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Article ; Online: Evaluation of the prevalence of glucose-6-phosphate dehydrogenase deficiency in Al-Qassim region of Saudi Arabia

Ahmad AlShomar / Idris Sula / Waleed Al Abdulmonem / Nazmus Saquib

The Egyptian Journal of Internal Medicine, Vol 35, Iss 1, Pp 1-

2023 Volume 5

Abstract: Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked disorder that is more common in males, is the most prevalent blood enzyme deficiency, affecting 5% of the population worldwide. Its prevalence in Saudi Arabia varies ... ...

Abstract	Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked disorder that is more common in males, is the most prevalent blood enzyme deficiency, affecting 5% of the population worldwide. Its prevalence in Saudi Arabia varies greatly from one region to another (4.7% to 12%), and no related data are available for the country’s Al-Qassim region. Methods This was a retrospective medical record-based study. Eligible patients were those who visited Dr. Sulaiman Al-Habib Hospital in Al-Qassim, Saudi Arabia, between June 2021 and November 2022, and underwent the test for G6PD enzyme deficiency. The study sample consisted of (n = 313) randomly selected Saudi patients. G6PD enzyme activity was evaluated using spectrophotometry. Results The prevalence of G6PD deficiency was 2.9%. The proportion of male patients (100%) was significantly higher than that of female patients. 88.9% of patients with G6PD deficiency experienced episodes of acute hemolysis and reported a history of favism, whereas 77.8% of the patients had a family history of favism. Conclusion The prevalence of G6PD deficiency was low in Al-Qassim region of Saudi Arabia.
Keywords	Glucose-6-phosphate dehydrogenase ; G6PD deficiency ; Hemolytic anemia ; Al-Qassim ; Saudi Arabia ; Internal medicine ; RC31-1245
Subject code	590
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fermented camel milk enriched with plant sterols improves lipid profile and atherogenic index in rats fed high -fat and -cholesterol diets

Sami A. Althwab / Samar A. Alamro / Waleed Al Abdulmonem / Khaled S. Allemailem / Saud A. Alarifi / Essam M. Hamad

Heliyon, Vol 8, Iss 10, Pp e10871- (2022)

2022

Abstract: The current study was designed to explore the effect of fermented camel milk, plant sterols and their combination on the blood levels of sd-LDL and atherogenicity in rats fed on high-fat-cholesterol diets (HFC). Forty male Wistar rats were distributed ... ...

Abstract	The current study was designed to explore the effect of fermented camel milk, plant sterols and their combination on the blood levels of sd-LDL and atherogenicity in rats fed on high-fat-cholesterol diets (HFC). Forty male Wistar rats were distributed into five groups: Normal control (NC), Positive control (PC, HFC), plant sterol (PS, HFC containing 1% (w/w) β-sitosterol:Stigmasterols; 9:1), FM (HFC containing 4% (w/w) lyophilized fermented camel milk), and PSFM (HFC containing 1% (w/w) plant sterols +4% (w/w) lyophilized fermented camel milk). Antioxidant activity showed that β-sitosterol had the highest radical scavenging activity, followed by fermented camel milk and stigmasterol (p < 0.05). Feeding rats on HFC for 8 weeks resulted in a significant (p < 0.05) increase in blood lipids of PC group compared with NC group. Administration of PS, FM, and PSFM resulted in a significant reduction in atherogenic index (50, 24.5, and 41.5 %, p < 0.05), and sd-LDL levels (73, 45, and 59%, p < 0.05), respectively. Only the FM group showed a significant reduction in triglycerides levels of rats. Administration of PS, FM and PSFM decreased serum MDA levels significantly by 58.7, 45.4, and 69% (p < 0.05), and increased total antioxidant capacity by 35.9, 84.8, and 38.3% (p < 0.05), respectively. This is the first report to the best of our knowledge that shows fermented camel milk enriched with plant sterol could reduce atherogenesis and cardiovascular diseases activity via inhibition of the status of small dense LDL and oxidative stress.
Keywords	Cardiovascular disease ; Small dense LDL ; High fat cholesterol diet ; Plant sterols ; Fermented camel milk ; Oxidative stress ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	630
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

Zafar Rasheed / Naila Rasheed / Waleed Al Abdulmonem / Muhammad Ismail Khan

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract Abnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs) play a crucial role in human disorders including arthritis. In this study, we determined the effect of hsa-miR-125b-5p on interleukin (IL)-1β induced ... ...

Abstract	Abstract Abnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs) play a crucial role in human disorders including arthritis. In this study, we determined the effect of hsa-miR-125b-5p on interleukin (IL)-1β induced inflammatory genes in human osteoarthritic (OA) chondrocytes. Bioinformatics algorithms showed 3′untranslated region (3′UTR) of TRAF6 mRNA (NM_004620.3) has perfectly matched ‘seed-sequence’ for hsa-miR-125b-5p. Treatment of cells with IL-1β up-regulates TRAF6 mRNA and down-regulates hsa-miR-125b-5p expression. This negative correlation between TRAF6 and hsa-miR-125b-5p was verified by transfection with miR-125b mimic (pre-miR-125b). Moreover, transfection with miR-125b mimic caused marked inhibition of IL-1β-induced phosphorylation of p38-MAPK, JNK-MAPKs and ERK-MAPKs and also suppressed the nuclear levels of NF-κBp50, NF-κBp65 and inhibited the activation of IκBα. Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1β also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-γ, TGF-β1, IGFBP-1 and PGDF-BB. Importantly, this transfection also significantly inhibited IL-1β- induced MMP-13 expression/production. In short, this study concludes that hsa-miR-125b-5p acts as a negative co-regulator of inflammatory genes including MMP-13 via targeting TRAF6/MAPKs/NF-κB pathway in human OA chondrocytes.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Zafar Rasheed / Naila Rasheed / Waleed Al Abdulmonem / Muhammad Ismail Khan

Scientific Reports, Vol 9, Iss 1, Pp 1-

MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

2019 Volume 2

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experience of e-learning and online assessment during the COVID-19 pandemic at the College of Medicine, Qassim University

Ahmed Elzainy, MD / Abir El Sadik, MD / Waleed Al Abdulmonem, PhD

Journal of Taibah University Medical Sciences, Vol 15, Iss 6, Pp 456-

2020 Volume 462

Abstract: الملخص: أهداف البحث: بعد جائحة كوفيد-١٩، قامت المؤسسات الأكاديمية على الفور بتحويل جميع النشاطات الأكاديمية إلى التعليم الإليكتروني. يصف العمل الحالي الإجراءات المتزامنة للتعليم الإليكتروني والتقييم التي أجريت في كلية الطب، بجامعة القصيم، بالمملكة ... ...

Abstract	الملخص: أهداف البحث: بعد جائحة كوفيد-١٩، قامت المؤسسات الأكاديمية على الفور بتحويل جميع النشاطات الأكاديمية إلى التعليم الإليكتروني. يصف العمل الحالي الإجراءات المتزامنة للتعليم الإليكتروني والتقييم التي أجريت في كلية الطب، بجامعة القصيم، بالمملكة العربية السعودية. كما درسنا تأثير التعلم الإليكتروني والتقييم على أداء الطلاب وأعضاء هيئة التدريس، والتحديات التي تواجه استدامتها. طرق البحث: في هذه الدراسة المستعرضة الوصفية، قمنا برصد عدد ومدة الأنشطة التعليمية الإلكترونية المختلفة أثناء جائحة كوفيد-١٩. تم عقد الدورات التدريبية للإجراءات المختلفة للفصول الافتراضية والتقييم الإلكتروني للمعلمين والطلبة. ورتبت لجنة التقييم الإليكتروني المنشأة حديثا مختلف التقييمات الإليكترونية. تم مقارنة متوسط درجات نفس الطلبة أثناء جلسات التعلم القائم على حل المعضلات سواء عقدت وجها لوجه أو تم عقدها إلكترونيا. كما تم عمل وتحليل استبانة رضا الطلاب، والتقارير الأسبوعية لتصور أعضاء هيئة التدريس بالإضافة إلى خبرات جلسة مجموعة التركيز عن التعلم الإليكتروني. النتائج: تم تنفيذ ٦٢٠ فصلا افتراضية بنجاح على مدى ٩٩٤ ساعة شملت المحاضرات النظرية، وجلسات التعلم القائم على حل المعضلات، والندوات وحلقات النقاش. لاحظنا زيادة ذات دلالة إحصائية في متوسطدرجات الطالبات أثناء الجلسات الإلكترونية للتعلم القائم على حل المعضلات. عكس أكثر عدد ممكن ٥٢.٨٢٪ من طلاب السنوات الأساسية بالإضافة إلى أعضاء هيئة التدريس الرضى العالي تجاه الفصول الافتراضية، والتقييم الإليكتروني وورش العمل الإلكترونية. الاستنتاجات: أوضحت هذه الدراسة فوائد التعلم الإلكتروني والتقييم. لاحظنا ارتفاعا في إنجاز الطلاب وتصورا واعدا لأعضاء هيئة التدريس وتحسنا ملحوظا في مهاراتهم التكنولوجية. تدعم هذه النتائج التحول نحو التنفيذ المستقبلي لمزيد من المقررات الطبية الإليكترونية. Abstract: Objectives: During the COVID-19 pandemic, academic institutions are promptly shifting all educational activities to the e-learning format. The present work describes concurrent procedures for online teaching and assessment performed at the College of Medicine, Qassim University, KSA. We also explored the impact of e-learning and assessment on the performance of students and faculty, and the challenges to their ...
Keywords	COVID-19 ; e-Learning ; Online assessment ; Online PBL ; Pandemic ; Virtual classroom ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of meteorological parameters on COVID-19 pandemic

Mohammad Alkhowailed / Ali Shariq / Fuhaid Alqossayir / Osama A. Alzahrani / Zafar Rasheed / Waleed Al Abdulmonem

Informatics in Medicine Unlocked, Vol 20, Iss , Pp 100418- (2020)

A comprehensive study from Saudi Arabia

2020

Abstract: Background: The Coronavirus disease 2019 (COVID-19) has now been declared a global public health disaster with no currently available vaccine. This study was undertaken to analyse the effect of meteorological parameters such as temperature, humidity, and ...

Abstract	Background: The Coronavirus disease 2019 (COVID-19) has now been declared a global public health disaster with no currently available vaccine. This study was undertaken to analyse the effect of meteorological parameters such as temperature, humidity, and wind speed on the spread of ongoing COVID-19 in Saudi Arabia. Methods: The COVID-19 dashboard for five major cities of Saudi Arabia - Riyadh, Makah, Jeddah, Medina and Dammam was used for data collection. The data on weather were collected from the Weather Underground Company (IBM business GA, USA, 2020). The data were analysed by Spearman's rank correlations using JASP statistical software in two main sections. In the first section the data on COVID-19 from cities were combined to analyse the overall picture of COVID-19 and in the second section, different meteorological parameters such as temperature, humidity and wind speed were analysed. Results: Novel data revealed interesting facts on the spreading of COVID-19 in Saudi Arabia, the data showed that the number of COVID-19 positive cases increases due to the decrease of temperature or humidity, whereas an average decrease in the wind speed was also found to be associated with an elevation of the number of positive cases. Conclusions: This study determined the impact meteorological factors on the infectivity rate of COVID-19. An inverse association was found between the meteorological parameters with the spreading of COIVD-19. Therefore, this study directs the health authorities to implement specific measures against the spreading of this global pandemic based on weather patterns.
Keywords	COVID-19 ; Meteorological parameters ; Weather ; SARS-COV-2 ; Saudi Arabia ; Computer applications to medicine. Medical informatics ; R858-859.7 ; covid19
Subject code	910
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds

Md Mominur Rahman / Md Rezaul Islam / Shopnil Akash / Md Emon Hossain / Afroza Alam Tumpa / Galib Muhammad Abrar Ishtiaque / Limon Ahmed / Abdur Rauf / Anees Ahmed Khalil / Waleed Al Abdulmonem / Jesus Simal-Gandara

Heliyon, Vol 9, Iss 7, Pp e18090- (2023)

Comparison with conventional drugs acting on the same molecular mechanisms

2023

Abstract: Pomegranate, scientifically known as Punica granatum, has been a traditional medicinal remedy since ancient times. Research findings have shown that using pomegranate extracts can positively affect a variety of signaling pathways, including those ... ...

Abstract	Pomegranate, scientifically known as Punica granatum, has been a traditional medicinal remedy since ancient times. Research findings have shown that using pomegranate extracts can positively affect a variety of signaling pathways, including those involved in angiogenesis, inflammation, hyperproliferation, cellular transformation, the beginning stages of tumorigenesis, and lastly, a reduction in the final stages of metastasis and tumorigenesis. This is due to the fact that pomegranate extracts are rich in polyphenols, which are known to inhibit the activity of certain signaling pathways. In the United States, cancer is the second biggest cause of death after heart disease. The number of fatalities caused by cancer in the United States escalates yearly. Altering one's diet, getting involved in regular physical activity, and sustaining a healthy body weight are three easy steps an individual may follow to lower their cancer risk. Simply garnishing one's diet with vegetables and fruits has the potential to avert at least 20% of all cancer diagnoses and around 200,000 deaths caused by cancer each year. Vegetables, fruits, and other dietary constituents, such as minerals and phytochemicals, are currently being researched for their potential to prevent cancer. It is being done because they are safe, have minimal toxicity, possess antioxidant properties, and are universally accepted as dietary supplements. Ancient civilizations used the fruit of pomegranate (Punica granatum L.) to prevent and cure a number of diseases. The anti-tumorigenic, anti-inflammatory and anti-proliferative qualities of pomegranate have been shown in studies with the fruit, juice, extract, and oil of the pomegranate. Pomegranate has the capacity to affect several signaling pathways, which implies that it may have the potential to be employed not only as a chemopreventive agent but also as a chemotherapeutic drug. This article elaborates on some recent preclinical and clinical research which shows that pomegranate seems to have a role in the ...
Keywords	Pomegranate ; Neoplastic ; Cell dedifferentiation ; Angiogenesis ; Apoptosis ; Metastasis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of dietary forage-to-concentrate ratio on fat deposition, fatty acid composition, oxidative stability and mRNA expression of sirtuins genes of subcutaneous fat in sheep (Ovis aries)

Zhanhong Gao / Sayed Haidar Abbas Raza / Boyan Ma / Zhiyou Wang / Khairiah Mubarak Alwutayd / Waleed Al Abdulmonem / Yousef Mesfer Alharbi / Abdullah S.M. Aljohani / Shengzhen Hou / Linsheng Gui

Journal of Applied Animal Research, Vol 51, Iss 1, Pp 382-

2023 Volume 387

Abstract: ABSTRACTThis study was carried out to evaluate the effects of dietary concentrate: forage (C: F) ratio on fat deposition, fatty acid composition, oxidative stability and mRNA expression levels of sirtuins genes associated with adipose tissue metabolism ... ...

Abstract	ABSTRACTThis study was carried out to evaluate the effects of dietary concentrate: forage (C: F) ratio on fat deposition, fatty acid composition, oxidative stability and mRNA expression levels of sirtuins genes associated with adipose tissue metabolism of subcutaneous fat in Black Tibetan sheep. Three diets with different C: F (HC: 70:30, IC:50:50 and LC: 30:70) were fed to fifteen weaned male lambs (2-month-old, 10.05 ± 0.96 Kg). The experiment lasted for 120 d. Five lambs from each group were randomly selected and slaughtered at the end of the experiment. The subcutaneous fat thicknesses increased with increasing concentrate level (P < 0.05). The concentration of polyunsaturated fatty acid (PUFA), C15:1 and C18:2n decreased by feeding the HC diet (P < 0.05). Both glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities significantly increased as dietary concentration levels decreased (P < 0.05). Additionally, SIRT1 and SIRT2 expression level was downregulated (P < 0.05) with increasing concentration supplementation (P < 0.05 and P < 0.05, respectively). In conclusion, the addition of 70% concentration supplementation is not recommended in Black Tibetan sheep, considering that no benefits were observed for nutrient utilization, oxidative stability or economic returns, while the supplementation of C: F at 50:50 proved to be suitable for finishing lambs.
Keywords	Black Tibetan sheep ; forage-to-concentrate ratio ; fat deposition ; fatty acid composition ; gene expression ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and cytotoxic activity of new indolylpyrrole derivatives

Mohamed A.A. Radwan / Osamah Al Rugaie / Waleed Al Abdulmonem / Mohammad Y. Alfaifi / Serag Eldin I. Elbehairi

Arabian Journal of Chemistry, Vol 14, Iss 7, Pp 103209- (2021)

2021

Abstract: The current approach described the synthesis of a new series of indolylpyrrole derivatives through multicomponent reaction of α-cyano chalcones, appropriate aldehydes, and ammonium acetate in refluxed acetic acid. The chemical structures of the designed ... ...

Abstract	The current approach described the synthesis of a new series of indolylpyrrole derivatives through multicomponent reaction of α-cyano chalcones, appropriate aldehydes, and ammonium acetate in refluxed acetic acid. The chemical structures of the designed compounds were confirmed with spectroscopic data and elemental analysis and then tested for their in vitro cytotoxic activity by SRB assay method towards three cell lines involving human Prostate adenocarcinoma; metastatic cells (PC-3), human ovary adenocarcinoma (SKOV3) and human dukes' type B, colorectal adenocarcinoma (LS 174 T). Most significant activity provided with compounds 5c, 5h and, 5j against prostate cancer cells (PC-3) with IC50s of 3.30 ± 0.20, 3.60 ± 0.10, and 3.60 ± 0.90 µg/ml, respectively. In human ovarian carcinoma (SKOV3), the compounds 5a, and 5i have stronger cytotoxicity with IC50s of 1.20 ± 0.04, 1.90 ± 0.50 µg/ml, respectively than the standard doxorubicin (IC50 = 2.20 ± 0.02 µg/ml). On the other hand, only compound 5a has the ability to diminish the viability of LS174T cells in an active manner with IC50 2.80 ± 0.10 µg/ml. Consequently, this effort offers groundwork for additional examination of nominated indolylpyrroles as antiproliferative agents.
Keywords	Indole ; Pyrrole ; Cytotoxicity ; SRB assay ; PC-3 ; SKOV3 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Anti-cancer perspectives of resveratrol

Muhammad Junaid Anwar / Areeba Altaf / Muhammad Imran / Muhammad Amir / Suliman A. Alsagaby / Waleed Al Abdulmonem / Ahmed Mujtaba / Ahmed H. El-Ghorab / Mohammed M. Ghoneim / Muzzamal Hussain / Entessar Al Jbawi / Mohamed E. Shaker / Mohamed A. Abdelgawad

Food and Agricultural Immunology, Vol 34, Iss

a comprehensive review

2023 Volume 1

Abstract: ABSTRACTResveratrol (RVT) is well known for its chemo-preventive and therapeutic attributes against the various kinds of cancers such as breast, prostate, pancreatic, oral, brain, lung and liver. It has been found to inhibit glioblastoma cell growth, ... ...

Abstract	ABSTRACTResveratrol (RVT) is well known for its chemo-preventive and therapeutic attributes against the various kinds of cancers such as breast, prostate, pancreatic, oral, brain, lung and liver. It has been found to inhibit glioblastoma cell growth, declining uPAR and its mediator ERK1/2, inhibiting the cell lines (EC-9706) growth and ADAM9 expression, up-regulating the lncRNAs and PPARγ, inhibition of MTA1 to modulate oncogenic miR-34a, miR-22 and miR-17, enhance the E-cadherin expression and decreased the expressions of Twist1 and vimentin, inhibiting ADAM9 expression, downregulation of ATP2A2 and ATP2A3 genes expressions in different breast cell lines, reduction in IL-6 and COX-2 expression, inhibition of Tax activity of LTR and HTLV-1 in SIRT1 deacetylase, suppression of epithelial-to-mesenchymal transition (EMT) and eEF1A expression and fracas interactions between TEAD and YAP and activation of Hippo/YAP signalling. Consequently, it can be suggested that RVT is a promising agent for treating aforementioned cancers due to its curing characteristics.
Keywords	Anti-cancer activity ; cancer stages ; bioactive compounds ; medication via resveratrol ; chemopreventive ; Agriculture (General) ; S1-972 ; Immunologic diseases. Allergy ; RC581-607
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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