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Article ; Online: Vestibular Schwannoma Presenting with Cough-Induced Vertigo.

Walter, Jeffrey / Greene, J Scott / Gadre, Arun K

The journal of international advanced otology

2023 Volume 19, Issue 1, Page(s) 66–69

Abstract: Vestibular schwannomas often present with unilateral hearing loss, tinnitus, or dizziness. Imaging is commonly pursued in individuals with unexplained unilateral sensorineural hearing loss, deterioration in word recognition scores, or persistent tinnitus. ...

Abstract	Vestibular schwannomas often present with unilateral hearing loss, tinnitus, or dizziness. Imaging is commonly pursued in individuals with unexplained unilateral sensorineural hearing loss, deterioration in word recognition scores, or persistent tinnitus. We present the case of a 76-year-old male with cough-induced vertigo as his primary presenting symptom. Vestibular testing suggested a right vestibular hypofunction, and a small right-sided vestibular schwannoma was discovered using magnetic resonance imaging. Cough-induced vertigo and associated nystagmus may be a presenting feature of vestibular schwannoma.
MeSH term(s)	Male ; Humans ; Aged ; Neuroma, Acoustic/complications ; Neuroma, Acoustic/diagnosis ; Tinnitus/etiology ; Cough/etiology ; Vertigo/diagnosis ; Vertigo/etiology ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/etiology ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-02-14
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2561231-1
ISSN	2148-3817 ; 1308-7649 ; 2148-3817
ISSN (online)	2148-3817
ISSN	1308-7649 ; 2148-3817
DOI	10.5152/iao.2023.22634
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Article ; Online: Prevalence of "Reversal Nystagmus" in Benign Paroxysmal Positional Vertigo.

Walter, Jeffrey / Azeredo, W James / Greene, J Scott / Andera, Luke

Journal of the American Academy of Audiology

2021 Volume 32, Issue 1, Page(s) 35–38

Abstract: Purpose: To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV).: Study design: Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, ... ...

Abstract	Purpose: To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV). Study design: Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, canalithiasis type. Six trials of Dix-Hallpike testing were completed for each subject. Results: Reversal nystagmus was present in 129 out of 167 Dix-Hallpike maneuvers that were performed (77.2%). In 19 trials where nystagmus was absent with the dependent position of Dix-Hallpike testing, reversal nystagmus was nonetheless demonstrated in 11 trials (57.9%). Conclusion: Reversal nystagmus is commonly demonstrated in individuals with posterior canal BPPV, canalithiasis type. It is frequently evoked even when there is no nystagmus with the dependent position of Dix-Hallpike testing. Observation of reversal nystagmus may enhance the identification of BPPV during Dix-Hallpike testing.
MeSH term(s)	Benign Paroxysmal Positional Vertigo/epidemiology ; Environment ; Humans ; Nystagmus, Pathologic/diagnosis ; Nystagmus, Pathologic/epidemiology ; Prevalence ; Semicircular Canals
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1132599-9
ISSN	2157-3107 ; 1050-0545
ISSN (online)	2157-3107
ISSN	1050-0545
DOI	10.1055/s-0040-1718894
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Article: Prevalence of “Reversal Nystagmus” in Benign Paroxysmal Positional Vertigo

Walter, Jeffrey / Azeredo, W. James / Greene, J. Scott / Andera, Luke

Journal of the American Academy of Audiology

2021 Volume 32, Issue 01, Page(s) 35–38

Abstract: Purpose: To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV).: Study Design: Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, ... ...

Abstract	Purpose: To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV). Study Design: Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, canalithiasis type. Six trials of Dix-Hallpike testing were completed for each subject. Results: Reversal nystagmus was present in 129 out of 167 Dix-Hallpike maneuvers that were performed (77.2%). In 19 trials where nystagmus was absent with the dependent position of Dix-Hallpike testing, reversal nystagmus was nonetheless demonstrated in 11 trials (57.9%). Conclusion: Reversal nystagmus is commonly demonstrated in individuals with posterior canal BPPV, canalithiasis type. It is frequently evoked even when there is no nystagmus with the dependent position of Dix-Hallpike testing. Observation of reversal nystagmus may enhance the identification of BPPV during Dix-Hallpike testing.
Keywords	benign paroxysmal positional vertigo ; vestibular ; nystagmus ; dix-hallpike
Language	English
Publishing date	2021-01-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1132599-9
ISSN	2157-3107 ; 1050-0545
ISSN (online)	2157-3107
ISSN	1050-0545
DOI	10.1055/s-0040-1718894
Database	Thieme publisher's database

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Article ; Online: Optimizing Testing for BPPV - The Loaded Dix-Hallpike.

Andera, Luke / Azeredo, William James / Greene, Joseph Scott / Sun, Haiyan / Walter, Jeffrey

The journal of international advanced otology

2020 Volume 16, Issue 2, Page(s) 171–175

Abstract: Objectives: Although the Dix-Hallpike testing is generally considered as the gold standard for the identification of the posterior canal benign paroxysmal positional vertigo (BPPV), we investigated a modification of the maneuver termed the "loaded Dix- ... ...

Abstract	Objectives: Although the Dix-Hallpike testing is generally considered as the gold standard for the identification of the posterior canal benign paroxysmal positional vertigo (BPPV), we investigated a modification of the maneuver termed the "loaded Dix-Hallpike." Study design: Prospective randomized controlled trial. Materials and methods: Twenty-eight patients participated in this prospective study comparing the standard Dix-Hallpike (S-DH) to the loaded Dix-Hallpike (L-DH) test. Each patient underwent repeated testing with the S-DH and the L-DH. The patients were placed into two groups. Fourteen patients underwent 3 rounds of S-DH testing followed by 3 rounds of L-DH testing. The other fourteen patients underwent 3 rounds of L-DH testing followed by 3 rounds of S-DH testing. The duration of nystagmus and the latency prior to the onset of nystagmus were measured for each test. Additionally, the patients were asked to rate the severity of their symptoms following each test. Results: The duration of nystagmus of the L-DH was significantly longer than that of the S-DH (p<0.0001). The patients reported a higher severity score with L-DH as compared to with S-DH (p<0.001). The L-DH was found to be more sensitive than the S-DH (p=0.0131). Conclusion: The L-DH produces significantly longer duration of nystagmus, stronger symptoms, and improved sensitivity when compared to the S-DH.
MeSH term(s)	Benign Paroxysmal Positional Vertigo/diagnosis ; Benign Paroxysmal Positional Vertigo/physiopathology ; Eye Movements ; Female ; Humans ; Male ; Middle Aged ; Nystagmus, Pathologic/diagnosis ; Nystagmus, Pathologic/physiopathology ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index ; Time Factors ; Vestibular Function Tests/methods
Language	English
Publishing date	2020-07-30
Publishing country	Turkey
Document type	Journal Article ; Randomized Controlled Trial
ISSN	2148-3817
ISSN (online)	2148-3817
DOI	10.5152/iao.2020.7444
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Book ; Conference proceedings: Where innovative ideas merge with reality

Walter, Jeffrey

proceedings book

2000

Institution	ARC Society of Plastics Engineers / Recycling Division
Event/congress	ARC 2000 (7, 2000.11.08-09, DearbornMich.) ; Annual Recycling Conference (7, 2000.11.08-09, DearbornMich.)
Author's details	ARC 2000, 7th Annual Recycling Conference, November 8 - 9, 2000, Dearborn, Michigan. SPE Recycling Division. [Chair: Jeffrey Walter]
Language	English
Size	227 S
Publisher	Society of Plastics Engineers
Publishing place	Brookfield, Conn.
Document type	Book ; Conference proceedings
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Round window plugging in the treatment of superior semicircular canal dehiscence.

Succar, Eric F / Manickam, Periakaruppan V / Wing, Sara / Walter, Jeffrey / Greene, Joseph S / Azeredo, William J

The Laryngoscope

2017 Volume 128, Issue 6, Page(s) 1445–1452

Abstract: Objectives/hypothesis: Objectives were to describe the use of round window plugging for superior semicircular canal dehiscence syndrome and review further recommendations regarding the procedure based on our experience and to compare results with recent ...

Abstract	Objectives/hypothesis: Objectives were to describe the use of round window plugging for superior semicircular canal dehiscence syndrome and review further recommendations regarding the procedure based on our experience and to compare results with recent literature on round window plugging. Study design: Retrospective case series. Methods: Fourteen patients underwent round window plugging for superior semicircular canal dehiscence at our institution from 2012 to 2015. All patients underwent the same surgical procedure. Available pre- and postoperative data were reviewed. Results: Fourteen patient charts were reviewed. Symptoms of autophony improved in nine of 14 (64%) patients. Symptoms of pressure-induced vertigo improved in seven of 12 (58%) patients. Hennebert's sign that was positive preoperatively only improved in one of six (17%) patients. A positive preoperative vestibular evoked myogenic potential improved in only one of six (17%) patients. Six of 13 (46%) patients had increased air conduction thresholds postoperatively. Conclusions: Round window plugging has been described as a less-invasive treatment for patients with superior semicircular canal dehiscence. Although the procedure did benefit some of our patients, successful outcomes were not predictable. Improvement in at least one objective finding was seen in only 21% of the patients studied. Hennebert's sign and vestibular evoked myogenic potentials that were positive preoperatively only improved in 17% of patients. At our institution, round window plugging is no longer considered a reasonable treatment option for most patients with superior semicircular canal dehiscence. We recommend that further study on this topic follow a standardized pre- and postoperative assessment. Level of evidence: 4. Laryngoscope, 128:1445-1452, 2018.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Audiometry ; Female ; Humans ; Labyrinth Diseases/surgery ; Male ; Middle Aged ; Otologic Surgical Procedures/methods ; Retrospective Studies ; Round Window, Ear/surgery ; Semicircular Canals/pathology ; Semicircular Canals/surgery ; Treatment Outcome ; Vestibular Evoked Myogenic Potentials
Language	English
Publishing date	2017-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.26899
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Article ; Online: Intensive psychotherapy and case management for Karen refugees with major depression in primary care: a pragmatic randomized control trial.

Northwood, Andrea K / Vukovich, Maria M / Beckman, Alison / Walter, Jeffrey P / Josiah, Novia / Hudak, Leora / O'Donnell Burrows, Kathleen / Letts, James P / Danner, Christine C

BMC family practice

2020 Volume 21, Issue 1, Page(s) 17

Abstract: Background: Despite an unparalleled global refugee crisis, there are almost no studies in primary care addressing real-world conditions and longer courses of treatment that are typical when resettled refugees present to their physician with critical ... ...

Abstract	Background: Despite an unparalleled global refugee crisis, there are almost no studies in primary care addressing real-world conditions and longer courses of treatment that are typical when resettled refugees present to their physician with critical psychosocial needs and complex symptoms. We studied the effects of a year of psychotherapy and case management in a primary care setting on common symptoms and functioning for Karen refugees (a newly arrived population in St Paul, Minnesota) with depression. Methods: A pragmatic parallel-group randomized control trial was conducted at two primary care clinics with large resettled Karen refugee patient populations, with simple random allocation to 1 year of either: (1) intensive psychotherapy and case management (IPCM), or (2) care-as-usual (CAU). Eligibility criteria included Major Depression diagnosis determined by structured diagnostic clinical interview, Karen refugee, ages 18-65. IPCM (n = 112) received a year of psychotherapy and case management coordinated onsite between the case manager, psychotherapist, and primary care providers; CAU (n = 102) received care-as-usual from their primary care clinic, including behavioral health referrals and/or brief onsite interventions. Blinded assessors collected outcomes of mean changes in depression and anxiety symptoms (measured by Hopkins Symptom Checklist-25), PTSD symptoms (Posttraumatic Diagnostic Scale), pain (internally developed 5-item Pain Scale), and social functioning (internally developed 37-item instrument standardized on refugees) at baseline, 3, 6 and 12 months. After propensity score matching, data were analyzed with the intention-to-treat principle using repeated measures ANOVA with partial eta-squared estimates of effect size. Results: Of 214 participants, 193 completed a baseline and follow up assessment (90.2%). IPCM patients showed significant improvements in depression, PTSD, anxiety, and pain symptoms and in social functioning at all time points, with magnitude of improvement increasing over time. CAU patients did not show significant improvements. The largest mean differences observed between groups were in depression (difference, 5.5, 95% CI, 3.9 to 7.1, P < .001) and basic needs/safety (difference, 5.4, 95% CI, 3.8 to 7.0, P < .001). Conclusions: Adult Karen refugees with depression benefited from intensive psychotherapy and case management coordinated and delivered under usual conditions in primary care. Intervention effects strengthened at each interval, suggesting robust recovery is possible. Trial registration: clinicaltrials.gov Identifier: NCT03788408. Registered 20 Dec 2018. Retrospectively registered.
MeSH term(s)	Adult ; Ambulatory Care Facilities ; Anxiety/psychology ; Case Management ; Depression/psychology ; Depressive Disorder, Major/physiopathology ; Depressive Disorder, Major/psychology ; Depressive Disorder, Major/therapy ; Female ; Humans ; Male ; Middle Aged ; Minnesota ; Myanmar/ethnology ; Pain/physiopathology ; Pain/psychology ; Primary Health Care ; Psychological Trauma/therapy ; Psychotherapy/methods ; Psychotherapy/organization & administration ; Referral and Consultation ; Refugees/psychology ; Social Behavior ; Social Participation ; Stress Disorders, Post-Traumatic/psychology ; Torture/psychology ; Treatment Outcome
Language	English
Publishing date	2020-01-28
Publishing country	England
Document type	Journal Article ; Pragmatic Clinical Trial ; Randomized Controlled Trial
ISSN	1471-2296
ISSN (online)	1471-2296
DOI	10.1186/s12875-020-1090-9
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Article ; Online: Differences among formulary submission guidelines: implications for health technology assessment.

Mauskopf, Josephine / Walter, Jeffrey / Birt, Julie / Bowman, Lee / Copley-Merriman, Catherine / Drummond, Michael

International journal of technology assessment in health care

2011 Volume 27, Issue 3, Page(s) 261–270

Abstract: Objectives: This article provides a detailed understanding of the differences in selected formulary submission guidelines supplied by various health technology assessment (HTA) agencies and indicates how these differences can impact the evidence base ... ...

Abstract	Objectives: This article provides a detailed understanding of the differences in selected formulary submission guidelines supplied by various health technology assessment (HTA) agencies and indicates how these differences can impact the evidence base used to populate the HTA. Methods: Detailed summaries of the recommended methods for evidence generation, organized by topic areas relevant for clinical and economic data, for twelve countries in Europe, North America, and Australia where HTA processes are well developed were prepared. Using these summaries, we provide examples of the likely impact these differences in recommended methods could have on the evidence base used to evaluate new health technologies. Results: Areas where recommendations differed included methodologies for systematic literature reviews (e.g., preferred databases and study designs for inclusion); selection of appropriate comparators; guidance on critical appraisal and synthesis of clinical evidence; appropriate sources for health value measures, resource use, and cost data; and approaches to uncertainty analyses. Performing literature searches that capture all relevant studies and then creating subsets of the literature based on a listing of country-specific requirements could allow for direct comparison of the evidence bases associated with the different guidelines. Conclusions: If the formulary submission guidelines were followed as written, different (although overlapping) bodies of evidence likely would be generated for each country, which could contribute to disparate assessments and recommendations. This comparison of the formulary submission guidelines could contribute to an understanding of why clinical and reimbursement decisions vary across countries.
MeSH term(s)	Australia ; Developed Countries ; Economics, Pharmaceutical ; Europe ; Formularies as Topic ; Government Agencies ; Guidelines as Topic ; North America ; Technology Assessment, Biomedical/standards
Language	English
Publishing date	2011-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632573-7
ISSN	1471-6348 ; 0266-4623
ISSN (online)	1471-6348
ISSN	0266-4623
DOI	10.1017/S0266462311000274
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Article: Do different clinical evidence bases lead to discordant health-technology assessment decisions? An in-depth case series across three jurisdictions.

Spinner, Daryl S / Birt, Julie / Walter, Jeffrey W / Bowman, Lee / Mauskopf, Josephine / Drummond, Michael F / Copley-Merriman, Catherine

ClinicoEconomics and outcomes research : CEOR

2013 Volume 5, Page(s) 69–85

Abstract: Background: Health-technology assessment (HTA) plays an important role in informing drug-reimbursement decision-making in many countries. HTA processes for the Pharmaceutical Benefits Advisory Committee (PBAC) in Australia, the Common Drug Review (CDR) ... ...

Abstract	Background: Health-technology assessment (HTA) plays an important role in informing drug-reimbursement decision-making in many countries. HTA processes for the Pharmaceutical Benefits Advisory Committee (PBAC) in Australia, the Common Drug Review (CDR) in Canada, and the National Institute for Health and Clinical Excellence (NICE) in England and Wales are among the most established in the world. In this study, we performed nine in-depth case studies to assess whether different clinical evidence bases may have influenced listing recommendations made by PBAC, CDR, and NICE. Methods: Nine drugs were selected for which the three agencies had provided listing recommendations for the same indication between 2007 and 2010. We reviewed the evidence considered for each listing recommendation, identified the similarities and differences among the clinical evidence bases considered, and evaluated the extent to which different clinical evidence bases could have contributed to different decisions based on HTA body comments and public assessment of the evidence. Results: HTA agencies reached the same recommendation for reimbursement (recommended for listing) for four drugs and different recommendations for five drugs. In all cases, each agency used different evidence bases in their recommendations. The agencies considered overlapping sets of clinical comparators and trials when evaluating the same drug. While PBAC and NICE considered indirect and/or mixed-treatment comparisons, CDR did not. In some cases, CDR and/or NICE excluded trials from review if the drug and/or the comparator were not administered according to the relevant marketing authorization. Conclusions: In the listing recommendations reviewed, considerable variability exists in the clinical evidence considered by PBAC, CDR, and NICE for drug-listing recommendations. Differences in evidence resulted from differences in the consideration of indirect and mixed-treatment comparison data and differences in medical practice in each jurisdiction.
Language	English
Publishing date	2013-01-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520698-9
ISSN	1178-6981
ISSN	1178-6981
DOI	10.2147/CEOR.S39624
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Article ; Online: Serial analysis of gene expression (SAGE) in normal human trabecular meshwork.

Liu, Yutao / Munro, Drew / Layfield, David / Dellinger, Andrew / Walter, Jeffrey / Peterson, Katherine / Rickman, Catherine Bowes / Allingham, R Rand / Hauser, Michael A

Molecular vision

2011 Volume 17, Page(s) 885–893

Abstract: Purpose: To identify the genes expressed in normal human trabecular meshwork tissue, a tissue critical to the pathogenesis of glaucoma.: Methods: Total RNA was extracted from human trabecular meshwork (HTM) harvested from 3 different donors. ... ...

Abstract	Purpose: To identify the genes expressed in normal human trabecular meshwork tissue, a tissue critical to the pathogenesis of glaucoma. Methods: Total RNA was extracted from human trabecular meshwork (HTM) harvested from 3 different donors. Extracted RNA was used to synthesize individual SAGE (serial analysis of gene expression) libraries using the I-SAGE Long kit from Invitrogen. Libraries were analyzed using SAGE 2000 software to extract the 17 base pair sequence tags. The extracted sequence tags were mapped to the genome using SAGE Genie map. Results: A total of 298,834 SAGE tags were identified from all HTM libraries (96,842, 88,126, and 113,866 tags, respectively). Collectively, there were 107,325 unique tags. There were 10,329 unique tags with a minimum of 2 counts from a single library. These tags were mapped to known unique Unigene clusters. Approximately 29% of the tags (orphan tags) did not map to a known Unigene cluster. Thirteen percent of the tags mapped to at least 2 Unigene clusters. Sequence tags from many glaucoma-related genes, including myocilin, optineurin, and WD repeat domain 36, were identified. Conclusions: This is the first time SAGE analysis has been used to characterize the gene expression profile in normal HTM. SAGE analysis provides an unbiased sampling of gene expression of the target tissue. These data will provide new and valuable information to improve understanding of the biology of human aqueous outflow.
MeSH term(s)	Adult ; Aged ; Cell Cycle Proteins ; Chromosome Mapping/methods ; Cluster Analysis ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Expressed Sequence Tags/chemistry ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Female ; Gene Expression ; Gene Expression Profiling/methods ; Gene Library ; Genome ; Glaucoma/genetics ; Glaucoma/metabolism ; Glaucoma/pathology ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Humans ; Male ; Membrane Transport Proteins ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Trabecular Meshwork/cytology ; Trabecular Meshwork/metabolism ; Transcription Factor TFIIIA/genetics ; Transcription Factor TFIIIA/metabolism
Chemical Substances	Cell Cycle Proteins ; Cytoskeletal Proteins ; Eye Proteins ; Glycoproteins ; Membrane Transport Proteins ; OPTN protein, human ; RNA, Messenger ; Transcription Factor TFIIIA ; WDR36 protein, human ; trabecular meshwork-induced glucocorticoid response protein
Language	English
Publishing date	2011-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2017540-1
ISSN	1090-0535 ; 1090-0535
ISSN (online)	1090-0535
ISSN	1090-0535
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