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  1. Article ; Online: Aedes albopictus invasion across Africa: the time is now for cross-country collaboration and control.

    Longbottom, Joshua / Walekhwa, Abel W / Mwingira, Victor / Kijanga, Oliver / Mramba, Furaha / Lord, Jennifer S

    The Lancet. Global health

    2023  Volume 11, Issue 4, Page(s) e623–e628

    Abstract: The distribution of Aedes albopictus across west Africa is well documented. However, little has been done to synthesise data and establish the current distribution of this invasive vector in central and east Africa. In this Viewpoint, we show that A ... ...

    Abstract The distribution of Aedes albopictus across west Africa is well documented. However, little has been done to synthesise data and establish the current distribution of this invasive vector in central and east Africa. In this Viewpoint, we show that A albopictus is establishing across Africa, how this is potentially related to urbanisation, and how establishment poses risks of near-term increases in arbovirus transmission. We then use existing species distribution maps for A albopictus and Aedes aegypti to produce consensus estimates of suitability and make these estimates accessible. Although urban development and increased trade have economic and other societal gains, the resulting potential changes in Aedes-borne virus epidemiology require a discussion of how cross-country collaboration and mitigation could be facilitated. Failure to respond to species invasion could result in increased transmission of Aedes-associated pathogens, including dengue, chikungunya, and Rift Valley fever viruses.
    MeSH term(s) Animals ; Humans ; Aedes ; Dengue/epidemiology ; Mosquito Vectors ; Africa/epidemiology ; Chikungunya Fever/epidemiology
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00046-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Barriers and opportunities for improving management of snakebites: Perspectives of healthcare workers in Northern Uganda.

    Wafula, Solomon T / Namakula, Lydia N / Ninsiima, Lesley R / Ssekamatte, Noah Kiwanuka / Walekhwa, Abel W / Mugume, Innocent B / Musoke, David

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0291032

    Abstract: Background: Snakebites are a neglected public health problem that pose a significant burden on affected individuals and communities in many sub-Saharan African countries, including Uganda. However, the barriers and facilitators to snakebite management ... ...

    Abstract Background: Snakebites are a neglected public health problem that pose a significant burden on affected individuals and communities in many sub-Saharan African countries, including Uganda. However, the barriers and facilitators to snakebite management within healthcare settings are not as well understood and well-documented. The aim of this study was to explore the experiences and perspectives of healthcare workers involved in handling snakebite incidents at individual and health system levels in Arua and Gulu districts in Northern Uganda. We sought to understand how healthcare workers manage snakebite cases, what challenges they encounter, and what opportunities they perceive for improvement.
    Methods: We conducted a qualitative study using in-depth interviews with 18 healthcare workers from different cadres, seniority levels, and facility types. We used iterative thematic analysis to explore the management procedures, challenges, and opportunities for snakebite management. Using thematic analysis, we identified the overarching themes and subthemes related to snakebite management and associated barriers and opportunities.
    Results: The main barriers to snakebite management identified by healthcare workers were inadequate knowledge and skills; limited availability of antivenom; lack of protocols for snakebite management; delayed treatment-seeking for patients; and poor referral systems. The main opportunities for improvement were regular in-service training; increasing public education and awareness about snakebite prevention and management; and increased funding and research.
    Conclusion: This study highlights the need for interventions to address the identified barriers while leveraging the existing opportunities to enhance snakebite management in Uganda. Specifically, we recommend the provision of regular training and support to healthcare workers, developing clinical guidelines, and improving the availability of antivenoms.
    MeSH term(s) Humans ; Antivenins/therapeutic use ; Black People ; Health Personnel ; Snake Bites/epidemiology ; Snake Bites/therapy ; Uganda/epidemiology ; Health Services Accessibility ; Attitude of Health Personnel
    Chemical Substances Antivenins
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Healthcare practitioners' knowledge of snakebite management and associated factors in high-burden, low-resource settings in Uganda.

    Wafula, Solomon T / Mugume, Innocent B / Namakula, Lydia N / Nalugya, Aisha / Naggayi, Vencia / Walekhwa, Abel W / Musoke, David

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2023  Volume 117, Issue 8, Page(s) 569–579

    Abstract: Background: Snakebites cause significant morbidity and mortality in Uganda. Effective management of snakebites requires knowledge of the appropriate first aid measures, as well as knowledge of the appropriate antivenom to use, but little is known about ... ...

    Abstract Background: Snakebites cause significant morbidity and mortality in Uganda. Effective management of snakebites requires knowledge of the appropriate first aid measures, as well as knowledge of the appropriate antivenom to use, but little is known about familiarity with effective snakebite management techniques and associated factors among healthcare practitioners (HCPs) in Uganda.
    Methods: In May 2022, we collected data on sociodemographic characteristics, knowledge of snakebite first aid, envenomation signs, diagnosis and antivenom administration among 311 HCPs from two snakebite high-incidence districts in Uganda using a semi-structured questionnaire.
    Results: Of the 311 HCPs, 64.3% had ever treated snakebite cases, 87.1% were confident to provide supportive treatment, but only 9.6% had ever been trained on snakebite management. Overall, 22.8% of HCPs had high knowledge of snakebite management. Higher education (at least degree vs certificate; PR=2.21 95% CI 1.508 to 4.56), older age (30-45 vs <30 y; PR=1.97, 95% CI 1.22 to 3.21) and previous training (PR=1.82, 95% CI 1.08 to 3.05) were associated with high knowledge of snakebite diagnosis and management.
    Conclusions: Overall, knowledge of snakebite management was limited. Training, level of education and age of the HCP all had an impact on knowledge. Deliberate efforts are required to increase HCPs' knowledge of snakebite case care in high-burden regions to manage incident cases.
    MeSH term(s) Humans ; Snake Bites/diagnosis ; Snake Bites/epidemiology ; Snake Bites/therapy ; Antivenins/therapeutic use ; Uganda/epidemiology ; Incidence ; Delivery of Health Care
    Chemical Substances Antivenins
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trad015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Indoor air pollutants and respiratory symptoms among residents of an informal urban settlement in Uganda: A cross-sectional study.

    Wafula, Solomon T / Nalugya, Aisha / Mendoza, Hilbert / Kansiime, Winnifred K / Ssekamatte, Tonny / Walekhwa, Abel W / Mugambe, Richard K / Walter, Florian / Ssempebwa, John C / Musoke, David

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0290170

    Abstract: Background: Indoor air pollutants (IAP) and household conditions such as dampness, crowding and chemical exposures have been associated with acute and chronic respiratory infections. In Uganda, literature on the effects of IAP on respiratory outcomes in ...

    Abstract Background: Indoor air pollutants (IAP) and household conditions such as dampness, crowding and chemical exposures have been associated with acute and chronic respiratory infections. In Uganda, literature on the effects of IAP on respiratory outcomes in informal settlements is limited.
    Methods: We describe the baseline household characteristics of 284 adults and their children in an informal settlement in Uganda from April to May 2022. We monitored same-day indoor concentrations of particulate matter PM2.5, PM10, Carbon monoxide (CO), relative humidity %, and temperature from 9 am to 2 pm and interviewed caregivers/mothers about their respiratory symptoms and those of their children in the previous 30 days. We employed robust Poisson regressions to evaluate the associations between indoor air indicators and respiratory health symptoms.
    Results: Approximately 94.7% of households primarily used biomass fuels and 32.7% cooked from inside their dwelling rooms. The median PM2.5, PM10 and CO levels were 49.5 (Interquartile range (IQR) = 31.1,86.2) μg/m3, 73.6 (IQR = 47.3,130.5) μg/m3 and 7.70 (IQR = 4.1,12.5) ppm respectively. Among adults, a 10 unit increase in PM2.5 was associated with cough (Prevalence Ratio (PR) = 3.75, 95%CI 1.15-1.55). Dwelling unit dampness was associated with phlegm (PR = 2.53, 95%CI = 1.39-4.61) and shortness of breath (PR = 1.78, 95% CI 1.23-2.54) while cooking from outside the house was protective against shortness of breath (PR = 0.62, 95% CI = 0.44-0.87). In children, dampness was associated with phlegm (PR = 13.87, 95% CI 3.16-60.91) and cough (PR = 1.62, 95% CI 1.12-2.34) while indoor residual spraying was associated with phlegm (PR = 3.36, 95%CI 1.71-6.61).
    Conclusion: Poor indoor air conditions were associated with respiratory symptoms in adults and children. Efforts to address indoor air pollution should be made to protect adults and children from adverse health effects.
    MeSH term(s) Adult ; Child ; Humans ; Air Pollutants/adverse effects ; Cross-Sectional Studies ; Uganda/epidemiology ; Cough/epidemiology ; Cough/etiology ; Particulate Matter/adverse effects ; Alarmins ; Drug-Related Side Effects and Adverse Reactions ; Dyspnea
    Chemical Substances Air Pollutants ; Particulate Matter ; Alarmins
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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