCC but significantly less effective in two CC measures, including a lower reported percentage who received CC and greater reported percentage who needed extra help. Qualitative data revealed a range of positive meanings and challenges associated with FCC and identified areas of help needed beyond CC, including physical and mental health care and emotional connection, especially for low-income single Black female caregivers. Our mixed-method approach identified strengths in FCC, barriers to CC, and suggestions for developing more pragmatic questions in national surveys that address experiences of quality-of-care among low-income, racial minority families of children with ASD.
MeSH term(s)	Autism Spectrum Disorder/therapy ; Child ; Female ; Humans ; Minority Groups ; Patient-Centered Care ; Poverty ; Surveys and Questionnaires
Language	English
Publishing date	2021-07-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-021-01086-5
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Article ; Online: Association of glial tau pathology and LATE-NC in the ageing brain.

Forrest, Shelley L / Wagner, Stephanie / Kim, Ain / Kovacs, Gabor G

Neurobiology of aging

2022 Volume 119, Page(s) 77–88

Abstract: Ageing-related pathologies of the brain include neurofibrillary tangles, argyrophilic grains, ageing-related tau astrogliopathy (ARTAG), limbic-predominant age-related TDP-43 encephalopathy-neuropathological change (LATE-NC), vascular pathology and ... ...

Abstract	Ageing-related pathologies of the brain include neurofibrillary tangles, argyrophilic grains, ageing-related tau astrogliopathy (ARTAG), limbic-predominant age-related TDP-43 encephalopathy-neuropathological change (LATE-NC), vascular pathology and corpora amylacea. This study used an unbiased approach to evaluate a broad range of pathologies in an unselected European community-dwelling ageing cohort of 101 individuals (77-90 years). Pathological alterations observed included neurofibrillary tangles and corpora amylacea in all cases, ARTAG (79%), Thal amyloid-β phase >1 (60%), cerebral amyloid angiopathy (39%), Lewy bodies (22%), LATE-NC (21%), oligodendroglial tau-positive coiled bodies (33%), and argyrophilic grains (15%). We demonstrate association of LATE-NC with the previously unappreciated age-related tau oligodendrogliopathy (ARTOG) and highlight the association of LATE-NC with various ARTAG types pointing toward common pathogenic aspects. Only neurofibrillary tangles and LATE-NC were associated with cognitive decline. This study broadens the spectrum of age-related brain pathologies and highlights a novel ageing-related tau pathology in oligodendroglia. Results from this study suggest overlapping pathogenic mechanisms between LATE-NC and glial tau pathologies in the medial temporal lobe.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/genetics ; Aging/pathology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Brain/metabolism ; Brain/pathology ; DNA-Binding Proteins/metabolism ; Dementia/genetics ; Dementia/pathology ; Humans ; Neurofibrillary Tangles/genetics ; Neurofibrillary Tangles/pathology ; Neuroglia/metabolism ; Neuroglia/pathology ; Oligodendroglia/metabolism ; Oligodendroglia/pathology ; TDP-43 Proteinopathies/genetics ; TDP-43 Proteinopathies/pathology ; Temporal Lobe/metabolism ; Temporal Lobe/pathology ; tau Proteins/genetics ; tau Proteins/metabolism
Chemical Substances	DNA-Binding Proteins ; tau Proteins
Language	English
Publishing date	2022-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2022.07.010
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Development and validation of a questionnaire to measure the severity of pain, functional limitations, and reduction of sports ability for german-speaking patients with osteochondral lesions of the ankle (OCLA-G).

Lohrer, Heinz / Wagner, Stephanie / Wenning, Markus / Kühle, Jan / Schmal, Hagen / Gollhofer, Albert

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 340

Abstract: Background: There is no patient-reported functional scale specific for osteochondral lesion of the ankle (OCLA). Therefore, the objectives of this study were to develop a questionnaire that measures symptom severity, function, and sports capacity in ... ...

Abstract	Background: There is no patient-reported functional scale specific for osteochondral lesion of the ankle (OCLA). Therefore, the objectives of this study were to develop a questionnaire that measures symptom severity, function, and sports capacity in patients with osteochondral lesions of the ankle and to determine the psychometric properties of the tool in German language (OCLA-G). Methods: The OCLA-G questionnaire was developed according to the COSMIN guidelines. Scalable items were generated from a literature search, based on an evaluation of 71 own OCLA patients, and from expert opinions. Following a twofold item reduction the questionnaire underwent explorative data analysis and principal component analysis. Validity and reliability were analysed in four groups of participants (40 patients with OCLA, 40 patients with other foot and ankle injuries, 40 asymptomatic athletes serving as a population at risk, and 40 asymptomatic persons playing sports not at risk). The minimum age for participation in the study was set at 18 years. The mean age was 39.3 ± 15.1 years. Results: The final OCLA-G questionnaire consists of eight and five questions to mirror activities of daily life (ADL) and sports, respectively. Excellent internal consistency (Cronbach's α = 0.950 for the ADL subscore and 0.965 for the sport subscale, respectively) was found. Spearman's rank correlation coefficients for test-retest reliability were 0.992 for the ADL subscore and 0.999 for the sport subscale (p < 0.001). The results of the exploratory and confirmatory factor analyses indicated that item difficulty was between 23.4 and 62.8. The Pearson correlation for the OCLA subscales ADL and sport was 0.853 (p < 0.001). Construct validity as tested against the SF-12 questionnaire subscales (Physical and Mental component scale) were r = -0.164 to -0.663 (p < 0.05). Statistically, there was no ADL and sport OCLA mean score difference between OCLA patients and patients with other foot and ankle injuries (p = 0.993 and 0.179, respectively), but both groups differed from the uninjured control groups (p < 0.001). There were no ceiling or floor effects. Conclusions: The OCLA-G was successfully developed as the first patient reported and injury specific outcome scale to measure the impact of OCLA induced symptoms on activities of daily living and sport. This study provides evidence for the reliability and validity of the OCLA-G assessing patients with OCLA. Trial registration: The registration trial number is DRKS00009401 on DRKS. 'Retrospectively registered'. Date of registration: 10/12/2015.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Adolescent ; Ankle ; Activities of Daily Living ; Reproducibility of Results ; Disability Evaluation ; Surveys and Questionnaires ; Language ; Ankle Injuries ; Intra-Articular Fractures ; Psychometrics/methods ; Pain
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06445-3
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Article ; Online: Differences in mobile food market customer outcomes between 2019 and 2021.

Horning, Melissa L / Bell, Adrianna / Porter, Leah / Wagner, Stephanie / Alver, Bonnie / Kamdar, Nipa

Public health nursing (Boston, Mass.)

2023 Volume 40, Issue 5, Page(s) 603–611

Abstract: Objectives: To evaluate the outcomes of increasing mobile market service from mostly biweekly in 2019 to weekly in 2021.: Design: Repeated, cross-sectional customer intercept surveys.: Sample: Mobile market customers in Summers 2019 (N = 302) and ... ...

Abstract	Objectives: To evaluate the outcomes of increasing mobile market service from mostly biweekly in 2019 to weekly in 2021. Design: Repeated, cross-sectional customer intercept surveys. Sample: Mobile market customers in Summers 2019 (N = 302) and 2021 (N = 72). Intervention: Mobile food markets bring affordable, high-quality foods to communities that lack such access. Measures/analysis: Outcomes included food security, fruit/vegetable intake, and food-related characteristics and behaviors. General linear and logistic regression models were used to assess associations between outcomes and survey year and length of mobile market shopping. Models were adjusted for economic assistance use, race, and ethnicity. Results: No outcomes were significantly different between 2019 (with mostly biweekly service) and 2021 (with weekly service). Length of mobile market shopping (e.g., >2 years, 1-2 years, etc.) was positively associated with affordable, quality food access (β = 0.20, SE = 0.10, p = .03) and fruit/vegetable intake (β = 0.28, SE = 0.08, p < .001) as well as lower odds of food insecurity in the last 12 months (aOR = 0.79, 95% CI = 0.64, 0.99). Conclusions: Despite COVID-19 interrupting scheduled market service, the length of time that a survey respondent identified as a full-service mobile market customer was associated with higher food access and fruit/vegetable intake and reduced food insecurity odds. These findings suggest promise and encourage further evaluation.
MeSH term(s)	Humans ; Diet ; Fruit ; Vegetables ; Cross-Sectional Studies ; Food Supply ; Surveys and Questionnaires ; Food Assistance
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	632563-4
ISSN	1525-1446 ; 0737-1209
ISSN (online)	1525-1446
ISSN	0737-1209
DOI	10.1111/phn.13202
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Article: Social vulnerability and COVID-19: A call to action for paediatric clinicians.

Prodanuk, Michael / Wagner, Stephanie / Orkin, Julia / Noone, Damien

Paediatrics & child health

2020 Volume 26, Issue 1, Page(s) 1–3

Abstract: The COVID-19 pandemic has had dramatic effects on the lives of children globally. However, socially vulnerable children have been particularly impacted. Certain populations have increased vulnerabilities, including children and youth experiencing ... ...

Abstract	The COVID-19 pandemic has had dramatic effects on the lives of children globally. However, socially vulnerable children have been particularly impacted. Certain populations have increased vulnerabilities, including children and youth experiencing homelessness. Increased infection risk due to congregant living and challenges with physical distancing are contributing factors. An urgent need exists for a wholistic approach to care with unique cross-sectoral partnerships across disciplines. A recognition of the unintended consequence of the COVID-19 pandemic on this population is urgently required by all those supporting children. Families should receive direct support in clinical settings to identify their social needs. Partnership with community agencies and advocacy for appropriate isolation facilities for patients experiencing homelessness are critical.
Language	English
Publishing date	2020-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2106767-3
ISSN	1918-1485 ; 1205-7088
ISSN (online)	1918-1485
ISSN	1205-7088
DOI	10.1093/pch/pxaa121
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Article ; Online: BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.

O'Connor, Susan M / Sleebs, Brad E / Street, Ian P / Flynn, Bernard L / Baell, Jonathan B / Coles, Carolyn / Quazi, Nurul / Paul, Dharam / Poiraud, Etienne / Huyard, Bertrand / Wagner, Stephanie / Andriambeloson, Emile / de Souza, Errol B

Neuropharmacology

2024 Volume 246, Page(s) 109836

Abstract: This work describes the characterization of BNC210 (6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one), a selective, small molecule, negative allosteric modulator (NAM) of α7 nicotinic acetylcholine ... ...

Abstract	This work describes the characterization of BNC210 (6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one), a selective, small molecule, negative allosteric modulator (NAM) of α7 nicotinic acetylcholine receptors (α7 nAChR). With the aim to discover a non-sedating, anxiolytic compound, BNC210 was identified during phenotypic screening of a focused medicinal chemistry library using the mouse Light Dark (LD) box to evaluate anxiolytic-like activity and the mouse Open Field (OF) (dark) test to detect sedative and/or motor effects. BNC210 exhibited anxiolytic-like activity with no measurable sedative or motor effects. Electrophysiology showed that BNC210 did not induce α7 nAChR currents by itself but inhibited EC
MeSH term(s)	Rats ; Male ; Mice ; Humans ; Animals ; alpha7 Nicotinic Acetylcholine Receptor/metabolism ; Anti-Anxiety Agents/pharmacology ; Rodentia/metabolism ; Receptors, Nicotinic/metabolism ; Antidepressive Agents ; Hypnotics and Sedatives ; Allosteric Regulation
Chemical Substances	alpha7 Nicotinic Acetylcholine Receptor ; Anti-Anxiety Agents ; Receptors, Nicotinic ; Antidepressive Agents ; Hypnotics and Sedatives
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2024.109836
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Book ; Online ; Thesis: Reduzierte Expression der miRNA196a2 führt über den Transkriptionsfaktor ERG zu einer Hochregulation der Transkriptionsvariante 1 von DUSP4 im malignen Melanom

Wagner, Stephanie

2013

Author's details	vorgelegt von Stephanie Wagner
Language	German
Size	Online-Ressource, Ill., graph. Darst.
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Regensburg, 2013
Database	Former special subject collection: coastal and deep sea fishing

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Article: The use of the dynamic weight bearing test to assess the effects of acute, intramuscularly administered botulinum neurotoxin type A1 in rats

Cornet, Sylvie / Périer, Cindy / Wagner, Stéphanie / Andriambeloson, Emile / Pouzet, Bruno / Kalinichev, Mikhail

Toxicon: X. 2020 Sept., v. 7

2020

Abstract: Assessing the efficacy of botulinum neurotoxin (BoNT) in vivo is essential given the growing number of BoNT products used in the clinic. Here, we evaluated the dynamic weight bearing (DWB) test for sensitivity to paralytic effects of BoNT-A following ... ...

Abstract	Assessing the efficacy of botulinum neurotoxin (BoNT) in vivo is essential given the growing number of BoNT products used in the clinic. Here, we evaluated the dynamic weight bearing (DWB) test for sensitivity to paralytic effects of BoNT-A following intramuscular administration. The toxin was administered into the gastrocnemius lateralis as a single bolus or into the gastrocnemius lateralis and medialis as two boluses. The effects of BoNT-A in DWB were compared to those in the compound muscle action potential (CMAP) and the Digit Abduction Score (DAS) tests. Female Sprague-Dawley rats received an acute, intramuscular (i.m.) injection of BoNT-A1 (0.1, 1, 10 pg/rat) into the right gastrocnemius muscle, while the left received vehicle. The DWB and CMAP tests were performed one-two days after the injection in order to detect the onset of sub-maximal BoNT-A activity. Both tests were preceded by the DAS test. BoNT-A produced dose-related reductions in both the weight-bearing and surface-bearing outcomes of up to 60% while showing moderate activity in the DAS. BoNT-A effects in the DWB test were well-aligned with those in the CMAP test, which showed dose-dependent reductions in CMAP amplitude and the area under the curve (AUC; up to 100%) as well as increases in latency (up to 130%). The efficacy of BoNT-A in DWB and CMAP was more pronounced with two boluses. Thus, the DWB test can be used to assess the properties of BoNTs following i.m. administration. It can be used to assess the candidate therapies and is more ethical than the mouse lethality assay.
Keywords	action potentials ; botulinum toxin ; death ; dose response ; ethics ; females ; intramuscular injection ; mice ; muscles ; rats
Language	English
Dates of publication	2020-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ISSN	2590-1710
DOI	10.1016/j.toxcx.2020.100041
Database	NAL-Catalogue (AGRICOLA)

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