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  1. Book ; Online ; E-Book: Medical pharmacology and therapeutics

    Waller, Derek / Sampson, Anthony / Hitchings, Andrew

    2022  

    Abstract: Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA. This all-round textbook covers basic ... ...

    Author's details Derek G. Waller, Anthony Sampson, and Andrew Hitchings
    Abstract Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA. This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class. Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines. A clinical focus throughout - suitable for medical, nursing and other healthcare students throughout their training Thorough update of clinically-relevant medicines to ensure best practice Information aligned with the British National Formulary (BNF), NICE guidelines and relevant professional benchmarks Comprehensive drug compendia allow all drugs to be identified and placed within their respective classes Extensive self-assessment questions to support learning and revision New to this edition Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19 Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19
    Keywords Chemotherapy ; Drugs ; Pharmacology ; Therapeutics
    Subject code 615.1
    Language English
    Size 1 online resource :, illustrations (chiefly color)
    Edition Sixth edition.
    Publisher Elsevier Limited
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-7020-8160-4 ; 0-7020-8159-0 ; 978-0-7020-8160-6 ; 978-0-7020-8159-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Thoracic intervention & surgery to cure lung cancer: margin not lobe is the new gold standard.

    Waller, David

    Journal of the Royal Society of Medicine

    2018  Volume 112, Issue 5, Page(s) 180–184

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Diagnostic Imaging/methods ; Diagnostic Imaging/trends ; Humans ; Inventions ; Lung/diagnostic imaging ; Lung/pathology ; Lung/surgery ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Margins of Excision ; Organ Sparing Treatments/methods ; Organ Sparing Treatments/standards ; Organs at Risk ; Pneumonectomy/methods ; Pneumonectomy/standards ; Thoracic Surgery/trends
    Language English
    Publishing date 2018-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/0141076818775078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.114: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Conditions for maintaining and eroding pseudo-overdominance and its contribution to inbreeding depression

    Abu-Awad, Diala / Waller, Donald

    Peer Community Journal, Vol 3, Iss , Pp - (2023)

    2023  

    Abstract: Classical models that ignore linkage predict that deleterious recessive mutations should purge or fix within inbred populations, yet inbred populations often retain moderate to high segregating load. True overdominance could generate balancing selection ... ...

    Abstract Classical models that ignore linkage predict that deleterious recessive mutations should purge or fix within inbred populations, yet inbred populations often retain moderate to high segregating load. True overdominance could generate balancing selection strong enough to sustain inbreeding depression even within inbred populations, but this is considered rare. However, arrays of deleterious recessives linked in repulsion could generate appreciable pseudo-overdominance that would also sustain segregating load. We used simulations to explore how long pseudo-overdominant (POD) zones persist once created (e.g., by hybridization between populations fixed for alternative mildly deleterious mutations). Balanced haplotype loads, tight linkage, and moderate to strong cumulative selective effects all serve to maintain POD zones. Tight linkage is key, suggesting that such regions are most likely to arise and persist in low recombination regions (like inversions). Selection and drift unbalance the load, eventually eliminating POD zones, but this process is quite slow under strong pseudo-overdominance. Background selection accelerates the loss of weak POD zones but reinforces strong ones in inbred populations by disfavoring homozygotes. Models and empirical studies of POD dynamics within populations help us understand how POD zones may allow the load to persist, greatly affecting load dynamics and mating systems evolution
    Keywords Archaeology ; CC1-960 ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Peer Community In
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A rare case of 'ring-sling complex' in a symptomatic adult patient: A left pulmonary artery sling with complete tracheal rings.

    Lee, Michelle / Baranowski, Ralitsa / Oo, Aung / Waller, David

    JRSM open

    2023  Volume 14, Issue 11, Page(s) 20542704231205388

    Abstract: Pulmonary artery sling (PAS) is a rare congenital condition, in which the left pulmonary artery (LPA) originates from the right pulmonary artery instead of the main pulmonary artery. It courses between the oesophagus and the trachea, forming a sling and ... ...

    Abstract Pulmonary artery sling (PAS) is a rare congenital condition, in which the left pulmonary artery (LPA) originates from the right pulmonary artery instead of the main pulmonary artery. It courses between the oesophagus and the trachea, forming a sling and causes compression of both structures. We report a very rare case of a symptomatic adult patient with PAS and a coexisting tracheal anomaly with complete tracheal rings, referred to as a 'ring-sling complex'.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2762955-7
    ISSN 2054-2704
    ISSN 2054-2704
    DOI 10.1177/20542704231205388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mise en route spontanée du travail à terme et le rôle des contractons utérines

    Waller, Diane

    Obstetrica : das Hebammenfachmagazin = Obstetrica : la revue spécialisée des sages-femmes ; 2941879-3 ; 2624-7747 ; 117 ; 2019 ; 9 ; 36

    2019  

    Publisher Schweizerischer Hebammenverband
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Mise en route spontanée du travail à terme et rôle des contractions utérines

    Waller, Diane

    Obstetrica

    2019  , Issue 9, Page(s) 36–39

    Language German
    Document type Article
    ISSN 2624-7747
    Database bibnet.org

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  7. Article ; Online: Development and implementation of Australian State, territory, and national policy on the health and wellbeing of adolescents and young adults: An exploration of policy actor perspectives using the Consolidated Framework for Implementation Research.

    Waller, Daniel / Kang, Melissa / Gibson, Sally / Brooks, Fiona / Medlow, Sharon / Steinbeck, Katharine / Perry, Lin

    Australian and New Zealand journal of public health

    2024  Volume 48, Issue 1, Page(s) 100112

    Abstract: Objectives: Government policies that support the health and wellbeing of young people (aged 10 to 25) can have important individual and societal impacts. The aim of this study was to explore policy actor perspectives on the development and ... ...

    Abstract Objectives: Government policies that support the health and wellbeing of young people (aged 10 to 25) can have important individual and societal impacts. The aim of this study was to explore policy actor perspectives on the development and implementation of Australian government policies focussed on the health and wellbeing of young people.
    Methods: We utilised a qualitative research design consisting of semi-structured interviews with policy actors with experience working with Australian youth health policies. Our interview guide and analyses were informed by the Consolidated Framework for Implementation Research (CFIR). We interviewed 19 participants from various national, state, and territory bodies.
    Results: Several specific barriers and facilitators to policy development and implementation were identified using the Consolidated Framework for Implementation Research. Key policy development barriers were limited available resources (e.g. staffing and funding) and low relative priority within health and political systems. Key policy implementation barriers were limited available resources, limited policy compatibility with health services, cosmopolitanism issues related to interagency collaboration, and a lack of policy evaluation. Meaningful engagement of young people could also be improved.
    Conclusions: Although Australian youth health policies are perceived as evidence-based and comprehensively developed, the ability to promote implementation remains stalled.
    Implications for public health: The development of policy implementation plans, monitoring and evaluation mechanisms, funding and resources, and a strong commitment to removing barriers to working across multiple departments and systems is required to improve outcomes for young people.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Australia ; Health Policy ; Policy Making ; Health Services Accessibility ; Qualitative Research
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1323548-5
    ISSN 1753-6405 ; 1326-0200
    ISSN (online) 1753-6405
    ISSN 1326-0200
    DOI 10.1016/j.anzjph.2023.100112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Bronchoscopic Lung Volume Reduction as the Treatment of Choice versus Robotic-Assisted Lung Volume Reduction Surgery in Similar Patients with Emphysema - An Initial Experience of the Benefits and Complications.

    Lee, Michelle / Dhanji, Al-Rehan / Perikleous, Periklis / Baranowski, Ralitsa / Lau, Kelvin Kar Wing / Waller, David

    International journal of chronic obstructive pulmonary disease

    2024  Volume 19, Page(s) 1021–1032

    Abstract: Objective: There is an assumption that because EBLVR requires less use of hospital resources, offsetting the higher cost of endobronchial valves, it should therefore be the treatment of choice wherever possible. We have tested this hypothesis in a ... ...

    Abstract Objective: There is an assumption that because EBLVR requires less use of hospital resources, offsetting the higher cost of endobronchial valves, it should therefore be the treatment of choice wherever possible. We have tested this hypothesis in a retrospective analysis of the two in similar groups of patients.
    Methods: In a 4-year experience, we performed 177 consecutive LVR procedures: 83 patients underwent Robot Assisted Thoracoscopic (RATS) LVRS and 94 EBLVR. EBLVR was intentionally precluded by evidence of incomplete fissure integrity or intra-operative assessment of collateral ventilation. Unilateral RATS LVRS was performed in these cases together with those with unsuitable targets for EBLVR.
    Results: EBLVR was uncomplicated in 37 (39%) cases; complicated by post-procedure spontaneous pneumothorax (SP) in 28(30%) and required revision in 29 (31%). In the LVRS group, 7 (8%) patients were readmitted with treatment-related complications, but no revisional procedure was needed. When compared with uncomplicated EBLVR, LVRS had a significantly longer operating time: 85 (14-82) vs 40 (15-151) minutes (p<0.001) and hospital stay: 7.5 (2-80) vs 2 (1-14) days (p<0.01). However, LVRS had a similar total operating time to both EBLVR requiring revision: 78 (38-292) minutes and hospital stay to EBLVR complicated by pneumothorax of 11.5 (6.5-24.25) days. Use of critical care was significantly longer in RATS group, and it was also significantly longer in EBV with SP group than in uncomplicated EBV group.
    Conclusion: Endobronchial LVR does use less hospital resources than RATS LVRS in comparable groups if the recovery is uncomplicated. However, this advantage is lost if one includes the resources needed for the treatment of complications and revisional procedures. Any decision to favour EBLVR over LVRS should not be based on the assumption of a smoother, faster perioperative course.
    MeSH term(s) Humans ; Retrospective Studies ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Male ; Middle Aged ; Bronchoscopy/instrumentation ; Bronchoscopy/methods ; Bronchoscopy/adverse effects ; Pulmonary Emphysema/surgery ; Pulmonary Emphysema/physiopathology ; Aged ; Female ; Treatment Outcome ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Time Factors ; Lung/surgery ; Lung/physiopathology ; Length of Stay ; Postoperative Complications/etiology ; Operative Time ; Risk Factors ; Pneumothorax/surgery ; Clinical Decision-Making ; Patient Readmission
    Language English
    Publishing date 2024-05-09
    Publishing country New Zealand
    Document type Journal Article ; Comparative Study
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S442380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Why sacrifice normal lung just for nodal disease in non-small-cell lung cancer?

    Waller, David / Batchelor, Tim / Wilson, Henrietta / Stamenkovic, Sasha / Lau, Kelvin

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 64, Issue 3

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/surgery ; Consensus ; Pneumonectomy ; Lung Neoplasms/surgery ; Lung
    Language English
    Publishing date 2023-08-31
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Effects of Preserving the Diaphragm on Early and Late Outcome of Lung-Sparing Radical Surgery for Malignant Pleural Mesothelioma.

    Lee, Michelle / Ventura, Luigi / Baranowski, Ralitsa / Hargrave, Joanne / Waller, David

    Journal of clinical medicine

    2022  Volume 11, Issue 22

    Abstract: Background: The accepted aim of radical surgery for malignant pleural mesothelioma (MPM) is the achievement of macroscopic complete resection (MCR) whilst reducing perioperative morbidity by preserving normal tissue. Whilst preservation of the lung by ... ...

    Abstract Background: The accepted aim of radical surgery for malignant pleural mesothelioma (MPM) is the achievement of macroscopic complete resection (MCR) whilst reducing perioperative morbidity by preserving normal tissue. Whilst preservation of the lung by pleurectomy/decortication (PD) has become widely utilised, there remains debate regarding the management of the diaphragm. Muscle-sparing complete excision of the diaphragmatic pleura is technically challenging; thus, surgeons may proceed to extended PD with phrenectomy and possible increased morbidity or to preserve the diaphragmatic pleura at the expense of MCR with potential survival deficit. We aimed to evaluate the effects of an intentional change in protocol to diaphragm-sparing PD whilst maintaining MCR as the treatment of choice for MPM.
    Methods: In a series of 136 patients (111M:25F, median age 68(63-73) years) undergoing radical surgery for MPM, we identified 28 patients (22M:6F, median age 67(60-71) years) in whom MCR was achieved without phrenectomy (PD group). We compared their perioperative outcomes and survival with a historical control group of 18 patients (18M:0F, median age 69(57-78) years) in whom MCR had been achieved with phrenectomy (EPD group) but in whom there was no histological evidence of diaphragm muscle invasion and who, in retrospect, could have undergone muscle-sparing MCR if this procedure had been attempted.
    Results: There was no significant intergroup difference in demographics or tumour cell type; the majority of both groups were found to be epithelial (PD 85.7%, EPD 77.8%). The EPD group was found to be more locally advanced (T3 55.56%) than the PD group (T1 46.43%) (
    Conclusions: A surgical strategy of attempting to spare the diaphragm whilst still achieving MCR wherever possible is justified by improved perioperative outcomes without compromising OS.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11226839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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