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  1. Article ; Online: Nitric oxide in the gastrointestinal tract: opportunities for drug development.

    Wallace, John L

    British journal of pharmacology

    2018  Volume 176, Issue 2, Page(s) 147–154

    Abstract: Nitric oxide (NO) plays important roles in gastrointestinal mucosal defence, as well as in the pathogenesis of several gastrointestinal diseases (e.g. irritable bowel syndrome and inflammatory bowel disease). The potent cytoprotective effects of NO have ... ...

    Abstract Nitric oxide (NO) plays important roles in gastrointestinal mucosal defence, as well as in the pathogenesis of several gastrointestinal diseases (e.g. irritable bowel syndrome and inflammatory bowel disease). The potent cytoprotective effects of NO have been demonstrated in a range of animal models. However, in some disease states, inhibition of NO synthesis is beneficial. Several attempts have been made to develop drugs for ulcerative and/or inflammatory disorders of the gastrointestinal tract, with varying degrees of success. Covalently linking a NO-releasing group to non-steroidal anti-inflammatory drugs or to drugs used in the treatment of inflammatory bowel disease and irritable bowel syndrome has shown some benefit, although no drug of this type has yet been fully developed. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Drug Development ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/pathology ; Humans ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/metabolism
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2018-12-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Eicosanoids in the gastrointestinal tract.

    Wallace, John L

    British journal of pharmacology

    2018  Volume 176, Issue 8, Page(s) 1000–1008

    Abstract: Eicosanoids play important roles in modulating inflammation throughout the body. The gastrointestinal (GI) tract, in part because of its intimate relationship with the gut microbiota, is in a constant state of low-grade inflammation. Eicosanoids like PGs, ...

    Abstract Eicosanoids play important roles in modulating inflammation throughout the body. The gastrointestinal (GI) tract, in part because of its intimate relationship with the gut microbiota, is in a constant state of low-grade inflammation. Eicosanoids like PGs, lipoxins and leukotrienes play essential roles in maintenance of mucosal integrity. On the other hand, in some circumstances, these mediators can become major drivers of inflammatory processes when the lining of the GI tract is breached. Drugs such as nonsteroidal anti-inflammatories, by altering the production of various eicosanoids, can dramatically impact the ability of the GI tract to respond appropriately to injury. Disorders such as inflammatory bowel disease appear to be driven in part by altered production of eicosanoids. Several classes of drugs have been developed that target eicosanoids. LINKED ARTICLES: This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Eicosanoids/metabolism ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/metabolism ; Humans ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/microbiology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Eicosanoids
    Language English
    Publishing date 2018-04-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14178
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  3. Book ; Conference proceedings: Biotechnology and nutrition

    Wallace, John L.

    symposium of the Canadian Federation of Biological Societies, Windsor, Ontario, Canada, June 17, 1993 = Biotechnologie et nutrition

    1994  

    Title variant Biotechnologie et nutrition
    Institution Canadian Federation of Biological Societies
    Author's details special ed.: John L. Wallace
    Keywords Nutrition / congresses ; Food Supply / congresses ; Biotechnology / congresses
    Language English
    Publishing country Canada
    Document type Book ; Conference proceedings
    Note In: Canadian journal of physiology and pharmacology. - ISSN 0008-4212. - 72 (1994), S. [403] - 439
    HBZ-ID HT006330749
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 589 -72- verfügbar in Königswinter Königswinter

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  4. Book ; Conference proceedings: Nutrition and gastrointestinal development

    Wallace, John L.

    symposium of the Canadian Federation of Biological Societies, Windsor, Ontario, Canada, June 18, 1993 = Nutrition et développement gastro-intestinal

    1994  

    Title variant Nutrition et développement gastro-intestinal
    Institution Canadian Federation of Biological Societies
    Author's details special ed.: John L. Wallace
    Keywords Nutrition / physiology / congresses ; Gastrointestinal System / metabolism / congresses
    Language English
    Publishing country Canada
    Document type Book ; Conference proceedings
    Note In: Canadian journal of physiology and pharmacology. - ISSN 0008-4212. - 72 (1994), S. [249] - 274
    HBZ-ID HT006330525
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Prevention of NSAID-Enteropathy: A Soluble Problem?

    Wallace, John L

    Digestive diseases and sciences

    2016  Volume 61, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Arthritis, Experimental/drug therapy ; Dietary Fiber/administration & dosage ; Galactans/administration & dosage ; Indomethacin/toxicity ; Intestinal Mucosa/drug effects ; Intestine, Small/drug effects ; Joints/drug effects ; Male ; Mannans/administration & dosage ; Pectins/administration & dosage ; Plant Gums/administration & dosage ; Ulcer/prevention & control
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Dietary Fiber ; Galactans ; Mannans ; Pectins ; Plant Gums ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-015-3963-7
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  6. Book: Immunopharmacology of the gastrointestinal system

    Wallace, John L.

    (The handbook of immunopharmacology)

    1993  

    Author's details ed. by John L. Wallace
    Series title The handbook of immunopharmacology
    Keywords Gastrointestinal System / immunology ; Gastrointestinal Diseases / therapy ; Immunotherapy ; Adjuvants, Immunologic / therapeutic use ; Gastrointestinaltrakt ; Immunpharmakologie
    Subject Immunopharmakologie ; Magen-Darm-Kanal ; Magen-Darm-Trakt ; Magen-Darmtrakt
    Language English
    Size X, 198 S. : graph. Darst.
    Publisher Acad. Press
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004986309
    ISBN 0-12-732860-2 ; 978-0-12-732860-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2851 order for loan Magazin

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  7. Book: Endogenous mediators of gastrointestinal disease

    Wallace, John L.

    1989  

    Author's details ed. John L. Wallace
    Keywords Gastric Mucosa / metabolism ; Gastrointestinal Diseases / immunology ; Magenschleimhaut ; Mediator ; Pathophysiologie
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Mediatorsubstanz
    Size 223 S. : Ill., graph. Darst.
    Publisher CRC Pr
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book
    HBZ-ID HT003472334
    ISBN 0-8493-4574-X ; 978-0-8493-4574-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 1532 order for loan Magazin

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  8. Article ; Online: Exploiting endogenous anti-inflammatory pathways as a therapeutic approach to multiorgan inflammatory disease.

    Wallace, John L

    The American journal of pathology

    2014  Volume 184, Issue 8, Page(s) 2154–2155

    Abstract: This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing ... ...

    Abstract This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing therapeutics.
    MeSH term(s) Animals ; Arthritis, Experimental/metabolism ; Arthritis, Rheumatoid/metabolism ; Male ; Periodontal Diseases/metabolism ; Receptor, Melanocortin, Type 3/metabolism
    Chemical Substances Receptor, Melanocortin, Type 3
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2014.05.001
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  9. Article: Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology.

    Danielak, Aleksandra / Wallace, John L / Brzozowski, Tomasz / Magierowski, Marcin

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 657457

    Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most widely used classes of drugs and play a pivotal role in the therapy of numerous inflammatory diseases. However, the adverse effects of these drugs, especially when applied ... ...

    Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most widely used classes of drugs and play a pivotal role in the therapy of numerous inflammatory diseases. However, the adverse effects of these drugs, especially when applied chronically, frequently affect gastrointestinal (GI) tract, resulting in ulceration and bleeding, which constitutes a significant limitation in clinical practice. On the other hand, it has been recently discovered that gaseous mediators nitric oxide (NO), hydrogen sulfide (H
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.657457
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  10. Article ; Online: Polypharmacy of osteoarthritis: the perfect intestinal storm.

    Wallace, John L

    Digestive diseases and sciences

    2013  Volume 58, Issue 11, Page(s) 3088–3093

    Abstract: Osteoarthritis is an increasingly prevalent disorder with an incidence rate that rises sharply with age. Unfortunately, the most commonly used medications for providing symptomatic relief, nonsteroidal anti-inflammatory drugs (NSAIDs), can cause ... ...

    Abstract Osteoarthritis is an increasingly prevalent disorder with an incidence rate that rises sharply with age. Unfortunately, the most commonly used medications for providing symptomatic relief, nonsteroidal anti-inflammatory drugs (NSAIDs), can cause significant gastrointestinal (GI) ulceration. There is recent evidence that agents commonly employed to protect the upper GI tract actually increase the incidence and severity of ulceration and bleeding in the lower intestine. Intestinal injury is more difficult to diagnose and treat than upper GI damage, and symptoms correlate poorly with the severity of tissue injury. Moreover, use of low-dose aspirin for cardioprotection (a common co-treatment with the selective cyclooxygenase-2 inhibitors) further augments intestinal damage, particularly when enteric-coated aspirin is used. Thus, by focusing entirely on prevention of NSAID-induced damage to the upper GI tract, physicians may be inadvertently placing their patients at risk of serious, difficult-to-diagnose injury for which there are no proven-effective therapies and are associated with significantly higher rates of morbidity and mortality.
    MeSH term(s) Aging ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Gastrointestinal Diseases/chemically induced ; Humans ; Osteoarthritis/drug therapy ; Polypharmacy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2013-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-013-2777-8
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