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Article ; Online: Accuracy of automated analyzers for the estimation of CSF cell counts: A systematic review and meta-analysis.

Waldrop, Greer E / Cocuzzo, Kaitlyn / Schneider, Colleen L / Kim, Carla Y / Goetz, Teddy G / Chomba, Mashina S / Delaurentis, Clare E / Smithgall, Marie C / Francis, Richard O / Thakur, Kiran T

International journal of laboratory hematology

2024 Volume 46, Issue 2, Page(s) 234–242

Abstract: This systematic review evaluates the evidence for accuracy of automated analyzers that estimate cerebrospinal fluid (CSF) white blood cell counts (WBC) compared to manual microscopy. Inclusion criteria of original research articles included human ... ...

Abstract	This systematic review evaluates the evidence for accuracy of automated analyzers that estimate cerebrospinal fluid (CSF) white blood cell counts (WBC) compared to manual microscopy. Inclusion criteria of original research articles included human subjects, English language, and manual microscopy comparator. PUBMED, EMBASE and Cochrane Review databases were searched through 2019 and QUADAS-2 Tool was used for assessment of bias. Data were pooled and analyzed by comparison method, using random effects estimation. Among 652 titles, 554 abstracts screened, 104 full-text review, 111 comparisons from 41 studies were included. Pooled estimates of sensitivity and specificity (n = 7) were 95% (95%-CI 93%-97%) and 84% (95%-CI: 64%-96%), respectively. Pooled R
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14236
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Article ; Online: Clinical Significance of Positive Results of the BioFire Cerebrospinal Fluid FilmArray Meningitis/Encephalitis Panel at a Tertiary Medical Center in the United States.

Waldrop, Greer / Zucker, Jason / Boubour, Alexandra / Radmard, Sara / Green, Daniel A / Thakur, Kiran T

Archives of pathology & laboratory medicine

2021 Volume 146, Issue 2, Page(s) 194–200

Abstract: Context.—: The FilmArray Meningitis/Encephalitis (ME) panel is the first US Food and Drug Administration-cleared multiplex polymerase chain reaction panel for the detection of central nervous system infections. While the assay's performance ... ...

Abstract	Context.—: The FilmArray Meningitis/Encephalitis (ME) panel is the first US Food and Drug Administration-cleared multiplex polymerase chain reaction panel for the detection of central nervous system infections. While the assay's performance characteristics have been described, the real-world significance of positive results has not been fully characterized. Objective.—: To evaluate the clinical significance of positive ME panel results in a tertiary care medical center in New York, New York. Design.—: Four physicians independently performed retrospective clinical assessments of all positive ME panel results at Columbia University Irving Medical Center, including the Children's Hospital of New York, during an 18-month period. Each reviewer determined the likelihood of central nervous system infection for all cases and whether cases fit Brighton diagnostic criteria for meningitis, encephalitis, or meningoencephalitis. Results.—: Among 119 cases, there was 75% positive agreement (95% CI, 54%-89%) between ME panel results and clinical consensus, which varied among panel targets. Conclusions.—: The ME panel showed good agreement with expert clinical consensus for patients presenting with acute meningitis/encephalitis. Factors contributing to clinically insignificant ME positive results included low pretest probability, traumatic lumbar puncture, specimen contamination, and detection of incidental viral targets such as human herpesvirus 6. Notably, the ME panel detected more than twice the number of cases of bacterial meningitis detected by culture alone, particularly among patients receiving empiric antimicrobial therapy before lumbar puncture. Appropriate test use and contextual interpretation of results are critical to leveraging the advantages of the platform while avoiding potential pitfalls.
MeSH term(s)	Child ; Encephalitis/cerebrospinal fluid ; Encephalitis/diagnosis ; Humans ; Meningitis/cerebrospinal fluid ; Meningitis/diagnosis ; Multiplex Polymerase Chain Reaction/methods ; Retrospective Studies ; Tertiary Care Centers ; United States
Language	English
Publishing date	2021-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2020-0380-OA
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Article ; Online: The Association Between Magnetic Resonance Imaging Disc Pathology and Provocative Discography at the Lumbar Level.

Waldrop, Greer / Trent, Graham / Dagher, Azar P / Reinig, James / Thompson, Kerry J

Journal of computer assisted tomography

2020 Volume 45, Issue 1, Page(s) 146–150

Abstract: Objective: The objective of this study was to show that degenerative lumbar magnetic resonance imaging findings variably increase discography pain by level.: Methods: Lumbar discography and magnetic resonance imaging of 736 patients were ... ...

Abstract	Objective: The objective of this study was to show that degenerative lumbar magnetic resonance imaging findings variably increase discography pain by level. Methods: Lumbar discography and magnetic resonance imaging of 736 patients were retrospectively reviewed. Univariate/multivariate logistic regressions calculated the odds ratio (OR) (95% confidence interval, P < 0.05). Results: L3-4 multivariate regression OR for a degenerative disc is 9.9; for bulge, 10.9; for annular tear, 38.9; for herniation, 51.5; and for degenerative facet, 2.158. Endplate changes were not significant. L4-5 OR for a degenerative disc is 4.52; for bulge, 13.74, for tear, 19.13; for herniation, 28.65; for endplate edema, 3.47; and fatty change, 3.84. Degenerative facet ORs were not significant. L5-S1 OR for a degenerative disc is 6.86; for bulge, 5.65; for tear, 40.56; and for herniation, 77.98. Endplate changes and degenerative facet OR's were not significant. Conclusions: Advancing degeneration increases pain at L5-S1 followed by L3-4. Endplate signal is significant only at L4-5.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/pathology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pain Measurement/methods ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000000956
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Article ; Online: Reply: Trading Lower HbA1c for Increased Adverse Events: A Zero Sum Game?

Rajagopalan, Sanjay / Waldrop, Greer / Zhong, Jixin

Journal of the American College of Cardiology

2016 Volume 68, Issue 12, Page(s) 1373–1374

MeSH term(s)	Diabetes Mellitus/drug therapy ; Glycated Hemoglobin A ; Humans
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2016--20
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2016.07.716
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incretin-Based Therapy for Diabetes: What a Cardiologist Needs to Know.

Waldrop, Greer / Zhong, Jixin / Peters, Matthew / Rajagopalan, Sanjay

Journal of the American College of Cardiology

2016 Volume 67, Issue 12, Page(s) 1488–1496

Abstract: Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes because of their efficacy, safety, and ease of use. Both glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 ... ...

Abstract	Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes because of their efficacy, safety, and ease of use. Both glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used for glycemic control as adjuncts to metformin, other oral antiglycemic agents, or insulin. Glucagon-like peptide-1 receptor agonists may have additional effects, such as weight loss, that may be advantageous in obese patients. There is a large body of evidence from randomized controlled clinical trials supporting the cardiovascular safety of dipeptidyl peptidase-4 inhibitors and some glucagon-like peptide-1 receptor agonists, at least in the short term. However, concerns have been raised, particularly regarding their safety in patients with heart failure. In this review, the authors provide a brief but practical evidence-based analysis of the use of incretin-based agents in patients with diabetes, their efficacy, and cardiovascular safety.
MeSH term(s)	Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Incretins/therapeutic use ; Practice Guidelines as Topic ; Treatment Outcome
Chemical Substances	Blood Glucose ; Incretins
Language	English
Publishing date	2016-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2015.12.058
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Stable patients and patients with advanced disease: consensus definitions to support sustained scale up of antiretroviral therapy.

Waldrop, Greer / Doherty, Meg / Vitoria, Marco / Ford, Nathan

Tropical medicine & international health : TM & IH

2016 Volume 21, Issue 9, Page(s) 1124–1130

Abstract: Objective: As guidelines are evolving towards recommending starting antiretroviral therapy (ART) in all HIV-positive individuals irrespective of clinical and immunological status, HIV programmes will be challenged to manage an increasingly diverse set ... ...

Abstract	Objective: As guidelines are evolving towards recommending starting antiretroviral therapy (ART) in all HIV-positive individuals irrespective of clinical and immunological status, HIV programmes will be challenged to manage an increasingly diverse set of patient needs. To support global guideline recommendations for differentiated service delivery, WHO developed consensus definitions for two distinct patient populations: patients presenting with advanced disease and patients who are stable on ART. Methods: An expert panel consisting of 73 respondents from 28 countries across all six WHO regions supported the development of these definitions. The panel included clinicians, researchers, programme managers, technical advisors and patient group representatives. Results: Patients presenting with advanced disease at presentation to care were defined as CD4 count <200 CD4 cells/mm(3) or WHO Stage III & IV defining illness. Patients stable on ART were defined as those who were receiving ART for at least 1 year with no adverse drug reactions requiring regular monitoring, no current illnesses or pregnancy, a good understanding of lifelong adherence, and evidence of treatment success. Treatment success was defined as two consecutive undetectable viral load measures or, in the absence of viral load monitoring, rising CD4 counts or CD4 counts above 200 cells/mm(3) and an objective adherence measure. Conclusions: Patients who are stable on ART should be offered a less intensive care package that can lead to improved outcomes while saving resources, including less frequent clinic visits, out-of-clinic drug refills and reduced laboratory monitoring. This will allow for clinic resources to be directed towards reducing morbidity and mortality among patients presenting with advanced disease.
MeSH term(s)	Adult ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; Consensus ; Disease Progression ; HIV Infections/drug therapy ; Health Status ; Humans ; Patient Selection ; Severity of Illness Index ; Treatment Outcome ; Viral Load
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2016-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1314080-2
ISSN	1365-3156 ; 1360-2276
ISSN (online)	1365-3156
ISSN	1360-2276
DOI	10.1111/tmi.12746
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Article ; Online: Positive Predictive Values of Lumbar Spine Magnetic Resonance Imaging Findings for Provocative Discography.

Chelala, Lydia / Trent, Graham / Waldrop, Greer / Dagher, Azar P / Reinig, James W

Journal of computer assisted tomography

2019 Volume 43, Issue 4, Page(s) 568–571

Abstract: Purpose: The purpose of this study was to calculate the positive predictive value (PPV) of lumbar spine magnetic resonance imaging (MRI) findings for a painful disc using provocative discography.: Materials and methods: Lumbar spine discography ... ...

Abstract	Purpose: The purpose of this study was to calculate the positive predictive value (PPV) of lumbar spine magnetic resonance imaging (MRI) findings for a painful disc using provocative discography. Materials and methods: Lumbar spine discography records and prediscography MRIs of 736 patients (2457 discs) who underwent discography for diagnostic purposes from 2003 to 2007 were retrospectively reviewed in an Institutional Review Board-exempt and Health Insurance Portability and Accountability Act-compliant protocol. Each level was identified as having high-intensity zone (HIZ) disc, disc protrusion, disc extrusion, or combination (any herniation type), disc bulge, disc degeneration, and spondylolisthesis. Statistical analysis used a 2 × 2 contingency table of significant discography results for each of the MRI variables to calculate P value and PPV with a confidence interval from a binomial distribution. Results: An HIZ disc has a PPV of 0.71 (0.65-0.76, P = 4.31E - 44) for a provocative discography. A disc protrusion has a PPV of 0.79 (0.73-0.83, P = 2.68E - 53). A disc extrusion has a PPV of 0.93 (0.79-0.98, P = 1.34E - 14), a bulge of 0.43 (0.37-0.48, P = 0.002), and a degenerative disc of 0.32 (0.28-0.35, P = 0.08), and spondylolisthesis has a PPV of 0.67 (0.59-0.73, P = 1.70E - 20). A herniation of either type (extrusion or protrusion) has a PPV of 0.80 (0.75-0.84, P = 5.86E - 69). Conclusions: Disc herniations and HIZ discs have high predictive value in identifying a pain generator. An extruded disc herniation has the highest PPV for discogenic pain.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/pathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Spinal Diseases/diagnostic imaging ; Spinal Diseases/pathology ; Young Adult
Language	English
Publishing date	2019-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000000885
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Article ; Online: The World Health Organization's Essential Diagnostics List: Diagnostics for neurologic disorders.

Waldrop, Greer / Goetz, Teddy G / Siddiqi, Omar K / Koralnik, Igor J / Shah, Hiral / Thakur, Kiran T

Neurology

2019 Volume 93, Issue 15, Page(s) 680–683

MeSH term(s)	Drugs, Essential/standards ; Head/diagnostic imaging ; Humans ; Leukocytes/cytology ; Nervous System Diseases/cerebrospinal fluid ; Nervous System Diseases/diagnosis ; World Health Organization
Chemical Substances	Drugs, Essential
Language	English
Publishing date	2019-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000008247
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Book ; Online: Stable patients and patients with advanced disease

Waldrop, Greer / Vitoria, Marco / Ford, Nathan / Doherty, Meg

consensus definitions to support sustained scale up of antiretroviral therapy

2016

Abstract: Review ... Journal Article ... As guidelines are evolving towards recommending starting antiretroviral therapy (ART) in all HIV-positive individuals irrespective of clinical and immunological status, HIV programmes will be challenged to manage an ... ...

Abstract	Review Journal Article As guidelines are evolving towards recommending starting antiretroviral therapy (ART) in all HIV-positive individuals irrespective of clinical and immunological status, HIV programmes will be challenged to manage an increasingly diverse set of patient needs. To support global guideline recommendations for differentiated service delivery, WHO developed consensus definitions for two distinct patient populations: patients presenting with advanced disease and patients who are stable on ART.An expert panel consisting of 73 respondents from 28 countries across all six WHO regions supported the development of these definitions. The panel included clinicians, researchers, programme managers, technical advisors, and patient group representatives.Patients presenting with advanced disease at presentation to care were defined as CD4 count < 200 CD4 cells/mm(3) or WHO Stage III & IV defining illness. Patients stable on ART were defined as those who were receiving ART for at least 1 year, with no adverse drug reactions requiring regular monitoring, no current illnesses or pregnancy, a good understanding of lifelong adherence, and evidence of treatment success. Treatment success was defined as 2 consecutive undetectable viral load measures or, in the absence of viral load monitoring, rising CD4 counts or CD4 counts above 200 cells/mm(3) and an objective adherence measure.Patients who are stable on ART should be offered a less intensive care package that can lead to improved outcomes while saving resources, including less frequent clinic visits, out-of-clinic drug refills, and reduced laboratory monitoring. This will allow for clinic resources to be directed towards reducing morbidity and mortality among patients presenting with advanced disease. This article is protected by copyright. All rights reserved.
Language	English
Publishing date	2016-07-02
Document type	Book ; Online
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Article ; Online: Hispanic/Latino-Serving Hospitals Provide Less Targeted Temperature Management Following Out-of-Hospital Cardiac Arrest.

Morris, Nicholas A / Mazzeffi, Michael / McArdle, Patrick / May, Teresa L / Waldrop, Greer / Perman, Sarah M / Burke, James F / Bradley, Steven M / Agarwal, Sachin / Figueroa, Jose F / Badjatia, Neeraj

Journal of the American Heart Association

2021 Volume 10, Issue 24, Page(s) e017773

Abstract: Background Variation exists in outcomes following out-of-hospital cardiac arrest (OHCA), but whether racial and ethnic disparities exist in post-arrest provision of targeted temperature management (TTM) is unknown. Methods and Results We performed a ... ...

Abstract	Background Variation exists in outcomes following out-of-hospital cardiac arrest (OHCA), but whether racial and ethnic disparities exist in post-arrest provision of targeted temperature management (TTM) is unknown. Methods and Results We performed a retrospective analysis of a prospectively collected cohort of patients who survived to admission following OHCA from the Cardiac Arrest Registry to Enhance Survival, whose catchment area represents ~50% of the United States from 2013-2019. Our primary exposure was race/ethnicity and primary outcome was utilization of TTM. We built a mixed-effects model with both state of arrest and admitting hospital modeled as random intercepts to account for clustering. Among 96,695 patients (24.6% Black, 8.0% Hispanic/Latino, 63.4% White), a smaller percentage of Hispanic/Latino patients received TTM than Black or White patients (37.5% vs. 45.0 % vs 43.3%, P < .001) following OHCA. In the mixed-effects model, Black patients (Odds Ratio [OR] 1.153, 95% Confidence Interval [CI] 1.102-1.207, P < .001) and Hispanic/Latino patients (OR 1.086, 95% CI 1.017-1.159, P < .001) were slightly more likely to receive TTM compared to White patients, perhaps due to worse admission neurological status. We did find community level disparity as Hispanic/Latino-serving hospitals (defined as the top decile of hospitals that cared for the highest proportion of Hispanic/Latino patients) provided less TTM (OR 0.587, 95% CI 0.474 to 0.742, P < .001). Conclusions Reassuringly, we did not find evidence of intrahospital or interpersonal racial or ethnic disparity in the provision of TTM. However, we did find inter-hospital, community level disparity. Hispanic/Latino-serving hospitals provided less guideline-recommended TTM after OHCA.
MeSH term(s)	Healthcare Disparities ; Hispanic or Latino ; Hospitals/statistics & numerical data ; Humans ; Hypothermia, Induced/statistics & numerical data ; Out-of-Hospital Cardiac Arrest/ethnology ; Out-of-Hospital Cardiac Arrest/therapy ; Retrospective Studies ; United States/epidemiology
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.023934
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