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  1. Article ; Online: Chemical derivatization strategy for mass spectrometry-based lipidomics.

    Xia, Fangbo / Wan, Jian-Bo

    Mass spectrometry reviews

    2021  Volume 42, Issue 1, Page(s) 432–452

    Abstract: Lipids, serving as the structural components of cellular membranes, energy storage, and signaling molecules, play the essential and multiple roles in biological functions of mammals. Mass spectrometry (MS) is widely accepted as the first choice for lipid ...

    Abstract Lipids, serving as the structural components of cellular membranes, energy storage, and signaling molecules, play the essential and multiple roles in biological functions of mammals. Mass spectrometry (MS) is widely accepted as the first choice for lipid analysis, offering good performance in sensitivity, accuracy, and structural characterization. However, the untargeted qualitative profiling and absolute quantitation of lipids are still challenged by great structural diversity and high structural similarity. In recent decade, chemical derivatization mainly targeting carboxyl group and carbon-carbon double bond of lipids have been developed for lipidomic analysis with diverse advantages: (i) offering more characteristic structural information; (ii) improving the analytical performance, including chromatographic separation and MS sensitivity; (iii) providing one-to-one chemical isotope labeling internal standards based on the isotope derivatization regent in quantitative analysis. Moreover, the chemical derivatization strategy has shown great potential in combination with ion mobility mass spectrometry and ambient mass spectrometry. Herein, we summarized the current states and advances in chemical derivatization-assisted MS techniques for lipidomic analysis, and their strengths and challenges are also given. In summary, the chemical derivatization-based lipidomic approach has become a promising and reliable technique for the analysis of lipidome in complex biological samples.
    MeSH term(s) Animals ; Lipidomics ; Mass Spectrometry/methods ; Ion Mobility Spectrometry ; Lipids/analysis ; Carbon ; Mammals
    Chemical Substances Lipids ; Carbon (7440-44-0)
    Language English
    Publishing date 2021-09-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491946-1
    ISSN 1098-2787 ; 0277-7037
    ISSN (online) 1098-2787
    ISSN 0277-7037
    DOI 10.1002/mas.21729
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  2. Article ; Online: Biopolymer Food Packaging Films Incorporated with Essential Oils.

    Tian, Bingren / Liu, Jiayue / Yang, Wanzhexi / Wan, Jian-Bo

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 3, Page(s) 1325–1347

    Abstract: Petroleum-based packaging materials are typically nonbiodegradable, which leads to significant adverse environmental and health issues. Therefore, developing novel efficient, biodegradable, and nontoxic food packaging film materials has attracted ... ...

    Abstract Petroleum-based packaging materials are typically nonbiodegradable, which leads to significant adverse environmental and health issues. Therefore, developing novel efficient, biodegradable, and nontoxic food packaging film materials has attracted increasing attention from researchers. Due to significant research and advanced technology, synthetic additives in packaging materials are progressively replaced with natural substances such as essential oils (EOs). EOs demonstrate favorable antioxidant and antibacterial properties, which would be an economical and effective alternative to synthetic additives. This review summarized the possible antioxidant and antimicrobial mechanisms of various EOs. We analyzed the properties and performance of food packaging films based on various biopolymers incorporated with EOs. The progress in intelligent packaging materials has been discussed as a prospect of food packaging materials. Finally, the current challenges regarding the practical application of EOs-containing biopolymer films in food packaging and areas of future research have been summarized.
    MeSH term(s) Food Packaging/methods ; Oils, Volatile ; Antioxidants/analysis ; Biopolymers ; Anti-Infective Agents
    Chemical Substances Oils, Volatile ; Antioxidants ; Biopolymers ; Anti-Infective Agents
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c07409
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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  3. Article: Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice.

    Zou, Jian / Yan, Chunyan / Wan, Jian-Bo

    Chinese medicine

    2022  Volume 17, Issue 1, Page(s) 17

    Abstract: Background: Red yeast rice (RYR), a nutraceutical with a profound cholesterol-lowering effect, was found to attenuate non-alcoholic fatty liver disease (NAFLD) in mice. Despite monacolin K in RYR being a specific inhibitor of hydroxymethylglutaryl- ... ...

    Abstract Background: Red yeast rice (RYR), a nutraceutical with a profound cholesterol-lowering effect, was found to attenuate non-alcoholic fatty liver disease (NAFLD) in mice. Despite monacolin K in RYR being a specific inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMCGR), the mechanisms underlying the protective effects of RYR against NAFLD are not fully elucidated.
    Methods: Using a mouse model of high-fat diet (HFD) feeding and a cellular model of HepG2 cells challenged by lipopolysaccharide (LPS) and palmitic acid (PA), the possible molecular mechanisms were exploited in the aspects of NF-κB/NLRP3 inflammasome and mTORC1-SREBPs signaling pathways by examining the relevant gene/protein expressions. Subsequently, the correlation between these two signals was also verified using cellular experiments.
    Results: RYR ameliorated lipid accumulation and hepatic inflammation in vivo and in vitro. RYR improved lipid metabolism through modulating mTORC1-SREBPs and their target genes related to triglyceride and cholesterol synthesis. Furthermore, RYR suppressed hepatic inflammation by inhibiting the NF-κB/NLRP3 inflammasome signaling. Interestingly, the treatment with RYR or MCC950, a specific NLRP3 inhibitor, resulted in the reduced lipid accumulation in HepG2 cells challenged by LPS plus PA, suggesting that the inhibitory effects of RYR on NLRP3 inflammasome-mediated hepatic inflammation may partially, in turn, contribute to the lipid-lowering effect of RYR.
    Conclusions: The modulation of NF-κB/NLRP3 inflammasome and lipid synthesis may contribute to the ameliorative effects of RYR against HFD-induced NAFLD.
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-022-00573-z
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  4. Article ; Online: Integrating diverse plant bioactive ingredients with cyclodextrins to fabricate functional films for food application: a critical review

    Tian, Bingren / Liu, Jiayue / Liu, Yumei / Wan, Jian-Bo

    Critical Reviews in Food Science and Nutrition. 2023 Oct. 3, v. 63, no. 25 p.7311-7340

    2023  

    Abstract: The popularity of plant bioactive ingredients has become increasingly apparent in the food industry. However, these plant bioactive ingredients have many deficiencies, including low water solubility, poor stability, and unacceptable odor. Cyclodextrins ( ... ...

    Abstract The popularity of plant bioactive ingredients has become increasingly apparent in the food industry. However, these plant bioactive ingredients have many deficiencies, including low water solubility, poor stability, and unacceptable odor. Cyclodextrins (CDs), as cyclic molecules, have been extensively studied as superb vehicles of plant bioactive ingredients. These CD inclusion compounds could be added into various film matrices to fabricate bioactive food packaging materials. Therefore, in the present review, we summarized the extraction methods of plant bioactive ingredients, the addition of these CD inclusion compounds into thin-film materials, and their applications in food packaging. Furthermore, the release model and mechanism of active film materials based on various plant bioactive ingredients with CDs were highlighted. Finally, the current challenges and new opportunities based on these film materials have been discussed.
    Keywords cyclodextrins ; food industry ; food science ; models ; nutrition ; odors ; water solubility ; Cyclodextrin ; film ; food application ; mechanism ; plant bioactive ingredients
    Language English
    Dates of publication 2023-1003
    Size p. 7311-7340.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2022.2045560
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    In stock of ZB MED Bonn / Germany

    Z 2732: Show issues

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  5. Article ; Online: Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice.

    Zou, Jian / Yang, Rujie / Feng, Ruibing / Liu, Jiayue / Wan, Jian-Bo

    Journal of pharmaceutical analysis

    2023  Volume 13, Issue 9, Page(s) 999–1012

    Abstract: Heavy alcohol consumption results in alcoholic liver disease (ALD) with inadequate therapeutic options. Here, we first report the potential beneficial effects of ginsenoside Rk2 (Rk2), a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng, ...

    Abstract Heavy alcohol consumption results in alcoholic liver disease (ALD) with inadequate therapeutic options. Here, we first report the potential beneficial effects of ginsenoside Rk2 (Rk2), a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng, against alcoholic liver injury in mice. Chronic-plus-single-binge ethanol feeding caused severe liver injury, as manifested by significantly elevated serum aminotransferase levels, hepatic histological changes, increased lipid accumulation, oxidative stress, and inflammation in the liver. These deleterious effects were alleviated by the treatment with Rk2 (5 and 30 mg/kg). Acting as an nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inhibitor, Rk2 ameliorates alcohol-induced liver inflammation by inhibiting NLRP3 inflammasome signaling in the liver. Meanwhile, the treatment with Rk2 alleviated the alcohol-induced intestinal barrier dysfunction via enhancing NLRP6 inflammasome in the intestine. Our findings indicate that Rk2 is a promising agent for the prevention and treatment of ALD and other NLPR3-driven diseases.
    Language English
    Publishing date 2023-05-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.05.005
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  6. Article ; Online: Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS.

    Yang, Ru-Jie / Zou, Jian / Liu, Jia-Yue / Dai, Jiang-Kun / Wan, Jian-Bo

    Journal of pharmaceutical analysis

    2023  Volume 13, Issue 10, Page(s) 1221–1231

    Abstract: Fatty acids (FAs), which were initially recognized as energy sources and essential building blocks of biomembranes, serve as the precursors of important signaling molecules. Tracing FA metabolism is essential to understanding the biochemical activity and ...

    Abstract Fatty acids (FAs), which were initially recognized as energy sources and essential building blocks of biomembranes, serve as the precursors of important signaling molecules. Tracing FA metabolism is essential to understanding the biochemical activity and role of FAs in physiological and pathological events. Inspired by the advances in click chemistry for protein enrichment, we herein established a click chemistry-based enrichment (CCBE) strategy for tracing the cellular metabolism of eicosapentaenoic acid (EPA, 20:5
    Language English
    Publishing date 2023-05-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.05.001
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  7. Article ; Online: Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in vivo and in vitro.

    Qiu, Ling / Feng, Ruibing / Wu, Qiu-Shuang / Wan, Jian-Bo / Zhang, Qing-Wen

    Journal of ethnopharmacology

    2023  Volume 317, Page(s) 116785

    Abstract: Ethnopharmacological relevance: Panax japonicus (T. Nees) C.A. Mey. (PJ) has been used as a tonic traditional Chinese medicine (TCM) for years. Based on its meridian tropism in liver, spleen, and lung, PJ was popularly used to enhance the function of ... ...

    Abstract Ethnopharmacological relevance: Panax japonicus (T. Nees) C.A. Mey. (PJ) has been used as a tonic traditional Chinese medicine (TCM) for years. Based on its meridian tropism in liver, spleen, and lung, PJ was popularly used to enhance the function of these organs. It is originally recorded with detoxicant effect on binge drink in Ben Cao Gang Mu Shi Yi, a persuasive Chinese materia medica. And binge dink has a close relationship with alcoholic liver disease (ALD). Hence, it's meaningful to investigate whether PJ exerts liver protection against binge drink toxicity.
    Aim of the study: This investigation was carried out not only to emphasize the right recognition of total saponins from PJ (SPJ), but also to study on its sober-up effectiveness and defensive mechanism against acute alcoholic liver injury in vivo and in vitro.
    Materials and methods: SPJ constituents were verified by HPLC-UV analysis. In vivo, acute alcoholic liver oxidative stress and hepatosteatosis were established by continuous ethanol gavage to C57BL/6 mice for 3 days. SPJ was pre-administered for 7 days to investigate its protective efficacy. Loss of righting reflex (LORR) assay was employed to assess anti-inebriation effect of SPJ. Transaminases levels and hematoxylin and eosin (H&E) staining were measured to indicate the alcoholic liver injury. Antioxidant enzymes were measured to evaluate the oxidative stress degree in liver. Measurement of hepatic lipid accumulation was based on Oil Red O staining. Levels of inflammatory cytokines were evaluated by enzyme-linked immunosorbent assay (ELISA). In vitro, HepG2 cells were treated with ethanol for 24 h, and SPJ was pre-administered for 2 h. 2,7-dichlorofluorescein diacetate (DCFH-DA) was used as a probe to indicate reactive oxygen species (ROS) generation. Nrf2 activation was verified by the favor of specific inhibitor, ML385. The nuclear translocation of Nrf2 was indicated with immunofluorescence analysis. Proteins expressions of related pathways were determined by Western blotting.
    Results: Oleanane-type saponins are the most abundant constituents of SPJ. In this acute model, SPJ released inebriation of mice in a dose dependent manner. It decreased levels of serum ALT and AST, and hepatic TG. Besides, SPJ inhibited CYP2E1 expression and reduced MDA level in liver, with upregulations of antioxidant enzymes GSH, SOD and CAT. p62-related Nrf2 pathway was activated by SPJ with downstream upregulations of GCLC and NQO1 in liver. AMPK-ACC/PPARα axis was upregulated by SPJ to alleviate hepatic lipidosis. Hepatic IL-6 and TNF-α levels were downregulated by SPJ, which indicated a regressive lipid peroxidation in liver. In HepG2 cells, SPJ reduced ethanol-exposed ROS generation. Activated p62-related Nrf2 pathway was verified to contribute to the alleviation of alcohol-induced oxidative stress in hepatic cells.
    Conclusion: This attenuation of hepatic oxidative stress and steatosis suggested the therapeutic value of SPJ for ALD.
    MeSH term(s) Mice ; Animals ; Antioxidants/pharmacology ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; PPAR alpha/metabolism ; AMP-Activated Protein Kinases/metabolism ; Panax ; Saponins/pharmacology ; Saponins/therapeutic use ; Saponins/metabolism ; Mice, Inbred C57BL ; Oxidative Stress ; Liver ; Fatty Liver/drug therapy ; Liver Diseases, Alcoholic/drug therapy ; Liver Diseases, Alcoholic/prevention & control ; Ethanol/pharmacology
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; NF-E2-Related Factor 2 ; PPAR alpha ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Saponins ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-06-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116785
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Integrating diverse plant bioactive ingredients with cyclodextrins to fabricate functional films for food application: a critical review.

    Tian, Bingren / Liu, Jiayue / Liu, Yumei / Wan, Jian-Bo

    Critical reviews in food science and nutrition

    2022  Volume 63, Issue 25, Page(s) 7311–7340

    Abstract: The popularity of plant bioactive ingredients has become increasingly apparent in the food industry. However, these plant bioactive ingredients have many deficiencies, including low water solubility, poor stability, and unacceptable odor. Cyclodextrins ( ... ...

    Abstract The popularity of plant bioactive ingredients has become increasingly apparent in the food industry. However, these plant bioactive ingredients have many deficiencies, including low water solubility, poor stability, and unacceptable odor. Cyclodextrins (CDs), as cyclic molecules, have been extensively studied as superb vehicles of plant bioactive ingredients. These CD inclusion compounds could be added into various film matrices to fabricate bioactive food packaging materials. Therefore, in the present review, we summarized the extraction methods of plant bioactive ingredients, the addition of these CD inclusion compounds into thin-film materials, and their applications in food packaging. Furthermore, the release model and mechanism of active film materials based on various plant bioactive ingredients with CDs were highlighted. Finally, the current challenges and new opportunities based on these film materials have been discussed.
    MeSH term(s) Cyclodextrins ; Food ; Food Packaging ; Plants ; Antioxidants
    Chemical Substances Cyclodextrins ; Antioxidants
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2022.2045560
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1459: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Natural and synthetic β-carboline as a privileged antifungal scaffolds.

    Dai, Jiang-Kun / Dan, Wen-Jia / Wan, Jian-Bo

    European journal of medicinal chemistry

    2021  Volume 229, Page(s) 114057

    Abstract: The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline scaffold has attracted extensive attention in the scientific community ... ...

    Abstract The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline scaffold has attracted extensive attention in the scientific community due to its potent and diverse biological activities with nine successfully marketed β-carboline-based drugs. In this review, we summarized the current states and advances in the antifungal activity of natural and synthetic β-carbolines. Additionally, the structure-activity relationships and their antifungal mechanisms targeting biofilm, cell wall, cell membrane, and fungal intracellular targets were also systematically discussed. In summary, β-carbolines have the great potential to develop new efficient scaffolds to combat fungal infections.
    MeSH term(s) Animals ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Biological Products/chemistry ; Biological Products/pharmacology ; Carbolines/chemical synthesis ; Carbolines/pharmacology ; Drug Discovery ; Female ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Mycoses/drug therapy ; Protein Binding ; Signal Transduction ; Structure-Activity Relationship
    Chemical Substances Antifungal Agents ; Biological Products ; Carbolines
    Language English
    Publishing date 2021-12-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2021.114057
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  10. Article ; Online: Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review.

    Tian, Bingren / Liu, Jiayue / Guo, Songlin / Li, Aiqin / Wan, Jian-Bo

    International journal of biological macromolecules

    2023  Volume 243, Page(s) 125161

    Abstract: The role of regenerative medicine in clinical therapies is becoming increasingly vital. Under specific conditions, mesenchymal stem cells (MSCs) are capable of differentiating into mesoblastema (i.e., adipocytes, chondrocytes, and osteocytes) and other ... ...

    Abstract The role of regenerative medicine in clinical therapies is becoming increasingly vital. Under specific conditions, mesenchymal stem cells (MSCs) are capable of differentiating into mesoblastema (i.e., adipocytes, chondrocytes, and osteocytes) and other embryonic lineages. Their application in regenerative medicine has attracted a great deal of interest among researchers. To maximize the potential applications of MSCs, materials science could provide natural extracellular matrices and provide an effective means to understand the various mechanisms of differentiation for the growth of MSCs. Pharmaceutical fields are represented among the research on biomaterials by macromolecule-based hydrogel nanoarchitectonics. Various biomaterials have been used to prepare hydrogels with their unique chemical and physical properties to provide a controlled microenvironment for the culture of MSCs, laying the groundwork for future practical applications in regenerative medicine. This article currently describes and summarizes the sources, characteristics, and clinical trials of MSCs. In addition, it describes the differentiation of MSCs in various macromolecule-based hydrogel nanoarchitectonics and highlights the preclinical studies of MSCs-loaded hydrogel materials in regenerative medicine conducted over the past few years. Finally, the challenges and prospects of MSC-loaded hydrogels are discussed, and the future development of macromolecule-based hydrogel nanoarchitectonics is outlined by comparing the current literature.
    MeSH term(s) Regenerative Medicine ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Mesenchymal Stem Cells ; Biocompatible Materials/pharmacology ; Cell Differentiation
    Chemical Substances Hydrogels ; Biocompatible Materials
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125161
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    Zs.B 2374: Show issues Location:
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