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  1. Book ; Thesis: HLA-Klasse-II-Moleküle in der Pathogenese der rheumatoiden Arthritis

    Wagner, Ulf

    die Bedeutung der immunologischen Synapse

    2002  

    Author's details vorgelegt von Ulf Wagner
    Language German ; English
    Size IV, 136 Bl. : Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Habil.-Schr., 2003
    Note Beitr. teilw. dt., teilw. engl. - Enth. 8 Sonderabdr. aus verschiedenen Zeitschr.
    HBZ-ID HT014002497
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 D 2757 order to use in reading room Magazin

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  2. Article: Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation.

    Werner, Lina Emilia / Wagner, Ulf

    Frontiers in physiology

    2023  Volume 13, Page(s) 1078569

    Abstract: The calcium-sensing receptor (CaSR) is expressed in many cell types - including immune cells and in particular circulating monocytes. Here, the receptor plays an important physiological role as a regulator of constitutive macropinocytosis. This review ... ...

    Abstract The calcium-sensing receptor (CaSR) is expressed in many cell types - including immune cells and in particular circulating monocytes. Here, the receptor plays an important physiological role as a regulator of constitutive macropinocytosis. This review article provides an overview of the literature on the role of the calcium sensing receptor in the context of inflammatory processes. Special emphasis is laid upon the importance for monocytes in the context of rheumatoid arthritis. We have shown previously, that stimulation of the receptor by increased extracellular Ca
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1078569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: HLA-Klasse-II-Genotypisierng bei Patienten mit rheumatoider Arthritis

    Wagner, Ulf

    Korrelation zum klinischen Verlauf

    1996  

    Author's details eingereicht von Ulf Wagner
    Language German
    Size 73, [14] S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 1996
    HBZ-ID HT007146541
    Database Catalogue ZB MED Medicine, Health

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    96 D 1288 order for loan Magazin

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  4. Article: Influenza, Pneumococcal and Herpes Zoster Vaccination Rates in Patients with Autoimmune Inflammatory Rheumatic Diseases.

    Krasselt, Marco / Wagner, Ulf / Seifert, Olga

    Vaccines

    2023  Volume 11, Issue 4

    Abstract: Background: Vaccination rates are known to be low in patients with autoimmune inflammatory rheumatic diseases (AIIRD). We therefore aimed to determine current vaccination rates against influenza, Streptococcus pneumoniae and herpes zoster in a cohort of ...

    Abstract Background: Vaccination rates are known to be low in patients with autoimmune inflammatory rheumatic diseases (AIIRD). We therefore aimed to determine current vaccination rates against influenza, Streptococcus pneumoniae and herpes zoster in a cohort of patients with AIIRD in Germany.
    Methods: Consecutive adult patients with an AIIRD were recruited from our outpatient clinic during their regular consultations. The individual vaccination status regarding influenza, Streptococcus pneumoniae and herpes zoster was obtained by reviewing the vaccination documents.
    Results: A total of 222 AIIRD patients (mean age 62.9 ± 13.9 years) were included. In total, 68.5% were vaccinated against influenza, 34.7% against Streptococcus pneumoniae and 13.1% against herpes zoster (HZ). The pneumococcal vaccination was outdated in 29.4% of the vaccinated patients. Vaccination rates were significantly higher in patients ≥60 years old (odds ratio (OR) 2.167, 95% confidence interval (CI) 1.213-3.870,
    Conclusions: The frequencies of vaccinations against influenza, Streptococcus pneumoniae and HZ have increased during recent years. While this can be partly explained by continuous efforts in patient education during the outpatient visits, the COVID-19 pandemic might also have contributed. Nevertheless, the persistently high incidence and mortality of these preventable diseases in patients with AIIRDs mandates further efforts to increase vaccination coverage, particularly in SLE patients.
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11040760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Conference proceedings: Development of an in-tube diagnostic assay for cellular autoimmune monitoring in psoriatic arthritis

    Wagner, Ulf / Krasselt, Marco / Gruz, Natalya

    2023  , Page(s) ET.20

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh040
    Database German Medical Science

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  6. Article: IL-10 Induced by mTNF Crosslinking-Mediated Reverse Signaling in a Whole Blood Assay Is Predictive of Response to TNFi Therapy in Rheumatoid Arthritis.

    Krasselt, Marco / Gruz, Natalya / Pierer, Matthias / Baerwald, Christoph / Wagner, Ulf

    Journal of personalized medicine

    2022  Volume 12, Issue 6

    Abstract: 1) Background: To date, the response of patients with rheumatoid arthritis (RA) to the various biologic DMARD available cannot be predicted due to a lack of reliable biomarkers. Based on our preliminary work on tmTNF reverse signaling, we developed a ... ...

    Abstract (1) Background: To date, the response of patients with rheumatoid arthritis (RA) to the various biologic DMARD available cannot be predicted due to a lack of reliable biomarkers. Based on our preliminary work on tmTNF reverse signaling, we developed a whole-blood assay measuring tmTNF crosslinking-induced IL-10 production to predict the response to TNF inhibitor (TNFi) therapy. (2) Methods: This prospective study included patients with active RA. Depending on the clinical judgment of the attending rheumatologist, either therapy with a TNF or JAK inhibitor was initiated. Clinical parameters and blood samples were obtained at baseline and after 8 weeks of therapy. The blood samples were collected using a newly developed whole-blood assay based on the principle of tmTNF reverse signalling. Subsequently, IL-10 was measured via enzyme-linked immunosorbent assay (ELISA) technique. (3) Results: 63 patients with RA were enrolled. In fifteen patients, TNFi therapy was initiated, while eight patients started a JAKi treatment. The cross-sectional analysis of all patients showed a positive correlation between tmTNF crosslinking-induced IL-10 and parameters of disease activity (CRP [r = 0.4091,
    Language English
    Publishing date 2022-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12061003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: IMPAM TP1: Migration und Retention von CD4+ T-Zellen in der rheumatoiden Synovialmembran, IMPAM TP8A: CD44 and the pathogenic rheumatic memory

    Kunz, Manfred / Wagner, Ulf

    Schlussbericht ; Berichtzeitraum: 01.07.2010 - 30.06.2013

    2014  

    Author's details Autoren/Projektleiter: Ulf Wagner; Manfred Kunz
    Language German ; English
    Size Online-Ressource (PDF-Datei: 9 S., 239 KB)
    Publisher Techn. Informationsbibl. und Univ.-Bibl ; Univ. Leipzig, Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Klinik für Dermatologie, Venerologie und Allergologie
    Publishing place Hannover ; Leipzig
    Document type Book ; Online
    Note Zsfassungen in dt. u. engl. Sprache ; Förderkennzeichen BMBF 01EC1008A. - Verbund-Nr. 01079982 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online ; Thesis: Medikamentenadhärenz bei Patienten mit rheumatoider Arthritis: Untersuchung zu Einflussfaktoren unter besonderer Berücksichtigung des Fibromyalgie-Syndroms

    Jugel, Corinna [Verfasser] / Seifert, Olga [Akademischer Betreuer] / Wagner, Ulf [Gutachter] / Keyßer, Gernot [Gutachter]

    2023  

    Author's details Corinna Jugel ; Gutachter: Ulf Wagner, Gernot Keyßer ; Betreuer: Olga Seifert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Leipzig
    Publishing place Leipzig
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article ; Online: Expansion of CD4+CD8+ double-positive T cells in rheumatoid arthritis patients is associated with erosive disease.

    Nguyen, Phuong / Melzer, Marc / Beck, Felix / Krasselt, Marco / Seifert, Olga / Pierer, Matthias / Rothe, Kathrin / Wagner, Ulf

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue 3, Page(s) 1282–1287

    Abstract: Objectives: CD4+CD8+ double-positive (DP) T cells are expanded in the peripheral blood of a subset of patients with RA. This study examines the clinical significance of DP T cells in RA.: Methods: In 70 RA patients, DP T cells were measured by flow ... ...

    Abstract Objectives: CD4+CD8+ double-positive (DP) T cells are expanded in the peripheral blood of a subset of patients with RA. This study examines the clinical significance of DP T cells in RA.
    Methods: In 70 RA patients, DP T cells were measured by flow cytometry. Clinical data were obtained, and hand and feet radiographs were scored according to the Sharp/van der Heijde (SvdH) method. The association between DP T cell frequency and erosive joint destruction was analysed by correlation and multiple logistic regression analysis.
    Results: Nineteen RA patients (27.1%) displayed increased DP T cell frequencies, which correlated with age (r = 0.288, P =0.016). Expansion of DP T cells was associated with the occurrence of erosions (94,7% vs 43,1%, P <0.001), with a higher SvdH joint damage score (24.5 vs 6, P =0.008) and with more frequent use of biologic or targeted-synthetic DMARDs (68.4% vs 38%, P =0.02). In patients with non-erosive disease, DP T cell frequencies correlated with the joint space narrowing score (n = 28, r = 0.44, P =0.02). Logistic regression revealed DP T cells to be associated with erosive disease (OR 1.90, P <0.05).
    Conclusion: Expansion of DP T cells is associated with joint damage and frequent escalation of therapy, possibly suggesting a contribution to more severe RA.
    MeSH term(s) Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/pathology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Disease Progression ; Humans
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  10. Article ; Online: Humoral and cellular response to COVID-19 vaccination in patients with autoimmune inflammatory rheumatic diseases under real-life conditions.

    Krasselt, Marco / Wagner, Ulf / Nguyen, Phuong / Pietsch, Corinna / Boldt, Andreas / Baerwald, Christoph / Pierer, Matthias / Seifert, Olga

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue SI2, Page(s) SI180–SI188

    Abstract: Objectives: Successful vaccination is key to overcoming the COVID-19 pandemic. Immunosuppressive medication is known to potentially compromise vaccination responses, and expansion of our knowledge on vaccination efficacy in patients with autoimmune ... ...

    Abstract Objectives: Successful vaccination is key to overcoming the COVID-19 pandemic. Immunosuppressive medication is known to potentially compromise vaccination responses, and expansion of our knowledge on vaccination efficacy in patients with autoimmune inflammatory rheumatic diseases (AIIRD) is therefore of utmost importance.
    Methods: We conducted a single-centre observational study and evaluated the efficacy of approved COVID-19 vaccines in 303 adult AIIRD patients. Serum levels of IgG antibodies against the S1 subunit of SARS-CoV-2 spike proteins (anti-S IgG) were measured at least two weeks after vaccination. In a subgroup of patients without humoral response, T-cell responses were determined using an interferon-γ gamma release assay.
    Results: Overall seropositivity rate was 78.5% and was significantly lower in patients under immunosuppressive therapy (75.7 vs 93.2%, P = 0.009). No difference regarding the vaccination type was observed. Glucocorticoids, mycophenolate-mofetil, TNF inhibitors, tocilizumab, abatacept and rituximab were all associated with non-response after proper vaccination. The risk was highest under RTX therapy (OR 0.004, 95% CI 0.001, 0.023, P < 0.0001). A strong negative correlation was observed between time since vaccination with an mRNA vaccine and anti-S antibody levels (r=-0.6149, P < 0.0001). In patients without humoral response, a T-cell response was found in 50%.
    Conclusions: COVID-19 vaccination in patients with AIIRD is effective using any approved vaccine. Humoral response might be impaired depending on the individual immunosuppressive medication. The risk of non-response is highest under rituximab therapy. Anti-S IgG antibody levels wane over time after mRNA vaccination. Importantly, 50% of humoral non-responders showed a T-cellular response, suggesting T-cell-mediated protection to a certain extent.
    MeSH term(s) Adult ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; Immunoglobulin G ; Pandemics ; Rheumatic Diseases/complications ; Rituximab/therapeutic use ; SARS-CoV-2 ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin G ; Vaccines, Synthetic ; mRNA Vaccines ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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