Article ; Online: Prenatal vitamin D supplementation mitigates inflammation-related alveolar remodeling in neonatal mice.
American journal of physiology. Lung cellular and molecular physiology
2023 Volume 325, Issue 2, Page(s) L95–L103
Abstract: The development of chronic lung disease in the neonate, also known as bronchopulmonary dysplasia (BPD), is the most common long-term complication in prematurely born infants. In BPD, the disease-characteristic inflammatory response culminates in ... ...
Abstract | The development of chronic lung disease in the neonate, also known as bronchopulmonary dysplasia (BPD), is the most common long-term complication in prematurely born infants. In BPD, the disease-characteristic inflammatory response culminates in nonreversible remodeling of the developing gas exchange area, provoked by the impact of postnatal treatments such as mechanical ventilation (MV) and oxygen treatment. To evaluate the potential of prenatal treatment regimens to modulate this inflammatory response and thereby impact the vulnerability of the lung toward postnatal injury, we designed a multilayered preclinical mouse model. After administration of either prenatal vitamin D-enriched (VitD+; 1,500 IU/g food) or -deprived (VitD-; <10 IU/kg) food during gestation in C57B6 mice (the onset of mating until birth), neonatal mice were exposed to hyperoxia (Fi |
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MeSH term(s) | Humans ; Pregnancy ; Female ; Infant, Newborn ; Animals ; Mice ; Animals, Newborn ; Lung Injury/metabolism ; Vitamin D/pharmacology ; Vitamin D/metabolism ; Lung/metabolism ; Bronchopulmonary Dysplasia/drug therapy ; Bronchopulmonary Dysplasia/prevention & control ; Bronchopulmonary Dysplasia/metabolism ; Pneumonia/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Hyperoxia/metabolism ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/metabolism ; Dietary Supplements |
Chemical Substances | Vitamin D (1406-16-2) |
Language | English |
Publishing date | 2023-05-31 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1013184-x |
ISSN | 1522-1504 ; 1040-0605 |
ISSN (online) | 1522-1504 |
ISSN | 1040-0605 |
DOI | 10.1152/ajplung.00367.2022 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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