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Article: Does exercising the quadriceps muscle of patients on extracorporeal membrane oxygenation (ECMO) with electrical stimulation affect the blood flow to their feet? A feasibility study.

McCormack, Paul F / Tronstad, Oystein / Walsh, James R

2020 Volume 24, Issue 3 Suppl, Page(s) 41–43

Language	English
Publishing date	2020-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2701626-2
ISSN	1751-1437 ; 1751-1437
ISSN (online)	1751-1437
ISSN	1751-1437
DOI	10.1177/1751143720970373
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Article ; Online: Patient perspectives of airway clearance techniques in bronchiectasis.

Franks, Lisa J / Walsh, James R / Hall, Kathleen / Adsett, Julie A / Morris, Norman R

Physiotherapy theory and practice

2022 Volume 40, Issue 3, Page(s) 505–515

Abstract: Introduction: While airway clearance techniques (ACTs) are recommended for individuals with bronchiectasis, data suggests the use of and adherence to ACTs is poor.: Objective: This study aimed to identify patient perceptions regarding ACTs, the ... ...

Abstract	Introduction: While airway clearance techniques (ACTs) are recommended for individuals with bronchiectasis, data suggests the use of and adherence to ACTs is poor. Objective: This study aimed to identify patient perceptions regarding ACTs, the barriers and facilitators to ACTs, and factors affecting adherence. Methods: A multi-center qualitative study using in-depth semi-structured interviews of individuals with bronchiectasis was undertaken. All interviews were audio recorded and transcribed verbatim. Data was analyzed using the thematic framework approach described by Braun and Clark. NVIVO™ 12 software assisted with coding and thematic analysis of the interview transcripts. Data saturation was achieved when no new common themes were identified. Findings were summarized into major conceptual themes. Participant demographic data was also obtained. Results: Twenty-four participants participated in semi-structured interviews. The main facilitators to using ACTs included a perceived health and quality of life benefit, a tailored approach to ACTs and the use of self-management strategies. Main barriers included lack of time and motivation, lack of access to resources, and a lack of perceived health benefit. A number of factors were identified by participants that may help promote adherence including combining and trialing different ACTs, receiving regular ACT reviews and education from physiotherapists, and having good social support. Conclusion: To assist the personalized prescription of ACTs, these facilitators and barriers should be considered by clinicians to help promote adherence and improve patient outcomes.
MeSH term(s)	Humans ; Quality of Life ; Bronchiectasis/therapy ; Qualitative Research
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2022.2126741
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Zs.A 2190: Show issues

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Article ; Online: Physiotherapist perspectives of airway clearance techniques in bronchiectasis.

Franks, Lisa J / Walsh, James R / Hall, Kathleen / Adsett, Julie A / Morris, Norman R

Physiotherapy theory and practice

2022 Volume 39, Issue 4, Page(s) 785–793

Abstract: Introduction: Our understanding regarding the personalization of airway clearance techniques (ACTs) in bronchiectasis is limited.: Objective: This study aimed to determine physiotherapist perceptions regarding the prescription of ACTs in inpatients ... ...

Abstract	Introduction: Our understanding regarding the personalization of airway clearance techniques (ACTs) in bronchiectasis is limited. Objective: This study aimed to determine physiotherapist perceptions regarding the prescription of ACTs in inpatients and outpatients with bronchiectasis. Methods: A single-center qualitative study using semi-structured interviews of physiotherapists who treated individuals with bronchiectasis was undertaken. All interviews were audio recorded and transcribed verbatim. Data was analyzed using the thematic framework approach described by Braun and Clark. NVivo 12 software assisted with coding and thematic analysis of the interview transcripts. Findings were summarized into major conceptual themes. Participant demographic data was also obtained. Results: Eleven physiotherapists participated in the interviews. Central to all themes was the complexity of physiotherapy clinical decision-making regarding ACT prescription. Main themes included: organizational factors (i.e. workload, scope of service, access to resources/ACTs); patient-related factors (i.e. symptom severity, finances, disease-specific knowledge, social commitments, clinical setting, and perceived benefit); and physiotherapist/profession-related factors (i.e. clinical experience, access to professional support and education, awareness of evidence of ACTs, and evaluating ACT effectiveness). Conclusion: Physiotherapists regularly and routinely prescribe ACTs for individuals with bronchiectasis allowing for a multitude of competing factors. These factors should be considered by physiotherapists to enhance the personalized prescription of ACTs and may help promote patient adherence to ACTs to improve outcomes.
MeSH term(s)	Humans ; Physical Therapists/education ; Physical Therapy Modalities ; Qualitative Research ; Bronchiectasis/therapy ; Patient Compliance
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2022.2028326
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Zs.A 2190: Show issues

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Article ; Online: Exertional Dyspnoea responses reported in the Dyspnoea Challenge and measures of disease severity in COPD.

Aitken, Craig R / Walsh, James R / Stewart, Glenn M / Sabapathy, Surendran / Adams, Lewis / Morris, Norman R

Respiratory physiology & neurobiology

2022 Volume 304, Page(s) 103941

Abstract: Background: The Dyspnoea Challenge has been developed to facilitate the field-based measure of exertional dyspnoea(ED). To further validate the test, we aimed to; investigate the relationship between end-exercise ED, generated by a fixed-intensity ... ...

Abstract	Background: The Dyspnoea Challenge has been developed to facilitate the field-based measure of exertional dyspnoea(ED). To further validate the test, we aimed to; investigate the relationship between end-exercise ED, generated by a fixed-intensity Dyspnoea Challenge(DC Methods: Thirty-two individuals (15 female) with COPD (GOLD II-IV) (age: 69.7 ± 9.4 yrs; FEV Results: End-exercise ED measured during the DC Conclusions: The Dyspnoea Challenge is correlated to different parameters of disease severity and produces a similar physiological and ED response to that of the 6MWT with the added benefit of being appropriate for longitudinal assessment of ED.
MeSH term(s)	Aged ; Dyspnea/diagnosis ; Dyspnea/etiology ; Exercise Test ; Exercise Tolerance ; Female ; Forced Expiratory Volume ; Humans ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/complications ; Severity of Illness Index
Language	English
Publishing date	2022-06-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2022.103941
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Zs.A 519: Show issues

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Article ; Online: Optimising the Dyspnoea Challenge: exertional dyspnoea responses to changing treadmill gradients.

Aitken, Craig R / Walsh, James R / Sabapathy, Surendran / Adams, Lewis / Morris, Norman R / Stewart, Glenn M

Respiratory physiology & neurobiology

2022 Volume 302, Page(s) 103915

Abstract: Background: The Dyspnoea Challenge is a two-minute treadmill walk designed to measure exertional dyspnoea(ED). To efficiently individualise workload, we aimed to assess; 1) whether the Dyspnoea Challenge is responsive to 1% changes in treadmill gradient ...

Abstract	Background: The Dyspnoea Challenge is a two-minute treadmill walk designed to measure exertional dyspnoea(ED). To efficiently individualise workload, we aimed to assess; 1) whether the Dyspnoea Challenge is responsive to 1% changes in treadmill gradient and 2) the minimum gradient variation necessary to generate a clinically meaningful change in ED (≥1 modified Borg scale). Methods: Thirty individuals with COPD(GOLD II-IV) (age: 69.2 ± 9.2 years; FEV Results: Higher treadmill gradients generated stronger intensities of ED (3%:2.6 ± 1.8; 4%:2.8 ± 2.2; 5%:3.2 ± 2.2; 6%:3.4 ± 2.2; 7%:3.7 ± 1.8; 8%:4.0 ± 2.1units). Statistical changes were observed in ED(e.g.,3 vs. 5%: P = .03) and the MDP discomfort data(e.g.,4 vs. 6%: P = .04) at ≥ a 2% variation in treadmill gradient. Linear regression found a 4% variation in treadmill gradient corresponded to a rise in ED ≥ 1unit. Increases in ED intensity corresponded to heightened sensations of work/effort(P < .01) and breathing frequency(P < .01). There were no changes in emotional constructs(P = .27). While there was an increase in HR with increasing gradient(P < .01), no differences were observed in end-exercise S Conclusion: To significantly change ED, the treadmill gradient must be manipulated by ≥ 2%, with a ≥ 4% change in gradient required to induce a clinically meaningful change in ED.
MeSH term(s)	Aged ; Dyspnea ; Exercise Test/methods ; Exercise Tolerance/physiology ; Fatigue ; Humans ; Middle Aged ; Respiratory Function Tests
Language	English
Publishing date	2022-04-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2022.103915
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Zs.A 519: Show issues

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Article ; Online: Measuring airway clearance outcomes in bronchiectasis: a review.

Franks, Lisa J / Walsh, James R / Hall, Kathleen / Morris, Norman R

European respiratory review : an official journal of the European Respiratory Society

2020 Volume 29, Issue 156

Abstract: While airway clearance techniques (ACTs) are recommended for individuals with bronchiectasis, many trials have demonstrated inconsistent benefits or failed to reach their primary outcome. This review determined the most common clinical and patient- ... ...

Abstract	While airway clearance techniques (ACTs) are recommended for individuals with bronchiectasis, many trials have demonstrated inconsistent benefits or failed to reach their primary outcome. This review determined the most common clinical and patient-reported outcome measures used to evaluate the efficacy of ACTs in bronchiectasis. A literature search of five databases using relevant keywords and filtering for studies published in English, up until the end of August 2019, was completed. Studies included randomised controlled trials, using crossover or any other trial design, and abstracts. Studies were included where the control was placebo, no intervention, standard care, usual care or an active comparator. Adults with bronchiectasis not related to cystic fibrosis were included. Extracted data comprised study authors, design, duration, intervention, outcome measures and results. The search identified 27 published studies and one abstract. The most common clinical outcome measures were sputum volume (n=23), lung function (n=17) and pulse oximetry (n=9). The most common patient-reported outcomes were health-related quality of life (measured with St George's Respiratory Questionnaire, n=4), cough-related quality of life (measured with Leicester Cough Questionnaire, n=4) and dyspnoea (measured with Borg/modified Borg scale, n=8). Sputum volume, lung function, dyspnoea and health- and cough-related quality of life appear to be the most common clinical and patient-reported measures of airway clearance treatment efficacy.
MeSH term(s)	Bronchi/physiopathology ; Bronchiectasis/diagnosis ; Bronchiectasis/metabolism ; Bronchiectasis/physiopathology ; Bronchiectasis/therapy ; Functional Status ; Humans ; Lung Volume Measurements ; Mucociliary Clearance ; Oximetry ; Patient Reported Outcome Measures ; Predictive Value of Tests ; Quality of Life ; Recovery of Function ; Respiratory Function Tests ; Sputum/metabolism ; Symptom Assessment ; Treatment Outcome
Language	English
Publishing date	2020-04-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0161-2019
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Zs.A 3265: Show issues

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Article ; Online: The Emerging Importance of Skeletal Muscle Function in Assessing Candidates for Transplantation.

Walsh, James R / Chambers, Daniel C / Hopkins, Peter M A

Transplantation

2018 Volume 101, Issue 9, Page(s) 1967–1968

MeSH term(s)	Humans ; Lung Transplantation ; Muscle, Skeletal/physiology
Language	English
Publishing date	2018-03-31
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000001784
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Sarcopenia in lung transplant candidates: A novel biomarker to estimate skeletal muscle mass.

Walsh, James R / Hopkins, Peter M A

Clinical transplantation

2018 Volume 32, Issue 3, Page(s) e13200

MeSH term(s)	Biomarkers ; Humans ; Lung Transplantation ; Muscle, Skeletal ; Sarcopenia
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-03-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13200
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Zs.A 2204: Show issues

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Article ; Online: Exertional dyspnea responses to the Dyspnea Challenge in heart failure: Comparison to chronic obstructive pulmonary disease.

Aitken, Craig R / Stewart, Glenn M / Walsh, James R / Palmer, Tanya / Adams, Lewis / Sabapathy, Surendran / Morris, Norman R

Heart & lung : the journal of critical care

2022 Volume 58, Page(s) 108–115

Abstract: Background: In heart failure (HF), exertional dyspnea is a common symptom, but validated field-based tests for its measurement are limited. The Dyspnea Challenge is a two-minute uphill treadmill walk designed to measure exertional dyspnea in ... ...

Abstract	Background: In heart failure (HF), exertional dyspnea is a common symptom, but validated field-based tests for its measurement are limited. The Dyspnea Challenge is a two-minute uphill treadmill walk designed to measure exertional dyspnea in cardiopulmonary disease. Objectives: The purpose of this study was to establish the test-retest reliability of the Dyspnea Challenge in HF and to compare the exercise responses to a group with chronic obstructive pulmonary disease (COPD). Methods: The study was an experimental, single-blind, randomized, multi-site project that recruited individuals with HF (New York Heart Association I-III) and COPD (Global Initiative for Chronic Obstructive Lung Disease II-IV). Participants completed two visits. On the first visit, participants performed two six-minute walk tests (6MWT), followed by two to three Dyspnea Challenges to calculate treadmill speed and gradient. At Visit Two, participants performed two separate Dyspnea Challenges, with one including measures of pulmonary gas exchange and central hemodynamics. Results: Twenty-one individuals with HF (10 female; 66±11years; ejection fraction:45.3 ± 6.1%; six-minute distance(6MWD) 520 ± 97 m), and 25 COPD (11 female; 68 ± 10 yr; forced expiratory volume in 1 s:47.6 ± 11.5%; 6MWD: 430 ± 101 m). Intraclass correlation coefficients demonstrated excellent test-retest reliability for HF (0.94, P<.01) and COPD (0.95, P<.01). While achieving similar end-exercise exertional dyspnea intensities (P=.60), the HF group walked at a higher average speed (4.2 ± 0.8 vs. 3.5 ± 0.8km·h Conclusions: The Dyspnea Challenge is a reliable test-retest measure of exertional dyspnea in HF. Typical to their pathologies, HF seemed limited by an inadequate modulation of cardiac output, while ventilatory constraints hampered those with COPD.
MeSH term(s)	Female ; Humans ; Dyspnea ; Exercise Test ; Exercise Tolerance/physiology ; Heart Failure/complications ; Oxygen ; Pulmonary Disease, Chronic Obstructive ; Reproducibility of Results ; Single-Blind Method
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2022.11.010
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Zs.A 1035: Show issues

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Article ; Online: Comparing the Performance Characteristics of Different Positive Expiratory Pressure Devices.

Franks, Lisa J / Walsh, James R / Hall, Kathleen / Jacuinde, Guillermo / Yerkovich, Stephanie / Morris, Norman R

Respiratory care

2019 Volume 64, Issue 4, Page(s) 434–444

Abstract: Background: Positive expiratory pressure (PEP) devices are widely used in clinical settings, yet the performance characteristics of these devices remain relatively unknown. This study compared the performance characteristics of 6 airway clearance ... ...

Abstract	Background: Positive expiratory pressure (PEP) devices are widely used in clinical settings, yet the performance characteristics of these devices remain relatively unknown. This study compared the performance characteristics of 6 airway clearance devices by varying resistance and flow. Methods: Mean PEP, peak PEP, oscillation frequency, and amplitude PEP of the Flutter, Pari PEP S, Acapella Choice, Acapella DM, Acapella DH, and Aerobika devices were obtained across flows of 5, 10, 15, 20, 25 and 30 L/min and at low, medium, and high resistance using an experimental apparatus custom-built for this bench study. Results: Performance characteristics of the devices differed across flows and resistance settings (device × flow/resistance interaction; Conclusions: PEP devices produced small but statistically significant variations in performance characteristics across a range of flows and resistance settings. There appear to be flow-dependent and non-flow-dependent devices. Varying flow or resistance typically maintained or increased the production of mean, peak, and amplitude PEP and oscillation frequency.
MeSH term(s)	Airway Management/instrumentation ; Airway Management/methods ; Chest Wall Oscillation/instrumentation ; Chest Wall Oscillation/methods ; Comparative Effectiveness Research ; Equipment Design/methods ; Equipment Design/standards ; Humans ; Materials Testing ; Physical Therapy Modalities ; Positive-Pressure Respiration/instrumentation ; Pulmonary Elimination
Language	English
Publishing date	2019-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.06410
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