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  1. Article ; Online: Cooperation Between Japan's NIID and China CDC in Japan's COVID-19 Response.

    Wakita, Takaji

    China CDC weekly

    2021  Volume 2, Issue 45, Page(s) 884–886

    Language English
    Publishing date 2021-08-29
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2020.234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Hepatitis C virus / 1

    Miyamura, Tatsuo / Lemon, Stanley M. / Walker, Christopher M. / Wakita, Takaji

    cellular and molecular virology

    2016  

    Author's details Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita editors
    Collection Hepatitis C virus
    Language English
    Size 1 Online-Ressource (ix, 362 Seiten), Illustrationen, Diagramme
    Publishing country Japan
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019507017
    ISBN 978-4-431-56098-2 ; 9784431560968 ; 4-431-56098-X ; 4431560963
    DOI 10.1007/978-4-431-56098-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Hepatitis C virus / 2

    Miyamura, Tatsuo / Lemon, Stanley M. / Walker, Christopher M. / Wakita, Takaji

    cellular and molecular virology

    2016  

    Author's details Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita editors
    Collection Hepatitis C virus
    Language English
    Size 1 Online-Ressource (ix, 372 Seiten), Illustrationen
    Publishing country Japan
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019507053
    ISBN 978-4-431-56101-9 ; 9784431560999 ; 4-431-56101-3 ; 4431560998
    DOI 10.1007/978-4-431-56101-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book ; Online: Hepatitis C virus

    Miyamura, Tatsuo / Lemon, Stanley M. / Walker, Christopher M. / Wakita, Takaji

    cellular and molecular virology

    2016  

    Author's details Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita editors
    Language English
    Dates of publication 2016-9999
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Online
    HBZ-ID HT019507009
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Cell Culture Systems of HCV Using JFH-1 and Other Strains.

    Wakita, Takaji

    Cold Spring Harbor perspectives in medicine

    2019  Volume 9, Issue 11

    Abstract: Hepatitis C virus (HCV) infection is seen worldwide and is a significant cause of severe chronic liver diseases. Recently, a large number of direct-acting antivirals (DAAs) have been developed against HCV infection, resulting in significant improvements ... ...

    Abstract Hepatitis C virus (HCV) infection is seen worldwide and is a significant cause of severe chronic liver diseases. Recently, a large number of direct-acting antivirals (DAAs) have been developed against HCV infection, resulting in significant improvements in treatment efficacy. Rapid progress in HCV research has been largely dependent on the development of HCV culture systems and small animal infection models. In the development of HCV cell culture systems, the discovery of the JFH-1 clone, an HCV strain isolated from a fulminant hepatitis C patient, was a key finding. The JFH-1 strain was the first infectious HCV strain belonging to genotype 2a. JFH-1 replicated efficiently in cultured cell lines without acquiring adaptive mutations, providing the secretion of infectious viral particles into the culture medium. Recently, other HCV strains also were reported to be infectious in cultured cells with adaptive viral mutations, but genotype-1b infectious HCV clones and virus culture systems for clinical isolates are still missing. These infectious HCV systems have provided powerful tools to study the viral life cycle, to construct antiviral strategies, and to develop effective vaccines.
    MeSH term(s) Animals ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Genotype ; Hepacivirus/genetics ; Hepacivirus/growth & development ; Hepacivirus/physiology ; Humans ; RNA, Viral ; Virus Cultivation/methods ; Virus Replication
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a036806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Hepatitis virus culture and anti-viral development].

    Wakita, Takaji

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 9, Page(s) 63–68

    MeSH term(s) Antiviral Agents/pharmacology ; Cell Culture Techniques ; Drug Evaluation, Preclinical ; Hepatitis Viruses/drug effects ; Hepatitis Viruses/physiology ; Humans ; Virus Internalization
    Chemical Substances Antiviral Agents
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Small Animal Models of Hepatitis E Virus Infection.

    Li, Tian-Cheng / Wakita, Takaji

    Cold Spring Harbor perspectives in medicine

    2019  Volume 9, Issue 8

    Abstract: Novel hepeviruses have been recovered from many different animal species in recent years, increasing the diversity known to exist among ... ...

    Abstract Novel hepeviruses have been recovered from many different animal species in recent years, increasing the diversity known to exist among the
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Chickens ; Disease Models, Animal ; Ferrets ; Gerbillinae ; Hepatitis E/drug therapy ; Hepatitis E/pathology ; Hepatitis E/prevention & control ; Hepatitis E virus/growth & development ; Hepatitis E virus/pathogenicity ; Mice ; Rabbits ; Rats ; Tupaiidae ; Viral Hepatitis Vaccines/immunology
    Chemical Substances Antiviral Agents ; Viral Hepatitis Vaccines
    Language English
    Publishing date 2019-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a032581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface.

    Nishimura, Yorihiro / Sato, Kei / Koyanagi, Yoshio / Wakita, Takaji / Muramatsu, Masamichi / Shimizu, Hiroyuki / Bergelson, Jeffrey M / Arita, Minetaro

    PLoS pathogens

    2024  Volume 20, Issue 2, Page(s) e1012022

    Abstract: Enterovirus A71 (EV-A71) infection involves a variety of receptors. Among them, two transmembrane protein receptors have been investigated in detail and shown to be critical for infection: P-selectin glycoprotein ligand-1 (PSGL-1) in lymphocytes (Jurkat ... ...

    Abstract Enterovirus A71 (EV-A71) infection involves a variety of receptors. Among them, two transmembrane protein receptors have been investigated in detail and shown to be critical for infection: P-selectin glycoprotein ligand-1 (PSGL-1) in lymphocytes (Jurkat cells), and scavenger receptor class B member 2 (SCARB2) in rhabdomyosarcoma (RD) cells. PSGL-1 and SCARB2 have been reported to be expressed on the surface of Jurkat and RD cells, respectively. In the work reported here, we investigated the roles of PSGL-1 and SCARB2 in the process of EV-A71 entry. We first examined the expression of SCARB2 in Jurkat cells, and detected it within the cytoplasm, but not on the cell surface. Further, using PSGL-1 and SCARB2 knockout cells, we found that although both PSGL-1 and SCARB2 are essential for virus infection of Jurkat cells, virus attachment to these cells requires only PSGL-1. These results led us to evaluate the cell surface expression and the roles of SCARB2 in other EV-A71-susceptible cell lines. Surprisingly, in contrast to the results of previous studies, we found that SCARB2 is absent from the surface of RD cells and other susceptible cell lines we examined, and that although SCARB2 is essential for infection of these cells, it is dispensable for virus attachment. These results indicate that a receptor other than SCARB2 is responsible for virus attachment to the cell and probably for internalization of virions, not only in Jurkat cells but also in RD cells and other EV-A71-susceptible cells. SCARB2 is highly concentrated in lysosomes and late endosomes, where it is likely to trigger acid-dependent uncoating of virions, the critical final step of the entry process. Our results suggest that the essential interactions between EV-A71 and SCARB2 occur, not at the cell surface, but within the cell.
    MeSH term(s) Humans ; Enterovirus/metabolism ; Enterovirus A, Human/genetics ; Enterovirus A, Human/metabolism ; Enterovirus Infections ; Cell Membrane/metabolism ; Cell Line ; Receptors, Scavenger/genetics ; Receptors, Scavenger/metabolism ; Lysosomal Membrane Proteins/genetics
    Chemical Substances SCARB2 protein, human ; Receptors, Scavenger ; Lysosomal Membrane Proteins
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Hepatitis C virus culture and its application].

    Wakita, Takaji

    Nihon rinsho. Japanese journal of clinical medicine

    2011  Volume 69 Suppl 4, Page(s) 69–74

    MeSH term(s) Hepacivirus/growth & development ; Hepacivirus/pathogenicity ; Hepatitis C/virology ; Humans ; Receptors, Virus/chemistry
    Chemical Substances Receptors, Virus
    Language Japanese
    Publishing date 2011-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of

    Murata, Takayuki / Iwahori, Satoko / Okuno, Yusuke / Nishitsuji, Hironori / Yanagi, Yusuke / Watashi, Koichi / Wakita, Takaji / Kimura, Hiroshi / Shimotohno, Kunitada

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: N6-methyladenosine ( ... ...

    Abstract N6-methyladenosine (m
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Hepatitis B virus/metabolism ; Viral Regulatory and Accessory Proteins/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Virus Replication/genetics ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Hepatitis B
    Chemical Substances Viral Regulatory and Accessory Proteins ; Trans-Activators ; RNA, Viral
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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