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  1. Article ; Online: Novel therapies upon failure of HMA plus venetoclax.

    Chan, Onyee / Walker, Alison R

    Hematology. American Society of Hematology. Education Program

    2023  Volume 2023, Issue 1, Page(s) 702–708

    Abstract: The efficacy and tolerability of the combination of hypomethylating agents with venetoclax (HMA-VEN) in patients with newly diagnosed acute myeloid leukemia has been a practice-changing milestone in the field. However, treatment failure and relapse ... ...

    Abstract The efficacy and tolerability of the combination of hypomethylating agents with venetoclax (HMA-VEN) in patients with newly diagnosed acute myeloid leukemia has been a practice-changing milestone in the field. However, treatment failure and relapse remain major barriers to prolonged survival. TP53 mutation is a predictor of primary induction failure and portends especially poor outcomes. Prelinical data suggest that VEN resistance stems from these genetic changes, which lead to increases in antiapoptotic proteins such as MCL-1 and BCLXL. For patients who discontinue HMA-VEN for reasons other than disease progression, such as post allotransplantation, infection, and personal preference, rechallenge with HMA-VEN at the time of relapse may be considered. For those who progress on HMA-VEN, clinical trials with novel agents or rational drug combinations are preferred if available. If no trial option is available, fit patients may benefit from intensive chemotherapy. Emerging therapies aim to overcome venetoclax resistance, target interactions that promote leukemogenesis, and harness the immune system to irradicate leukemic blasts and stem cells.
    MeSH term(s) Humans ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Disease Progression ; Leukemia ; Recurrence ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Antineoplastic Combined Chemotherapy Protocols ; Retrospective Studies
    Chemical Substances venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2023000456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How to approach shared decision making when determining consolidation, maintenance therapy, and transplantation in acute myeloid leukemia.

    Walker, Alison R

    Hematology. American Society of Hematology. Education Program

    2020  Volume 2020, Issue 1, Page(s) 51–56

    Abstract: Until recently, treatment options for patients with acute myeloid leukemia (AML) were limited to cytotoxic chemotherapeutic agents that possessed little specificity for the cytogenetic and molecular mutations known to risk stratify patients with this ... ...

    Abstract Until recently, treatment options for patients with acute myeloid leukemia (AML) were limited to cytotoxic chemotherapeutic agents that possessed little specificity for the cytogenetic and molecular mutations known to risk stratify patients with this disease. With the approval of multiple new therapies, not only have the agents that we treat patients with changed, but the way we talk about these options, decide on, and manage therapy has also been transformed. Given these complexities, it is important that we help patients make an informed decision by weighing the risk of relapse with patient wishes and desired quality of life. Shared decision making (SDM) is an approach to medical decision making for those situations in which most clinicians would agree that there is more than 1 correct choice for a patient. Here we review the principles of SDM and provide an overview of the 3-talk model and how it may be incorporated into the care of patients with AML.
    MeSH term(s) Clinical Decision-Making ; Consolidation Chemotherapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/therapy ; Maintenance Chemotherapy ; Quality of Life
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2020000088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Adult dental health survey

    Kelly, Maureen / Walker, Alison

    oral health in the United Kingdom 1998 ; a survey commissioned by the United Kingdom Health Departments

    2000  

    Institution Großbritannien / Social Survey Division
    Author's details carried out by the Social Survey Division of the Office for National Statistics ... Maureen Kelly ... Ed. by Alison Walker
    Language English
    Size X, 577 S. : graph. Darst.
    Publisher The Stationary Office
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012972459
    ISBN 0-11-621268-3 ; 978-0-11-621268-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 A 3287 order for loan Magazin

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  4. Article ; Online: Consensus on acute behavioural disturbance in the UK: a multidisciplinary modified Delphi study to determine what it is and how it should be managed.

    Humphries, Christopher / Kelly, Anthony / Sadik, Aws / Walker, Alison / Smith, Jason

    Emergency medicine journal : EMJ

    2023  Volume 41, Issue 1, Page(s) 4–12

    Abstract: Background: Acute behavioural disturbance (ABD) is a term used in law enforcement and healthcare, but there is a lack of clarity regarding its meaning. Common language should be used across staff groups to support the identification, prioritisation and ... ...

    Abstract Background: Acute behavioural disturbance (ABD) is a term used in law enforcement and healthcare, but there is a lack of clarity regarding its meaning. Common language should be used across staff groups to support the identification, prioritisation and delivery of care to this group of patients. The terminology currently used is inconsistent and confusing. This study aimed to reach a consensus on the criteria for identification and management of ABD, and to agree when other care pathways or guidelines might be more appropriately used.
    Methods: A modified Delphi study with participation from stakeholder organisation representatives was conducted in January-April 2023 online. In round 1, statements were generated by participants in response to broad questions. Participants then rated their level of agreement with statements in subsequent rounds, with statements achieving a consensus removed for inclusion in the final derived consensus statement. Non-consensus statement responses were assessed for stability.
    Results: Of 430 unique statements presented for rating, 266 achieved a consensus among 30 participants representing eight stakeholder organisations. A derived consensus statement was generated from these statements. The median group response to statements which failed to achieve a consensus was reliable (Krippendorff's alpha=0·67).
    Conclusions: There is a consensus across stakeholder organisations that ABD is not a separate entity to agitation, and guidance should instead be altered to address the full range of presentations of agitation. While the features of concern in this severely agitated group of patients can be described, the advice for recognition may vary depending on staff group. Criteria for recognition are provided and potential new terminology is described.
    MeSH term(s) Humans ; Delphi Technique ; Consensus ; United Kingdom
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2023-213335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1941: Show issues Location:
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  5. Article ; Online: Dying a fiery death: pyroptosis in MDS.

    Walker, Alison R

    Blood

    2016  Volume 128, Issue 25, Page(s) 2875–2877

    MeSH term(s) Apoptosis ; Caspase 1 ; Humans ; Pyroptosis
    Chemical Substances Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2016-12-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-10-746719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  6. Book: Health and the environment

    Godlee, Fiona / Walker, Alison

    1992  

    Author's details Fiona Godlee and Alison Walker
    Keywords Environmental Pollution / collected works ; Environmental Health / collected works
    Language English
    Size XIII, 126 S. : Ill., graph. Darst., Kt.
    Publisher British Medical Journal
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004487030
    ISBN 0-7279-0318-7 ; 978-0-7279-0318-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 B 410 order for loan Magazin

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  7. Article: Monte carlo studies of electronic processes in dye-sensitized solar cells.

    Walker, Alison B

    Topics in current chemistry

    2014  Volume 352, Page(s) 237–256

    Abstract: This topic reviews random walk Monte Carlo simulation models of charge transport in DSSC. The main electron transport approaches used are covered. Monte Carlo methods and results are explained, addressing the continuous time random walk model developed ... ...

    Abstract This topic reviews random walk Monte Carlo simulation models of charge transport in DSSC. The main electron transport approaches used are covered. Monte Carlo methods and results are explained, addressing the continuous time random walk model developed for transport in disordered materials in the context of the large number of trap states present in the electron transporting material. Multiple timescale MC models developed to look at the morphology dependence of electron transport are described. The concluding section looks at future applications of these methods and the related MC models for polymer blend cells.
    Language English
    Publishing date 2014
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0340-1022
    ISSN 0340-1022
    DOI 10.1007/128_2013_472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comment on "Personal Protective Equipment and COVID-19 - A Review for Surgeons".

    Nunoo-Mensah, Joseph W / Walker, Alison / Rizk, Mariam

    Annals of surgery

    2020  Volume 274, Issue 6, Page(s) e798–e799

    MeSH term(s) COVID-19 ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; Personal Protective Equipment ; SARS-CoV-2 ; Surgeons
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000004446
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    Uk I Zs.35/1: Show issues Location:
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  9. Article ; Online: 3D-to-2D Transition of Anion Vacancy Mobility in CsPbBr

    Smolders, Thijs J A M / Walker, Alison B / Wolf, Matthew J

    The journal of physical chemistry letters

    2021  , Page(s) 5169–5177

    Abstract: Anion vacancy migration in the ... ...

    Abstract Anion vacancy migration in the orthorhombic
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.1c00554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Drug routes in out-of-hospital cardiac arrest: A summary of current evidence.

    Hooper, Amy / Nolan, Jerry P / Rees, Nigel / Walker, Alison / Perkins, Gavin D / Couper, Keith

    Resuscitation

    2022  Volume 181, Page(s) 70–78

    Abstract: Recent evidence showing the clinical effectiveness of drug therapy in cardiac arrest has led to renewed interest in the optimal route for drug administration in adult out-of-hospital cardiac arrest. Current resuscitation guidelines support use of the ... ...

    Abstract Recent evidence showing the clinical effectiveness of drug therapy in cardiac arrest has led to renewed interest in the optimal route for drug administration in adult out-of-hospital cardiac arrest. Current resuscitation guidelines support use of the intravenous route for intra-arrest drug delivery, with the intraosseous route reserved for patients in whom intravenous access cannot be established. We sought to evaluate current evidence on drug route for administration of cardiac arrest drugs, with a specific focus on the intravenous and intraosseous route. We identified relevant animal, manikin, and human studies through targeted searches of MEDLINE in June 2022. Across pre-hospital systems, there is wide variation in use of the intraosseous route. Early administration of cardiac arrest drugs is associated with improved patient outcomes. Challenges in obtaining intravenous access mean that the intraosseous access may facilitate earlier drug administration. However, time from administration to the central circulation is unclear with pharmacokinetic data limited mainly to animal studies. Observational studies comparing the effect of intravenous and intraosseous drug administration on patient outcomes are challenging to interpret because of resuscitation time bias and other confounders. To date, no randomised controlled trial has directly compared the effect on patient outcomes of intraosseous compared with intravenous drug administration in cardiac arrest. The International Liaison Committee on Resuscitation has described the urgent need for randomised controlled trials comparing the intravenous and intraosseous route in adult out-of-hospital cardiac arrest. Ongoing clinical trials will directly address this knowledge gap.
    MeSH term(s) Adult ; Animals ; Humans ; Out-of-Hospital Cardiac Arrest/drug therapy ; Pharmaceutical Preparations ; Infusions, Intraosseous ; Infusions, Intravenous ; Administration, Intravenous ; Cardiopulmonary Resuscitation
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2022-10-26
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2022.10.015
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