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  1. Book ; Online: Metabolism and Metabolomics of Liver in Health and Disease

    Wahli, Walter / Guillou, Hervé

    2021  

    Keywords Medicine ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; Fibrosis ; Liver biopsy ; Genomics ; Metabolomics ; Proteomics ; Transcriptomics ; nicotinamide ; NAFLD ; steatosis ; heat stress ; primary mouse hepatocytes ; metabolic profile ; GC-MS ; multivariate statistical analysis ; arachidonic acid ; docosahexaenoic acid ; inflammation ; fibrosis ; lipidomics ; mass spectrometry ; in vitro ; HepaRG ; sodium saccharin ; reference toxicants ; de novo lipogenesis ; carbohydrate response element-binding protein ; ChREBP ; diabetes ; glucose production ; glycogen ; glycolysis ; glycogen storage disease type I ; hexosamine ; pentose phosphate pathway ; acupuncture ; imflammation ; lipid metabolism ; oxidative stress ; metabolomics quantitative profiling ; 1H-NMR spectroscopy ; liver ; bile acids ; metabolomics ; rat plasma ; tandem mass spectrometry ; liquid chromatography ; acetaminophen ; hepatotoxicity ; biomarker ; premalignant ; alcoholic liver disease ; cholestasis ; cirrhosis ; NAFL ; NASH ; standard operating procedures ; urine ; blood ; feces ; tissue ; cells ; liver function ; nonalcoholic fatty liver ; liquid chromatography-mass spectrometry ; nuclear magnetic resonance spectroscopy ; metabolic pathway ; non-alcoholic fatty liver disease ; non-alcoholic steatohepatitis ; transcription factors ; metabolic stress ; lipid homeostasis ; glucose homeostasis
    Size 1 electronic resource (268 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044661
    ISBN 9783039436361 ; 3039436368
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: PPARs as Key Mediators of Metabolic and Inflammatory Regulation

    Vázquez-Carrera, Manuel / Wahli, Walter

    2022  

    Keywords Research & information: general ; Biology, life sciences ; Biochemistry ; nuclear receptor ; gene transcription ; inflammation ; molecular docking ; PPARβ/δ ; lung ; pulmonary artery ; GW0742 ; GSK3787 ; docking ; lipopolysaccharide (LPS) ; PPARγ ligand ; coumarin ; fluorescent ligand ; screening ; crystal structure ; PPAR ; atopic dermatitis ; psoriasis ; metabolic reprograming ; glucose ; fatty acids ; mycobacteria ; M. tuberculosis ; M. leprae ; PPARs ; lipid droplets ; metabolic alterations ; hepatic damage ; nuclear factors ; pharmacological targets ; AMPK ; GDF15 ; insulin resistance ; type 2 diabetes mellitus ; peroxisome proliferator-activated receptor gamma (PPARγ) ; real-time PCR ; ELISA ; immunohistochemistry ; signaling pathway ; PPAR gamma ; brain ; neural stem cells ; infection ; neuroinflammation ; HIV ; Zika ; cytomegalovirus ; neurogenesis ; microglia ; liver damage ; toll-like receptor 4 ; P2Y2 receptor ; metabolic syndrome ; resveratrol ; quercetin ; PPARα ; peroxisome ; β-oxidation ; PPRE ; ligand ; coregulator ; micronutrients ; PPARα knockout ; adipose tissue ; browning ; lipid metabolism ; depression ; PPARg ; neuropathology ; corticotropin releasing hormone ; norepinephrine ; subgenual prefrontal cortex ; amygdala ; nucleus accumbens ; common carotid artery occlusion ; electroretinography ; fibroblast growth factor 21 ; pemafibrate ; peroxisome proliferator-activated receptor alpha ; retinal ischemia ; skeletal muscle ; substrate metabolism ; nonalcoholic fatty liver disease (NAFLD) ; sex dimorphism ; lipidomics ; hepatic sex-biased gene expression ; PPARγ ; pulmonary arterial hypertension ; TGFβ ; vascular injury ; proliferation ; kidney fibrosis ; pattern-recognition receptors ; phagocytosis ; nitric oxide synthase ; fenofibrate ; oleoylethanolamide ; palmitoylethanolamide ; cancer ; immunity ; obesity ; diabetes ; miRNA ; DNA methylation ; histone modification ; peroxisome-proliferator-activated receptor ; fatty acid oxidation ; doping control ; regulatory T cells ; exercise ; nuclear receptors ; nutrigenomics ; energy homeostasis ; dairy animals ; non-alcoholic fatty liver disease (NAFLD) ; non-alcoholic steatohepatitis (NASH) ; peroxisome proliferator-activated receptors (PPAR) ; bezafibrate ; fenofibric acid ; peroxisome proliferator-activated receptor ; dual/pan agonist ; X-ray crystallography ; n/a
    Language 0|e
    Size 1 electronic resource (456 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610751
    ISBN 9783036541914 ; 3036541918
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: PPARs in Cellular and Whole Body Energy Metabolism

    Wahli, Walter / Tee, Rachel

    2019  

    Abstract: At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, ... ...

    Abstract At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny! However, there is more to energy balance than alterations in body weight. In the 1990s, it was found that fatty acids not only function as fuel molecules only, but also serve as signaling molecules. They bind nuclear hormone receptors, the Peroxisome Proliferator-Activated Receptors, commonly referred to by the acronym PPARs. PPARs are transcription factors that directly control the expression of genes of metabolism, thereby impacting a multitude of pathways crucial for whole body physiology. PPARs are also activated by synthetic agonists, which are drugs used for lowering triglycerides and blood sugar. This book features articles that address tools for the identification of novel PPAR ligands, as well as the roles of the receptors in several organs, such as the brain, heart, liver, adipose tissue, gut, and muscle. As such, this book documents the multifaceted roles of these nuclear receptors that continue to attract significant attention, not least because of their still not fully realized potential to treat several health conditions
    Keywords Genetics ; Biology (General)
    Size 1 electronic resource (582 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099779
    ISBN 9783038974611 ; 9783038974628 ; 3038974617 ; 3038974625
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: PPARs as Key Transcription Regulators at the Crossroads of Metabolism and Inflammation.

    Vázquez-Carrera, Manuel / Wahli, Walter

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: The metabolic and immune systems are complex networks of organs, cells, and proteins that are involved in the extraction of energy from food; this is to run complex cellular processes and defend the body against infections while protecting its own ... ...

    Abstract The metabolic and immune systems are complex networks of organs, cells, and proteins that are involved in the extraction of energy from food; this is to run complex cellular processes and defend the body against infections while protecting its own tissues, respectively [...].
    MeSH term(s) Humans ; Inflammation/metabolism ; Inflammation/genetics ; Animals ; Peroxisome Proliferator-Activated Receptors/metabolism ; Peroxisome Proliferator-Activated Receptors/genetics ; Gene Expression Regulation
    Chemical Substances Peroxisome Proliferator-Activated Receptors
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.

    Vázquez-Carrera, Manuel / Wahli, Walter

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes [ ... ]. ...

    Abstract Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes [...].
    MeSH term(s) Humans ; Inflammation/genetics ; Inflammation/metabolism ; Lipid Metabolism ; Peroxisome Proliferator-Activated Receptors/metabolism ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Transcription Factors/metabolism
    Chemical Substances Peroxisome Proliferator-Activated Receptors ; Receptors, Cytoplasmic and Nuclear ; Transcription Factors
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm.

    Duszka, Kalina / Wahli, Walter

    Nutrients

    2020  Volume 12, Issue 11

    Abstract: The circadian rhythm plays a chief role in the adaptation of all bodily processes to internal and environmental changes on the daily basis. Next to light/dark phases, feeding patterns constitute the most essential element entraining daily oscillations, ... ...

    Abstract The circadian rhythm plays a chief role in the adaptation of all bodily processes to internal and environmental changes on the daily basis. Next to light/dark phases, feeding patterns constitute the most essential element entraining daily oscillations, and therefore, timely and appropriate restrictive diets have a great capacity to restore the circadian rhythm. One of the restrictive nutritional approaches, caloric restriction (CR) achieves stunning results in extending health span and life span via coordinated changes in multiple biological functions from the molecular, cellular, to the whole-body levels. The main molecular pathways affected by CR include mTOR, insulin signaling, AMPK, and sirtuins. Members of the family of nuclear receptors, the three peroxisome proliferator-activated receptors (PPARs), PPARα, PPARβ/δ, and PPARγ take part in the modulation of these pathways. In this non-systematic review, we describe the molecular interconnection between circadian rhythm, CR-associated pathways, and PPARs. Further, we identify a link between circadian rhythm and the outcomes of CR on the whole-body level including oxidative stress, inflammation, and aging. Since PPARs contribute to many changes triggered by CR, we discuss the potential involvement of PPARs in bridging CR and circadian rhythm.
    MeSH term(s) Animals ; Caloric Restriction ; Circadian Rhythm ; Humans ; Inflammation/metabolism ; Longevity ; Oxidative Stress ; Peroxisome Proliferator-Activated Receptors/metabolism ; Signal Transduction
    Chemical Substances Peroxisome Proliferator-Activated Receptors
    Language English
    Publishing date 2020-11-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12113476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Fatty acids control gene expression through members of the nuclear receptor superfamily

    Wahli, Walter

    (Schering lecture ; 18)

    1993  

    Author's details Walter Wahli
    Series title Schering lecture ; 18
    Collection
    Size 24 S. : Ill.
    Publishing place Berlin
    Document type Book
    HBZ-ID HT006388523
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 8127 order for loan Magazin

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  8. Article ; Online: Striking a gut-liver balance for the antidiabetic effects of metformin.

    Barroso, Emma / Montori-Grau, Marta / Wahli, Walter / Palomer, Xavier / Vázquez-Carrera, Manuel

    Trends in pharmacological sciences

    2023  Volume 44, Issue 7, Page(s) 457–473

    Abstract: Metformin is the most prescribed drug for the treatment of type 2 diabetes mellitus (T2DM), but its mechanism of action has not yet been completely elucidated. Classically, the liver has been considered the major site of action of metformin. However, ... ...

    Abstract Metformin is the most prescribed drug for the treatment of type 2 diabetes mellitus (T2DM), but its mechanism of action has not yet been completely elucidated. Classically, the liver has been considered the major site of action of metformin. However, over the past few years, advances have unveiled the gut as an additional important target of metformin, which contributes to its glucose-lowering effect through new mechanisms of action. A better understanding of the mechanistic details of metformin action in the gut and the liver and its relevance in patients remains the challenge of present and future research and may impact drug development for the treatment of T2DM. Here, we offer a critical analysis of the current status of metformin-driven multiorgan glucose-lowering effects.
    MeSH term(s) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Metformin/pharmacology ; Metformin/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Liver ; Glucose
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-05-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 6: Show issues

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  9. Article ; Online: Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.

    Duszka, Kalina / Wahli, Walter

    International journal of molecular sciences

    2018  Volume 19, Issue 8

    Abstract: Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. ...

    Abstract Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota⁻gut⁻brain axis.
    MeSH term(s) Animals ; Bacteria/metabolism ; Bacterial Physiological Phenomena ; Brain/physiology ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/physiology ; Humans ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction
    Chemical Substances Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2018-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19082210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PPARs and Microbiota in Skeletal Muscle Health and Wasting.

    Manickam, Ravikumar / Duszka, Kalina / Wahli, Walter

    International journal of molecular sciences

    2020  Volume 21, Issue 21

    Abstract: Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy production and has the capacity to remodel itself in response to exercise and fasting. Skeletal muscle wasting occurs in many diseases and during aging. Muscle ... ...

    Abstract Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy production and has the capacity to remodel itself in response to exercise and fasting. Skeletal muscle wasting occurs in many diseases and during aging. Muscle wasting is often accompanied by chronic low-grade inflammation associated to inter- and intra-muscular fat deposition. During aging, muscle wasting is advanced due to increased movement disorders, as a result of restricted physical exercise, frailty, and the pain associated with arthritis. Muscle atrophy is characterized by increased protein degradation, where the ubiquitin-proteasomal and autophagy-lysosomal pathways, atrogenes, and growth factor signaling all play an important role. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family of transcription factors, which are activated by fatty acids and their derivatives. PPARs regulate genes that are involved in development, metabolism, inflammation, and many cellular processes in different organs. PPARs are also expressed in muscle and exert pleiotropic specialized responses upon activation by their ligands. There are three PPAR isotypes, viz., PPARα, -β/δ, and -γ. The expression of PPARα is high in tissues with effective fatty acid catabolism, including skeletal muscle. PPARβ/δ is expressed more ubiquitously and is the predominant isotype in skeletal muscle. It is involved in energy metabolism, mitochondrial biogenesis, and fiber-type switching. The expression of PPARγ is high in adipocytes, but it is also implicated in lipid deposition in muscle and other organs. Collectively, all three PPAR isotypes have a major impact on muscle homeostasis either directly or indirectly. Furthermore, reciprocal interactions have been found between PPARs and the gut microbiota along the gut-muscle axis in both health and disease. Herein, we review functions of PPARs in skeletal muscle and their interaction with the gut microbiota in the context of muscle wasting.
    MeSH term(s) Animals ; Energy Metabolism ; Humans ; Microbiota ; Muscle Weakness/metabolism ; Muscle Weakness/microbiology ; Muscle Weakness/pathology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/microbiology ; Muscle, Skeletal/pathology ; Muscular Atrophy/metabolism ; Muscular Atrophy/microbiology ; Muscular Atrophy/pathology ; Peroxisome Proliferator-Activated Receptors/metabolism ; Signal Transduction
    Chemical Substances Peroxisome Proliferator-Activated Receptors
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21218056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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