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  1. AU="Wakisaka, Takuya"
  2. AU="den Brok, P."
  3. AU="Scholl, Victoria"
  4. AU="Sulejczak, Dorota"
  5. AU="Carvalho, Ana C"
  6. AU="Guo, Mengmeng" AU="Guo, Mengmeng"
  7. AU="Boehler, Michael"
  8. AU="Mirfakhraei, Mahdi"
  9. AU="de Jongste, Johan C"
  10. AU="Holmgren, A Jay"
  11. AU="Mićanović, S"
  12. AU="Chiu, Joanne S"
  13. AU=D'Amora Paulo
  14. AU="Jansen, Hans"
  15. AU=Beukes Eldre W
  16. AU="Francis, Sarah"
  17. AU="Camara, Amadou K.S."
  18. AU="Chaudhari, Sachin R."
  19. AU="Ovchinnikova, Tatiana V"
  20. AU="Aït Ali, F"
  21. AU="Jeong, Jae Cheon"
  22. AU="Luca Baldassari"
  23. AU="Wakfie-Corieh, C G"
  24. AU="Desouza, Cyrus V"
  25. AU="Esaka, Naoki"
  26. AU="Haruka Wada"
  27. AU="Klouda, Timothy"
  28. AU="Olsson-Brown, Anna C."
  29. AU="Schmauß, Max"
  30. AU="Raza, Syed Tasleem"
  31. AU="Humphreys, H"
  32. AU="Robert A Casero Jr"
  33. AU="Marinec, Paul S"
  34. AU="Rajebhosale, Prithviraj"

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  1. Artikel ; Online: Decreased nerve conduction velocity may be a predictor of fingertip dexterity and subjective complaints.

    Fukumoto, Yuki / Wakisaka, Takuya / Misawa, Koichi / Hibi, Masanobu / Suzuki, Toshiaki

    Experimental brain research

    2023  Band 241, Heft 2, Seite(n) 661–675

    Abstract: We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their activities of daily living. We calculated nerve conduction velocity, absolute error during force adjustment ... ...

    Abstract We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their activities of daily living. We calculated nerve conduction velocity, absolute error during force adjustment tasks, and fingertip dexterity test scores for 30 young (21-34 years old) and 30 elderly (60-74 years old) participants to identify age-related changes. We also assessed subjective complaints of pain, motor function, and numbness. Motor nerve (young: 55.8 ± 3.7 m/s; elderly: 52.2 ± 5.0 m/s) and sensory nerve (young: 59.4 ± 3.4 m/s; elderly: 55.5 ± 5.3 m/s) conduction velocities decreased in an age-dependent manner. Moreover, the decrease of motor nerve conduction velocity was associated with decreased fingertip dexterity (objective index), while the decrease of sensory nerve conduction velocity was associated with subjective complaints of pain and motor function (subjective index).
    Mesh-Begriff(e) Humans ; Aged ; Young Adult ; Adult ; Middle Aged ; Neural Conduction/physiology ; Activities of Daily Living ; Quality of Life ; Fingers/physiology ; Pain
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-023-06556-2
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  2. Artikel ; Online: Decreased nerve conduction velocity may be a predictor of fingertip dexterity and subjective complaints

    Fukumoto, Yuki / Wakisaka, Takuya / Misawa, Koichi / Hibi, Masanobu / Suzuki, Toshiaki

    Exp Brain Res. 2023 Feb., v. 241, no. 2, p. 661-675

    2023  , Seite(n) 661–675

    Abstract: We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their activities of daily living. We calculated nerve conduction velocity, absolute error during force adjustment ... ...

    Abstract We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their activities of daily living. We calculated nerve conduction velocity, absolute error during force adjustment tasks, and fingertip dexterity test scores for 30 young (21–34 years old) and 30 elderly (60–74 years old) participants to identify age-related changes. We also assessed subjective complaints of pain, motor function, and numbness. Motor nerve (young: 55.8 ± 3.7 m/s; elderly: 52.2 ± 5.0 m/s) and sensory nerve (young: 59.4 ± 3.4 m/s; elderly: 55.5 ± 5.3 m/s) conduction velocities decreased in an age-dependent manner. Moreover, the decrease of motor nerve conduction velocity was associated with decreased fingertip dexterity (objective index), while the decrease of sensory nerve conduction velocity was associated with subjective complaints of pain and motor function (subjective index).
    Schlagwörter brain ; elderly ; nerve tissue ; pain ; quality of life
    Sprache Englisch
    Erscheinungsverlauf 2023-02
    Umfang p. 661-675
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel ; Online
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-023-06556-2
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  3. Artikel ; Online: Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men.

    Takahashi, Masaki / Ozaki, Mamiho / Miyashita, Masashi / Fukazawa, Mayuko / Nakaoka, Takashi / Wakisaka, Takuya / Matsui, Yuji / Hibi, Masanobu / Osaki, Noriko / Shibata, Shigenobu

    The Journal of nutritional biochemistry

    2019  Band 73, Seite(n) 108221

    Abstract: Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of ... ...

    Abstract Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.
    Mesh-Begriff(e) Adult ; Blood Glucose/analysis ; Catechin/administration & dosage ; Catechin/analogs & derivatives ; Circadian Rhythm ; Cross-Over Studies ; Double-Blind Method ; Fasting ; Fatty Acids, Nonesterified/blood ; Gastric Inhibitory Polypeptide/blood ; Glucagon-Like Peptide 1/blood ; Humans ; Insulin/blood ; Male ; Meals ; Placebos ; Postprandial Period ; Tea ; Time Factors ; Triglycerides/blood ; Young Adult
    Chemische Substanzen Blood Glucose ; Fatty Acids, Nonesterified ; Insulin ; Placebos ; Tea ; Triglycerides ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide 1 (89750-14-1) ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL)
    Sprache Englisch
    Erscheinungsdatum 2019-08-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2019.108221
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    Zs.A 2838: Hefte anzeigen Standort:
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  4. Artikel: Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men

    Takahashi, Masaki / Fukazawa, Mayuko / Hibi, Masanobu / Matsui, Yuji / Miyashita, Masashi / Nakaoka, Takashi / Osaki, Noriko / Ozaki, Mamiho / Shibata, Shigenobu / Wakisaka, Takuya

    Journal of nutritional biochemistry. 2019 Nov., v. 73

    2019  

    Abstract: Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of ... ...

    Abstract Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.
    Schlagwörter blood glucose ; blood sampling ; catechin ; fasting ; gastric inhibitory polypeptide ; glucose ; green tea ; ingestion ; men ; metabolism ; polyphenols
    Sprache Englisch
    Erscheinungsverlauf 2019-11
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2019.108221
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  5. Artikel ; Online: Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women.

    Takahashi, Masaki / Miyashita, Masashi / Suzuki, Katsuhiko / Bae, Seong-Ryu / Kim, Hyeon-Ki / Wakisaka, Takuya / Matsui, Yuji / Takeshita, Masao / Yasunaga, Koichi

    The British journal of nutrition

    2014  Band 112, Heft 9, Seite(n) 1542–1550

    Abstract: Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ... ...

    Abstract Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ingestion of catechin-rich green tea on postprandial hyperglycaemia and oxidative stress in healthy postmenopausal women. Participants were randomly assigned into the placebo (P, n 11) or green tea (GT, n 11) group. The GT group consumed a catechin-rich green tea (catechins 615 mg/350 ml) beverage per d for 4 weeks. The P group consumed a placebo (catechins 92 mg/350 ml) beverage per d for 4 weeks. At baseline and after 4 weeks, participants of each group consumed their designated beverages with breakfast and consumed lunch 3 h after breakfast. Venous blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. Postprandial glucose concentrations were 3 % lower in the GT group than in the P group (three-factor ANOVA, group × time interaction, P< 0·05). Serum concentrations of the derivatives of reactive oxygen metabolites increased after meals (P< 0·05), but no effect of catechin-rich green tea intake was observed. Conversely, serum postprandial thioredoxin concentrations were 5 % higher in the GT group than in the P group (three-factor ANOVA, group × time interaction, P< 0·05). These findings indicate that an acute ingestion of catechin-rich green tea has beneficial effects on postprandial glucose and redox homeostasis in postmenopausal women.
    Mesh-Begriff(e) Aged ; Blood Glucose/analysis ; Catechin/administration & dosage ; Double-Blind Method ; Exercise ; Fasting ; Female ; Humans ; Middle Aged ; Oxidative Stress/drug effects ; Placebos ; Postmenopause/blood ; Postprandial Period ; Reactive Oxygen Species/blood ; Tea ; Thioredoxins/blood
    Chemische Substanzen Blood Glucose ; Placebos ; Reactive Oxygen Species ; Tea ; Thioredoxins (52500-60-4) ; Catechin (8R1V1STN48)
    Sprache Englisch
    Erscheinungsdatum 2014-11-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114514002530
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.184: Hefte anzeigen Standort:
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  6. Artikel: Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women

    Takahashi, Masaki / Miyashita, Masashi / Suzuki, Katsuhiko / Bae, Seong-ryu / Kim, Hyeon-Ki / Wakisaka, Takuya / Matsui, Yuji / Takeshita, Masao / Yasunaga, Koichi

    British journal of nutrition. 2014 Nov. 14, v. 112, no. 9

    2014  

    Abstract: Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ... ...

    Abstract Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ingestion of catechin-rich green tea on postprandial hyperglycaemia and oxidative stress in healthy postmenopausal women. Participants were randomly assigned into the placebo (P, n 11) or green tea (GT, n 11) group. The GT group consumed a catechin-rich green tea (catechins 615 mg/350 ml) beverage per d for 4 weeks. The P group consumed a placebo (catechins 92 mg/350 ml) beverage per d for 4 weeks. At baseline and after 4 weeks, participants of each group consumed their designated beverages with breakfast and consumed lunch 3 h after breakfast. Venous blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. Postprandial glucose concentrations were 3 % lower in the GT group than in the P group (three-factor ANOVA, group × time interaction, P< 0·05). Serum concentrations of the derivatives of reactive oxygen metabolites increased after meals (P< 0·05), but no effect of catechin-rich green tea intake was observed. Conversely, serum postprandial thioredoxin concentrations were 5 % higher in the GT group than in the P group (three-factor ANOVA, group × time interaction, P< 0·05). These findings indicate that an acute ingestion of catechin-rich green tea has beneficial effects on postprandial glucose and redox homeostasis in postmenopausal women.
    Schlagwörter analysis of variance ; antioxidant activity ; beverages ; blood sampling ; blood serum ; breakfast ; catechin ; glucose ; green tea ; homeostasis ; hyperglycemia ; ingestion ; lunch ; noninsulin-dependent diabetes mellitus ; oxidative stress ; placebos ; postmenopause ; reactive oxygen species ; risk ; women
    Sprache Englisch
    Erscheinungsverlauf 2014-1114
    Umfang p. 1542-1550.
    Erscheinungsort Cambridge University Press
    Dokumenttyp Artikel
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114514002530
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    Z 916: Hefte anzeigen

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  7. Artikel: Lymphatic absorption of plasmalogen in rats.

    Hara, Hiroshi / Wakisaka, Takuya / Aoyama, Yoritaka

    The British journal of nutrition

    2003  Band 90, Heft 1, Seite(n) 29–32

    Abstract: Plasmalogen is a subclass of phospholipids that is widely distributed in man and animals. Many physiological roles have been proposed for this lipid; however, there have been no reports on the intestinal absorption of plasmalogen. In the present study, ... ...

    Abstract Plasmalogen is a subclass of phospholipids that is widely distributed in man and animals. Many physiological roles have been proposed for this lipid; however, there have been no reports on the intestinal absorption of plasmalogen. In the present study, we examined lymphatic absorption of plasmalogen after the duodenal infusion of emulsified brain phospholipids (BPL) containing plasmalogen (22 mol % of total phospholipids) and soyabean lecithin (SPL) (100 g emulsified phospholipid/l). Male Wistar rats with implanted cannulas in the mesenteric lymph duct and the duodenum were kept in a Bollman-type restraining cage, and were infused the emulsion after 1 d recovery with duodenal infusion of a glucose-NaCl solution. Lymphatic plasmalogen output was increased at 2-4 h after the switch to BPL emulsion, and peaked at 4-6 h. However, no increases were observed after SPL infusion. Lymphatic recovery of plasmalogen for 8 h was 198 nmol, which was 0.22 mol % of the total plasmalogen disappeared from the intestine. We did not detect any increases in long-chain fatty aldehydes, which are the degradation product of plasmalogen, either in the blood or the small intestine. We conclude that a small percentage but a significant amount of the plasmalogen was absorbed into the lymph.
    Mesh-Begriff(e) Animals ; Duodenum ; Intestinal Absorption/physiology ; Lymph Nodes/metabolism ; Male ; Mesentery ; Plasmalogens/administration & dosage ; Plasmalogens/metabolism ; Rats ; Rats, Wistar
    Chemische Substanzen Plasmalogens
    Sprache Englisch
    Erscheinungsdatum 2003-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1079/bjn2003879
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats.

    Nishimukai, Megumi / Wakisaka, Takuya / Hara, Hiroshi

    Lipids

    2002  Band 38, Heft 12, Seite(n) 1227–1235

    Abstract: Plasmalogens, a subclass of phospholipids, are widely distributed in human and animals, and are taken into the body as food. However, no data exist on the intestinal absorption or fate of ingested plasmalogen. Here, we determined whether dietary ... ...

    Abstract Plasmalogens, a subclass of phospholipids, are widely distributed in human and animals, and are taken into the body as food. However, no data exist on the intestinal absorption or fate of ingested plasmalogen. Here, we determined whether dietary plasmalogen is absorbed and whether blood and tissue concentrations increased in normal male Wistar rats by using four separate experiments. Phospholipids containing more than 20 wt% of plasmalogen extracted from the bovine brain were incorporated into test diets (10-15 wt%). In experiment 1, we estimated the absorption rate by measuring the plasmalogen vinyl ether bonds remaining in the alimentary tract of rats after the ingestion of 2 g of test diet containing 91 micromol plasmalogen. The absorption rate of plasmalogen was nearly 80 mol% after 4 h, comparable to the total phospholipid content in the test diet. In experiment 2, we observed no degradation of the plasmalogen vinyl ether bonds under in vitro conditions simulating those of the stomach and small intestinal lumen. In experiment 3 we confirmed a comparable absorption (36 mol%) by using a closed loop of the upper small intestine in anesthetized rats 90 min after injecting a 10 wt% brain phospholipid emulsion. Feeding a test diet containing 10 wt% brain phospholipids for 7 d increased plasmalogen concentration threefold in blood plasma and by 25% in the liver; however, no increases were seen in blood cells, skeletal muscle, brain, lungs, kidneys, or adipose tissue (experiment 4). We concluded that dietary plasmalogen is absorbed from the intestine and contributes to a large increase in plasmalogen levels in blood plasma.
    Mesh-Begriff(e) Animals ; Diet ; Intestinal Mucosa/metabolism ; Liver/metabolism ; Male ; Phospholipids/administration & dosage ; Phospholipids/blood ; Phospholipids/pharmacokinetics ; Plasmalogens/administration & dosage ; Plasmalogens/blood ; Plasmalogens/pharmacokinetics ; Rats ; Rats, Wistar ; Time Factors
    Chemische Substanzen Phospholipids ; Plasmalogens
    Sprache Englisch
    Erscheinungsdatum 2002-09-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1007/s11745-003-1183-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism.

    Murase, Takatoshi / Aoki, Masafumi / Wakisaka, Takuya / Hase, Tadashi / Tokimitsu, Ichiro

    Journal of lipid research

    2002  Band 43, Heft 8, Seite(n) 1312–1319

    Abstract: We examined the long-term effects of dietary diacylglycerol (DG) and triacylglycerol (TG) with similar fatty acid compositions on the development of obesity in C57BL/6J mice. We also analyzed the expression of genes involved in lipid metabolism at an ... ...

    Abstract We examined the long-term effects of dietary diacylglycerol (DG) and triacylglycerol (TG) with similar fatty acid compositions on the development of obesity in C57BL/6J mice. We also analyzed the expression of genes involved in lipid metabolism at an early stage of obesity development in these mice. Compared with mice fed the high-TG diet, mice fed the high-DG diet accumulated significantly less body fat during the 8-month study period. Within the first 10 days, dietary DG stimulated beta-oxidation and lipid metabolism-related gene expression, including acyl-CoA oxidase, medium-chain acyl-CoA dehydrogenase, and uncoupling protein-2 in the small intestine but not in the liver, skeletal muscle, or brown adipose tissue, suggesting the predominant contribution of intestinal lipid metabolism to the effects of DG. Furthermore, analysis of digestion products of [(14)C]DG and those of [(14)C]TG revealed that the radioactivity levels detected in fatty acid, 1-monoacylglycerol, and 1,3-DG in intestinal mucosa were significantly higher after intrajejunal injection of DG rather than TG. Thus, dietary DG reduces body weight gain that accompanies the stimulation of intestinal lipid metabolism, and these effects may be related to the characteristic metabolism of DG in the small intestine.
    Mesh-Begriff(e) Animals ; Anti-Obesity Agents/administration & dosage ; Anti-Obesity Agents/pharmacology ; Diglycerides/administration & dosage ; Diglycerides/pharmacology ; Intestinal Mucosa/metabolism ; Intestines/drug effects ; Lipid Metabolism ; Male ; Mice ; Mice, Inbred C57BL
    Chemische Substanzen Anti-Obesity Agents ; Diglycerides
    Sprache Englisch
    Erscheinungsdatum 2002-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Dietary α-Linolenic Acid–Rich Diacylglycerols Reduce Body Weight Gain Accompanying the Stimulation of Intestinal β-Oxidation and Related Gene Expressions in C57BL/KsJ-db/db Mice

    Murase, Takatoshi / Nagasawa, Azumi / Suzuki, Junko / Wakisaka, Takuya / Hase, Tadashi / Tokimitsu, Ichiro

    Journal of nutrition. 2002 Oct., v. 132, no. 10

    2002  

    Abstract: Dietary fat contributes to the development of obesity. We examined the effect of dietary diacylglycerol (DG), which is a minor component of edible oils, on the development of obesity and expression of genes involved in energy homeostasis in C57BL/KsJ-db/ ... ...

    Abstract Dietary fat contributes to the development of obesity. We examined the effect of dietary diacylglycerol (DG), which is a minor component of edible oils, on the development of obesity and expression of genes involved in energy homeostasis in C57BL/KsJ-db/db mice. Mice were fed diets containing either 14 g/100 g (%) triacylglycerol (TG), 10% TG + 4% α-linolenic acid-rich TG (ALATG), or 10% TG + 4% α-linolenic acid-rich diacylglycerol (ALADG) for 1 mo. Mice fed ALADG, but not ALATG had less body weight gain and higher rectal temperature than the TG-fed controls. These effects were accompanied by up-regulation of acyl-CoA oxidase, medium-chain acyl-CoA dehydrogenase, fatty acid binding protein, and uncoupling protein (UCP)-2 mRNA and β-oxidation activity in the small intestine. In contrast, the treatments did not affect β-oxidation and related gene expressions in the liver or UCP-3 mRNA level in skeletal muscle. These results indicate that stimulation of lipid metabolism in the small intestine might be closely related to the antiobesity and thermogenic effects of dietary DG. In addition, structural differences between DG and TG, not variations in the composition of fatty acids, are responsible for the different effects of the lipids.
    Schlagwörter acyl coenzyme A ; acyl-CoA dehydrogenase ; beta oxidation ; diacylglycerols ; dietary fat ; energy ; fatty acid composition ; fatty acid-binding proteins ; gene expression ; gene expression regulation ; genes ; homeostasis ; liver ; messenger RNA ; mice ; obesity ; oils ; skeletal muscle ; small intestine ; temperature ; triacylglycerols ; weight gain
    Sprache Englisch
    Erscheinungsverlauf 2002-10
    Umfang p. 3018-3022.
    Dokumenttyp Artikel
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    Datenquelle NAL Katalog (AGRICOLA)

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