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  1. Article ; Online: Structural determination and modeling of ciliary microtubules.

    Walton, Travis / Doran, Matthew H / Brown, Alan

    Acta crystallographica. Section D, Structural biology

    2024  Volume 80, Issue Pt 4, Page(s) 220–231

    Abstract: The axoneme, a microtubule-based array at the center of every cilium, has been the subject of structural investigations for decades, but only recent advances in cryo-EM and cryo-ET have allowed a molecular-level interpretation of the entire complex to be ...

    Abstract The axoneme, a microtubule-based array at the center of every cilium, has been the subject of structural investigations for decades, but only recent advances in cryo-EM and cryo-ET have allowed a molecular-level interpretation of the entire complex to be achieved. The unique properties of the nine doublet microtubules and central pair of singlet microtubules that form the axoneme, including the highly decorated tubulin lattice and the docking of massive axonemal complexes, provide opportunities and challenges for sample preparation, 3D reconstruction and atomic modeling. Here, the approaches used for cryo-EM and cryo-ET of axonemes are reviewed, while highlighting the unique opportunities provided by the latest generation of AI-guided tools that are transforming structural biology.
    MeSH term(s) Microtubules/chemistry ; Axoneme ; Cilia/chemistry ; Molecular Biology
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968623-4
    ISSN 2059-7983 ; 0907-4449
    ISSN (online) 2059-7983
    ISSN 0907-4449
    DOI 10.1107/S2059798324001815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: On Implant Prosthodontics: One Narrative, Twelve Voices - 11.

    Walton, Terry

    The International journal of prosthodontics

    2018  Volume 31 Suppl, Page(s) s70–s76

    Abstract: No abstract available. ...

    Abstract No abstract available.
    MeSH term(s) Dental Implantation, Endosseous/trends ; Forecasting ; Humans ; Prosthodontics/trends
    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645046-5
    ISSN 1942-4426 ; 0893-2174
    ISSN (online) 1942-4426
    ISSN 0893-2174
    DOI 10.11607/ijp.2018.suppl.TW
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2430: Show issues Location:
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  3. Article: My road to discovering lymphoedema and beyond.

    Walton, Trevor

    British journal of community nursing

    2018  Volume 23, Issue Sup4, Page(s) S32–S33

    MeSH term(s) Aged ; Compression Bandages ; England ; Humans ; Lower Extremity ; Lymph Node Excision ; Lymphedema/therapy ; Male ; Patient Education as Topic ; Postoperative Complications/therapy ; Prostatic Neoplasms/surgery ; Self Care
    Language English
    Publishing date 2018-07-26
    Publishing country England
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2146386-4
    ISSN 1462-4753
    ISSN 1462-4753
    DOI 10.12968/bjcn.2018.23.Sup4.S32
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    Zs.MO 529: Show issues

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  4. Book: Treating anxiety disorders

    Roth, Walton T.

    (Jossey-Bass library of current clinical technique)

    1997  

    Author's details Walton T. Roth, ed
    Series title Jossey-Bass library of current clinical technique
    Keywords Anxiety Disorders / therapy
    Language English
    Size XXVIII, 302 S. : graph. Darst.
    Edition 1. ed.
    Publisher Jossey-Bass
    Publishing place San Francisco
    Publishing country United States
    Document type Book
    HBZ-ID HT010847396
    ISBN 0-7879-0316-7 ; 978-0-7879-0316-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 4971 order for loan Magazin

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  5. Article ; Online: Quality Improvement Capacity in a Department of Family Medicine: A Mixed-Methods Study.

    Oshman, Lauren / Walton, Taylor / Schultz, Paul / Barry, Robin / Speer, Linda

    PRiMER (Leawood, Kan.)

    2023  Volume 7, Page(s) 17

    Abstract: Background and objectives: Quality improvement capacity is defined as ongoing commitment to sustained quality improvement (QI) and requires knowledge of QI methods and commitment to QI activities from practice leadership and staff. The aim of this ... ...

    Abstract Background and objectives: Quality improvement capacity is defined as ongoing commitment to sustained quality improvement (QI) and requires knowledge of QI methods and commitment to QI activities from practice leadership and staff. The aim of this project was to identify the major facilitators and barriers to developing quality improvement capacity in a teaching practice of a department of family medicine.
    Methods: We conducted an exploratory, sequential, mixed-methods study, inviting key informants to participate in qualitative interviews and then conducting a survey of faculty, resident physicians, and staff at a community residency teaching practice affiliated with an academic medical center in the Midwest United States.
    Results: Among 12 qualitative key informant interviewees, facilitators of QI capacity included a strong motivation to provide high-quality care and a desire to leverage team-based care in QI interventions. Barriers included competing clinical and educational priorities, lack of faculty expertise in quality and scholarship, and lack of infrastructure to turn QI into scholarship. The survey response rate was 75% (48 of 64 total team members). The most common motivation for participation in QI work was "making a difference" (41, 85%), while the biggest barriers were prioritization of patient care (25, 53%), and teaching (19, 40%).
    Conclusion: This mixed-methods study identified key barriers and facilitators to QI capacity, of which addressing competing priorities, improving QI training, and creating infrastructure for scholarship may improve QI capacity.
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 2575-7873
    ISSN (online) 2575-7873
    DOI 10.22454/PRiMER.2023.889614
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  6. Article ; Online: Multimorbidity in rheumatoid arthritis: common mechanistic links and impact and challenges in routine clinical practice.

    Surandran, Sanggeeta / Ahmed, Saad / Walton, Tom / Nikiphorou, Elena / Dey, Mrinalini

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue SI3, Page(s) SI260–SI270

    Abstract: Early identification and management of multimorbidity in patients with rheumatic and musculoskeletal diseases (RMDs), such as RA, is an integral, but often neglected, aspect of care. The prevalence and incidence of conditions such as osteoporosis, ... ...

    Abstract Early identification and management of multimorbidity in patients with rheumatic and musculoskeletal diseases (RMDs), such as RA, is an integral, but often neglected, aspect of care. The prevalence and incidence of conditions such as osteoporosis, cardiovascular disease, pulmonary disease and malignancies, often co-existing with RA, continues to have significant implications for the management of this patient group. Multimorbidity in RMDs can be associated with inflammatory disease activity and target organ damage. Lifestyle factors, such as smoking and inactivity, further contribute to the burden of disease. Inflammation is the underlying factor, not just in RA but also many comorbidities. The current framework of a treat-to-target approach focuses on achieving early remission and inflammatory activity suppression. We describe how the comorbidity burden in people with RMDs impacts on disease outcome and treatment response. The importance of addressing comorbidity at an early stage and adopting a patient centred approach is critical in modern practice.
    MeSH term(s) Humans ; Multimorbidity ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/complications ; Comorbidity ; Osteoporosis/epidemiology ; Osteoporosis/therapy ; Osteoporosis/complications ; Musculoskeletal Diseases/epidemiology ; Musculoskeletal Diseases/therapy
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead489
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  7. Book: Core concepts in health

    Insel, Paul M. / Roth, Walton T.

    2007  

    Author's details Paul M. Insel ; Walton T. Roth
    Keywords Health ; Hygiene
    Subject code 13
    Language English
    Edition brief 10. ed. update
    Publisher McGraw-Hill
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT015313536
    ISBN 978-0-07-352964-6 ; 0-07-352964-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 A 6160 order for loan Magazin

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  8. Article ; Online: Firearm Retailers and Suicide: Results from a Survey Assessing Willingness to Engage in Prevention Efforts.

    Walton, Thomas / Stuber, Jennifer

    Suicide & life-threatening behavior

    2019  Volume 50, Issue 1, Page(s) 83–94

    Abstract: Objective: Firearms are a highly lethal and commonly used means of suicide. Firearm retailers may be an important group of community members to train as they guide sales and have conversations about firearm-related laws and safety issues with customers. ...

    Abstract Objective: Firearms are a highly lethal and commonly used means of suicide. Firearm retailers may be an important group of community members to train as they guide sales and have conversations about firearm-related laws and safety issues with customers. This study presents findings from the largest survey to date of independently owned firearm retailers (n = 178) in Washington State with the goal of ascertaining the extent of willingness to engage in suicide prevention efforts and factors that may underlie willingness.
    Methods: Descriptive analyses and logistic regressions assess factors related to self-reported willingness to engage in suicide prevention activities guided by a well-tested theoretical model.
    Results: Respondents are unaware that suicide is the leading type of firearm fatality and have high levels of exposure to suicide in their personal and professional lives. The majority endorse a willingness to learn and engage in suicide prevention activities. Knowledge about warning signs of suicide and beliefs about the preventability of suicide are predictive of a willingness to engage in prevention efforts. Reluctance to discuss personal issues with customers is negatively associated with willingness to engage in prevention efforts.
    Conclusions: Suggestions for how to improve outreach to firearm retailers to enhance suicide prevention efforts are discussed.
    MeSH term(s) Commerce ; Communication ; Female ; Firearms ; Humans ; Male ; Ownership ; Suicide/prevention & control ; Surveys and Questionnaires
    Language English
    Publishing date 2019-07-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 750058-0
    ISSN 1943-278X ; 0047-4592 ; 0363-0234
    ISSN (online) 1943-278X
    ISSN 0047-4592 ; 0363-0234
    DOI 10.1111/sltb.12574
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  9. Article ; Online: Dislocation of the hip after normal sonographic screening examination: a case report and literature review.

    Walton, T J / Chatterton, B D / Dover, C / Kiely, N T

    Annals of the Royal College of Surgeons of England

    2022  Volume 104, Issue 6, Page(s) e187–e189

    Abstract: We report the case of a five-month-old girl presenting with a subluxed left hip following normal neonatal clinical examination and serial ultrasound screening. Her only risk factor for developmental dysplasia of the hip (DDH) was breech presentation. She ...

    Abstract We report the case of a five-month-old girl presenting with a subluxed left hip following normal neonatal clinical examination and serial ultrasound screening. Her only risk factor for developmental dysplasia of the hip (DDH) was breech presentation. She underwent closed reduction with successful concentric reduction. This case demonstrates that hip subluxation can occur after normal ultrasound screening, and has important clinical and medicolegal implications. Consideration should be given to further follow-up in children with overt risk factors for DDH, even after normal ultrasound examination.
    MeSH term(s) Breech Presentation ; Child ; Female ; Hip ; Hip Dislocation, Congenital/diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Joint Dislocations ; Neonatal Screening ; Pregnancy ; Risk Factors ; Ultrasonography
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2021.0280
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  10. Article ; Online: Structure of a microtubule-bound axonemal dynein.

    Walton, Travis / Wu, Hao / Brown, Alan

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 477

    Abstract: Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins ... ...

    Abstract Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localization and function are poorly understood. Here, we report a single-particle cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isolated from cilia. The slanted conformation of the axonemal dynein causes interaction of its motor domains with the neighboring dynein complex. Our structure shows how a heterotrimeric docking complex specifically localizes the linear array of axonemal dyneins to the doublet microtubule by directly interacting with the heavy chains. Our structural analysis establishes the arrangement of conserved heavy, intermediate and light chain subunits, and provides a framework to understand the roles of individual subunits and the interactions between dyneins during ciliary waveform generation.
    MeSH term(s) Axonemal Dyneins/chemistry ; Axonemal Dyneins/metabolism ; Cell Movement ; Chlamydomonas reinhardtii ; Cilia/metabolism ; Cryoelectron Microscopy ; Cytoskeleton/metabolism ; Flagella/chemistry ; Flagella/metabolism ; Microtubules/chemistry ; Microtubules/metabolism ; Molecular Docking Simulation
    Chemical Substances Axonemal Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-20735-7
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