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Book ; Online: Nonparametric Stochastic Analysis of Dynamic Frequency in Power Systems

Wan, Can / Ren, Yupeng / Ju, Ping

A Generalized Ito Process Model

2023

Abstract: The large-scale integration of intermittent renewable energy has brought serious challenges to the frequency security of power systems. In this paper, a novel nonparametric stochastic analysis method of system dynamic frequency is proposed to accurately ... ...

Abstract	The large-scale integration of intermittent renewable energy has brought serious challenges to the frequency security of power systems. In this paper, a novel nonparametric stochastic analysis method of system dynamic frequency is proposed to accurately analyze the impact of renewable energy uncertainty on power system frequency security, independent of any parametric distribution assumption. The nonparametric uncertainty of renewable generation disturbance is quantified based on probabilistic forecasting. Then, a novel generalized Ito process is proposed as a linear combination of several Gaussian Ito processes, which can represent any probability distribution. Furthermore, a stochastic model of power system frequency response is constructed by considering virtual synchronization control of wind power. On basis of generalized Ito process, the complex nonlinear stochastic differential equation is transformed into a linear combination of several linear stochastic differential equations to approximate nonparametric probability distribution of the system dynamic frequency. Finally, the validity of the proposed method is verified by the single-machine system and IEEE 39-Bus system.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	620
Publishing date	2023-12-18
Publishing country	us
Document type	Book ; Online
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Article ; Online: Polarization-independent plasmon-induced transparency and slow light effects in a fully continuous symmetric cross-shaped monolayer graphene structure.

Wan, Can / Xiong, Cuixiu / Tan, Meng / Wei, Chengya / Wang, Jie / Zhang, Saiwen

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 25, Page(s) 17034–17042

Abstract: A fully continuous geometric center symmetric cross-shaped graphene structure is proposed. Each cross-shaped graphene unit cell is composed of a central graphene region and four completely symmetric graphene chips, where each graphene chip acts as both ... ...

Abstract	A fully continuous geometric center symmetric cross-shaped graphene structure is proposed. Each cross-shaped graphene unit cell is composed of a central graphene region and four completely symmetric graphene chips, where each graphene chip acts as both bright and dark modes simultaneously, while the central graphene region always acts as the bright mode. Through destructive interference, the structure can realize the single plasmon-induced transparency (PIT) phenomenon, where the optical responses are independent of the polarization direction of the linearly polarized light due to the symmetry of the structure. Combining numerical simulations with coupled mode theory (CMT) calculations, the modulation of the Fermi energy of graphene to the optical spectra is investigated. The results show that the spectra are blue shifted as the Fermi energy increases, and the absorption of the two absorption peaks is basically equal (48.7%) when the Fermi energy increases to 0.667 eV. Theoretical calculations show that the slow light performance of the designed structure enhances with the increase of Fermi energy, where the maximum group index is high up to 424.73. Furthermore, it is worth noting that the electrode can be made very small due to its fully continuous structure. This work provides guidance in terms of terahertz modulators, tunable absorbers, and slow light devices.
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01370g
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Article ; Online: Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress.

Wan, Can / Liu, Xiao-Qi / Chen, Mei / Ma, Hui-Han / Wu, Guang-Liang / Qiao, Li-Jun / Cai, Ye-Feng / Zhang, Shi-Jie

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 34

Abstract: Background: The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer's disease (AD). Thus, improving BMEC function may be beneficial for AD treatment. ...

Abstract	Background: The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer's disease (AD). Thus, improving BMEC function may be beneficial for AD treatment. Tanshinone IIA (Tan IIA) has been proved to ameliorate the cognitive dysfunction of AD. Herein, we explored how Tan IIA affected the function of BMECs in AD. Methods: Aβ Results: Molecular docking and qPCR results showed that Tan IIA mainly acted on Sirtuin1 (SIRT1) in Sirtuins family. The inhibitor of SIRT1 (EX527) was employed to further substantiate that Tan IIA could attenuate SIRT1-mediated endoplasmic reticulum stress (ER stress) in BMECs. Behavioral tests suggested that Tan IIA could improve the cognitive deficits in APP/PS1 mice. Tan IIA administration increased SIRT1 expression and alleviated ER stress in APP/PS1 mice. In addition, LRP1 expression was increased and RAGE expression was decreased after Tan IIA administration in both animals and cells. Conclusion: Tan IIA could promote Aβ transportation by alleviating SIRT1-mediated ER stress in BMECs, which ameliorated cognitive deficits in APP/PS1 mice.
MeSH term(s)	Mice ; Animals ; Endothelial Cells/metabolism ; Sirtuin 1/metabolism ; Molecular Docking Simulation ; Endoplasmic Reticulum Stress ; Alzheimer Disease/drug therapy ; Disease Models, Animal
Chemical Substances	Sirtuin 1 (EC 3.5.1.-) ; tanshinone (03UUH3J385) ; Sirt1 protein, mouse (EC 3.5.1.-)
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03889-y
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Article ; Online: Taohong siwu decoction ameliorates cognitive dysfunction through SIRT6/ER stress pathway in Alzheimer's disease.

Tan, Hong-Yu / Wan, Can / Wu, Guang-Liang / Qiao, Li-Jun / Cai, Ye-Feng / Wang, Qi / Zhang, Shi-Jie

Journal of ethnopharmacology

2023 Volume 314, Page(s) 116580

Abstract: Ethnopharmacological relevance: A growing number of people suffer from Alzheimer's disease (AD), but there is currently no effective treatment yet. Taohong Siwu Decoction (TSD) has been proved to take strong neuropharmacological activity on dementia, ... ...

Abstract	Ethnopharmacological relevance: A growing number of people suffer from Alzheimer's disease (AD), but there is currently no effective treatment yet. Taohong Siwu Decoction (TSD) has been proved to take strong neuropharmacological activity on dementia, but the effect and mechanism of TSD against AD are still elusive. Aim of study: To investigate whether TSD could be effective in ameliorating cognitive deficits through SIRT6/ER stress pathway. Materials and methods: Herein, the APP/PS1 mice, an AD model, and HT-22 cell lines were utilized. Different dosages of TSD (4.25, 8.50 and 17.00 g/kg/d) were administered to the mice for 10 weeks by gavage. Following the behavioral tests, oxidative stress levels were measured using malondialdehyde (MDA) and superoxide dismutase (SOD) kits. Nissl staining and Western blot analyses were used to detect the neuronal function. Then, immunofluorescence and Western blot analysis were applied to evaluate silent information regulator 6 (SIRT6) and ER Stress related protein levels in APP/PS1 mice and HT-22 cells. Results: Behavioral tests revealed that APP/PS1 mice administered with TSD orally took more time in the target quadrant, crossed more times in the target quadrant, had a higher recognition coefficient, and spent more time in the central region. In addition, TSD could ameliorate oxidative stress and inhibit neuronal apoptosis in APP/PS1 mice. Furthermore, TSD could up-regulate the SIRT6 protein expression and inhibit ER sensing proteins expressions, such as p-PERK and ATF6, in APP/PS1 mice and Aβ Conclusion: According to the abovementioned findings, TSD could alleviate cognitive dysfunction in AD by modulating the SIRT6/ER stress pathway.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Cognitive Dysfunction/drug therapy ; Sirtuins ; Mice, Transgenic ; Disease Models, Animal
Chemical Substances	Taohong Siwu decoction II ; Drugs, Chinese Herbal ; Sirtuins (EC 3.5.1.-) ; Sirt6 protein, mouse (EC 2.4.2.31)
Language	English
Publishing date	2023-05-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116580
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Article ; Online: Hydroxysafflor Yellow A Exerts Neuroprotective Effect by Reducing Aβ Toxicity Through Inhibiting Endoplasmic Reticulum Stress in Oxygen-Glucose Deprivation/Reperfusion Cell Model.

Ma, Hui-Han / Wen, Jun-Ru / Fang, Hao / Su, Shan / Wan, Can / Zhang, Chao / Lu, Fang-Mei / Fan, Ling-Ling / Wu, Guang-Liang / Zhou, Zi-Yi / Qiao, Li-Jun / Zhang, Shi-Jie / Cai, Ye-Feng

Rejuvenation research

2023 Volume 26, Issue 2, Page(s) 57–67

Abstract: Ischemia stroke is thought to be one of the vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism ... ...

Abstract	Ischemia stroke is thought to be one of the vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism remains unclear. In this study, SH-SY5Y cell model treated with oxygen-glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from cell counting kit-8 (CCK-8) showed that 10 μM HSYA restored the cell viability after OGD 2 hours/R 24 hours. HSYA reduced the levels of malondialdehyde and reactive oxygen species, while improved the levels of superoxide dismutase and glutathione peroxidase. Furthermore, apoptosis was inhibited, and the expression of brain-derived neurotrophic factor was improved after HSYA treatment. In addition, the expression levels of amyloid-β peptides (Aβ) and BACE1 were decreased by HSYA, as well as the expression levels of binding immunoglobulin heavy chain protein, PKR-like endoplasmic reticulum (ER) kinase pathway, and activating transcription factor 6 pathway, whereas the expression level of protein disulfide isomerase was increased. Based on these results, HSYA might reduce Aβ toxicity after OGD/R by interfering with apoptosis, oxidation, and neurotrophic factors, as well as relieving ER stress.
MeSH term(s)	Humans ; Oxygen/metabolism ; Neuroprotective Agents/pharmacology ; Amyloid Precursor Protein Secretases/pharmacology ; Glucose/metabolism ; Aspartic Acid Endopeptidases/pharmacology ; Neuroblastoma ; Quinones/pharmacology ; Apoptosis ; Chalcone/pharmacology ; Reperfusion Injury/metabolism ; Stroke ; Reperfusion ; Endoplasmic Reticulum Stress
Chemical Substances	Oxygen (S88TT14065) ; Neuroprotective Agents ; hydroxysafflor yellow A (146087-19-6) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Glucose (IY9XDZ35W2) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Quinones ; Chalcone (5S5A2Q39HX)
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2150779-X
ISSN	1557-8577 ; 1549-1684
ISSN (online)	1557-8577
ISSN	1549-1684
DOI	10.1089/rej.2022.0054
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Book ; Online: Convex Relaxation of Combined Heat and Power Dispatch

Jiang, Yibao / Wan, Can / Botterud, Audun / Song, Yonghua / Shahidehpour, Mohammad

2020

Abstract: Combined heat and power dispatch promotes interactions and synergies between electric power systems and district heating systems. However, nonlinear and nonconvex heating flow imposes significant challenges on finding qualified solutions efficiently. ... ...

Abstract	Combined heat and power dispatch promotes interactions and synergies between electric power systems and district heating systems. However, nonlinear and nonconvex heating flow imposes significant challenges on finding qualified solutions efficiently. Most existing methods rely on constant flow assumptions to derive a linear heating flow model, sacrificing optimality for computational simplicity. This paper proposes a novel convex combined heat and power dispatch model based on model simplification and constraint relaxation, which improves solution quality and avoids assumptions on operating regimes of district heating systems. To alleviate mathematical complexity introduced by the commonly used node method, a simplified thermal dynamic model is proposed to capture temperature changes in networked pipelines. Conic and polyhedral relaxations are then applied to convexify the original problems with bilinear and quadratic equality constraints. Furthermore, an adaptive solution algorithm is proposed to successively reduce relaxation gaps based on dynamic bivariate partitioning, improving solution optimality with desirable computational efficiency. The proposed method is verified on a 33-bus electric power system integrated with a 30-node district heating system and compared to nonlinear programming solvers and constant-flow-based solutions.
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
Subject code	621
Publishing date	2020-06-06
Publishing country	us
Document type	Book ; Online
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Article ; Online: Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model.

Ma, Hui-Han / Wan, Can / Zhang, Lu-Di / Zhang, Rong-Rong / Peng, Dong / Qiao, Li-Jun / Zhang, Shi-Jie / Cai, Ye-Feng / Huang, Hong-Qiang

Metabolic brain disease

2022 Volume 37, Issue 4, Page(s) 989–1001

Abstract: Alzheimer's disease (AD) is a most common neurodegenerative disease. Sodium Tanshinone IIA Sulfonate (STS) has been reported to ameliorate AD pathology. However, the underlying mechanism is still unclear. In this study, AD transgenic mouse model (APP/PS1) ...

Abstract	Alzheimer's disease (AD) is a most common neurodegenerative disease. Sodium Tanshinone IIA Sulfonate (STS) has been reported to ameliorate AD pathology. However, the underlying mechanism is still unclear. In this study, AD transgenic mouse model (APP/PS1) was used to explore the potential mechanism of STS against AD. Morris water maze and Y-maze tests showed that administration of STS improved learning and memory abilities of APP/PS1 mice. STS reduced the levels of reactive oxygen species and malondialdehyde, while improved the activity of superoxide dismutase in both hippocampus and cortex in APP/PS1 mice. STS inhibited the activity of acetylcholinesterase, while improved the activity of choline acetyltransferase in APP/PS1 mice. In addition, STS elevated the protein expressions of neurotrophic factors and synapse-related proteins in both the hippocampus and cortex in APP/PS1 mice. At last, STS improved the protein expressions of glucose transporter 1 (GLUT1) and low-density lipoprotein receptor-related protein 1 (LRP1). These results indicated that the potential mechanism of STS on AD might be related to Aβ transportation function via GLUT1/LRP1 pathway. HIGHLIGHTS: STS improves cognitive impairment of APP/PS1 mice. STS ameliorates the oxidative stress damage and improves the cholinergic system. STS protects against neuronal dysfunction and enhances the synaptic plasticity. STS mediates the Aβ transportation of BMECs.
MeSH term(s)	Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Animals ; Cognitive Dysfunction/drug therapy ; Disease Models, Animal ; Glucose Transporter Type 1 ; Mice ; Mice, Transgenic ; Neurodegenerative Diseases ; Phenanthrenes
Chemical Substances	Glucose Transporter Type 1 ; Phenanthrenes ; tanshinone II A sodium sulfonate (69659-80-9) ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632824-6
ISSN	1573-7365 ; 0885-7490
ISSN (online)	1573-7365
ISSN	0885-7490
DOI	10.1007/s11011-022-00911-y
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Article ; Online: Predictive value on diffusion weighted imaging scores for basilar artery occlusion after endovascular treatment.

Wan, Can / Wu, Guangliang / Jin, Xing / Liao, Shaojun / Zhang, Foming / Hu, Mingzhe / Meng, Miaomiao / Guo, Yixin / You, Jinsong

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2020 Volume 27, Issue 1, Page(s) 81–87

Abstract: Purpose: To assess the predictive value of three scoring systems based on diffusion weighted imaging in basilar artery occlusion patients after endovascular treatment.: Methods: We analyzed clinical and radiological data of patients with basilar ... ...

Abstract	Purpose: To assess the predictive value of three scoring systems based on diffusion weighted imaging in basilar artery occlusion patients after endovascular treatment. Methods: We analyzed clinical and radiological data of patients with basilar artery occlusion from January 2010 to June 2019, with modified Rankin Scale of 0-2 and 3-6 defined as favorable outcome and unfavorable outcome at three months. Diffusion weighted imaging posterior circulation ASPECTS Score (DWI pc-ASPECT Score), Renard diffusion weighted imaging Score, and diffusion weighted imaging Brainstem Score were used to evaluate the early ischemic changes. Results: There were a total of 88 basilar artery occlusion patients enrolled in the study after endovascular treatment, with 33 of them getting a favorable outcome. According to the analysis, the time from onset to puncture within 12 h (odds ratio: 4.34; 95% confidence interval: 1.55-12.16; Conclusions: Renard diffusion weighted imaging score may be an independent predictor of functional outcome in basilar artery occlusion patients after endovascular treatment.
MeSH term(s)	Arterial Occlusive Diseases ; Basilar Artery/diagnostic imaging ; Humans ; Thrombectomy ; Treatment Outcome ; Vertebrobasilar Insufficiency/diagnostic imaging
Language	English
Publishing date	2020-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/1591019920940514
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Book ; Online: Efficient Robust Dispatch of Combined Heat and Power Systems

Jiang, Yibao / Wan, Can / Botterud, Audun / Song, Yonghua / Dong, Zhao Yang

2020

Abstract: Combined heat and power systems facilitate efficient interactions between individual energy sectors for higher renewable energy accommodation. However, the feasibility of operational strategies is difficult to guarantee due to the presence of substantial ...

Abstract	Combined heat and power systems facilitate efficient interactions between individual energy sectors for higher renewable energy accommodation. However, the feasibility of operational strategies is difficult to guarantee due to the presence of substantial uncertainties pertinent to renewable energy and multi-energy loads. This paper proposes a novel efficient robust dispatch model of combined heat and power systems based on extensions of disturbance invariant sets. The approach has high computational efficiency and provides flexible and robust strategies with an adjustable level of conservativeness. In particular, the proposed robust dispatch method obtains operational strategies by solving a nominal uncertainty-free dispatch problem, whose complexity is identical to a deterministic problem. The robustness against uncertainties is enhanced by endowing the nominal dispatch model with properly tightened constraints considering time-variant uncertainty sets. Towards this end, a novel direct constraint tightening algorithm is developed based on the dual norm to calculate multi-period tightened constraints efficiently without linear programming iterations. Furthermore, the budget uncertainty set is newly combined with constraint tightening to flexibly adjust the conservativeness level of robust solutions. The effectiveness of the proposed robust method is demonstrated in simulation studies of a test system in terms of computational efficiency, decision robustness and cost optimality. Comment: 8 pages, 12 figures
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
Subject code	670
Publishing date	2020-04-08
Publishing country	us
Document type	Book ; Online
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Article ; Online: The minor wall-networks between monolignols and interlinked-phenolics predominantly affect biomass enzymatic digestibility in Miscanthus.

Li, Zhengru / Zhao, Chunqiao / Zha, Yi / Wan, Can / Si, Shengli / Liu, Fei / Zhang, Rui / Li, Fengcheng / Yu, Bin / Yi, Zili / Xu, Ning / Peng, Liangcai / Li, Qing

PloS one

2014 Volume 9, Issue 8, Page(s) e105115

Abstract: Plant lignin is one of the major wall components that greatly contribute to biomass recalcitrance for biofuel production. In this study, total 79 representative Miscanthus germplasms were determined with wide biomass digestibility and diverse monolignol ... ...

Abstract	Plant lignin is one of the major wall components that greatly contribute to biomass recalcitrance for biofuel production. In this study, total 79 representative Miscanthus germplasms were determined with wide biomass digestibility and diverse monolignol composition. Integrative analyses indicated that three major monolignols (S, G, H) and S/G ratio could account for lignin negative influence on biomass digestibility upon NaOH and H2SO4 pretreatments. Notably, the biomass enzymatic digestions were predominately affected by the non-KOH-extractable lignin and interlinked-phenolics, other than the KOH-extractable ones that cover 80% of total lignin. Furthermore, a positive correlation was found between the monolignols and phenolics at p<0.05 level in the non-KOH-extractable only, suggesting their tight association to form the minor wall-networks against cellulases accessibility. The results indicated that the non-KOH-extractable lignin-complex should be the target either for cost-effective biomass pretreatments or for relatively simply genetic modification of plant cell walls in Miscanthus.
MeSH term(s)	Biomass ; Cellulases/metabolism ; Lignin/metabolism ; Phenols/metabolism ; Poaceae/genetics ; Poaceae/metabolism
Chemical Substances	Phenols ; Lignin (9005-53-2) ; Cellulases (EC 3.2.1.-)
Language	English
Publishing date	2014-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0105115
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