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  1. Article ; Online: "Unless they bring it up, I won't go digging": Psychiatric nurses' experiences of developing therapeutic relationships with adult survivors of child sexual abuse.

    Walsh, Chloe / Bradley, Stephen K / Goodwin, John

    Perspectives in psychiatric care

    2022  Volume 58, Issue 4, Page(s) 2497–2504

    Abstract: Purpose: The purpose of this study is to explore psychiatric nurses' experiences of developing therapeutic relationships with adult survivors of child sexual abuse (CSA).: Design and methods: A qualitative descriptive design was adopted. ... ...

    Abstract Purpose: The purpose of this study is to explore psychiatric nurses' experiences of developing therapeutic relationships with adult survivors of child sexual abuse (CSA).
    Design and methods: A qualitative descriptive design was adopted. Semistructured interviews were conducted with six registered psychiatric nurses. Data were analyzed using reflexive thematic analysis.
    Findings: Although participants were able to develop therapeutic relationships with survivors and cited the importance of interpersonal skills, they felt uncomfortable discussing CSA.
    Practice implications: Given the importance of developing trusting relationships, more support needs to be provided for nurses so they can build stronger alliances with survivors of CSA.
    MeSH term(s) Adult ; Child ; Humans ; Child Abuse, Sexual ; Psychiatric Nursing ; Survivors ; Trust ; Nurses ; Adult Survivors of Child Abuse/psychology
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391097-0
    ISSN 1744-6163 ; 0031-5990
    ISSN (online) 1744-6163
    ISSN 0031-5990
    DOI 10.1111/ppc.13085
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    Zs.B 631: Show issues Location:
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  2. Article ; Online: Natural spider silk nanofibrils produced by assembling molecules or disassembling fibers.

    Perera, Dinidu / Li, Linxuan / Walsh, Chloe / Silliman, Jacob / Xiong, Yawei / Wang, Qijue / Schniepp, Hannes C

    Acta biomaterialia

    2023  Volume 168, Page(s) 323–332

    Abstract: Spider silk is biocompatible, biodegradable, and rivals some of the best synthetic materials in terms of strength and toughness. Despite extensive research, comprehensive experimental evidence of the formation and morphology of its internal structure is ... ...

    Abstract Spider silk is biocompatible, biodegradable, and rivals some of the best synthetic materials in terms of strength and toughness. Despite extensive research, comprehensive experimental evidence of the formation and morphology of its internal structure is still limited and controversially discussed. Here, we report the complete mechanical decomposition of natural silk fibers from the golden silk orb-weaver Trichonephila clavipes into ≈10 nm-diameter nanofibrils, the material's apparent fundamental building blocks. Furthermore, we produced nanofibrils of virtually identical morphology by triggering an intrinsic self-assembly mechanism of the silk proteins. Independent physico-chemical fibrillation triggers were revealed, enabling fiber assembly from stored precursors "at-will". This knowledge furthers the understanding of this exceptional material's fundamentals, and ultimately, leads toward the realization of silk-based high-performance materials. STATEMENT OF SIGNIFICANCE: Spider silk is one of the strongest and toughest biomaterials, rivaling the best man-made materials. The origins of these traits are still under debate but are mostly attributed to the material's intriguing hierarchical structure. Here we fully disassembled spider silk into 10 nm-diameter nanofibrils for the first time and showed that nanofibrils of the same appearance can be produced via molecular self-assembly of spider silk proteins under certain conditions. This shows that nanofibrils are the key structural elements in silk and leads toward the production of high-performance future materials inspired by spider silk.
    MeSH term(s) Animals ; Silk/chemistry ; Biocompatible Materials/metabolism ; Spiders/metabolism
    Chemical Substances Silk ; Biocompatible Materials
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.06.044
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  3. Article ; Online: Barriers to Healthcare for Persons with Autism: A Systematic Review of the Literature and Development of A Taxonomy.

    Walsh, Chloe / Lydon, Sinéad / O'Dowd, Emily / O'Connor, Paul

    Developmental neurorehabilitation

    2020  Volume 23, Issue 7, Page(s) 413–430

    Abstract: ... ...

    Abstract Purpose
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280007-4
    ISSN 1751-8431 ; 1751-8423
    ISSN (online) 1751-8431
    ISSN 1751-8423
    DOI 10.1080/17518423.2020.1716868
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  4. Article ; Online: Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients.

    Wellbelove, Zoe / Walsh, Chloe / Perinpanathan, Tanaraj / Lillie, Patrick / Barlow, Gavin

    The Journal of infection

    2020  Volume 82, Issue 3, Page(s) 414–451

    MeSH term(s) COVID-19 ; Community-Acquired Infections ; Humans ; Organ Dysfunction Scores ; SARS-CoV-2 ; Sepsis
    Keywords covid19
    Language English
    Publishing date 2020-10-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.10.015
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  5. Article ; Online: Digital remote monitoring for screening and early detection of urinary tract infections.

    Capstick, Alexander / Palermo, Francesca / Zakka, Kimberley / Fletcher-Lloyd, Nan / Walsh, Chloe / Cui, Tianyu / Kouchaki, Samaneh / Jackson, Raphaella / Tran, Martin / Crone, Michael / Jensen, Kirsten / Freemont, Paul / Vaidyanathan, Ravi / Kolanko, Magdalena / True, Jessica / Daniels, Sarah / Wingfield, David / Nilforooshan, Ramin / Barnaghi, Payam

    NPJ digital medicine

    2024  Volume 7, Issue 1, Page(s) 11

    Abstract: Urinary Tract Infections (UTIs) are one of the most prevalent bacterial infections in older adults and a significant contributor to unplanned hospital admissions in People Living with Dementia (PLWD), with early detection being crucial due to the ... ...

    Abstract Urinary Tract Infections (UTIs) are one of the most prevalent bacterial infections in older adults and a significant contributor to unplanned hospital admissions in People Living with Dementia (PLWD), with early detection being crucial due to the predicament of reporting symptoms and limited help-seeking behaviour. The most common diagnostic tool is urine sample analysis, which can be time-consuming and is only employed where UTI clinical suspicion exists. In this method development and proof-of-concept study, participants living with dementia were monitored via low-cost devices in the home that passively measure activity, sleep, and nocturnal physiology. Using 27828 person-days of remote monitoring data (from 117 participants), we engineered features representing symptoms used for diagnosing a UTI. We then evaluate explainable machine learning techniques in passively calculating UTI risk and perform stratification on scores to support clinical translation and allow control over the balance between alert rate and sensitivity and specificity. The proposed UTI algorithm achieves a sensitivity of 65.3% (95% Confidence Interval (CI) = 64.3-66.2) and specificity of 70.9% (68.6-73.1) when predicting UTIs on unseen participants and after risk stratification, a sensitivity of 74.7% (67.9-81.5) and specificity of 87.9% (85.0-90.9). In addition, feature importance methods reveal that the largest contributions to the predictions were bathroom visit statistics, night-time respiratory rate, and the number of previous UTI events, aligning with the literature. Our machine learning method alerts clinicians of UTI risk in subjects, enabling earlier detection and enhanced screening when considering treatment.
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-023-00995-5
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  6. Book ; Online: Natural Spider Silk Nanofibrils Produced by Assembling Molecules or Disassembling Fibers

    Perera, Dinidu / Li, Linxuan / Walsh, Chloe / Wang, Qijue / Schniepp, Hannes C.

    2022  

    Abstract: Spider silk is biocompatible, biodegradable, and rivals some of the best synthetic materials in terms of strength and toughness. Despite extensive research, comprehensive experimental evidence of the formation and morphology of its internal structure is ... ...

    Abstract Spider silk is biocompatible, biodegradable, and rivals some of the best synthetic materials in terms of strength and toughness. Despite extensive research, comprehensive experimental evidence of the formation and morphology of its internal structure is still limited and controversially discussed. Here, we report the complete mechanical decomposition of natural silk fibers from the golden silk orb-weaver Trichonephila clavipes into ~10 nm-diameter nanofibrils, the material's apparent fundamental building blocks. Furthermore, we produced nanofibrils of virtually identical morphology by triggering an intrinsic self-assembly mechanism of the silk proteins. Independent physico-chemical fibrillation triggers were revealed, enabling fiber assembly from stored precursors "at-will". This knowledge furthers the understanding of this exceptional material's fundamentals, and ultimately, leads toward the realization of silk-based high-performance materials.

    Comment: 21 pages, 4 figures
    Keywords Condensed Matter - Materials Science ; Physics - Applied Physics
    Publishing date 2022-07-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: TIHM: An open dataset for remote healthcare monitoring in dementia.

    Palermo, Francesca / Chen, Yu / Capstick, Alexander / Fletcher-Loyd, Nan / Walsh, Chloe / Kouchaki, Samaneh / True, Jessica / Balazikova, Olga / Soreq, Eyal / Scott, Gregory / Rostill, Helen / Nilforooshan, Ramin / Barnaghi, Payam

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 606

    Abstract: Dementia is a progressive condition that affects cognitive and functional abilities. There is a need for reliable and continuous health monitoring of People Living with Dementia (PLWD) to improve their quality of life and support their independent living. ...

    Abstract Dementia is a progressive condition that affects cognitive and functional abilities. There is a need for reliable and continuous health monitoring of People Living with Dementia (PLWD) to improve their quality of life and support their independent living. Healthcare services often focus on addressing and treating already established health conditions that affect PLWD. Managing these conditions continuously can inform better decision-making earlier for higher-quality care management for PLWD. The Technology Integrated Health Management (TIHM) project developed a new digital platform to routinely collect longitudinal, observational, and measurement data, within the home and apply machine learning and analytical models for the detection and prediction of adverse health events affecting the well-being of PLWD. This work describes the TIHM dataset collected during the second phase (i.e., feasibility study) of the TIHM project. The data was collected from homes of 56 PLWD and associated with events and clinical observations (daily activity, physiological monitoring, and labels for health-related conditions). The study recorded an average of 50 days of data per participant, totalling 2803 days.
    MeSH term(s) Humans ; Activities of Daily Living ; Delivery of Health Care ; Dementia ; Health Facilities ; Quality of Life
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02519-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Systematic review of interventions to improve gender equity in graduate medicine.

    Lydon, Sinéad / O'Dowd, Emily / Walsh, Chloe / O'Dea, Angela / Byrne, Dara / Murphy, Andrew W / O'Connor, Paul

    Postgraduate medical journal

    2021  Volume 98, Issue 1158, Page(s) 300–307

    Abstract: Women are substantially underrepresented in senior and leadership positions in medicine and experience gendered challenges in their work settings. This systematic review aimed to synthesise research that has evaluated interventions for improving gender ... ...

    Abstract Women are substantially underrepresented in senior and leadership positions in medicine and experience gendered challenges in their work settings. This systematic review aimed to synthesise research that has evaluated interventions for improving gender equity in medicine. English language electronic searches were conducted across MEDLINE, CINAHL, Academic Search Complete, PsycINFO and Web of Science. Reference list screening was also undertaken. Peer-reviewed studies published between 2000 and March 2020 that evaluated interventions to improve gender equity, or the experiences of women, in academic or clinical medicine were reviewed. Dual reviewer data extraction on setting, participants, type of intervention, measurement and outcomes was completed. Methodological rigour and strength of findings were evaluated. In total, 34 studies were included. Interventions were typically focused on
    MeSH term(s) Female ; Gender Equity ; Humans ; Leadership ; Research Design
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-138864
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  9. Article ; Online: Development and preliminary evaluation of a novel physician-report tool for assessing barriers to providing care to autistic patients.

    Walsh, Chloe / Lydon, Sinéad / Geoghegan, Rosemary / Carey, Cornelia / Creed, Michael / O'Loughlin, Lauren / Walsh, Ellen / Byrne, Dara / O'Connor, Paul

    BMC health services research

    2021  Volume 21, Issue 1, Page(s) 873

    Abstract: Background: Individuals on the autism spectrum face significant disparities in health and physicians often report difficulties in providing care to autistic patients. In order to improve the quality of care autistic individuals receive, it is important ... ...

    Abstract Background: Individuals on the autism spectrum face significant disparities in health and physicians often report difficulties in providing care to autistic patients. In order to improve the quality of care autistic individuals receive, it is important to identify the barriers that physicians experience in providing care so that these may be addressed. This paper reports the initial development and preliminary evaluation of a physician-report 'Barriers to Providing Healthcare' measurement tool.
    Method: An established taxonomy of healthcare barriers for autistic individuals informed the initial draft of a 22-item measurement tool. This measurement tool was distributed to physicians working in various healthcare specialties and settings. Exploratory factor analysis (EFA) was conducted to determine the construct validity of the tool; discriminant validity between, and internal consistency of, the resultant factors were assessed. Multiple regressions were used to explore variables potentially associated with barriers endorsed by physicians.
    Results: A total of 203 physicians were included in the analyses. The EFA resulted in a 17-item tool with three distinct factors which explained 37.6% of the variance: 1) Patient-related barriers (Cronbach's α = 0.83; e.g., the patient's reactivity to the healthcare environment); 2) Healthcare provider (HCP)/family-related barriers (Cronbach's α = 0.81; e.g., a lack of providers willing to work with autistic patients); and 3) System-related barriers (Cronbach's α = 0.84; e.g., there is a lack of support for patients and families). Discriminant validity between the factors was adequate (r < .8). The barriers that were most frequently endorsed as occurring 'often' or 'very often' included a lack of support for patients and families (endorsed by 79.9% of physicians); communication difficulties (73.4%); and a lack of coordination between services (69.9%). The regression analyses identified no significant associated variables.
    Conclusion: A preliminary version of a novel physician-report tool to assess barriers to providing care to autistic patients has been developed although further validation work is required. The use of this tool will help physicians to identify issues specific to different medical specialities and healthcare settings. This information may help identify the supports physicians require to recognise and implement the required accommodations. Future research which elucidates barriers to healthcare provision for autistic patients is required to support systemic change in healthcare so as to improve care experiences and health outcomes for people on the autism spectrum.
    MeSH term(s) Autistic Disorder/diagnosis ; Autistic Disorder/therapy ; Communication ; Delivery of Health Care ; Health Personnel ; Humans ; Physicians
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-021-06842-1
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  10. Article: Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients

    Wellbelove, Zoe / Walsh, Chloe / Perinpanathan, Tanaraj / Lillie, Patrick / Barlow, Gavin

    J. infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #894035
    Database COVID19

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