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  1. Article ; Online: Antegrade cerebral perfusion-in pursuit of the holy grail of perfusion in type A aortic dissection.

    Wahba, Alexander

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 60, Issue 6, Page(s) 1445–1446

    MeSH term(s) Aneurysm, Dissecting/surgery ; Cerebrovascular Circulation ; Humans ; Perfusion
    Language English
    Publishing date 2021-08-04
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Serotonin-A Driver of Progressive Heart Valve Disease.

    Waldum, Helge / Wahba, Alexander

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 774573

    Abstract: It is well known that some serotoninergic drugs and neuroendocrine tumors producing serotonin (5-HT) may induce valvular heart disease by stimulation of proliferation of valvular ... ...

    Abstract It is well known that some serotoninergic drugs and neuroendocrine tumors producing serotonin (5-HT) may induce valvular heart disease by stimulation of proliferation of valvular cells
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.774573
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  3. Article ; Online: Serotonin and valvular heart disease.

    Waldum, Helge / Wiseth, Rune / Wahba, Alexander

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 10, Page(s) 823–826

    MeSH term(s) Humans ; Serotonin ; Heart Valve Diseases/drug therapy ; Aortic Valve
    Chemical Substances Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2158082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Re: Er det overvekt eller vektfokus som er helseskadelig?

    Wahba, Alexander

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2015  Volume 135, Issue 3, Page(s) 214–215

    Title translation Re: Is it obesity or weight focus that is harmful?.
    MeSH term(s) Body Image/psychology ; Humans ; Obesity ; Social Stigma
    Language Norwegian
    Publishing date 2015-02-10
    Publishing country Norway
    Document type Comment ; Letter
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.15.0070
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  5. Book ; Thesis: Untersuchungen zur Funktion des Retikuloendothelialen Systems an der isoliert perfundierten Meerschweinleber

    Wahba, Alexander

    1988  

    Keywords Kupffer Cells / physiology ; Liver / drug effects ; Fat Emulsions, Intravenous / pharmacology ; Cell Hypoxia ; Albumins / diagnostic use ; Liver Function Tests ; Perfusion ; Guinea Pigs
    Size 89, [4] S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 1989
    HBZ-ID HT003597006
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    90 D 1745 order for loan Magazin

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  6. Article ; Online: Evaluation of Quatsome Morphology, Composition, and Stability for

    Du, Changyue / Woolcott, Sascha / Wahba, Alexander Sean / Hamry, Sally R / Odette, William L / Thibodeaux, Christopher J / Marchand, Patrick / Mauzeroll, Janine

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 3, Page(s) 1623–1632

    Abstract: Biofilm infections are a major cause of food poisoning and hospital-acquired infections. Quaternary ammonium compounds are a group of effective disinfectants widely used in industry and households, yet their efficacy is lessened when used as antibiofilm ... ...

    Abstract Biofilm infections are a major cause of food poisoning and hospital-acquired infections. Quaternary ammonium compounds are a group of effective disinfectants widely used in industry and households, yet their efficacy is lessened when used as antibiofilm agents compared to that against planktonic bacteria. It is therefore necessary to identify alternative formulations of quaternary ammonium compounds to achieve an effective biofilm dispersal. Quaternary ammonium amphiphiles can form vesicular structures termed "quatsomes" in the presence of cholesterol. In addition to their intrinsic antimicrobial properties, quatsomes can also be used for the delivery of other types of antibiotics or biomarkers. In this study, quatsomes were prepared from binary mixtures of cholesterol and mono- or dialkyl-quaternary ammonium compounds; then, the integrity and stability of their vesicular structure were assessed and related to monomer chain number and chain length. The quatsomes were used to treat
    MeSH term(s) Pseudomonas aeruginosa ; Quaternary Ammonium Compounds ; Biofilms ; Anti-Infective Agents ; Anti-Bacterial Agents/pharmacology ; Cholesterol ; Microbial Sensitivity Tests
    Chemical Substances Quaternary Ammonium Compounds ; Anti-Infective Agents ; Anti-Bacterial Agents ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c02491
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  7. Article: Strategies in heparin-induced thrombocytopenia.

    Wahba, Alexander

    Multimedia manual of cardiothoracic surgery : MMCTS

    2011  Volume 2011, Issue 126, Page(s) mmcts.2010.004481

    Abstract: Heparin-induced thrombocytopenia (HIT) is an uncommon condition that may confront cardio-thoracic surgeons with difficult problems. The underlying cause of HIT is the formation of antibodies against platelet factor 4/heparin complexes, leading to ... ...

    Abstract Heparin-induced thrombocytopenia (HIT) is an uncommon condition that may confront cardio-thoracic surgeons with difficult problems. The underlying cause of HIT is the formation of antibodies against platelet factor 4/heparin complexes, leading to platelet activation and intravascular platelet aggregation. HIT occurs following heparin administration usually with a time delay of 5-10 days. Clinical suspicion and laboratory tests for platelet-activating antibodies are the cornerstone of diagnosis. Appropriate strategies in HIT are stopping heparin and use of alternative anticoagulants. In addition, surgery with extracorporeal circulation (ECC) should be postponed whenever possible or alternative anticoagulants have to be used during ECC.
    Language English
    Publishing date 2011-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280156-X
    ISSN 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2010.004481
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  8. Article ; Online: Long-term follow-up after surgery for atrial fibrillation with concomitant open heart surgery.

    Andersen, Knut Sverre / Grong, Ketil / Hoff, Per-Ivar / Wahba, Alexander

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2021  Volume 141, Issue 1

    Abstract: Background: Patients with atrial fibrillation and atrial flutter scheduled to undergo open heart surgery can receive ablation treatment of arrhythmogenic foci during the same intervention. Sinus rhythm is restored in the majority in the short term, but ... ...

    Title translation Langtidsoppfølging etter atrieflimmeroperasjon og samtidig åpen hjertekirurgi.
    Abstract Background: Patients with atrial fibrillation and atrial flutter scheduled to undergo open heart surgery can receive ablation treatment of arrhythmogenic foci during the same intervention. Sinus rhythm is restored in the majority in the short term, but the long-term results are more uncertain. This study, which is part of the international CURE-AF trial, evaluates results after Cox-Maze IV surgery for atrial fibrillation in Norway at six-year follow-up.
    Material and method: Nineteen patients were included in this prospective cohort study. Atrial fibrillation had persisted for 40 months in the group with long-standing persistent atrial fibrillation (n = 12) and 6 months in the group with persistent atrial fibrillation (n = 7). Surgery for atrial fibrillation was performed according to the Cox-Maze IV procedure in the CURE-AF protocol. Follow-up in the first 12 months was strictly according to the CURE-AF protocol, thereafter conducted by the primary health service.
    Results: Sinus rhythm was restored in 11 patients at the time of discharge and in 14 patients six months postoperatively. After 5-6 years of follow-up, all patients with long-standing persistent atrial fibrillation had experienced recurrence. Two achieved sinus rhythm after electroconversion. Six of the seven in the group with persistent atrial fibrillation had sinus rhythm after 5-6 years.
    Interpretation: The results were good initially, with restoration of sinus rhythm in more than two thirds of the patients after 6-9 months. Five years later, a high recurrence rate was found in patients with long-standing persistent atrial fibrillation. Several recurrences had not been detected by the public health service or treatment had not been attempted.
    MeSH term(s) Atrial Fibrillation/surgery ; Cardiac Surgical Procedures ; Catheter Ablation ; Follow-Up Studies ; Humans ; Norway/epidemiology ; Prospective Studies ; Treatment Outcome
    Language Norwegian
    Publishing date 2021-01-05
    Publishing country Norway
    Document type Clinical Trial ; Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction: Long-term follow-up after surgery for atrial fibrillation with concomitant open heart surgery.

    Andersen, Knut Sverre / Grong, Ketil / Hoff, Per-Ivar / Wahba, Alexander

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2021  Volume 141, Issue 2

    Title translation Rettelse: Langtidsoppfølging etter atrieflimmeroperasjon og samtidig åpen hjertekirurgi.
    Language Norwegian
    Publishing date 2021-01-06
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.21.0003
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  10. Article ; Online: Cardiorespiratory fitness and the incidence of coronary surgery and postoperative mortality: the HUNT study.

    Smenes, Benedikte Therese / Nes, Bjarne Martens / Letnes, Jon Magne / Slagsvold, Katrine Hordnes / Wisløff, Ulrik / Wahba, Alexander

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2022  Volume 62, Issue 3

    Abstract: Objectives: Low physical activity and cardiorespiratory fitness are known risk factors for coronary artery disease, but how they affect the risk of undergoing coronary artery bypass graft surgery is not established. We explored how physical activity and ...

    Abstract Objectives: Low physical activity and cardiorespiratory fitness are known risk factors for coronary artery disease, but how they affect the risk of undergoing coronary artery bypass graft surgery is not established. We explored how physical activity and estimated cardiorespiratory fitness affect the risk of coronary surgery and postoperative outcome.
    Methods: Participants with no history of coronary disease from the second wave of the Trøndelag Health Study (HUNT2) were cross-linked with the local heart surgery register and the Norwegian Cause of Death Registry. Cardiorespiratory fitness was estimated by a previously developed algorithm using clinical and self-reported information. Fine-Gray competing risk analyses were used to calculate the risk of undergoing isolated coronary surgery across physical activity groups and estimated cardiorespiratory fitness (mL/kg/min) as quintiles and per 1 metabolic equivalent of task (MET) (3.5 mL/kg/min).
    Results: We included 45,491 participants. The mean population age was 46.0 [standard deviation (SD) 15.8] years, and the mean estimated fitness was 41.3 (SD 8.9) mL/kg/min. A total of 672 (1.5%) participants underwent coronary surgery during the follow-up period. The risk of undergoing isolated coronary surgery was 26% [95% confidence interval (CI) 3-44] lower for those classified as highly active compared to those classified as least active. Further, an 11% (95% CI 6-15) lower risk per 1-MET (3.5 mL/kg/min) of higher fitness. Finally, we observed a 15% (95% CI 5-23) lower mortality risk after surgery per 1-MET of higher fitness among those undergoing surgery.
    Conclusions: High levels of physical activity and high estimated fitness levels were inversely associated with the risk of developing coronary disease requiring surgery and overall mortality after surgery.
    MeSH term(s) Adolescent ; Cardiorespiratory Fitness ; Coronary Artery Bypass/adverse effects ; Coronary Artery Disease/surgery ; Exercise Test ; Humans ; Incidence ; Risk Factors
    Language English
    Publishing date 2022-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezac126
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