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Article ; Online: TGF-β Regulation of T Cells.

Chen, WanJun

2023 Volume 41, Page(s) 483–512

Abstract: Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In ... ...

Abstract	Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4
MeSH term(s)	Animals ; Humans ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Immunity, Innate ; Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Transforming Growth Factor beta1
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-101921-045939
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Book ; Online: Statistical Machine Learning for Human Behaviour Analysis

Moeslund, Thomas / Escalera, Sergio / Anbarjafari, Gholamreza / Nasrollahi, Kamal / Wan, Jun

2020

Keywords	History of engineering & technology ; multi-objective evolutionary algorithms ; rule-based classifiers ; interpretable machine learning ; categorical data ; hand sign language ; deep learning ; restricted Boltzmann machine (RBM) ; multi-modal ; profoundly deaf ; noisy image ; ensemble methods ; adaptive classifiers ; recurrent concepts ; concept drift ; stock price direction prediction ; toe-off detection ; gait event ; silhouettes difference ; convolutional neural network ; saliency detection ; foggy image ; spatial domain ; frequency domain ; object contour detection ; discrete stationary wavelet transform ; attention allocation ; attention behavior ; hybrid entropy ; information entropy ; single pixel single photon image acquisition ; time-of-flight ; action recognition ; fibromyalgia ; Learning Using Concave and Convex Kernels ; Empatica E4 ; self-reported survey ; speech emotion recognition ; 3D convolutional neural networks ; k-means clustering ; spectrograms ; context-aware framework ; accuracy ; false negative rate ; individual behavior estimation ; statistical-based time-frequency domain and crowd condition ; emotion recognition ; gestures ; body movements ; Kinect sensor ; neural networks ; face analysis ; face segmentation ; head pose estimation ; age classification ; gender classification ; singular point detection ; boundary segmentation ; blurring detection ; fingerprint image enhancement ; fingerprint quality ; speech ; committee of classifiers ; biometric recognition ; multimodal-based human identification ; privacy ; privacy-aware
Size	1 electronic resource (300 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044282
ISBN	9783039362295 ; 3039362291
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Gene copy number, gene configuration and LC/HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines.

Lee, Zion / Wan, Jun / Shen, Amy / Barnard, Gavin

Biotechnology progress

2024 , Page(s) e3433

Abstract: The augmentation of transgene copy numbers is a prevalent approach presumed to enhance transcriptional activity and product yield. CHO cell lines engineered via targeted integration (TI) offer an advantageous platform for investigating the interplay ... ...

Abstract	The augmentation of transgene copy numbers is a prevalent approach presumed to enhance transcriptional activity and product yield. CHO cell lines engineered via targeted integration (TI) offer an advantageous platform for investigating the interplay between gene copy number, mRNA abundance, product yield, and product quality. Our investigation revealed that incrementally elevating the gene copy numbers of both IgG heavy chain (HC) and light chain (LC) concurrently resulted in the attainment of plateaus in mRNA levels and product titers, notably occurring beyond four to five gene copies integrated at the same TI site. Furthermore, maintaining a fixed gene copy number while varying the position of genes within the vector influenced the LC/HC mRNA ratio, which subsequently exerted a substantial impact on product titer. Moreover, manipulation of the LC/HC gene ratio through the introduction of surplus LC gene copies led to heightened LC mRNA expression and a reduction in the levels of high molecular weight species. It is noteworthy that the effects of excess LC on product titer were dependent on the specific molecule under consideration. The strategic utilization of PCR tags enabled precise quantification of transcription from each expression slot within the vector, facilitating the identification of highly expressive and less expressive slots. Collectively, these findings significantly enhance our understanding of stable antibody production in TI CHO cell lines.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	165657-0
ISSN	1520-6033 ; 8756-7938
ISSN (online)	1520-6033
ISSN	8756-7938
DOI	10.1002/btpr.3433
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Article ; Online: Dual Balanced Class-Incremental Learning With im-Softmax and Angular Rectification.

Zhi, Ruicong / Meng, Yicheng / Hou, Junyi / Wan, Jun

IEEE transactions on neural networks and learning systems

2024 Volume PP

Abstract: Owing to the superior performances, exemplar-based methods with knowledge distillation (KD) are widely applied in class incremental learning (CIL). However, it suffers from two drawbacks: 1) data imbalance between the old/learned and new classes causes ... ...

Abstract	Owing to the superior performances, exemplar-based methods with knowledge distillation (KD) are widely applied in class incremental learning (CIL). However, it suffers from two drawbacks: 1) data imbalance between the old/learned and new classes causes the bias of the new classifier toward the head/new classes and 2) deep neural networks (DNNs) suffer from distribution drift when learning sequence tasks, which results in narrowed feature space and deficient representation of old tasks. For the first problem, we analyze the insufficiency of softmax loss when dealing with the problem of data imbalance in theory and then propose the imbalance softmax (im-softmax) loss to relieve the imbalanced data learning, where we re-scale the output logits to underfit the head/new classes. For another problem, we calibrate the feature space by incremental-adaptive angular margin (IAAM) loss. The new classes form a complete distribution in feature space yet the old are squeezed. To recover the old feature space, we first compute the included angle of normalized features and normalized anchor prototypes, and use the angle distribution to represent the class distribution, then we replenish the old distribution with the deviation from the new. Each anchor prototype is predefined as a learnable vector for a designated class. The proposed im-softmax reduces the bias in the linear classification layer. IAAM rectifies the representation learning, reduces the intra-class distance, and enlarges the inter-class margin. Finally, we seamlessly combine the im-softmax and IAAM in an end-to-end training framework, called the dual balanced class incremental learning (DBL), for further improvements. Experiments demonstrate the proposed method achieves state-of-the-art (SOTA) performances on several benchmarks, such as CIFAR10, CIFAR100, Tiny-ImageNet, and ImageNet-100.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2024.3368341
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Article ; Online: Impact of obesity on outcomes of rotator cuff repair: A systematic review and meta-analysis.

Ma, Xiaojun / Shen, Jia / Wan, Jun

PloS one

2024 Volume 19, Issue 3, Page(s) e0299125

Abstract: Background: To synthesize the existing evidence on the association between obesity and rotator cuff repair outcomes such as pain, shoulder function, range of motion, and complications.: Methods: We searched PubMed, EMBASE, and Scopus databases for ... ...

Abstract	Background: To synthesize the existing evidence on the association between obesity and rotator cuff repair outcomes such as pain, shoulder function, range of motion, and complications. Methods: We searched PubMed, EMBASE, and Scopus databases for relevant observational studies (cohort and case-control) and randomized controlled trials (RCTs). The target population in the included studies comprised adults who had undergone rotator cuff repair procedures. The outcomes of interest were functional outcomes (such as range of motion), pain scores, patient-reported outcome measures, and complication rates (such as re-repair and readmission rates). We applied random-effects models and calculated pooled effect sizes reported as standardized mean differences (SMDs) or relative risks (RRs) with 95% confidence intervals. Results: We analysed data from 11 studies. In most, the follow-up periods ranged from 12 to 60 months. Obese individuals experienced greater pain (SMD 0.30; 95% CI, 0.10, 0.50) and lower shoulder function (SMD -0.33; 95% CI, -0.54, -0.12) than other individuals in the long-term post-operative follow-up. Obese individuals also had higher risks of complications (RR 1.48; 95% CI, 1.11, 1.98) and readmission (RR 1.35; 95% CI, 1.27, 1.43), but a similar likelihood of re-repair (RR, 1.27; 95% CI, 0.82, 1.95) than non-obese/normal BMI individuals. While the forward flexion and external rotation functions were comparable, obese individuals displayed less internal rotation function than other individuals (SMD -0.59; 95% CI, -0.87, -0.30). Conclusion: Obesity was associated with unfavourable outcomes after rotator cuff surgery, including increased pain, reduced shoulder function, high risks of complications, and readmission. These findings emphasize the importance of addressing obesity-related factors to improve post-operative outcomes.
MeSH term(s)	Adult ; Humans ; Rotator Cuff/surgery ; Rotator Cuff Injuries/complications ; Rotator Cuff Injuries/surgery ; Shoulder ; Shoulder Pain/complications ; Range of Motion, Articular ; Arthroscopy/methods ; Obesity/complications ; Treatment Outcome
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299125
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A potential treatment of COVID-19 with TGF-β blockade.

Chen, WanJun

International journal of biological sciences

2020 Volume 16, Issue 11, Page(s) 1954–1955

MeSH term(s)	COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Fibrosis/drug therapy ; Humans ; Immunotherapy ; Inflammation/drug therapy ; Lung/immunology ; Lung/pathology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Transforming Growth Factor beta/antagonists & inhibitors
Chemical Substances	Transforming Growth Factor beta
Keywords	covid19
Language	English
Publishing date	2020-04-21
Publishing country	Australia
Document type	Editorial ; Research Support, N.I.H., Intramural
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.46891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young.

Gauthier, Thierry / Chen, WanJun

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2022 Volume 42, Issue 12, Page(s) 643–654

Abstract: Interferon gamma (IFN-γ) and transforming growth factor beta (TGF-β), both pleiotropic cytokines, have been long studied and described as critical mediators of the immune response, notably in T cells. One of the investigators who made seminal and ... ...

Abstract	Interferon gamma (IFN-γ) and transforming growth factor beta (TGF-β), both pleiotropic cytokines, have been long studied and described as critical mediators of the immune response, notably in T cells. One of the investigators who made seminal and critical discoveries in the field of IFN-γ biology is Dr. Howard Young. In this review, we provide an overview of the biology of IFN-γ as well as its role in cancer and autoimmunity with an emphasis on Dr. Young's critical work in the field. We also describe how Dr. Young's work influenced our own research studying the role of TGF-β in the modulation of immune responses.
MeSH term(s)	Interferon-gamma ; Transforming Growth Factor beta ; Cytokines ; Tumor Cells, Cultured ; Immunity
Chemical Substances	Interferon-gamma (82115-62-6) ; Transforming Growth Factor beta ; Cytokines
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Intramural
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2022.0132
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Zs.A 1748: Show issues

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Article ; Online: MiR-449b-5p Ameliorates Hypoxia-induced Cardiomyocyte Injury through Activating PI3K/AKT Pathway by Targeting BCL2L13.

Jiang, Yang / Liu, Zeyan / Ye, Li / Cheng, Jinglin / Wan, Jun

Applied biochemistry and biotechnology

2024

Abstract: Recent reports show miR-449b-5p reduces liver and renal ischemia/reperfusion (I/R) injury, but its effects on hypoxia-induced cardiomyocyte injury in ischemic heart disease are still unknown. In this study, AC16 human cardiomyocytes underwent hypoxic ... ...

Abstract	Recent reports show miR-449b-5p reduces liver and renal ischemia/reperfusion (I/R) injury, but its effects on hypoxia-induced cardiomyocyte injury in ischemic heart disease are still unknown. In this study, AC16 human cardiomyocytes underwent hypoxic conditions for durations of 24, 48, and 72 h. We observed that miR-449b-5p expression was significantly downregulated in hypoxic AC16 cardiomyocytes. Elevating the levels of miR-449b-5p in these cells resulted in enhanced cell survival, diminished release of LDH, and a reduction in cell apoptosis and oxidative stress using CCK-8, LDH assays, flow cytometry, TUNEL staining, and various commercial kits. Conversely, reducing miR-449b-5p levels resulted in the opposite effects. Through bioinformatics analysis and luciferase reporter assays, BCL2-like 13 (BCL2L13) was determined to be a direct target of miR-449b-5p. Inhibiting BCL2L13 greatly inhibited hypoxia-induced cell viability loss, LDH release, cell apoptosis, and excessive production of oxidative stress, whereas increasing BCL2L13 negated miR-449b-5p's protective impact in hypoxic AC16 cardiomyocytes. Additionally, miR-449b-5p elevated the levels of the proteins p-PI3K, p-AKT, and Bcl-2, while decreasing Bax expression in hypoxic AC16 cardiomyocytes by targeting BCL2L13. In summary, the research indicates that the protective effects of miR-449b-5p are facilitated through the activation of the PI3K/AKT pathway, which promotes cell survival, and by targeting BCL2L13, which inhibits apoptosis, offering a potential therapeutic strategy for ischemic heart disease by mitigating hypoxia-induced cardiomyocyte injury.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-024-04931-5
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Article ; Online: Preparation of Mn-doped sludge biochar and its catalytic activity to persulfate for phenol removal.

Yan, Chongchong / Yu, Chao / Ti, Xueyi / Bao, Kai / Wan, Jun

Environmental science and pollution research international

2024 Volume 31, Issue 12, Page(s) 18737–18749

Abstract: In recent years, the increasing prevalence of phenolic pollutants emitted into the environment has posed severe hazards to ecosystems and living organisms. Consequently, there is an urgent need for a green and efficient method to address environmental ... ...

Abstract	In recent years, the increasing prevalence of phenolic pollutants emitted into the environment has posed severe hazards to ecosystems and living organisms. Consequently, there is an urgent need for a green and efficient method to address environmental pollution. This study utilized waste sludge as a precursor and employed a hydrothermal-calcination co-pyrolysis method to prepare manganese (Mn)-doped biochar composite material (Mn@SBC-HP). The material was used to activate peroxydisulfate (PDS) for the removal of phenol. The study investigated various factors (such as the type and amount of doping metal, pyrolysis temperature, catalyst dosage, PDS dosage, pH value, initial phenol concentration, inorganic anions, and salinity) affecting phenol removal and the mechanisms within the Mn@SBC-HP/PDS system. Results indicated that under optimal conditions, the Mn@SBC-HP/PDS system achieved 100% removal of 100 mg/L phenol within 180 min, with a TOC removal efficiency of 82.7%. Additionally, the phenol removal efficiency of the Mn@SBC-HP/PDS system remained above 90% over a wide pH range (3-9). Free radical quenching experiments and electron spin resonance (ESR) results suggested that hydroxyl radicals (·OH) and sulfate radicals (SO
MeSH term(s)	Phenol ; Sewage ; Manganese ; Ecosystem ; Water Pollutants, Chemical/analysis ; Phenols ; Charcoal/chemistry ; Environmental Pollutants ; Water
Chemical Substances	Phenol (339NCG44TV) ; Sewage ; biochar ; Manganese (42Z2K6ZL8P) ; Water Pollutants, Chemical ; Phenols ; Charcoal (16291-96-6) ; Environmental Pollutants ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32232-1
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Article ; Online: Mechanochemical Control of Symmetry Breaking in the Caenorhabditis elegans Zygote

Wan Jun Gan / Fumio Motegi

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 8

Abstract: Cell polarity is the asymmetric organization of cellular components along defined axes. A key requirement for polarization is the ability of the cell to break symmetry and achieve a spatially biased organization. Despite different triggering cues in ... ...

Abstract	Cell polarity is the asymmetric organization of cellular components along defined axes. A key requirement for polarization is the ability of the cell to break symmetry and achieve a spatially biased organization. Despite different triggering cues in various systems, symmetry breaking (SB) usually relies on mechanochemical modulation of the actin cytoskeleton, which allows for advected movement and reorganization of cellular components. Here, the mechanisms underlying SB in Caenorhabditis elegans zygote, one of the most popular models to study cell polarity, are reviewed. A zygote initiates SB through the centrosome, which modulates mechanics of the cell cortex to establish advective flow of cortical proteins including the actin cytoskeleton and partitioning defective (PAR) proteins. The chemical signaling underlying centrosomal control of the Aurora A kinase–mediated cascade to convert the organization of the contractile actomyosin network from an apolar to polar state is also discussed.
Keywords	symmetry breaking ; polarization ; cortical contractility ; Aurora-A ; Caenorhabditis elegans ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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