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Article ; Online: 3D-printed microfluidic device for high-throughput production of lipid nanoparticles incorporating SARS-CoV-2 spike protein mRNA.

Lin, Wan-Zhen Sophie / Bostic, William Kristian Vu / Malmstadt, Noah

2024 Volume 24, Issue 2, Page(s) 162–170

Abstract: Lipid nanoparticles (LNPs) are drug carriers for protecting nucleic acids for cellular delivery. The first mRNA vaccines authorized by the United States Food and Drug Administration are the mRNA-1273 (Moderna) and BNT162b (BioNTech/Pfizer) vaccines ... ...

Abstract	Lipid nanoparticles (LNPs) are drug carriers for protecting nucleic acids for cellular delivery. The first mRNA vaccines authorized by the United States Food and Drug Administration are the mRNA-1273 (Moderna) and BNT162b (BioNTech/Pfizer) vaccines against coronavirus disease 2019 (COVID-19). We designed a 3D printed Omnidirectional Sheath-flow Enabled Microfluidics (OSEM) device for producing mRNA-loaded LNPs that closely resemble the Moderna vaccine: we used the same lipid formulations to encapsulate mRNA encoding SARS-CoV-2 spike protein. The OSEM device is made of durable methacrylate-based materials that can support flow rates in the mL min
MeSH term(s)	United States ; Humans ; Spike Glycoprotein, Coronavirus/genetics ; RNA, Messenger/genetics ; COVID-19 ; SARS-CoV-2/genetics ; Nanoparticles/chemistry ; Liposomes ; Lab-On-A-Chip Devices ; Printing, Three-Dimensional
Chemical Substances	Lipid Nanoparticles ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; RNA, Messenger ; Liposomes
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d3lc00520h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Amplitude Reordering Accelerates the Adaptive Variational Quantum Eigensolver Algorithms.

Lan, Zhihao / Liang, WanZhen

Journal of chemical theory and computation

2022 Volume 18, Issue 9, Page(s) 5267–5275

Abstract: The variational quantum eigensolver (VQE) algorithm can simulate the chemical systems such as molecules in the noisy-intermediate-scale quantum devices and shows promising applications in quantum chemistry simulations. The accuracy and computational cost ...

Abstract	The variational quantum eigensolver (VQE) algorithm can simulate the chemical systems such as molecules in the noisy-intermediate-scale quantum devices and shows promising applications in quantum chemistry simulations. The accuracy and computational cost of the VQE simulations are determined by the underlying ansatz. Therefore, the most important issue is to generate a compact and accurate ansatz, which requires a shallower parametric quantum circuit and can achieve an acceptable accuracy. The newly developed adaptive algorithms (AAs) such as the adaptive derivative-assembled pseudo-Trotter VQE (ADAPT-VQE) can solve this issue via generating compact and accurate ansatzes. However, these AAs show very low computational efficiency because they require a large number of additional measurements. Here we propose an amplitude reordering (AR) strategy to accelerate the promising but expensive AAs by adding operators in a "batched" fashion in a way that their order is still quasi-optimal. We first introduce the AR method into ADAPT-VQE and build the AR-ADAPT-VQE algorithm. We then endow the energy-sorting VQE (ES-VQE) algorithm with the adaptive feature and introduce the AR into AES-VQE to form the AR-AES-VQE algorithm. To demonstrate the performance of these algorithms, we calculate the dissociation curves of three small molecules, LiH, linear BeH
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.2c00403
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Article ; Online: Role of SLC39A6 in the development and progression of liver cancer.

Wan, Zhen / Wang, Xuzhen

Oncology letters

2022 Volume 23, Issue 3, Page(s) 77

Abstract: Liver cancer is one of the most common malignant solid tumor types worldwide. The solute carrier (SLC)39A family is a main member of the SLC group of membrane transport proteins, which transfer zinc to the cytoplasm when cells are depleted of zinc; thus, ...

Abstract	Liver cancer is one of the most common malignant solid tumor types worldwide. The solute carrier (SLC)39A family is a main member of the SLC group of membrane transport proteins, which transfer zinc to the cytoplasm when cells are depleted of zinc; thus, it may provide a novel therapeutic target for human cancer. However, the prognostic value of SLC39A genes in patients with liver cancer has remained elusive. Therefore, the present study aimed to explore whether SLC39A family genes are associated with the survival rate of patients with liver cancer and to investigate the role of key genes of the SLC39A family in liver cancer. The mRNA expression of the SLC39A family in liver cancer was obtained from the UALCAN database. Survival curve analysis was performed to investigate the prognostic value of SLC39A family genes in the overall survival of patients with liver cancer. In addition to the bioinformatics analysis, SLC39A6 was knocked down in HepG2 and Hep3B cells to examine the effect on the proliferation, migration and invasion of liver cancer cells. The results suggested that SLC39A6 was significantly upregulated in liver cancer tissues compared with normal liver tissues. High expression of SLC39A6 was significantly associated with poor overall survival of patients with liver cancer. Furthermore, knockdown of SLC39A6 inhibited the proliferation, migration and invasion of liver cancer cells
Language	English
Publishing date	2022-01-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2022.13197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-sensitivity fiber optic graphene resonant accelerometer.

Liu, Yujian / Li, Cheng / Li, Jing / Wan, Zhen / Fan, Shangchun

Optics letters

2024 Volume 49, Issue 7, Page(s) 1790–1793

Abstract: This study proposes a high-sensitivity resonant graphene accelerometer based on a pressure-induced sensing mechanism. The accelerometer design encompasses an optical fiber and a vacuum-sealed graphene resonator affixed to a silicon sensitive film, ... ...

Abstract	This study proposes a high-sensitivity resonant graphene accelerometer based on a pressure-induced sensing mechanism. The accelerometer design encompasses an optical fiber and a vacuum-sealed graphene resonator affixed to a silicon sensitive film, incorporating a proof mass. This indirect sensing mechanism effectively mitigates the vibration mode aliasing of graphene and the proof mass while ensuring a minimal energy loss in the operating resonator. The mechanical vibration of graphene is excited and detected through an all-fiber optical system. Notably, the proposed sensor demonstrates a sensitivity of 34.3 kHz/g within the range of 0-3.5 g, which is eight times higher than comparable accelerometers utilizing a proof mass on a graphene membrane. This work exhibits a novel, to the best of our knowledge, approach to an acceleration measurement using 2D resonators, exhibiting distinct advantages in terms of compact size and heightened sensitivity.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.521357
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Article ; Online: Analytical derivative couplings within the framework of time-dependent density functional theory coupled with conductor-like polarizable continuum model: Formalism, implementation, and applications.

Huang, Xunkun / Pei, Zheng / Liang, WanZhen

The Journal of chemical physics

2023 Volume 158, Issue 4, Page(s) 44122

Abstract: The nonadiabatic phenomena, which are characterized by a strong coupling between electronic and nuclear motions, are ubiquitous. The nonadiabatic effect of the studied system can be significantly affected by the surrounding environment, such as solvents, ...

Abstract	The nonadiabatic phenomena, which are characterized by a strong coupling between electronic and nuclear motions, are ubiquitous. The nonadiabatic effect of the studied system can be significantly affected by the surrounding environment, such as solvents, in which such nonadiabatic process takes place. It is essential to develop the theoretical models to simulate these processes while accurately modeling the solvent environment. The time-dependent density functional theory (TDDFT) is currently the most efficient approach to describe the electronic structures and dynamics of complex systems, while the polarizable continuum model (PCM) represents one of the most successful examples among continuum solvation models. Here, we formulate the first-order derivative couplings (DCs) between the ground and excited states as well as between two excited states by utilizing time-independent equation of motion formalism within the framework of both linear response and spin flip formulations of TDDFT/CPCM (the conductor-like PCM), and implement the analytical DCs into the Q-CHEM electronic structure software package. The analytic implementation is validated by the comparison of the analytical and finite-difference results, and reproducing geometric phase effect in the protonated formaldimine test case. Taking 4-(N,N-dimethylamino)benzonitrile and uracil in the gas phase and solution as an example, we demonstrate that the solvent effect is essential not only for the excitation energies of the low-lying excited-states but also for the DCs between these states. Finally, we calculate the internal conversion rate of benzophenone in a solvent with DC being used. The current implementation of analytical DCs together with the existing analytical gradient and Hessian of TDDFT/PCM excited states allows one to study the nonadiabatic effects of relatively large systems in solutions with low computational cost.
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0130617
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Article ; Online: Why Do We Not Wear Masks Anymore during the COVID-19 Wave? Vaccination Precludes the Adoption of Personal Non-Pharmaceutical Interventions: A Quantitative Study of Taiwanese Residents.

Yang, Lee-Xieng / Lin, Chia-Yuan / Zhan, Wan-Zhen / Chiang, Bo-An / Chang, En-Chi

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines/therapeutic use ; Masks ; Cross-Sectional Studies ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020301
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Article ; Online: Probing Thermal Transport on a Suspended Ti

Wan, Zhen / Li, Cheng / Liu, Ronghui / Zhou, Wei / Fan, Wenjing / Huang, Chuanxue / Liu, Yang

ACS applied materials & interfaces

2024 Volume 16, Issue 4, Page(s) 4999–5008

Abstract: Two-dimensional (2D) ... ...

Abstract	Two-dimensional (2D) Ti
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16291
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Article ; Online: Identification of the interchromophore interaction in the electronic absorption and circular dichroism spectra of bis-phenanthrenes.

Xu, Yuchuan / Huang, Xunkun / Wang, Yu-Chen / Zhao, Yi / Liang, WanZhen

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 7, Page(s) 6155–6163

Abstract: We characterize the low-lying excited electronic states of a series of bis-phenanthrenes using our newly developed diabatic scheme called the fragment particle-hole density (FPHD) method and calculate both the electronic absorption and circular dichroism ...

Abstract	We characterize the low-lying excited electronic states of a series of bis-phenanthrenes using our newly developed diabatic scheme called the fragment particle-hole density (FPHD) method and calculate both the electronic absorption and circular dichroism (ECD) spectra using the time-dependent density functional theory (TDDFT) and the FPHD-based exciton model which couples intrachromophore local excitations (LEs) and the interchromophore charge-transfer excitations (CTEs). TDDFT treats each bis-phenanthrene as a single molecule while the mixed LE-CTE exciton model partitions the molecule into two phenanthrene-based aromatic moieties, and then applies the electronic coupling between the various quasi-diabatic states to cover the interactions. It is found that TDDFT and the mixed LE-CTE model reproduce all experimentally observed trends in the spectral profiles, and the hybridization between LE and CTE states is displayed differently in absorption and ECD spectral intensities, as it usually decreases the absorption maxima and affects the positive/negative extrema of the ECD irregularly. By comparing the results yielded by the LE-CTE model with and without the LE-CTE coupling, we identify the contribution of CTE on the main dipole-allowed transitions.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05684h
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Article ; Online: Clinical Outcomes of Tooth- and Implant-Supported Restorations Performed in a University-based Undergraduate Program after 13-15 Years.

Ermatinger, Sarah / Lee, Wan-Zhen / Thoma, Daniel S / Hüsler, Jürg / Hämmerle, Christoph H F / Naenni, Nadja

The International journal of prosthodontics

2024 , Page(s) 1–23

Abstract: Aims: To assess the clinical concept of patient treatment with fixed tooth- and implant-supported restorations in a university-based undergraduate program after 13 - 15 years.: Methods: Thirty patients (mean age 56 years) who had received multiple ... ...

Abstract	Aims: To assess the clinical concept of patient treatment with fixed tooth- and implant-supported restorations in a university-based undergraduate program after 13 - 15 years. Methods: Thirty patients (mean age 56 years) who had received multiple tooth- and implant-supported restorations were recalled after 13-15 years. The clinical assessment comprised of biological and technical parameters as well as patient satisfaction. Data were analyzed descriptively and the 13-15-year survival rates for tooth- and implant-supported single crowns and fixed dental prostheses were calculated. Results: The survival rate of tooth-supported restorations amounted to 88.3% (single crowns) and 69.6% (fixed dental prostheses); in implants it reached 100% for all types of reconstructions. Overall, 92.4% of all reconstructions were free of technical complications. The most common technical complication was chipping of the veneering ceramic (tooth-supported restorations: 5.5%; implant-supported restorations: 13-15.9%) regardless of the material used. At teeth, increased probing depth ≥5mm was the most frequent biological complication (22.8%), followed by endodontic complications of root-canal treated teeth (14%) and loss of vitality at abutment teeth (8.2%). Peri-implantitis was diagnosed in 10.2% of implants. Conclusion: Results of this study indicate that the clinical concept implemented in the undergraduate program and performed by undergraduate students works well. The clinical outcomes are similar to those reported in the literature. In general, the majority of biological complications occurrs in reconstructed teeth, whereas implant-supported restorations are more prone to technical complications.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	645046-5
ISSN	1942-4426 ; 0893-2174
ISSN (online)	1942-4426
ISSN	0893-2174
DOI	10.11607/ijp.8264
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Article ; Online: People with passive sleep delay have more severe depression and sleep problems than those with active sleep delays-a cross-sectional study after the COVID-19 pandemic

Wan, Zhen-Yu / Xiao, Ling / Wang, Gao-Hua

Heliyon. 2022 Dec., v. 8, no. 12 p.e11805-

2022

Abstract: This study was designed to investigate the effect of different types of sleep delay in depression and sleep characteristics after the pandemic. Meanwhile, risk factors for depression were also explored. The survey was conducted in Wuhan from March 1 to ... ...

Abstract	This study was designed to investigate the effect of different types of sleep delay in depression and sleep characteristics after the pandemic. Meanwhile, risk factors for depression were also explored. The survey was conducted in Wuhan from March 1 to May 30, 2021, and participants were recruited through a snowball process. A total of 1,583 people with sleep delays responded to the invitation, of which 1,296 were enrolled. Participants filled out a questionnaire including social demographics, sleep characteristics, Social Support Rating Scale (SSRS), Pittsburgh Sleep Quality Index (PSQI) and Patient Health Questionnaire-9 (PHQ-9). There were no significant differences in sex, social support and level of education between the two types of sleep delay (p = 0.961, p = 0.110, p = 0.090), but the average age of the passive sleep delay group was higher (p = 0.015). And most people with active sleep delay were caused by the use of electronic devices (73.6%), while most people with passive sleep delay were caused by work or study tasks (73.2%), with a significant difference between the two groups (p < 0.001). People who actively delayed sleep had more regular sleep (p < 0.001), better sleep quality and longer sleep duration (p < 0.001, p < 0.001). In addition, although they delayed sleep more frequently (p < 0.001), they had significantly lower depression degree than people who passively delayed sleep (p < 0.001). Passive sleep delays, usually caused by work or study, has higher levels of depression and more adverse sleep behaviors than active sleep delay. The findings help further understand the effects of delayed sleep and provide insight for people with delayed sleep to evaluate their own condition. Future studies are required to standardize and accurately classify sleep delay and further explore it.
Keywords	COVID-19 infection ; cross-sectional studies ; demographic statistics ; educational status ; pandemic ; patients ; people ; questionnaires ; risk ; sleep ; social support ; surveys ; Depression ; Sleep delay ; Sleep duration ; Sleep quality
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e11805
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