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  1. Book ; Thesis: Role of microglia in plasticity of visual motor behavior across the ages

    Lindner, Julia / Witte, Otto W. / Bauer, Reinhard / Waisman, Ari

    2021  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Julia Linder
    Keywords Mikroglia ; Altern
    Subject Alterungsprozess ; Altwerden ; Seneszenz ; Alterung
    Language English ; German
    Size ix, 65, XXV Seiten, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2021
    Note Zusammenfassungen in deutscher und englischer Sprache ; Kumulative Dissertation, enthält Zeitschriftenaufsätze. - Tag der Verteidigung: 30.11.2021
    HBZ-ID HT021367835
    Database Catalogue ZB MED Medicine, Health

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    2022 E 527 order for loan Magazin

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  2. Article ; Online: Microglia as Central Protagonists in the Chronic Stress Response.

    Schramm, Eva / Waisman, Ari

    Neurology(R) neuroimmunology & neuroinflammation

    2022  Volume 9, Issue 6

    Abstract: Chronic stress is a major risk factor for developing psychiatric conditions. In addition to elevating the levels of stress hormones released in the body, chronic stress activates the immune system, resulting in increased levels of proinflammatory ... ...

    Abstract Chronic stress is a major risk factor for developing psychiatric conditions. In addition to elevating the levels of stress hormones released in the body, chronic stress activates the immune system, resulting in increased levels of proinflammatory cytokines and innate immune cells in the circulation of rodents and humans. Furthermore, exposure to chronic stress alters the phenotype of microglia, a population of innate immune cells that reside in the CNS parenchyma. In rodent models, chronic stress activates microglia in defined brain regions and induces changes in their phenotype and functional properties. In this review, we discussed how microglia are activated in stressful situations. Furthermore, we described how microglia affect the CNS environment during chronic stress, through the production of cytokines, the induction of reactive oxygen species, and phagocytosis. We suggested that, due to their strategic location as immune cells within the CNS, microglia are important players in the induction of psychopathologies after chronic stress.
    MeSH term(s) Humans ; Microglia ; Cytokines ; Phagocytosis ; Reactive Oxygen Species
    Chemical Substances Cytokines ; Reactive Oxygen Species
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Winner of the Ronald Melzack -

    Katz, Joel / Waisman, Anna

    Canadian journal of pain = Revue canadienne de la douleur

    2022  Volume 6, Issue 1, Page(s) 121–123

    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Editorial
    ISSN 2474-0527
    ISSN (online) 2474-0527
    DOI 10.1080/24740527.2022.2094756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Modeling a complex disease: Multiple sclerosis-Update 2020.

    Regen, Tommy / Waisman, Ari

    Advances in immunology

    2021  Volume 149, Page(s) 25–34

    Abstract: Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with ... ...

    Abstract Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) with an unknown etiology. Thereby, MS is not a uniform disease but rather represents a spectrum of disorders, where each aspect needs to be modeled with specific requirements-for a systematic overview see our previous issue of this review (Kurschus, Wortge, & Waisman, 2011). However, there is broad consensus about the critical involvement of the immune system in the disease pathogenesis. To better understand how the immune system contributes to CNS autoimmunity, the model of experimental autoimmune encephalomyelitis (EAE) was developed. EAE can be induced in susceptible animals in many different ways, with the most popular protocol involving the activation of self-reactive T cells by a peptide based on the myelin oligodendrocyte glycoprotein sequence. In the last 10 years this model has led to major advances in our understanding of the immune system, especially the nature of IL-17-producing T cells (Th17 cells), host-microbiome interactions, the gut-brain axis and how the immune system can cause damage in different regions of the brain and the spinal cord. This update summarizes some of the main achievements in the field in the last 10 years.
    MeSH term(s) Animals ; Central Nervous System ; Encephalomyelitis, Autoimmune, Experimental ; Humans ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis ; Myelin-Oligodendrocyte Glycoprotein ; Th17 Cells
    Chemical Substances Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/bs.ai.2021.03.002
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    Ud II Zs.191: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The astrocyte LAMP lights a T cell TRAIL of death.

    Johann, Lisa / Waisman, Ari

    Neuron

    2021  Volume 109, Issue 9, Page(s) 1423–1425

    Abstract: In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on ... ...

    Abstract In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.
    MeSH term(s) Anti-Inflammatory Agents ; Astrocytes ; Central Nervous System ; Killer Cells, Natural ; T-Lymphocytes
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.04.009
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    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  6. Article ; Online: Painful reminders: Involvement of the autobiographical memory system in pediatric postsurgical pain and the transition to chronicity.

    Waisman, Anna / Pavlova, Maria / Noel, Melanie / Katz, Joel

    Canadian journal of pain = Revue canadienne de la douleur

    2022  Volume 6, Issue 2, Page(s) 121–141

    Abstract: Memory biases for previous pain experiences are known to be strong predictors of postsurgical pain outcomes in children. Until recently, much research on the subject in youth has assessed the sensory and affective components of recall using single-item ... ...

    Abstract Memory biases for previous pain experiences are known to be strong predictors of postsurgical pain outcomes in children. Until recently, much research on the subject in youth has assessed the sensory and affective components of recall using single-item self-report pain ratings. However, a newly emerging focus in the field has been on the episodic specificity of autobiographical pain memories. Still in its infancy, cross-sectional work has identified the presence of various memory biases in adults living with chronic pain, one of which concerns the lack of spatiotemporal specificity. Moreover, a recent prospective longitudinal study found that adults scheduled for major surgery who produced fewer specific pain memories before surgery were at greater risk of developing chronic postsurgical pain up to 12 months later. The present review draws on this research to highlight the timely need for a similar line of investigation into autobiographical pain memories in pediatric surgical populations. We (1) provide an overview of the literature on children's pain memories and underscore the need for further research pertaining to memory specificity and related neurobiological factors in chronic pain and an overview of the (2) important role of parent (and sibling) psychosocial characteristics in influencing children's pain development, (3) cognitive mechanisms underlying overgeneral memory, and (4) interplay between memory and other psychological factors in its contributions to chronic pain and (5) conclude with a discussion of the implications this research has for novel interventions that target memory biases to attenuate, and possibly eliminate, the risk that acute pain after pediatric surgery becomes chronic.
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2474-0527
    ISSN (online) 2474-0527
    DOI 10.1080/24740527.2022.2058474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cre-lox: Target Sensitivity Matters.

    Becher, B / Waisman, A / Lu, L F

    Immunity

    2019  Volume 51, Issue 4, Page(s) 595

    MeSH term(s) Animals ; Humans ; Integrases/genetics ; Integrases/metabolism ; Mice ; Mice, Transgenic ; Mutagenesis ; Phenotype ; Protein-Lysine 6-Oxidase/genetics ; Protein-Lysine 6-Oxidase/metabolism ; Recombination, Genetic ; Substrate Specificity
    Chemical Substances Protein-Lysine 6-Oxidase (EC 1.4.3.13) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2019-10-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.09.012
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    Zs.A 4227: Show issues Location:
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    Zs.MG 69: Show issues

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  8. Article ; Online: Time to activin on pathogenic T cells.

    Ebering, Anna / Waisman, Ari

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 23, Page(s) 12513–12514

    MeSH term(s) Activins ; Autoimmune Diseases ; Inflammation ; T-Lymphocytes ; Virulence
    Chemical Substances Activins (104625-48-1)
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2008491117
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    Zs.A 1148: Show issues Location:
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  9. Article ; Online: Natural antibodies are required for clearance of necrotic cells and recovery from acute liver injury.

    Mattos, Matheus Silvério / Vandendriessche, Sofie / Schuermans, Sara / Feyaerts, Lars / Hövelmeyer, Nadine / Waisman, Ari / Marques, Pedro Elias

    JHEP reports : innovation in hepatology

    2024  Volume 6, Issue 4, Page(s) 101013

    Abstract: Background & aims: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor ... ...

    Abstract Background & aims: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor recovery. This study investigated the role of natural antibodies (NAbs) in the clearance of necrotic cells in the injured liver, their impact on tissue regeneration and their potential as a therapy for acute liver injury.
    Methods: We used murine models of drug-induced liver injury and focal thermal injury in immunocompetent and antibody-deficient mice (
    Results: Both IgM and IgG NAbs bound necrotic liver areas and opsonized multiple debris molecules released during hepatocellular necrosis such as DNA, histones, actin, phosphoinositides and mitochondrial cardiolipin, but not phosphatidylserine.
    Conclusion: NAbs drive the phagocytosis of necrotic cells in liver injury and promote liver regeneration and recovery.
    Impact and implications: Treatment with natural antibodies after acute liver injury improved recovery by increasing the clearance of necrotic debris and by improving cellular proliferation in the liver. This preclinical study provides a basis for the development of an immunotherapy for patients with early-stage, reversible, liver injury that aims to prevent disease chronification into fibrosis and liver failure.
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2024.101013
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  10. Article ; Online: Unraveling the T-B tangle in anti-CD20 multiple sclerosis therapy.

    Waisman, Ari / Ebering, Anna

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 51, Page(s) 25376–25377

    MeSH term(s) Antigens, CD20 ; CD8-Positive T-Lymphocytes ; Humans ; Multiple Sclerosis ; Myelin Sheath
    Chemical Substances Antigens, CD20
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1919044116
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    Zs.A 1148: Show issues Location:
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