LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48

Search options

  1. Article: Discussion on the Indications for, and Technique of, Cæsarean Section and its Alternatives, in Women with Contracted Pelves, who have been long in Labour and exposed to Septic Infection.

    Wallace, A J

    Proceedings of the Royal Society of Medicine

    2009  Volume 4, Issue Obstet Gynaecol Sect, Page(s) 202–203

    Language English
    Publishing date 2009-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 209243-8
    ISSN 0035-9157
    ISSN 0035-9157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.114: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Meiotic variation in an intergenomic autopolyploid series. I. Chiasma frequency.

    Wallace, A J / Callow, R S

    Genome

    2008  Volume 38, Issue 1, Page(s) 122–132

    Abstract: Variation in chiasma frequency has been studied in PMCs of diploids and C0 autotetraploids of seven Lathyrus species exhibiting a range of genome size (10.8-19.9 pg DNA/2C). Variation in chiasma frequency showed no relation to changes in genome size, ... ...

    Abstract Variation in chiasma frequency has been studied in PMCs of diploids and C0 autotetraploids of seven Lathyrus species exhibiting a range of genome size (10.8-19.9 pg DNA/2C). Variation in chiasma frequency showed no relation to changes in genome size, either between species or between disomic sets within nuclei. Mean chiasma frequency of the tetraploids showed a 75% increase over that in the diploids. Half of this increase represents an additive effect of chromosome doubling. Total variance in chiasma frequency of autotetraploids increases by 80% over that in diploids, in line with the square of the multiplicative effect of chromosome doubling. At the diploid level, interspecific differences account for the major component of variance (63.1%). Phenotypic variation in chiasma frequency was apparent in all seven species but represented the smallest component of variance (2.8%). Chromosome doubling results in an eightfold increase in the absolute size of the phenotypic component of variance in chiasma frequency and a threefold increase in that of the cellular component. It has no effect on the absolute size of the interspecific component.
    Language English
    Publishing date 2008-05-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/g95-015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Meiotic variation in an intergenomic autopolyploid series. II. Pairing behaviour.

    Wallace, A J / Callow, R S

    Genome

    2008  Volume 38, Issue 1, Page(s) 133–139

    Abstract: Pairing behaviour has been studied in PMCs of C0 autotetraploids of seven Lathyrus species exhibiting a range of genome size (10.8-19.9 pg DNA/2C). Each tetrasome within a C0 autotetraploid is equally likely to form a quadrivalent and the great majority ... ...

    Abstract Pairing behaviour has been studied in PMCs of C0 autotetraploids of seven Lathyrus species exhibiting a range of genome size (10.8-19.9 pg DNA/2C). Each tetrasome within a C0 autotetraploid is equally likely to form a quadrivalent and the great majority of metaphase multivalents (96%) gave evidence of only a single synaptic exchange. Four components of variance in bivalent frequency were detected in the tetraploids. Both chiasma-dependent (0.5%) and chiasma-independent (4.2%) interspecific components were observed, whereas the only intraspecific component between plants (2.8%) was independent of variation in chiasma frequency. The only nonresidual component of variance in minimal incidence of synaptic exchange was interspecific (3.9%) and independent of variation in multivalent frequency.
    Language English
    Publishing date 2008-05-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/g95-016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Paravertebral blocks for analgesia following BM harvest.

    Ladlie, B L / Wallace, A J / Greengrass, R A

    Bone marrow transplantation

    2012  Volume 47, Issue 7, Page(s) 995–996

    MeSH term(s) Adult ; Analgesia, Epidural/methods ; Bone Marrow Cells/cytology ; Bone Marrow Transplantation/methods ; Female ; Humans ; Nerve Block/methods ; Pain/drug therapy ; Pain/etiology ; Tissue and Organ Harvesting/adverse effects ; Tissue and Organ Harvesting/methods
    Language English
    Publishing date 2012-07
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/bmt.2011.191
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Detection of unstable trinucleotide repeats.

    Wallace, A J

    Methods in molecular medicine

    1996  Volume 5, Page(s) 37–62

    Abstract: Unstable trinucleotide repeats are a newly recognized class of disease mutation. Several major human single gene disorders are now attributed to expansions of these highly unstable sequences (1-4). Their molecular analysis is particularly challenging, ... ...

    Abstract Unstable trinucleotide repeats are a newly recognized class of disease mutation. Several major human single gene disorders are now attributed to expansions of these highly unstable sequences (1-4). Their molecular analysis is particularly challenging, since: 1. Accurate allele sizing is essential; 2. Polymerase chain reaction (PCR) amplification across the repeat is hampered by extreme guanme cytosme (GC) content and strong secondary structure, and 3. Size differences between normal and mutated alleles may be great, for instance, in fragile X they can range from 6 to over 1000 repeats.
    Language English
    Publishing date 1996
    Publishing country United States
    Document type Journal Article
    ISSN 1543-1894
    ISSN 1543-1894
    DOI 10.1385/0-89603-346-5:37
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Balancing the intermolecular forces in peptide amphiphiles for controlling self-assembly transitions.

    Buettner, C J / Wallace, A J / Ok, S / Manos, A A / Nicholl, M J / Ghosh, A / Tweedle, M F / Goldberger, J E

    Organic & biomolecular chemistry

    2017  Volume 15, Issue 24, Page(s) 5220–5226

    Abstract: While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the rational control over the pH- and concentration-dependent self-assembly behaviour in stimuli responsive peptides ...

    Abstract While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the rational control over the pH- and concentration-dependent self-assembly behaviour in stimuli responsive peptides remains an elusive goal. Here, we show that different amphiphilic peptides can have similar self-assembly phase diagrams, providing the relative strengths of the attractive and repulsive forces are balanced. Using palmitoyl-YYAAEEEEK(DO3A:Gd)-NH
    MeSH term(s) Circular Dichroism ; Microscopy, Electron, Transmission ; Molecular Conformation ; Peptides/chemical synthesis ; Peptides/chemistry ; Surface-Active Agents/chemical synthesis ; Surface-Active Agents/chemistry
    Chemical Substances Peptides ; Surface-Active Agents
    Language English
    Publishing date 2017-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c7ob00875a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The BRCA2 polymorphic stop codon: stuff or nonsense?

    Higgs, J E / Harkness, E F / Bowers, N L / Howard, E / Wallace, A J / Lalloo, F / Newman, W G / Evans, D G

    Journal of medical genetics

    2015  Volume 52, Issue 9, Page(s) 642–645

    Abstract: Background: Despite classification of the BRCA2c.9976A>T, p.(Lys3326Ter) variant as a polymorphism, it has been associated with increased risks of pancreatic, lung, oesophageal and breast cancer.: Methods: We have noticed multiple co-occurrences of ... ...

    Abstract Background: Despite classification of the BRCA2c.9976A>T, p.(Lys3326Ter) variant as a polymorphism, it has been associated with increased risks of pancreatic, lung, oesophageal and breast cancer.
    Methods: We have noticed multiple co-occurrences of the BRCA2 c.9976A>T variant with the pathogenic BRCA2c.6275_6276delTT frameshift mutation p.(Leu2092ProfsTer7) and using a cohort study have assessed if this might account for these tumour risk associations.
    Results: We identified 52 families with BRCA2c.6275_6276delTT, all of which occur in cis with the BRCA2c.9976A>T variant allele as demonstrated by co-segregation in all family members tested. Of 3245 breast/ovarian cancer samples sequenced for BRCA2, only 43/3245 (1.3%) carried BRCA2 c.9976A>T alone, after excluding individuals with BRCA2c.6275_6276delTT (n=22) or other BRCA1 (n=3) or BRCA2 (n=2) pathogenic mutations. The resultant frequency (1.3%) after removal of co-occurring mutations is lower than the 1.7% and 1.67% frequencies from two control populations for BRCA2 c.9976A>T, but similar to the 1.39% seen in the Exome Aggregation Consortium database. We did not identify increased frequencies of oesophageal, pancreatic or lung cancer in families with just BRCA2 c.9976A>T using person-years at risk analysis.
    Conclusions: It is likely that the previous associations of increased cancer risks due to BRCA2c.9976A>T represent reporting bias and are contributed to because the variant is in LD with BRCA2c.6275_6276delTT.
    MeSH term(s) Breast Neoplasms/genetics ; Codon, Terminator ; Esophageal Neoplasms/genetics ; Europe ; Female ; Frameshift Mutation ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Lung Neoplasms/genetics ; Male ; Pancreatic Neoplasms/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances Codon, Terminator
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmedgenet-2015-103206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Tumour MLH1 promoter region methylation testing is an effective prescreen for Lynch Syndrome (HNPCC).

    Newton, K / Jorgensen, N M / Wallace, A J / Buchanan, D D / Lalloo, F / McMahon, R F T / Hill, J / Evans, D G

    Journal of medical genetics

    2014  Volume 51, Issue 12, Page(s) 789–796

    Abstract: Background and aims: Lynch syndrome (LS) patients have DNA mismatch repair deficiency and up to 80% lifetime risk of colorectal cancer (CRC). Screening of mutation carriers reduces CRC incidence and mortality. Selection for constitutional mutation ... ...

    Abstract Background and aims: Lynch syndrome (LS) patients have DNA mismatch repair deficiency and up to 80% lifetime risk of colorectal cancer (CRC). Screening of mutation carriers reduces CRC incidence and mortality. Selection for constitutional mutation testing relies on family history (Amsterdam and Bethesda Guidelines) and tumour-derived biomarkers. Initial biomarker analysis uses mismatch repair protein immunohistochemistry and microsatellite instability. Abnormalities in either identify mismatch repair deficiency but do not differentiate sporadic epigenetic defects, due to MLH1 promoter region methylation (13% of CRCs) from LS (4% of CRCs). A diagnostic biomarker capable of making this distinction would be valuable. This study compared two biomarkers in tumours with mismatch repair deficiency; quantification of methylation of the MLH1 promoter region using a novel assay and BRAF c.1799T>A, p.(Val600Glu) mutation status in the identification of constitutional mutations.
    Methods: Tumour DNA was extracted (formalin fixed, paraffin embedded, FFPE tissue) and pyrosequencing used to test for MLH1 promoter methylation and presence of the BRAF c.1799T>A, p.(Val600Glu) mutation 71 CRCs from individuals with pathogenic MLH1 mutations and 73 CRCs with sporadic MLH1 loss. Specificity and sensitivity was compared.
    Findingss: Unmethylated MLH1 promoter: sensitivity 94.4% (95% CI 86.2% to 98.4%), specificity 87.7% (95% CI 77.9% to 94.2%), Wild-type BRAF (codon 600): sensitivity 65.8% (95% CI 53.7% to 76.5%), specificity 98.6% (95% CI 92.4% to 100.0%) for the identification of those with pathogenic MLH1 mutations.
    Conclusions: Quantitative MLH1 promoter region methylation using pyrosequencing is superior to BRAF codon 600 mutation status in identifying constitutional mutations in mismatch repair deficient tumours.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adult ; Alleles ; Brain Neoplasms/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; CpG Islands ; DNA Methylation ; Genetic Testing/methods ; Genetic Testing/standards ; Heterozygote ; Humans ; Middle Aged ; MutL Protein Homolog 1 ; Mutation ; Neoplasms/genetics ; Neoplastic Syndromes, Hereditary/genetics ; Nuclear Proteins/genetics ; Promoter Regions, Genetic ; Proto-Oncogene Proteins B-raf/genetics ; Sensitivity and Specificity
    Chemical Substances Adaptor Proteins, Signal Transducing ; MLH1 protein, human ; Nuclear Proteins ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; MutL Protein Homolog 1 (EC 3.6.1.3)
    Language English
    Publishing date 2014-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmedgenet-2014-102552
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: The pride and the passion.

    Wallace, A J

    Journal of enterostomal therapy

    1982  Volume 9, Issue 6, Page(s) 42–43

    MeSH term(s) Canada ; Colostomy/rehabilitation ; Humans ; Ileostomy/rehabilitation ; Self-Help Groups ; United States
    Language English
    Publishing date 1982-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632827-1
    ISSN 0270-1170
    ISSN 0270-1170
    DOI 10.1097/00152192-198211000-00007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2157: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Neurofibromatosis 2 (NF2) and malignant mesothelioma in a man with a constitutional NF2 missense mutation.

    Baser, M E / Rai, H / Wallace, A J / Evans, D G R

    Familial cancer

    2005  Volume 4, Issue 4, Page(s) 321–322

    Abstract: Neurofibromatosis 2 (NF2) is caused by inactivating mutations of the NF2 tumor suppressor gene. Somatic NF2 mutations also occur in a high proportion of human primary malignant mesotheliomas. We report an elderly man with NF2, malignant mesothelioma, and ...

    Abstract Neurofibromatosis 2 (NF2) is caused by inactivating mutations of the NF2 tumor suppressor gene. Somatic NF2 mutations also occur in a high proportion of human primary malignant mesotheliomas. We report an elderly man with NF2, malignant mesothelioma, and a constitutional NF2 missense mutation. The long latent period for mesothelioma in this patient (61 years) raises the possibility that the type of mutant NF2 allele could affect mesothelioma tumorigenesis or progression.
    MeSH term(s) Aged ; Asbestos/adverse effects ; Genes, Neurofibromatosis 2 ; Humans ; Male ; Mesothelioma/complications ; Mesothelioma/genetics ; Mutation, Missense ; Neurofibromatosis 2/complications ; Neurofibromatosis 2/genetics ; Neuroma, Acoustic/etiology ; Occupational Exposure/adverse effects ; Pleural Neoplasms/complications ; Pleural Neoplasms/genetics ; Polymerase Chain Reaction
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2005
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1502496-9
    ISSN 1389-9600
    ISSN 1389-9600
    DOI 10.1007/s10689-005-0659-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top